Suche  |   Sitemap  |   Impressum  |   Kontakt  |    english   
Max-Planck-Gesellschaft
Max-Planck-Institut für Experimentelle Medizin
Forschung
Quintes, S., Brinkmann, B.G., Ebert, M., Fröb, F., Kungl, T., A. Arlt, F.A., Tarabykin, V., Huylebroeck, D., Meijer, D., Suter, U., Wegner, M., Sereda, M.W., and Nave, K.-A. (2016).
Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair.
Nat Neurosci. [Epub ahead of print]


Sociali G, Visigalli D, Prukop T, Cervellini I, Mannino E, Venturi C, Bruzzone S, Sereda MW, Schenone A (2016).
Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy.
Neurobiol Dis. pii: S0969-9961, 30173-30175


Ekins S, Litterman NK, Arnold RJ, Burgess RW, Freundlich JS, Gray SJ, Higgins JJ, Langley B, Willis DE, Notterpek L, Pleasure D, Sereda MW, Moore A (2015).
A brief review of recent Charcot-Marie-Tooth research and priorities.
F1000Res. 4, 53-53


Epplen DB, Prukop T, Nientiedt T, Albrecht P, Arlt FA, Stassart RM, Kassmann CM, Methner A, Nave KA, Werner HB, Sereda MW (2015).
Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease.
Ann Clin Transl Neurol. 2, 787-796


Pehlivan D, Beck CR, Okamoto Y, Harel T, Akdemir ZH, Jhangiani SN, Withers MA, Goksungur MT, Carvalho CM, Czesnik D, Gonzaga-Jauregui C, Wiszniewski W, Muzny DM, Gibbs RA, Rautenstrauss B, Sereda MW, Lupski JR (2015).
The role of combined SNV and CNV burden in patients with distal symmetric polyneuropathy.
Genet Med. 18, 443-451


Patzig J, Kusch K, Fledrich R, Eichel MA, Lüders KA, Möbius W, Sereda MW, Nave KA, Martini R, Werner HB (2015).
Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking.
Glia 64, 155-174


Prukop T, Epplen DB, Nientiedt T, Wichert SP, Fledrich R, Stassart RM, Rossner MJ, Edgar JM, Werner HB, Nave KA, Sereda MW (2014).
Progesterone Antagonist Therapy in a Pelizaeus-Merzbacher Mouse Model.
Am J Hum Genet. 94, 533-546


Mannil M, Solari A, Leha A, Pelayo-Negro AL, Berciano J, Schlotter-Weigel B, Walter MC, Rautenstrauss B, Schnizer TJ, Schenone A, Seeman P, Kadian C, Schreiber O, Angarita NG, Fabrizi GM, Gemignani F, Padua L, Santoro L, Quattrone A, Vita G, Calabrese D; CMT-TRIAAL/CMT-TRAUK Group, Young P, Laurà M, Haberlová J, Mazanec R, Paulus W, Beissbarth T, Shy ME, Reilly MM, Pareyson D, Sereda MW (2014).
Selected items from the Charcot-Marie-Tooth (CMT) Neuropathy Score and secondary clinical outcome measures serve as sensitive clinical markers of disease severity in CMT1A patients.
Neuromuscul Disord. 24, 1003-1017


Fledrich R, Stassart RM, Klink A, Rasch LM, Prukop T, Haag L, Czesnik D, Kungl T, Abdelaal TA, Keric N, Stadelmann C, Brück W, Nave KA, Sereda MW (2014).
Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A.
Nat Med. 20, 1055-1061


Avenali L, Narayanan P, Rouwette T, Cervellini I, Sereda M, Gomez-Varela D, Schmidt M (2014).
Annexin A2 Regulates TRPA1-Dependent Nociception.
J Neurosci. 34, 14506-14516


Chumakov I, Milet A, Cholet N, Primas G, Boucard A, Pereira Y, Graudens E, Mandel J, Laffaire J, Foucquier J, Glibert F, Bertrand V, Nave KA, Sereda MW, Vial E, Guedj M, Hajj R, Nabirotchkin S, Cohen D (2014).
Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy.
Orphanet J Rare Dis. 9, 201-201


Schwab MH, Sereda MW, Nave KA
Neuron–Glial Interactions.
In: RUBENSTEIN J. L. R. and RAKIC P. (ed.) Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing CNS and PNS, volume 1, pp. 851-869 Amsterdam: Elsevier. (2013)

Tönges L, Günther R, Suhr M, Jansen J, Balck A, Saal KA, Barski E, Nientied T, Götz AA, Koch JC, Mueller BK, Weishaupt JH, Sereda MW, Hanisch UK, Bähr M, Lingor P (2013).
Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis.
Glia 62, 217-232


Fledrich R, Schlotter-Weigel B, Schnizer TJ, Wichert SP, Stassart RM, Meyer Zu Hörste G, Klink A, Weiss BG, Haag U, Walter MC, Rautenstrauss B, Paulus W, Rossner MJ, Sereda MW (2012).
A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients.
Brain 135, 72-87


Makoukji J, Belle M, Meffre D, Stassart R, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F, Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C. (2012).
Lithium enhances remyelination of peripheral nerves.
Proc Natl Acad Sci U S A. 109, 3973-3978


Fünfschilling U, Supplie LM, Mahad D, Boretius S, Saab AS, Edgar J, Brinkmann BG, Kassmann CM, Tzvetanova ID, Möbius W, Diaz F, Meijer D, Suter U, Hamprecht B, Sereda MW, Moraes CT, Frahm J, Goebbels S, Nave KA (2012).
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.
Nature 485, 517-521


Goebbels S, Oltrogge JH, Wolfer S, Wieser GL, Nientiedt T, Pieper A, Ruhwedel T, Groszer M, Sereda MW, Nave KA (2012).
Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy.
EMBO Mol Med. 4, 486-499


Fledrich R, Stassart RM, Sereda MW (2012).
Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease.
Br Med Bull. 102, 89-113


Stassart RM, Fledrich R, Velanac V, Brinkmann BG, Schwab MH, Meijer D, Sereda MW, Nave KA (2012).
A role for Schwann cell-derived neuregulin-1 in remyelination.
Nat Neurosci. 16, 48-54


Kassmann CM, Quintes S, Rietdorf J, Möbius W, Sereda MW, Nientiedt T, Saher G, Baes M, Nave KA (2011).
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.
FEBS Lett. 585, 2205-2211


Gess B, Röhr D, Fledrich R, Sereda MW, Kleffner I, Humberg A, Nowitzki J, Strecker JK, Halfter H, Young P (2011).
Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system.
J Neurosci. 31, 17180-17192


Meyer Zu Horste G, Miesbach TA, Muller JI, Fledrich R, Stassart RM, Kieseier BC, Coleman MP, Sereda MW (2010).
The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration.
Neurobiol Dis. 42, 1-8


Schardt A, Brinkmann BG, Mitkovski M, Sereda MW, Werner HB, Nave KA (2009).
The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia.
J Neurosci Res. 87, 3465-3479


Leal A, Huehne K, Bauer F, Sticht H, Berger P, Suter U, Morera B, Del Valle G, Lupski JR, Ekici A, Pasutto F, Endele S, Barrantes R, Berghoff C, Berghoff M, Neundörfer B, Heuss D, Dorn T, Young P, Santolin L, Uhlmann T, Meisterernst M, Sereda MW, Stassart RM, Zu Horste GM, Nave KA, Reis A, Rautenstrauss B (2009).
Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models.
Neurogenetics 10, 275-287


Merkler D, Klinker F, Jürgens T, Glaser R, Paulus W, Brinkmann BG, Sereda MW, Stadelmann-Nessler C, Guedes RC, Brück W, Liebetanz D (2009).
Propagation of spreading depression inversely correlates with cortical myelin content.
Ann Neurol. 66, 355-365


Wessig C, Jestaedt L, Sereda MW, Bendszus M, Stoll G (2008).
Gadofluorine M-enhanced magnetic resonance nerve imaging: comparison between acute inflammatory and chronic degenerative demyelination in rats.
Exp Neurol 210, 137-143


Brinkmann BG, Agarwal A, Sereda MW, Garratt AN, Müller T, Wende H, Stassart RM, Nawaz S, Humml C, Velanac V, Radyushkin K, Goebbels S, Fischer TM, Franklin RJ, Lai C, Ehrenreich H, Birchmeier C, Schwab MH, Nave KA (2008).
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Neuron. 59, 581-595


Nave KA, Sereda MW, Ehrenreich H (2007).
Mechanisms of disease: inherited demyelinating neuropathies--from basic to clinical research.
Nat Clin Pract Neurol 3, 453-64


Ivanova N, Claeys KG, Deconinck T, Litvinenko I, Jordanova A, Auer-Grumbach M, Haberlova J, Löfgren A, Smeyers G, Nelis E, Mercelis R, Plecko B, Priller J, Zámecník J, Ceulemans B, Erichsen AK, Björck E, Nicholson G, Sereda MW, Seeman P, Kremensky I, Mitev V, De Jonghe P (2007).
Hereditary spastic paraplegia 3A associated with axonal neuropathy.
Arch. Neurol. 64, 706-13


Meyer zu Horste G, Prukop T, Liebetanz D, Mobius W, Nave KA, Sereda MW (2007).
Antiprogesterone therapy uncouples axonal loss from demyelination in a transgenic rat model of CMT1A neuropathy.
Ann. Neurol. 61, 61-72


Meyer zu Hörste G, Prukop T, Nave KA, Sereda MW (2006).
Myelin disorders: Causes and perspectives of Charcot-Marie-Tooth neuropathy.
J. Mol. Neurosci. 28, 77-88


Sereda MW, Nave KA (2006).
Animal models of Charcot-Marie-Tooth disease type 1A.
Neuromolecular Med. 8, 205-16


Vigo T, Nobbio L, Hummelen PV, Abbruzzese M, Mancardi G, Verpoorten N, Verhoeven K, Sereda MW, Nave KA, Timmerman V, Schenone A (2005).
Experimental Charcot-Marie-Tooth type 1A: a cDNA microarrays analysis.
Mol. Cell. Neurosci. 28, 703-14


Michailov GV, Sereda MW, Brinkmann BG, Fischer TM, Haug B, Birchmeier C, Role L, Lai C, Schwab MH, Nave KA (2004).
Axonal neuregulin-1 regulates myelin sheath thickness.
Science 304, 700-3


Grandis M, Leandri M, Vigo T, Cilli M, Sereda MW, Gherardi G, Benedetti L, Mancardi G, Abbruzzese M, Nave KA, Nobbio L, Schenone A (2004).
Early abnormalities in sciatic nerve function and structure in a rat model of Charcot-Marie-Tooth type 1A disease.
Exp. Neurol. 190, 213-23


Sereda MW, Meyer zu Hörste G, Suter U, Uzma N, Nave KA (2003).
Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A).
Nat. Med. 9, 1533-7


Schölz L, Sereda MW and Nave KA
Hereditäre Neuropathien
In: Schölz L, Riess O Neurogentik, Kohlhammer (2002)

Sereda MW, Schöls L and Nave KA
Molekulargenetische Grundlagen der Charcot-Marie-Tooth Neuropathie (CMT/HMSN).
In: Schöls L, Riess O Neurogenetik, Kohlhammer. (2002)

Schneider S, Bosse F, D'Urso D, Muller H, Sereda MW, Nave K, Niehaus A, Kempf T, Schnolzer M, Trotter J (2001).
The AN2 protein is a novel marker for the Schwann cell lineage expressed by immature and nonmyelinating Schwann cells.
J. Neurosci. 21, 920-33


Niemann S, Sereda MW, Suter U, Griffiths IR, Nave KA (2000).
Uncoupling of myelin assembly and schwann cell differentiation by transgenic overexpression of peripheral myelin protein 22.
J. Neurosci. 20, 4120-8


Niemann S, Sereda MW, Rossner M, Stewart H, Suter U, Meinck HM, Griffiths IR, Nave KA (1999).
The "CMT rat": peripheral neuropathy and dysmyelination caused by transgenic overexpression of PMP22.
Ann. N. Y. Acad. Sci. 883, 254-61


Werner H, Jung M, Klugmann M, Sereda M, Griffiths IR, Nave KA (1999).
Mouse models of myelin diseases.
Brain Pathol. 8, 771-93


Sereda MW (1999).
Altered protein synthesis in sciatic nerve by transgenic overexpression of PMP22 in the CMT rat.
Ann. N. Y. Acad. Sci. 883, 530-2


Sereda M, Griffiths I, Pühlhofer A, Stewart H, Rossner MJ, Zimmerman F, Magyar JP, Schneider A, Hund E, Meinck HM, Suter U, Nave KA (1996).
A transgenic rat model of Charcot-Marie-Tooth disease.
Neuron 16, 1049-60




© 2006, Max-Planck-Gesellschaft     realized by vokativ