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4.         Cited References (Department Members in Bold)

Andrews-Zwilling, Y.S., Kawabe, H., Reim, K., Varoqueaux, F. and Brose, N. (2006) Binding to Rab3A-Interacting-Molecule RIM Regulates the Presynaptic Recruitment of Munc13-1 and ubMunc13-2. J. Biol. Chem. 281, 19720-19731.

Augustin, I., Rosenmund, C., Südhof, T.C. and Brose, N. (1999) Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles. Nature 400, 457-461.

Basu, J., Betz, A., Brose, N. and Rosenmund, C. (2007) Munc13-1 C1-domain activation lowers the energy barrier for synaptic vesicle fusion. J. Neurosci. 27, 1200-1210.

Betz, A., Thakur, P., Junge, H.J., Ashery, U., Rhee, J.-S.,  Scheuss, V., Rosenmund, C., Rettig, J. and Brose, N. (2001) Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. Neuron 30, 183-196.

Brose, N. (2007) Autismus - wenn Nervenzellen kontaktscheu sind. Biospektrum 06.07, 614-616.

Brose, N. (2008a) Altered Complexin expression in psychiatric and neurological disorders: Cause or consequence? Mol. Cells 25, 7-19.

Brose, N. (2008b) For better of for worse: Complexins regulate SNARE function and vesicle fusion. Traffic, in press.

Brose, N., Betz, A. and Wegmeyer, H. (2004) Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals. Curr. Op. Neurobiol. 14, 328-340.

Brose, N. and Rosenmund, C. (2002) Move over protein kinase C, you’ve got company: alternative cellular effectors of diacylglycerol and phorbol esters. J. Cell Sci. 115, 4399-4411.

Brose, N., Rosenmund, C. and Rettig, J. (2000) Regulation of transmitter release by Unc-13 and its homologues. Curr. Op. Neurobiol. 10, 303-311.

Chubykin, A.A., Atasoy, D., Etherton, M.R., Brose, N., Kavalali, E.T., Gibson, J.R. and Südhof, T.C. (2007) Activity-dependent validation of excitatory vs. inhibitory synapses by Neuroligin-1 vs. Neuroligin-2. Neuron 54, 919-931.

Dimova, K., Kawabe, H., Betz, A., Brose, N. and Jahn, O. (2006) Characterization of the Munc13-calmodulin interaction by photoaffinity labeling. Biochim. Biophys. Acta (Mol. Cell Res.) 1763, 1256-1265.

Fouladkou, F., Landry, T., Kawabe, H., Neeb, A., Lu, C., Brose, N., Stambolic, V. and Rotin, D. (2008) The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc. Natl. Acad. Sci. U.S.A., in press.

Jamain, S., Radyushkin, K., Hammerschmidt, K., Granon, S., Boretius, S., Varoqueaux, F., Ramanantsoa, N., Gallego, J., Ronnenberg, A., Winter, D., Frahm, J., Fischer, J., Bourgeron, T., Ehrenreich, H. and Brose, N. (2008) Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc. Natl. Acad. Sci. U.S.A. 105, 1710-1715.

Jockusch, W., Speidel, D., Sigler, A., Sorensen, J., Varoqueaux, F., Rhee, J.-S. and Brose, N. (2007) CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell 131, 796-808.

Junge, H., Rhee, J.-S., Jahn, O., Varoqueaux, F., Spiess, J., Waxham, M.N., Rosenmund, C. and Brose, N. (2004) Calmodulin and Munc13 form a Ca2+-sensor/effector complex that controls short-term synaptic plasticity. Cell 118, 389-401.

Kalla, S., Stern, M., Basu, J., Varoqueaux, F., Reim, K., Rosenmund, C., Ziv, N.E. and Brose, N. (2006) Molecular dynamics of a presynaptic active zone protein studied in Munc13-1-EYFP knock-in mutant mice. J. Neurosci. 26, 13054-13066.

Kang, L., He, Z., Xu, P., Fan, J., Betz, A., Brose, N. and Xu, T. (2006) Munc13-1 is required for the sustained release of insulin from pancreatic b cells. Cell Metabol. 3, 463-468.

Kwan, E.P., Xie, L., Sheu, L., Nolan, C.J., Prentki, M., Betz, A., Brose, N. and Gaisano, H.Y. (2006) Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes 55, 1421-1429.

Reim, K., Mansour, M., Varoqueaux, F., McMahon, H.T., Südhof, T.C., Brose, N. and Rosenmund, C. (2001) Complexins regulate a late step in Ca2+-dependent neurotransmitter release. Cell 104, 71-81.

Reim, K., Wegmeyer, H., Brandstätter, J.H., Xue, M., Rosenmund, C., Dresbach, T., Hofmann, K. and Brose, N. (2005) Structurally and functionally unique Complexins at retinal ribbon synapses. J. Cell Biol. 169, 669-680.

Rhee, J.-S., Betz, A., Pyott, S., Reim, K., Varoqueaux, F., Augustin, I., Hesse, D., Südhof, T.C., Takahashi, M., Rosenmund, C. and Brose, N. (2002) b Phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell 108, 121-133.

Rosenmund, C., Rettig, J. and Brose, N. (2003) Molecular mechanisms of active zone function. Curr. Op. Neurobiol. 13, 509-519.

Rosenmund, C., Sigler, A., Augustin, I., Reim, K., Brose, N. and Rhee, J.-S. (2002) Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Neuron 33, 411-424.

Song, J., Ichtchenko, K., Südhof, T.C. and Brose, N. (1999) Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses. Proc. Natl. Acad. Sci. U.S.A. 96, 1100-1105.

Speidel, D., Bruederle, C.E., Enk, C., Voets, T., Varoqueaux, F., Reim, K., Becherer, B., Fornai, F., Holighaus, Y., Weihe, E., Bruns, D., Brose, N. and Rettig, J. (2005) CAPS1 regulates catecholamine loading of large dense-core vesicles. Neuron 46, 75-88.

Speidel, D., Salehi, A., Obermueller, S., Lundquist, I., Brose, N., Renström, E. and Rorsman, P. (2008) CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic b-cells. Cell Metabol. 7, 57-67.

Stevens, D.R., Wu, Z.-X., Matti, U., Junge, H.J., Schirra, C., Becherer, U., Wojcik, S.M., Brose, N. and Rettig, J. (2005) Identification of the minimal protein domain required for priming activity of Munc13-1. Curr. Biol. 15, 2243-2248.

Varoqueaux, F., Aramuni, G., Rawson, R.L., Mohrmann, R., Missler, M., Gottmann, K., Zhang, W., Südhof, T.C. and Brose, N. (2006) Neuroligins determine synapse maturation and function. Neuron 51, 741-754.

Varoqueaux, F., Sigler, A., Rhee, J.-S., Brose, N., Enk, C., Reim, K. and Rosenmund, C. (2002) Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc. Natl. Acad. Sci. U.S.A. 99, 9037-9042.

Wegmeyer, H., Egea, J., Rabe, N., Gezelius, H., Filosa, A., Enjin, A., Varoqueaux, F., Deininger, K., Schnütgen, F., Brose, N., Klein, R., Kullander, K. and Betz, A. (2007) EphA4-dependent axon guidance is mediated by the RacGAP a2-Chimaerin. Neuron 55, 756-767.

Wojcik, S.M. and Brose, N. (2007) Regulation of membrane fusion in synaptic excitation-secretion coupling: Speed and accuracy matter. Neuron 55, 11-24.

Xue, M., Reim, K., Chen, X., Chao, H.T., Deng, H., Rizo, J., Brose, N. and Rosenmund, C. (2007) Distinct domains of Complexin I differentially regulate neurotransmitter release. Nat. Stuct. Mol. Biol. 14, 949-958.

Xue, M., Stradomska, A., Chen, H., Brose, N., Zhang, W., Rosenmund, C. and Reim, K. (2008) Complexins are facilitators of neurotransmitter release at mammalian central excitatory and inhibitory synapses. Proc. Natl. Acad. Sci. U.S.A. 105, 7875-7880.

Zikich, D., Mezer, A., Varoqueaux, F., Sheinin, A., Junge, H.J., Nachliel, E., Melamed, R., Brose, N., Gutman, M. and Ashery, U. (2008) Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulin. J. Neurosci. 28, 1949-1960.



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