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Max-Planck-Gesellschaft
Max-Planck-Institut für Experimentelle Medizin
Publikationen

zurück zu selected Publications


Alle Publikationen der Abteilung Neurogenetik


2018

Weil MT, Heibeck S, Töpperwien M, Tom Dieck S, Ruhwedel T, Salditt T, Rodicio MC, Morgan JR, Nave KA, Möbius W, Werner HB (2018).
Axonal ensheathment in the nervous system of lamprey: Implications for the evolution of myelinating glia.
J Neurosci. [Epub ahead of print]


Cathomas F, Azzinnari D, Bergamini G, Sigrist H, Buerge M, Hoop V, Wicki B, Goetze L, Soares S, Kukelova D, Seifritz E, Goebbels S, Nave KA, Said Ghandour M, Seoighe C, Hildebrandt T, Leparc G, Klein H, Stupka E, Hengerer B, Pryce CR (2018).
Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice.
Genes Brain Behav. [Epub ahead of print]


He X, Zhang L, Queme LF, Liu X, Lu A, Waclaw RR, Dong X, Zhou W, Kidd G, Yoon SO, Buonanno A, Rubin JB, Xin M, Nave KA, Trapp BD, Jankowski MP, Lu QR (2018).
A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration.
Nat Med. [Epub ahead of print]


Pan H, Oliveira B, Saher G, Dere E, Tapken D, Mitjans M, Seidel J, Wesolowski J, Wakhloo D, Klein-Schmidt C, Ronnenberg A, Schwabe K, Trippe R, Mätz-Rensing K, Berghoff S, Al-Krinawe Y, Martens H, Begemann M, Stöcker W, Kaup FJ, Mischke R, Boretius S, Nave KA, Krauss JK, Hollmann M, Lühder F, Ehrenreich H (2018).
Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model.
Mol Psychiatry. [Epub ahead of print]


Duchesne M, Danigo A, Richard L, Vallat JM, Attarian S, Gonnaud PM, Lacour A, Péréon Y, Stojkovic T, Nave KA, Bertrand V, Nabirotchkin S, Cohen D, Demiot C, Magy L (2018).
Skin Biopsy Findings in Patients With CMT1A: Baseline Data From the CLN-PXT3003-01 Study Provide New Insights Into the Pathophysiology of the Disorder.
J Neuropathol Exp Neurol. [Epub ahead of print]


Cantuti-Castelvetri L, Fitzner D, Bosch-Queralt M, Weil MT, Su M, Sen P, Ruhwedel T, Mitkovski M, Trendelenburg G, Lütjohann D, Möbius W, Simons M (2018).
Defective cholesterol clearance limits remyelination in the aged central nervous system.
Science 359, 684-688


Nave KA, Ehrenreich H (2018).
A bloody brake on myelin repair.
Nature 553, 31-32


Micu I, Plemel JR, Caprariello AV, Nave KA, Stys PK (2018).
Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system.
Nat Rev Neurosci. 19, 49-58


2017

Bang ML, Vainshtein A, Yang HJ, Eshed-Eisenbach Y, Devaux J, Werner HB, Peles E (2017).
Glial M6B stabilizes the axonal membrane at peripheral nodes of Ranvier.
Glia [Epub ahead of print]


Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, Bittner RA, Pan H, Goebbels S, Begemann M, Gerwig UC, Langner S, Werner HB, Kittel-Schneider S, Homuth G, Davatzikos C, Völzke H, West BL, Reif A, Grabe HJ, Boretius S, Ehrenreich H, Nave KA (2017).
Microglia ablation alleviates myelin-associated catatonic signs in mice.
J Clin Invest. [Epub ahead of print]


Berghoff SA, Düking T, Spieth L, Winchenbach J, Stumpf SK, Gerndt N, Kusch K, Ruhwedel T, Möbius W, Saher G (2017).
Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model.
Acta Neuropathol Commun. 5, 94-94


Wang L, Winnewisser J, Federle C, Jessberger G, Nave KA, Werner HB, Kyewski B, Klein L, Hinterberger M (2017).
Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis.
Front Immunol. 8, 1511-1511


Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT (2017).
Building Bridges through Science.
Neuron 96, 730-735


Nave KA, Tzvetanova ID, Schirmeier S (2017).
Glial Cell Evolution: The Origins of a Lipid Store.
Cell Metab. 26, 701-702


Saab AS, Nave KA (2017).
Myelin dynamics: protecting and shaping neuronal functions.
Curr Opin Neurobiol. [Epub ahead of print]


Fledrich R, Mannil M, Leha A, Ehbrecht C, Solari A, Pelayo-Negro AL, Berciano J, Schlotter-Weigel B, Schnizer TJ, Prukop T, Garcia-Angarita N, Czesnik D, Haberlová J, Mazanec R, Paulus W, Beissbarth T, Walter MC, Triaal C, Hogrel JY, Dubourg O, Schenone A, Baets J, De Jonghe P, Shy ME, Horvath R, Pareyson D, Seeman P, Young P, Sereda MW (2017).
Biomarkers predict outcome in Charcot- Marie-Tooth disease 1A.
J Neurol Neurosurg Psychiatry. 88, 941-952


Lüders KA, Patzig J, Simons M, Nave KA, Werner HB (2017).
Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.
Glia 65, 1762-1776


Wehr MC, Hinrichs W, Brzózka MM, Unterbarnscheidt T, Herholt A, Wintgens JP, Papiol S, Soto-Bernardini MC, Kravchenko M, Zhang M, Nave KA, Wichert SP, Falkai P, Zhang W, Schwab MH, Rossner MJ (2017).
Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice.
EMBO Mol Med. 9, 1448-1462


Ghidinelli M, Poitelon Y, Shin YK, Ameroso D, Williamson C, Ferri C, Pellegatta M, Espino K, Mogha A, Monk K, Podini P, Taveggia C, Nave KA, Wrabetz L, Park HT, Feltri ML (2017).
Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination.
PLoS Biol. 15, e2001408-e2001408


Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MHG (2017).
Oligodendroglial myelination requires astrocyte-derived lipids.
PLoS Biol. 15, e1002605-e1002605


Kleinecke S, Richert S, de Hoz L, Brügger B, Kungl T, Asadollahi E, Quintes S, Blanz J, McGonigal R, Naseri K, Sereda MW, Sachsenheimer T, Lüchtenborg C, Möbius W, Willison H, Baes M, Nave KA, Kassmann CM (2017).
Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy.
Elife 6, e23332-e23332


Karamita M, Barnum C, Möbius W, Tansey MG, Szymkowski DE, Lassmann H, Probert L (2017).
Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia.
JCI Insight [Epub ahead of print]


Trevisiol A, Saab AS, Winkler U, Marx G, Imamura H, Möbius W, Kusch K, Nave KA, Hirrlinger J (2017).
Monitoring ATP dynamics in electrically active white matter tracts.
Elife 6, e24241-e24241


Vogelgesang S, Niebert S, Renner U, Möbius W, Hülsmann S, Manzke T, Niebert M (2017).
Analysis of the Serotonergic System in a Mouse Model of Rett Syndrome Reveals Unusual Upregulation of Serotonin Receptor 5b.
Front Mol Neurosci. [PubMed - in process]


Feldman EL, Nave KA, Jensen TS, Bennett DL (2017).
New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain
Neuron 93, 1296-1313


Supplie LM, Düking T, Campbell G, Diaz F, Moraes CT, Götz M, Hamprecht B, Boretius S, Mahad D, Nave KA (2017).
Respiration-deficient astrocytes survive as glycolytic cells in vivo.
J Neurosci. 37, 4231-4242


Tarasenko D, Barbot M, Jans DC, Kroppen B, Sadowski B, Heim G, Möbius W, Jakobs S, Meinecke M (2017).
The MICOS component Mic60 displays a conserved membrane-bending activity that is necessary for normal cristae morphology.
J Cell Biol 216, 889-899


Kusch K, Uecker M, Liepold T, Möbius W, Hoffmann C, Neumann H, Werner HB, Jahn O (2017).
Partial Immunoblotting of 2D-Gels: A Novel Method to Identify Post-Translationally Modified Proteins Exemplified for the Myelin Acetylome.
Proteomes 5, E3-E3


Wottawa M, Naas S, Böttger J, van Belle GJ, Möbius W, Revelo NH, Heidenreich D, von Ahlen M, Zieseniss A, Kröhnert K, Lutz S, Lenz C, Urlaub H, Rizzoli SO, Katschinski DM (2017).
Hypoxia-stimulated membrane trafficking requires T-Plastin.
Acta Physiol (Oxf). 221, 59-73


Khan S, Stott S, Chabrat A, Truckenbrodt AM, Spencer-Dene B, Nave KA, Guillemot F, Levesque M, Ang SL (2017).
Survival of a novel subset of midbrain dopaminergic neurons projecting to the lateral septum is dependent on NeuroD proteins.
J Neurosci. 37, 2305-2316


Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Böhler C, Barrette B, Stassart R, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G (2017).
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.
Nat Commun. 8, 14241-14241


Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner HB, Erwig MS, Möbius W, Kursula P, Nave KA, Simons M (2017).
Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.
Cell Rep. 18, 314-323


Weil MT, Ruhwedel T, Möbius W, Simons M (2017).
Intracerebral Injections and Ultrastructural Analysis of High-Pressure Frozen Brain Tissue.
Curr Protoc Neurosci. 78, 2.27.1-2.27.18


2016

Winchenbach J, Düking T, Berghoff SA, Stumpf SK, Hülsmann S, Nave KA, Saher G (2016).
Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice.
F1000Res. 5, 2934-2934


Ehrenreich H, Mitjans M, Van der Auwera S, Centeno TP, Begemann M, Grabe HJ, Bonn S, Nave KA (2016).
OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals.
Mol Psychiatry. [Epub ahead of print]


Tognatta R, Sun W, Goebbels S, Nave KA, Nishiyama A, Schoch S, Dimou L, Dietrich D (2016).
Transient Cnp expression by early progenitors causes Cre-Lox-based reporter lines to map profoundly different fates.
Glia 65, 342-359


Goebbels S, Wieser GL, Pieper A, Spitzer S, Weege B, Yan K, Edgar JM, Yagensky O, Wichert SP, Agarwal A, Karram K, Renier N, Tessier-Lavigne M, Rossner MJ, Káradóttir RT, Nave KA (2016).
A neuronal PI(3,4,5)P(3)-dependent program of oligodendrocyte precursor recruitment and myelination.
Nat Neurosci. 20, 10-15


Patzig J, Erwig MS, Tenzer S, Kusch K, Dibaj P, Möbius W, Goebbels S, Schaeren-Wiemers N, Nave KA, Werner HB (2016).
Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.
Elife. 5, pii: e17119-pii: e17119


Vingill S, Brockelt D, Lancelin C, Tatenhorst L, Dontcheva G, Preisinger C, Schwedhelm-Domeyer N, Joseph S, Mitkovski M, Goebbels S, Nave KA, Schulz JB, Marquardt T, Lingor P, Stegmüller J (2016).
Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice.
EMBO J. 35, 2008-2025


Poggi G, Boretius S, Möbius W, Moschny N, Baudewig J, Ruhwedel T, Hassouna I, Wieser GL, Werner HB, Goebbels S, Nave KA, Ehrenreich H (2016).
Cortical network dysfunction caused by a subtle defect of myelination.
Glia 64, 2025-2040


Sociali G, Visigalli D, Prukop T, Cervellini I, Mannino E, Venturi C, Bruzzone S, Sereda MW, Schenone A (2016).
Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy.
Neurobiol Dis. 95, 145-157


Weil MT, Möbius W, Winkler A, Ruhwedel T, Wrzos C, Romanelli E, Bennett JL, Enz L, Goebels N, Nave KA, Kerschensteiner M, Schaeren-Wiemers N, Stadelmann C, Simons M (2016).
Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases.
Cell Rep. 16, 314-322


Werner HB (2016).
On the evolution of myelin.
Brain Res. 1641, 1-3


Quintes, S., Brinkmann, B.G., Ebert, M., Fröb, F., Kungl, T., A. Arlt, F.A., Tarabykin, V., Huylebroeck, D., Meijer, D., Suter, U., Wegner, M., Sereda, M.W., and Nave, K.-A. (2016).
Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair.
Nature Neurosci. 19, 1050-1059


Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, Edinger AL, Jung S, Rossner MJ, Simons M (2016).
Age-related myelin degradation burdens the clearance function of microglia during aging.
Nat Neurosci. 19, 995-998


Saab A.S., Tzvetavona, I.D., Trevisiol, A., Baltan, S., Dibaj, P., Kusch, K., Möbius, W., Goetze, B., Jahn, H.M., Huang, W., Steffens, H., Schomburg, E.D., Pérez-Samartín, A., Pérez-Cerdá, F., Bakhtiari, D., Matute, C., Löwel, S., Griesinger, C., Hirrlinger, J., Frank Kirchhoff, F., and Nave, K.A. (2016).
Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism.
Neuron 91, 119-132


Thakurela S, Garding A, Jung RB, Müller C, Goebbels S, White R, Werner HB, Tiwari VK (2016).
The transcriptome of mouse central nervous system myelin.
Sci Rep. 6, 25828-25828


Syed YA, Zhao C, Mahad D, Möbius W, Altmann F, Foss F, González GA, Sentürk A, Acker-Palmer A, Lubec G, Lilley K, Franklin RJ, Nave KA, Kotter MR (2016).
Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.
Acta Neuropathol. 132, 157-157


Reichel JM, Bedenk BT, Gassen NC, Hafner K, Bura SA, Almeida-Correa S, Genewsky A, Dedic N, Giesert F, Agarwal A, Nave KA, Rein T, Czisch M, Deussing JM, Wotjak CT (2016).
Beware of your Cre-ation: lacZ expression impairs neuronal integrity and hippocampus-dependent memory.
Hippocampus 26, 1250-1264


Noseda R, Guerrero-Valero M, Alberizzi V, Previtali SC, Sherman DL, Palmisano M, Huganir RL, Nave KA, Cuenda A, Feltri ML, Brophy PJ, Bolino A (2016).
Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold.
PLoS Biol. 14, e1002440-e1002440


Hassouna I, Ott C, Wüstefeld L, Offen N, Neher RA, Mitkovski M, Winkler D, Sperling S, Fries L, Goebbels S, Vreja IC, Hagemeyer N, Dittrich M, Rossetti MF, Kröhnert K, Hannke K, Boretius S, Zeug A, Höschen C, Dandekar T, Dere E, Neher E, Rizzoli SO, Nave KA, Sirén AL, Ehrenreich H (2016).
Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus.
Mol Psychiatry. 21, 1752-1767


Saab AS, Nave KA (2016).
Neuroscience: A mechanism for myelin injury.
Nature 529, 474-475


Lee YI, Li Y, Mikesh M, Smith I, Nave KA, Schwab MH, Thompson WJ (2016).
Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated synapse elimination at developing neuromuscular junctions.
Proc Natl Acad Sci U S A. 113, E479-E487


2015

Brzózka MM, Havemann-Reinecke U, Wichert SP, Falkai P, Rossner MJ (2015).
Molecular Signatures of Psychosocial Stress and Cognition Are Modulated by Chronic Lithium Treatment.
Schizophr Bull. [Epub ahead of print]


Syed YA, Zhao C, Mahad D, Möbius W, Altmann F, Foss F, Sentürk A, Acker-Palmer A, Lubec G, Lilley K, Franklin RJ, Nave KA, Kotter MR (2015).
Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.
Acta Neuropathol. 132, 157-157


Brzózka MM, Unterbarnscheidt T, Schwab MH, Rossner MJ (2015).
OSO paradigm - a rapid behavioral screening method for acute psychosocial stress reactivity in mice.
Neuroscience 314, 1-11


Wehr MC, Rossner MJ (2015).
Split protein biosensor assays in molecular pharmacological studies.
Drug Discov Today. 21, 415-429


Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröeper M, Rossner MJ, Fluhrer R, Willem M, Haass C (2015).
Proteolytic processing of Neuregulin 1 type III by three intramembrane cleaving proteases.
J Biol Chem. 291, 318-333


Sharma K, Schmitt S, Bergner CG, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch UK, Philips MA, Rossner MJ, Mann M, Simons M (2015).
Cell type- and brain region-resolved mouse brain proteome.
Nat Neurosci. 18, 1819-1831


Herold S, Kumar P, Wichert SP, Kretzschmar B, Bähr M, Rossner MJ, Hein K (2015).
Neurodegeneration in Autoimmune Optic Neuritis Is Associated with Altered APP Cleavage in Neurons and Up-Regulation of p53.
PLoS One. 10, e0138852-e0138852


Brzózka MM, Rossner MJ, de Hoz L (2015).
Tcf4 transgenic female mice display delayed adaptation in an auditory latent inhibition paradigm.
Eur Arch Psychiatry Clin Neurosci. 266, 502-512


Patzig J, Kusch K, Fledrich R, Eichel MA, Lüders KA, Möbius W, Sereda MW, Nave KA, Martini R, Werner HB (2015).
Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking.
Glia 64, 155-174


Pehlivan D, Beck CR, Okamoto Y, Harel T, Akdemir ZH, Jhangiani SN, Withers MA, Goksungur MT, Carvalho CM, Czesnik D, Gonzaga-Jauregui C, Wiszniewski W, Muzny DM, Gibbs RA, Rautenstrauss B, Sereda MW, Lupski JR (2015).
The role of combined SNV and CNV burden in patients with distal symmetric polyneuropathy.
Genet Med. 18, 443-451


Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, Stadler H, Kawabe H, Zimmermann WH, Nave KA, Schulz-Schaeffer W, Jahn O, Ehrenreich H (2015).
Widespread expression of erythropoietin receptor in brain and its induction by injury.
Mol Med. [Epub ahead of print]


Maus F, Sakry D, Binamé F, Karram K, Rajalingam K, Watts C, Heywood R, Krüger R, Stegmüller J, Werner HB, Nave KA, Krämer-Albers EM, Trotter J (2015).
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2.
PLoS One. 10, e0137311-e0137311


Epplen DB, Prukop T, Nientiedt T, Albrecht P, Arlt FA, Stassart RM, Kassmann CM, Methner A, Nave KA, Werner HB, Sereda MW (2015).
Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease.
Ann Clin Transl Neurol. 2, 787-796


Trevisiol A, Nave KA. (2015).
Brain Energy Metabolism: Conserved Functions of Glycolytic Glial Cells.
Cell Metab. 22, 361-363


Simons M, Nave KA (2015).
Oligodendrocytes: Myelination and Axonal Support.
Cold Spring Harb Perspect Biol. 8, a020479-a020479


Shahmoradi A, Radyushkin K, Rossner MJ (2015).
Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex.
Proc Natl Acad Sci U S A. 112, E3582-E3589


Besser, S, Sicker, M, Marx, G, Winkler, U, Eulenburg, V, Hulsmann, S, Hirrlinger, J (2015).
A Transgenic Mouse Line Expressing the Red Fluorescent Protein tdTomato in GABAergic Neurons
PLoS One 10, e0129934-e0129934


Mitkovski M, Dahm L, Heinrich R, Monnheimer M, Gerhart S, Stegmüller J, Hanisch UK, Nave KA, Ehrenreich H (2015).
Erythropoietin dampens injury-induced microglial motility.
J Cereb Blood Flow Metab. 35, 1233-1236


Dibaj P, Schomburg ED, Steffens H (2015).
Contractile characteristics of gastrocnemius-soleus muscle in the SOD1G93A ALS mouse model.
Neurol Res. 37, 693-702


Ekins S, Litterman NK, Arnold RJ, Burgess RW, Freundlich JS, Gray SJ, Higgins JJ, Langley B, Willis DE, Notterpek L, Pleasure D, Sereda MW, Moore A (2015).
A brief review of recent Charcot-Marie-Tooth research and priorities.
F1000Res. 4, 53-53


Stassart RM, Nave KA (2015).
Nerve regeneration: Specific metabolic demands?
Exp Neurol. 269, 90-92


Falkai P, Rossner MJ, Schulze TG, Hasan A, Brzózka MM, Malchow B, Honer WG, Schmitt A (2015).
Kraepelin revisited: schizophrenia from degeneration to failed regeneration.
Mol Psychiatry. 20, 671-676


Jarjour, AA, Boyd, A, Dow, LE, Holloway, RK, Goebbels, S, Humbert, P O, Williams, A, ffrench-Constant, C (2015).
The polarity protein Scribble regulates myelination and remyelination in the central nervous system
PLoS Biol 13, e1002107-e1002107


Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH, Schneider A (2015).
Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation
Acta Neuropathol 129, 695-713


Schomburg, ED, Steffens, H, Pilyavskii, AI, Maisky, VA, Bruck, W, Dibaj, P, Sears, TA (2015).
Long lasting activity of nociceptive muscular afferents facilitates bilateral flexion reflex pattern in the feline spinal cord
Neurosci Res 95, 51-58


Bischof M, Weider M, Küspert M, Nave KA, Wegner M (2015).
Brg1-Dependent Chromatin Remodelling Is Not Essentially Required during Oligodendroglial Differentiation.
J Neurosci. 35, 21-35


Wehr MC, Galinski S, Rossner MJ (2015).
Monitoring G Protein-Coupled Receptor Activation Using the Protein Fragment Complementation Technique Split TEV.
Methods Mol Biol. 1272, 107-118


de Hoz L, Simons M (2015).
The emerging functions of oligodendrocytes in regulating neuronal network behaviour.
Bioessays 37, 60-69


2014

Chumakov I, Milet A, Cholet N, Primas G, Boucard A, Pereira Y, Graudens E, Mandel J, Laffaire J, Foucquier J, Glibert F, Bertrand V, Nave KA, Sereda MW, Vial E, Guedj M, Hajj R, Nabirotchkin S, Cohen D (2014).
Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy.
Orphanet J Rare Dis. 9, 201-201


Nolting JF, Möbius W, Köster S (2014).
Mechanics of Individual Keratin Bundles in Living Cells
Biophys J. 107, 2693-2699


Gritsch S, Lu J, Thilemann S, Wörtge S, Möbius W, Bruttger J, Karram K, Ruhwedel T, Blanfeld M, Vardeh D, Waisman A, Nave KA, Kuner R (2014).
Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice.
Nat Commun. 5, 5472-5472


Baier PC, Brzózka MM, Shahmoradi A, Reinecke L, Kroos C, Wichert SP, Oster H, Wehr MC, Taneja R, Hirrlinger J, Rossner MJ (2014).
Mice Lacking the Circadian Modulators SHARP1 and SHARP2 Display Altered Sleep and Mixed State Endophenotypes of Psychiatric Disorders.
PLoS One. 9, e110310-e110310


Nave KA, Werner HB (2014).
Myelination of the nervous system: mechanisms and functions.
Annu Rev Cell Dev Biol. 30, 503-533


Muneer Z, Wiesinger C, Voigtländer T, Werner HB, Berger J, Forss-Petter S (2014).
Abcd2 Is a Strong Modifier of the Metabolic Impairments in Peritoneal Macrophages of Abcd1-Deficient Mice.
PLoS One. 9, e108655-e108655


Tzvetanova ID, Nave KA (2014).
Axons hooked to Schwann cell metabolism.
Nat Neurosci. 17, 1293-1295


Badowska DM, Brzózka MM, Chowdhury A, Malzahn D, Rossner MJ (2014).
Data calibration and reduction allows to visualize behavioural profiles of psychosocial influences in mice towards clinical domains.
Eur Arch Psychiatry Clin Neurosci. 265, 483-496


Hsia HE, Kumar R, Luca R, Takeda M, Courchet J, Nakashima J, Wu S, Goebbels S, An W, Eickholt BJ, Polleux F, Rotin D, Wu H, Rossner MJ, Bagni C, Rhee JS, Brose N, Kawabe H (2014).
Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.
Proc Natl Acad Sci U S A. 111, 13205-13210


Fledrich R, Stassart RM, Klink A, Rasch LM, Prukop T, Haag L, Czesnik D, Kungl T, Abdelaal TA, Keric N, Stadelmann C, Brück W, Nave KA, Sereda MW (2014).
Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A.
Nat Med. 20, 1055-1061


Agarwal A, Zhang M, Trembak-Duff I, Unterbarnscheidt T, Radyushkin K, Dibaj P, Martins de Souza D, Boretius S, Brzózka MM, Steffens H, Berning S, Teng Z, Gummert MN, Tantra M, Guest PC, Willig KI, Frahm J, Hell SW, Bahn S, Rossner MJ, Nave KA, Ehrenreich H, Zhang W, Schwab MH (2014).
Dysregulated Expression of Neuregulin-1 by Cortical Pyramidal Neurons Disrupts Synaptic Plasticity.
Cell Rep. 8, 1130-1145


Hirrlinger J, Nave KA (2014).
Adapting brain metabolism to myelination and long-range signal transduction.
Glia 62, 1749-1761


Mannil M, Solari A, Leha A, Pelayo-Negro AL, Berciano J, Schlotter-Weigel B, Walter MC, Rautenstrauss B, Schnizer TJ, Schenone A, Seeman P, Kadian C, Schreiber O, Angarita NG, Fabrizi GM, Gemignani F, Padua L, Santoro L, Quattrone A, Vita G, Calabrese D; CMT-TRIAAL/CMT-TRAUK Group, Young P, Laurà M, Haberlová J, Mazanec R, Paulus W, Beissbarth T, Shy ME, Reilly MM, Pareyson D, Sereda MW (2014).
Selected items from the Charcot-Marie-Tooth (CMT) Neuropathy Score and secondary clinical outcome measures serve as sensitive clinical markers of disease severity in CMT1A patients.
Neuromuscul Disord. 24, 1003-1017


Mei L, Nave KA (2014).
Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases.
Neuron 83, 27-49


Mita S, de Monasterio-Schrader P, Fünfschilling U, Kawasaki T, Mizuno H, Iwasato T, Nave KA, Werner HB, Hirata T (2014).
Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance.
Cereb Cortex. 25, 4111-4125


Hammer C, Zerche M, Schneider A, Begemann M, Nave KA, Ehrenreich H (2014).
Apolipoprotein E4 carrier status plus circulating anti-NMDAR1 autoantibodies: association with schizoaffective disorder.
Mol Psychiatry. 19, 1054-1056


Rossner MJ, Tirard M (2014).
Thy1.2 driven expression of transgenic His(6)-SUMO2 in the brain of mice alters a restricted set of genes.
Brain Res. 1575, 1-11


Haenold R, Weih F, Herrmann KH, Schmidt KF, Krempler K, Engelmann C, Nave KA, Reichenbach JR, Löwel S, Witte OW, Kretz A (2014).
NF-kB determines axonal re- and degeneration by cell-specific balance of RelA and p50 subunits in the adult CNS.
J Cell Sci. 127, 3052-3065


Dere E, Winkler D, Ritter C, Ronnenberg A, Poggi G, Patzig J, Gernert M, Müller C, Nave KA, Ehrenreich H, Werner HB (2014).
Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist.
Behav Brain Res. 277, 254-263


de Hoz L, Martin SJ (2014).
Double dissociation between the contributions of the septal and temporal hippocampus to spatial learning: The role of prior experience.
Hippocampus 24, 990-1005


Ehrenreich H, Nave KA (2014).
Phenotype-Based Genetic Association Studies (PGAS)-Towards Understanding the Contribution of Common Genetic Variants to Schizophrenia Subphenotypes.
Genes (Basel) 5, 97-105


Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H (2014).
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
J Clin Invest. 124, 1987-1999


Prukop T, Epplen DB, Nientiedt T, Wichert SP, Fledrich R, Stassart RM, Rossner MJ, Edgar JM, Werner HB, Nave KA, Sereda MW (2014).
Progesterone Antagonist Therapy in a Pelizaeus-Merzbacher Mouse Model.
Am J Hum Genet. 94, 533-546


Nave KA, Ehrenreich H (2014).
Myelination and Oligodendrocyte Functions in Psychiatric Diseases.
JAMA Psychiatry. 71, 582-584


de Hoz L, Nelken I (2014).
Frequency tuning in the behaving mouse: different bandwidths for discrimination and generalization.
PLoS One. 9, e91676-e91676


Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgärtner W, Ulrich R (2014).
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Neuropathol Appl Neurobiol. 41, 347-370


Montani L, Buerki-Thurnherr T, Paes de Faria J, Pereira JA, Dias NG, Fernandes R, Gonçalves AF, Braun A, Benninger Y, Böttcher RT, Costell M, Nave KA, Franklin RJ, Meijer D, Suter U, Relvas JB (2014).
Profilin 1 is required for peripheral nervous system myelination.
Development 141, 1553-1561


Huang W, Zhao N, Bai X, Karram K, Trotter J, Goebbels S, Scheller A, Kirchhoff F (2014).
Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development.
Glia 62, 896-913


Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Schulz AM, Hoch G, Bartels M, Vogt G, Garnham CW, Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kügler S, Salditt T, de Hoz L, Strenzke N, Moser T (2014).
Optogenetic stimulation of the auditory pathway
J Clin Invest. 124, 1114-1129


Snaidero N, Möbius W, Czopka T, Hekking LH, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons DA, Nave KA, Simons M (2014).
Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue.
Cell 156, 277-290


Quednow BB, Brzózka MM, Rossner MJ (2014).
Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective.
Cell Mol Life Sci. 71, 2815-2835


Willig KI, Steffens H, Gregor C, Herholt A, Rossner MJ, Hell SW (2014).
Nanoscopy of filamentous actin in cortical dendrites of a living mouse.
Biophys J. 106, L01-L03


Kassmann CM (2014).
Myelin peroxisomes - essential organelles for the maintenance of white matter in the nervous system.
Biochimie 98, 111-118


2013

Mostowy S, Bi E, Füchtbauer EM, Goryachev AB, Montagna C, Nagata KI, Trimble WS, Werner HB, Yao X, Zieger B, Spiliotis ET (2013).
Highlight: The 5th International Workshop on Septin Biology.
Biol Chem. 395, 119-121


Tönges L, Günther R, Suhr M, Jansen J, Balck A, Saal KA, Barski E, Nientied T, Götz AA, Koch JC, Mueller BK, Weishaupt JH, Sereda MW, Hanisch UK, Bähr M, Lingor P (2013).
Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis.
Glia 62, 217-232


Werner HB (2013).
Do we have to reconsider the evolutionary emergence of myelin?
Front Cell Neurosci. 7, 217-217


Syed YA, Baer A, Hofer MP, González GA, Rundle J, Myrta S, Huang JK, Zhao C, Rossner MJ, Trotter MW, Lubec G, Franklin RJ, Kotter MR (2013).
Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination.
EMBO Mol Med. 5, 1918-1934


Richert S, Kleinecke S, Günther J, Schaumburg F, Edgar J, Nienhaus GU, Nave KA, Kassmann CM (2013).
In vivo labeling of peroxisomes by photoconvertible mEos2 in myelinating glia of mice.
Biochimie 98, 127-134


Grigoryan T, Stein S, Qi J, Wende H, Garratt AN, Nave KA, Birchmeier C, Birchmeier W (2013).
Wnt/Rspondin/?-catenin signals control axonal sorting and lineage progression in Schwann cell development.
Proc Natl Acad Sci U S A. 110, 18174-18179


Schnell C, Shahmoradi A, Wichert SP, Mayerl S, Hagos Y, Heuer H, Rossner MJ, Hülsmann S (2013).
The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes.
Brain Struct Funct. 220, 193-203


Fields RD, Araque A, Johansen-Berg H, Lim SS, Lynch G, Nave KA, Nedergaard M, Perez R, Sejnowski T, Wake H (2013).
Glial Biology in Learning and Cognition.
Neuroscientist. 20, 426-431


Saab AS, Tzvetanova ID, Nave KA (2013).
The role of myelin and oligodendrocytes in axonal energy metabolism.
Curr Opin Neurobiol. 23, 1065-1072


Patzig J, Dworschak MS, Martens AK, Werner HB (2013).
Septins in the glial cells of the nervous system.
Biol Chem. 395, 143-149


Nawaz S, Schweitzer J, Jahn O, Werner HB (2013).
Molecular evolution of myelin basic protein, an abundant structural myelin component.
Glia 61, 1364-1377


Pais TF, Szeg? ÉM, Marques O, Miller-Fleming L, Antas P, Guerreiro P, de Oliveira RM, Kasapoglu B, Outeiro TF (2013).
The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.
EMBO J. 32, 2603-2616


Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H (2013).
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.
Mol Psychiatry. 19, 1143-1149


Viganò F, Möbius W, Götz M, Dimou L (2013).
Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain.
Nat Neurosci. 16, 1370-1372


Barrette B, Nave KA, Edgar JM (2013).
Molecular triggers of neuroinflammation in mouse models of demyelinating diseases.
Biol Chem. 394, 1571-1581


Verrier JD, Jackson TC, Gillespie DG, Janesko-Feldman K, Bansal R, Goebbels S, Nave KA, Kochanek PM, Jackson EK (2013).
Role of CNPase in the oligodendrocytic extracellular 2',3'-cAMP-adenosine pathway.
Glia 61, 1595-1606


Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers EM (2013).
Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication.
PLoS Biol. 11, e1001604-e1001604


Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C (2013).
Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
EMBO J. 32, 2015-2028


Verheijden S, Bottelbergs A, Krysko O, Krysko DV, Beckers L, De Munter S, Van Veldhoven PP, Wyns S, Kulik W, Nave KA, Ramer MS, Carmeliet P, Kassmann CM, Baes M (2013).
Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation.
Neurobiol Dis. 58, 258-269


Ritter J, Schmitz T, Chew LJ, Bührer C, Möbius W, Zonouzi M, Gallo V (2013).
Neonatal hyperoxia exposure disrupts axon-oligodendrocyte integrity in the subcortical white matter.
J Neurosci. 33, 8990-9002


El-Kordi A, Kästner A, Grube S, Klugmann M, Begemann M, Sperling S, Hammerschmidt K, Hammer C, Stepniak B, Patzig J, de Monasterio-Schrader P, Strenzke N, Flügge G, Werner HB, Pawlak R, Nave KA, Ehrenreich H (2013).
A single gene defect causing claustrophobia.
Transl Psychiatry. 3, e254-e254


Vogl MR, Reiprich S, Küspert M, Kosian T, Schrewe H, Nave KA, Wegner M (2013).
Sox10 Cooperates with the Mediator Subunit 12 during Terminal Differentiation of Myelinating Glia.
J Neurosci. 33, 6679-6690


Wieser GL, Gerwig UC, Adamcio B, Barrette B, Nave KA, Ehrenreich H, Goebbels S (2013).
Neuroinflammation in white matter tracts of Cnp1 mutant mice amplified by a minor brain injury.
Glia 61, 869-880


Ufartes R, Schneider T, Mortensen LS, de Juan Romero C, Hentrich K, Knoetgen H, Beilinson V, Moebius W, Tarabykin V, Alves F, Pardo LA, Rawlins JN, Stuehmer W (2013).
Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice.
Hum Mol Genet. 22, 2247-2262


Bakhti M, Snaidero N, Schneider D, Aggarwal S, Möbius W, Janshoff A, Eckhardt M, Nave KA, Simons M (2013).
Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system.
Proc Natl Acad Sci U S A. 110, 3143-3148


Rahman J, Latal AT, Besser S, Hirrlinger J, Hülsmann S. (2013).
Mixed miniature postsynaptic currents resulting from co-release of glycine and GABA recorded from glycinergic neurons in the neonatal respiratory network.
Eur J Neurosci. 37, 1229-1241


Werner HB, Krämer-Albers EM, Strenzke N, Saher G, Tenzer S, Ohno-Iwashita Y, De Monasterio-Schrader P, Möbius W, Moser T, Griffiths IR, Nave KA (2013).
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.
Glia 61, 567-586


Bormuth I, Yan K, Yonemasu T, Gummert M, Zhang M, Wichert S, Grishina O, Pieper A, Zhang W, Goebbels S, Tarabykin V, Nave KA, Schwab MH (2013).
Neuronal Basic Helix-Loop-Helix Proteins Neurod2/6 Regulate Cortical Commissure Formation before Midline Interactions.
J Neurosci. 33, 641-651


Wehr MC, Holder MV, Gailite I, Saunders RE, Maile TM, Ciirdaeva E, Instrell R, Jiang M, Howell M, Rossner MJ, Tapon N (2013).
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.
Nat Cell Biol. 15, 61-71


Stassart RM, Fledrich R, Velanac V, Brinkmann BG, Schwab MH, Meijer D, Sereda MW, Nave KA (2013).
A role for Schwann cell-derived neuregulin-1 in remyelination.
Nat Neurosci. 16, 48-54


Zschüntzsch J, Schütze S, Hülsmann S, Dibaj P, Neusch C. (2013).
Heterologous expression of a glial Kir channel (KCNJ10) in a neuroblastoma spinal cord (NSC-34) cell line.
Physiol Res. 62, 95-105


Heermann S, Schwab MH (2013).
Molecular control of Schwann cell migration along peripheral axons: Keep moving!
Cell Adh Migr. 7, 18-22


Gogishvili T, Lühder F, Goebbels S, Beer-Hammer S, Pfeffer K, Hünig T (2013).
Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion.
Eur J Immunol. 43, 188-193


Jahn O, Tenzer S, Bartsch N, Patzig J, Werner HB
Myelin proteome analysis: methods and implications for the myelin cytoskeleton.
In: The Cytoskeleton: Imaging, Isolation, and Interaction. Neuromethods 79:335-354. Springer, ed: Dermietzel R. (2013) pp.

de Monasterio-Schrader P, Patzig J, Möbius W, Barrette B, Wagner TL, Edgar JM, Brophy PJ, Werner HB (2013).
Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2 (TSPAN2).
Glia 61, 1832-1847


Jahn O, Tenzer S, Werner HB (2013).
Proteomanalyse des Myelins, der Isolierschicht der Nerven.
Biospektrum 3/2013, 263-265


Schwab MH, Sereda MW, Nave KA
Neuron–Glial Interactions.
In: RUBENSTEIN J. L. R. and RAKIC P. (ed.) Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing CNS and PNS, volume 1, pp. 851-869 Amsterdam: Elsevier. (2013) pp. 851-869

2012

Dibaj P, Zschüntzsch J, Steffens H, Scheffel J, Göricke B, Weishaupt JH, Le Meur K, Kirchhoff F, Hanisch UK, Schomburg ED, Neusch C (2012).
Influence of Methylene Blue on Microglia-Induced Inflammation and Motor Neuron Degeneration in the SOD1(G93A) Model for ALS.
PLoS One. 7, e43963-e43963


Senthilan PR, Piepenbrock D, Ovezmyradov G, Nadrowski B, Bechstedt S, Pauls S, Winkler M, Möbius W, Howard J, Göpfert MC (2012).
Drosophila auditory organ genes and genetic hearing defects.
Cell 150, 1024-1054


Ip CW, Kroner A, Groh J, Huber M, Klein D, Spahn I, Diem R, Williams SK, Nave KA, Edgar JM, Martini R (2012).
Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse.
PLoS One. 7, e42554-e42554


Heermann S, Spittau B, Zajzon K, Schwab MH, Krieglstein K (2012).
Schwann cells migrate along axons in the absence of GDNF signaling.
BMC Neurosci. 13, 92-92


Saab AS, Neumeyer A, Jahn HM, Cupido A, Simek AA, Boele HJ, Scheller A, Le Meur K, Götz M, Monyer H, Sprengel R, Rubio ME, Deitmer JW, De Zeeuw CI, Kirchhoff F (2012).
Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination
Science 337, 749-753


Saher G, Rudolphi F, Corthals K, Ruhwedel T, Schmidt KF, Löwel S, Dibaj P, Barrette B, Möbius W, Nave KA (2012).
Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet.
Nat Med. 18, 1130-1135


Kästner A, Grube S, El-Kordi A, Stepniak B, Friedrichs H, Sargin D, Schwitulla J, Begemann M, Giegling I, Miskowiak KW, Sperling S, Hannke K, Ramin A, Heinrich R, Gefeller O, Nave KA, Rujescu D, Ehrenreich H (2012).
Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia.
Mol Med. 18, 1029-1040


Fünfschilling U, Jockusch WJ, Sivakumar N, Möbius W, Corthals K, Li S, Quintes S, Kim Y, Schaap IA, Rhee JS, Nave KA, Saher G (2012).
Critical Time Window of Neuronal Cholesterol Synthesis during Neurite Outgrowth.
J Neurosci. 32, 7632-7645


Slezak M, Grosche A, Niemiec A, Tanimoto N, Pannicke T, Münch TA, Crocker B, Isope P, Härtig W, Beck SC, Huber G, Ferracci G, Perraut M, Reber M, Miehe M, Demais V, Lévêque C, Metzger D, Szklarczyk K, Przewlocki R, Seeliger MW, Sage-Ciocca D, Hirrlinger J, Reichenbach A, Reibel S, Pfrieger FW (2012).
Relevance of Exocytotic Glutamate release from retinal glia.
Neuron 74, 504-516


Furusho M, Dupree JL, Nave KA, Bansal R (2012).
Fibroblast growth factor receptor signaling in oligodendrocytes regulates myelin sheath thickness.
J Neurosci. 32, 6631-6641


Fledrich R, Stassart RM, Sereda MW (2012).
Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease.
Br Med Bull. 102, 89-113


Goebbels S, Oltrogge JH, Wolfer S, Wieser GL, Nientiedt T, Pieper A, Ruhwedel T, Groszer M, Sereda MW, Nave KA (2012).
Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy.
EMBO Mol Med. 4, 486-499


Hagemeyer N, Goebbels S, Papiol S, Kästner A, Hofer S, Begemann M, Gerwig UC, Boretius S, Wieser GL, Ronnenberg A, Gurvich A, Heckers SH, Frahm J, Nave KA, Ehrenreich H (2012).
A myelin gene causative of a catatonia-depression syndrome upon aging.
EMBO Mol Med. 4, 528-539


Gazzerro E, Baldassari S, Giacomini C, Musante V, Fruscione F, La Padula V, Biancheri R, Scarfì S, Prada V, Sotgia F, Duncan ID, Zara F, Werner HB, Lisanti MP, Nobbio L, Corradi A, Minetti C (2012).
yccin, the Molecule Mutated in the Leukodystrophy Hypomyelination and Congenital Cataract (HCC), Is a Neuronal Protein.
PLoS One. 7, e32180-e32180


Schmitt A, Leonardi-Essmann F, Durrenberger PF, Wichert SP, Spanagel R, Arzberger T, Kretzschmar H, Zink M, Herrera-Marschitz M, Reynolds R, Rossner MJ, Falkai P, Gebicke-Haerter PJ (2012).
Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients.
Eur Arch Psychiatry Clin Neurosci. 262, 565-577


de Monasterio-Schrader P, Jahn O, Tenzer S, Wichert SP, Patzig J, Werner HB (2012).
Systematic approaches to central nervous system myelin.
Cell Mol Life Sci. 69, 2879-2894


Brankatschk B, Wichert SP, Johnson SD, Schaad O, Rossner MJ, Gruenberg J (2012).
Regulation of the EGF transcriptional response by endocytic sorting.
Sci Signal. 5, ra21-ra21


Makoukji J, Belle M, Meffre D, Stassart R, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F, Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C (2012).
Lithium enhances remyelination of peripheral nerves.
Proc Natl Acad Sci U S A. 109, 3973-3978


Makoukji J, Belle M, Meffre D, Stassart R, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F, Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C (2012).
Lithium enhances remyelination of peripheral nerves.
Proc Natl Acad Sci U S A. 109, 3973-3978


Sherman DL, Krols M, Wu LM, Grove M, Nave KA, Gangloff YG, Brophy PJ (2012).
Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR.
J Neurosci. 32, 1817-1825


Ivanovic A, Horresh I, Golan N, Spiegel I, Sabanay H, Frechter S, Ohno S, Terada N, Möbius W, Rosenbluth J, Brose N, Peles E (2012).
The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves.
J Cell Biol. 196, 337-344


Botvinik A, Rossner MJ (2012).
Integrated Measurement of Split TEV and Cis-Regulatory Assays Using EXT Encoded Reporter Libraries.
Methods Mol Biol. 812, 309-323


Heermann S, Schmücker J, Hinz U, Rickmann M, Unterbarnscheidt T, Schwab MH, Krieglstein K (2012).
Neuregulin 1 type III/ErbB signaling is crucial for Schwann cell colonization of sympathetic axons.
PLoS One. 6, e28692-e28692


Fledrich R, Schlotter-Weigel B, Schnizer TJ, Wichert SP, Stassart RM, Meyer Zu Hörste G, Klink A, Weiss BG, Haag U, Walter MC, Rautenstrauss B, Paulus W, Rossner MJ, Sereda MW (2012).
A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients.
Brain 135, 72-87


Fledrich R, Schlotter-Weigel B, Schnizer TJ, Wichert SP, Stassart RM, Meyer zu Hörste G, Klink A, Weiss BG, Haag U, Walter MC, Rautenstrauss B, Paulus W, Rossner MJ, Sereda MW (2012).
A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients.
Brain 135, 72-87


Fünfschilling, U., Supplie, L.M., Mahad, D., Boretius, S., Saab, A.S., Edgar, J.,Brinkmann, B.G., Kassmann, C.M., Tzvetanova, I.D., Möbius, W., Diaz, F., Meijer, D., Suter, U., Hamprecht, B., Sereda, M.W., Moraes, C.T., Frahm, J, Goebbels, S., and Nave, K.-A. (2012).
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.
Nature 485, 517-521


2011

Bode B, Shahmoradi A, Rossner MJ, Oster H (2011).
Genetic interaction of per1 and dec1/2 in the regulation of circadian locomotor activity.
J Biol Rhythms. 26, 530-540


Beham AW, Puellmann K, Laird R, Fuchs T, Streich R, Breysach C, Raddatz D, Oniga S, Peccerella T, Findeisen P, Kzhyshkowska J, Gratchev A, Schweyer S, Saunders B, Wessels JT, Möbius W, Keane J, Becker H, Ganser A, Neumaier M, Kaminski WE (2011).
A TNF-regulated recombinatorial macrophage immune receptor implicated in granuloma formation in tuberculosis.
PLoS Pathog. 7, e1002375-e1002375


Gess B, Röhr D, Fledrich R, Sereda MW, Kleffner I, Humberg A, Nowitzki J, Strecker JK, Halfter H, Young P (2011).
Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system.
J Neurosci. 31, 17180-17192


Bode B, Rossner MJ, Oster H (2011).
Advanced light-entrained activity onsets and restored free-running suprachiasmatic nucleus circadian rhythms in per2/dec mutant mice.
Chronobiol Int. 28, 737-750


Patzig J, Jahn O, Tenzer S, Wichert SP, de Monasterio-Schrader P, Rosfa S, Kuharev J, Yan K, Bormuth I, Bremer J, Aguzzi A, Orfaniotou F, Hesse D, Schwab MH, Möbius W, Nave KA, Werner HB (2011).
Quantitative and Integrative Proteome Analysis of Peripheral Nerve Myelin Identifies Novel Myelin Proteins and CandidateNeuropathy Loci.
J Neurosci. 31, 16369-16386


Velanac V, Unterbarnscheidt T, Hinrichs W, Gummert MN, Fischer TM, Rossner MJ, Trimarco A, Brivio V, Taveggia C, Willem M, Haass C, Möbius W, Nave KA, Schwab MH (2011).
Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination.
Glia 60, 203-217


Dhaunchak AS, Colman DR, Nave KA (2011).
Misalignment of PLP/DM20 Transmembrane Domains Determines Protein Misfolding in Pelizaeus-Merzbacher Disease.
J Neurosci. 31, 14961-14971


Botvinik A, Rossner MJ (2011).
Linking Cellular Signalling to Gene Expression Using EXT-Encoded Reporter Libraries.
Methods Mol Biol. 786, 151-166


Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schütz G, Nave KA, Eder M, Wotjak CT, Sillaber I, Holsboer F, Wurst W, Deussing JM (2011).
Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1.
Science 333, 1903-1907


Agarwal A, Dibaj P, Kassmann CM, Goebbels S, Nave KA, Schwab MH (2011).
In Vivo Imaging and Noninvasive Ablation of Pyramidal Neurons in Adult NEX-CreERT2 Mice.
Cereb Cortex. 22, 1473-1486


Deakin IH, Nissen W, Law AJ, Lane T, Kanso R, Schwab MH, Nave KA, Lamsa KP, Paulsen O, Bannerman DM, Harrison PJ (2011).
Transgenic Overexpression of the Type I Isoform of Neuregulin 1 Affects Working Memory and Hippocampal Oscillations but not Long-term Potentiation.
Cereb Cortex. 22, 1520-1529


Wilhelm F, Winkler U, Morawski M, Jäger C, Reinecke L, Rossner MJ, Hirrlinger PG, Hirrlinger J (2011).
The human ubiquitin C promoter drives selective expression in principal neurons in the brain of a transgenic mouse line.
Neurochem Int. 59, 976-980


Schieb H, Kratzin H, Jahn O, Möbius W, Rabe S, Staufenbiel M, Wiltfang J, Klafki HW (2011).
Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid.
J Biol Chem. 286, 33747-33758


Lioy DT, Garg SK, Monaghan CE, Raber J, Foust KD, Kaspar BK, Hirrlinger PG, Kirchhoff F, Bissonnette JM, Ballas N, Mandel G (2011).
A role for glia in the progression of Rett syndrome
Nature 475, 497-500


Mersmann N, Tkachev D, Jelinek R, Röth PT, Möbius W, Ruhwedel T, Rühle S, Weber-Fahr W, Sartorius A, Klugmann M (2011).
Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.
PLoS One. 6, e20336-e20336


Kassmann CM, Quintes S, Rietdorf J, Möbius W, Sereda MW, Nientiedt T, Saher G, Baes M, Nave KA (2011).
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.
FEBS Lett. 585, 2205-2211


Cherry TJ, Wang S, Bormuth I, Schwab M, Olson J, Cepko CL (2011).
NeuroD Factors Regulate Cell Fate and Neurite Stratification in the Developing Retina.
J Neurosci. 31, 7365-7379


Sargin D, El-Kordi A, Agarwal A, Muller M, Wojcik SM, Hassouna I, Sperling S, Nave KA, Ehrenreich H (2011).
Expression of constitutively active erythropoietin receptor in cortical neurons boosts higher cognitive functions in mice.
BMC Biol. 9, 27-27


Feldmann A, Amphornrat J, Schönherr M, Winterstein C, Möbius W, Ruhwedel T, Danglot L, Nave KA, Galli T, Bruns D, Trotter J, Krämer-Albers EM (2011).
Transport of the Major Myelin Proteolipid Protein Is Directed by VAMP3 and VAMP7.
J Neurosci. 31, 5659-5672


Grube S, Gerchen MF, Adamcio B, Pardo LA, Martin S, Malzahn D, Papiol S, Begemann M, Ribbe K, Friedrichs H, Radyushkin KA, Müller M, Benseler F, Riggert J, Falkai P, Bickeböller H, Nave KA, Brose N, Stühmer W, Ehrenreich H (2011).
A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia.
EMBO Mol Med. 3, 309-319


Chen Y, Wang H, Yoon SO, Xu X, Hottiger MO, Svaren J, Nave KA, Kim HA, Olson EN, Lu QR (2011).
HDAC-mediated deacetylation of NF-kB is critical for Schwann cell myelination.
Nat Neurosci. 14, 437-441


Syed YA, Hand E, Möbius W, Zhao C, Hofer M, Nave KA, Kotter MR (2011).
Inhibition of CNS Remyelination by the Presence of Semaphorin 3A.
J Neurosci. 31, 3719-3728


Saher G, Quintes S, Nave KA (2011).
Cholesterol: a novel regulatory role in myelin formation.
Neuroscientist. 17, 79-93


Djannatian MS, Galinski S, Fischer TM, Rossner MJ (2011).
Studying G Protein-Coupled Receptor Activation using Split-Tev assays.
Anal Biochem. 412, 141-152


Kroner A, Schwab N, Ip CW, Leder C, Nave KA, Mäurer M, Wiendl H, Martini R (2011).
Correction: PD-1 Regulates Neural Damage in Oligodendroglia-Induced Inflammation.
PLoS One 6


Papiol S, Begemann M, Rosenberger A, Friedrichs H, Ribbe K, Grube S, Schwab MH, Jahn H, Gunkel S, Benseler F, Nave KA, Ehrenreich H (2011).
A phenotype-based genetic association study reveals the contribution of neuregulin1 gene variants to age of onset and positive symptom severity in schizophrenia.
Am J Med Genet B Neuropsychiatr Genet. 156B, 340-345


Reich A, Spering C, Gertz K, Harms C, Gerhardt E, Kronenberg G, Nave KA, Schwab M, Tauber SC, Drinkut A, Harms K, Beier CP, Voigt A, Göbbels S, Endres M, Schulz JB (2011).
Fas/CD95 regulatory protein Faim2 is neuroprotective after transient brain ischemia.
J Neurosci. 31, 225-233


Wang H, Astarita G, Taussig MD, Bharadwaj KG, Dipatrizio NV, Nave KA, Piomelli D, Goldberg IJ, Eckel RH (2011).
Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity.
Cell Metab. 13, 105-113


Wüstenberg T, Begemann M, Bartels C, Gefeller O, Stawicki S, Hinze-Selch D, Mohr A, Falkai P, Aldenhoff JB, Knauth M, Nave KA, Ehrenreich H (2011).
EPO treatment preserves gray matter in discrete brain regions of chronic schizophrenic patients: indication of areas with most progressive neurodegeneration inherent to the disease process.
Mol Psychiatry. 16, 1-1


Meyer zu Horste G, Miesbach TA, Muller JI, Fledrich R, Stassart RM, Kieseier BC, Coleman MP, Sereda MW (2011).
The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration.
Neurobiol Dis. 42, 1-8


Chrast R, Saher G, Nave KA, Verheijen MH (2011).
Lipid metabolism in myelinating glial cells: lessons from human inheriteddisorders and mouse models.
J Lipid Res. 52, 419-434


Wüstenberg T, Begemann M, Bartels C, Gefeller O, Stawicki S, Hinze-Selch D, Mohr A, Falkai P, Aldenhoff JB, Knauth M, Nave KA, Ehrenreich H (2011).
Recombinant human erythropoietin delays loss of gray matter in chronic schizophrenia.
Mol Psychiatry. 16, 26-36


2010

Kolodziejczyk K, Saab AS, Nave KA, Attwell D (2010).
Why do oligodendrocyte lineage cells express glutamate receptors?
F1000 Biol Rep. 9, 57-57


Meyer Zu Horste G, Miesbach TA, Muller JI, Fledrich R, Stassart RM, Kieseier BC, Coleman MP, Sereda MW (2010).
The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration.
Neurobiol Dis. 42, 1-8


Brendel C, Belakhov V, Werner H, Wegener E, Gärtner J, Nudelman I, Baasov T, Huppke P (2010).
Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model.
J Mol Med. 89, 389-398


Nave KA (2010).
Myelination and support of axonal integrity by glia.
Nature 468, 244-252


Ribbe K, Friedrichs H, Begemann M, Grube S, Papiol S, Kastner A, Gerchen MF, Ackermann V, Tarami A, Treitz A, Flogel M, Adler L, Aldenhoff JB, Becker-Emner M, Becker T, Czernik A, Dose M, Folkerts H, Freese R, Gunther R, Herpertz S, Hesse D, Kruse G, Kunze H, Franz M, Lohrer F, Maier W, Mielke A, Muller-Isberner R, Oestereich C, Pajonk FG, Pollmacher T, Schneider U, Schwarz HJ, Kroner-Herwig B, Havemann-Reinecke U, Frahm J, Stuhmer W, Falkai P, Brose N, Nave KA, Ehrenreich H (2010).
The cross-sectional GRAS sample: A comprehensive phenotypical data collection of schizophrenic patients.
BMC Psychiatry. 10, 91-91


Ducic T, Quintes S, Nave KA, Susini J, Rak M, Tucoulou R, Alevra M, Guttmann P, Salditt T (2010).
Structure and composition of myelinated axons: a multimodal synchrotron spectro-microscopy study.
J Struct Biol. 173, 202-212


Möbius W, Cooper B, Kaufmann WA, Imig C, Ruhwedel T, Snaidero N, Saab AS, Varoqueaux F (2010).
Electron microscopy of the mouse central nervous system.
Methods Cell Biol. 96, 475-512


Begemann M, Grube S, Papiol S, Malzahn D, Krampe H, Ribbe K, Friedrichs H, Radyushkin KA, El-Kordi A, Benseler F, Hannke K, Sperling S, Schwerdtfeger D, Thanhäuser I, Gerchen MF, Ghorbani M, Gutwinski S, Hilmes C, Leppert R, Ronnenberg A, Sowislo J, Stawicki S, Stödtke M, Szuszies C, Reim K, Riggert J, Eckstein F, Falkai P, Bickeböller H, Nave KA, Brose N, Ehrenreich H (2010).
Modification of Cognitive Performance in Schizophrenia by Complexin 2 Gene Polymorphisms.
Arch Gen Psychiatry. 67, 879-888


Karim SA, Barrie JA, McCulloch MC, Montague P, Edgar JM, Iden DL, Anderson TJ, Nave KA, Griffiths IR, McLaughlin M (2010).
PLP/DM20 Expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease.
Glia 58, 1727-1738


Goebbels S, Oltrogge JH, Kemper R, Heilmann I, Bormuth I, Wolfer S, Wichert SP, Möbius W, Liu X, Lappe-Siefke C, Rossner MJ, Groszer M, Suter U, Frahm J, Boretius S, Nave KA (2010).
Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination.
J Neurosci. 30, 8953-8964


Bottelbergs A, Verheijden S, Hulshagen L, Gutmann DH, Goebbels S, Nave KA, Kassmann C, Baes M (2010).
Axonal integrity in the absence of functional peroxisomes from projection neurons and astrocytes.
Glia 58, 1532-1543


Brzózka MM, Radyushkin K, Wichert SP, Ehrenreich H, Rossner MJ (2010).
Cognitive and Sensorimotor Gating Impairments in Transgenic Mice Overexpressing the Schizophrenia Susceptibility Gene Tcf4 in the Brain.
Biol Psychiatry. 68, 33-40


Quintes S, Goebbels S, Saher G, Schwab MH, Nave KA (2010).
Neuron-glia signaling and the protection of axon function by Schwann cells.
J Peripher Nerv Syst. 15, 10-16


Werner HB, Jahn O (2010).
Myelin matters: proteomic insights into white matter disorders.
Expert Rev Proteomics. 7, 159-164


Gu C, Stein GH, Pan N, Goebbels S, Hörnberg H, Nave KA, Herrera P, White P, Kaestner KH, Sussel L, Lee JE (2010).
Pancreatic beta cells require NeuroD to achieve and maintain functional maturity.
Cell Metab. 11, 298-310


Nave KA (2010).
Oligodendrocytes and the "Micro Brake" of Progenitor Cell Proliferation.
Neuron 65, 577-579


Nave KA (2010).
Myelination and the trophic support of long axons.
Nat Rev Neurosci. 11, 275-283


Saher G, Simons M (2010).
Cholesterol and myelin biogenesis.
Subcell Biochem. 51, 489-508


Barrie JA, Montague P, Karim S, Kirkham D, Nave KA, Anderson TJ, Griffiths IR, McLaughlin M (2010).
Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms.
J Neurosci Res. 88, 2135-2145


Kawabe H, Neeb A, Dimova K, Young SM Jr, Takeda M, Katsurabayashi S, Mitkovski M, Malakhova OA, Zhang DE, Umikawa M, Kariya KI, Goebbels S, Nave KA, Rosenmund C, Jahn O, Rhee J, Brose N (2010).
Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development.
Neuron 65, 358-372


Bremer J, Baumann F, Tiberi C, Wessig C, Fischer H, Schwarz P, Steele AD, Toyka KV, Nave KA, Weis J, Aguzzi A (2010).
Axonal prion protein is required for peripheral myelin maintenance.
Nat Neurosci. 13, 310-318


Edgar JM, McCulloch MC, Montague P, Brown AM, Thilemann S, Pratola L, Gruenenfelder FI, Griffiths IR, Nave KA (2010).
Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease.
EMBO Mol Med. 2, 42-50


2009

Kroner A, Ip CW, Thalhammer J, Nave KA, Martini R (2009).
Ectopic T-Cell Specificity and Absence of Perforin and Granzyme B Alleviate Neural Damage in Oligodendrocyte Mutant Mice.
Am J Pathol. 176, 549-555


Botvinnik A, Wichert SP, Fischer TM, Rossner MJ (2009).
Integrated analysis of receptor activation and downstream signaling with EXTassays.
Nat Methods. 7, 74-80


Seuntjens E, Nityanandam A, Miquelajauregui A, Debruyn J, Stryjewska A, Goebbels S, Nave KA, Huylebroeck D, Tarabykin V (2009).
Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors.
Nat Neurosci. 12, 1373-1380


Deakin IH, Law AJ, Oliver PL, Schwab MH, Nave KA, Harrison PJ, Bannerman DM (2009).
Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice.
Neuroreport. 20, 1523-1528


Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST (2009).
Axonal transport defects in neurodegenerative diseases.
J. Neurosci. 29, 12776-12786


Merkler D, Klinker F, Jürgens T, Glaser R, Paulus W, Brinkmann BG, Sereda MW, Stadelmann-Nessler C, Guedes RC, Brück W, Liebetanz D (2009).
Propagation of spreading depression inversely correlates with cortical myelin content.
Ann Neurol. 66, 355-365


Edgar JM, Nave KA (2009).
The role of CNS glia in preserving axon function.
Curr Opin Neurobiol. 19, 498-504


Gao Z, Ure K, Ables JL, Lagace DC, Nave KA, Goebbels S, Eisch AJ, Hsieh J (2009).
Neurod1 is essential for the survival and maturation of adult-born neurons.
Nat Neurosci. 12, 1090-1092


He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL Jr, Rossner MJ, Nishino S, Fu YH (2009).
The transcriptional repressor DEC2 regulates sleep length in mammals.
Science 325, 866-870


Hüttemann M, Zhang Z, Mullins C, Bessert D, Lee I, Nave KA, Appikatla S, Skoff RP (2009).
Different proteolipid protein mutants exhibit unique metabolic defects.
ASN Neuro. 1, e00014-e00014


Möbius W, Patzig J, Nave KA, Werner HB (2009).
Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection.
Neuron Glia Biol. 4, 111-127


Ruf TF, Quintes S, Sternik P, Gottmann U (2009).
Atorvastatin reduces the expression of aldo-keto reductases in HUVEC and PTEC. A new approach to influence the polyol pathway.
Clin Invest Med. 32, E219-E228


Edgar JM, McLaughlin M, Werner HB, McCulloch MC, Barrie JA, Brown A, Faichney AB, Snaidero N, Nave KA, Griffiths IR. (2009).
Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1.
Glia 57, 1815-1824


Edgar JM, McLaughlin M, Werner HB, McCulloch MC, Barrie JA, Brown A, Faichney AB, Snaidero N, Nave KA, Griffiths IR (2009).
Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1.
Glia 57, 1815-1824


Jahn O, Tenzer S, Werner HB (2009).
Myelin proteomics: molecular anatomy of an insulating sheath.
Mol Neurobiol. 40, 55-72


Kroner A, Schwab N, Ip CW, Ortler S, Göbel K, Nave KA, Mäurer M, Martini R, Wiendl H (2009).
Accelerated Course of Experimental Autoimmune Encephalomyelitis in PD-1-Deficient Central Nervous System Myelin Mutants.
Am J Pathol. 174, 2290-2299


Saher G, Quintes S, Möbius W, Wehr MC, Krämer-Albers EM, Brügger B, Nave KA (2009).
Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction.
J Neurosci. 29, 6094-6104


Saito K, Dubreuil V, Arai Y, Wilsch-Bräuninger M, Schwudke D, Saher G, Miyata T, Breier G, Thiele C, Shevchenko A, Nave KA, Huttner WB (2009).
Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.
Proc Natl Acad Sci U S A. 106, 8350-8355


Nawaz S, Kippert A, Saab AS, Werner HB, Lang T, Nave KA, Simons M (2009).
Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium.
J Neurosci. 29, 4794-4807


Leal A, Huehne K, Bauer F, Sticht H, Berger P, Suter U, Morera B, Del Valle G, Lupski JR, Ekici A, Pasutto F, Endele S, Barrantes R, Berghoff C, Berghoff M, Neundörfer B, Heuss D, Dorn T, Young P, Santolin L, Uhlmann T, Meisterernst M, Sereda MW, Stassart RM, Zu Horste GM, Nave KA, Reis A, Rautenstrauss B (2009).
Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models.
Neurogenetics 10, 275-287


Berman SB, Chen YB, Qi B, McCaffery JM, Rucker EB 3rd, Goebbels S, Nave KA, Arnold BA, Jonas EA, Pineda FJ, Hardwick JM (2009).
Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons.
J Cell Biol. 184, 707-719


Kroner A, Schwab N, Ip CW, Leder C, Nave KA, Mäurer M, Wiendl H, Martini R (2009).
PD-1 regulates neural damage in oligodendroglia-induced inflammation.
PLoS ONE. 4, e4405-


Hirrlinger J, Scheller A, Hirrlinger PG, Kellert B, Tang W, Wehr MC, Goebbels S, Reichenbach A, Sprengel R, Rossner MJ, Kirchhoff F (2009).
Split-cre complementation indicates coincident activity of different genes in vivo.
PLoS ONE. 4, e4286-e4286


Schardt A, Brinkmann BG, Mitkovski M, Sereda MW, Werner HB, Nave KA (2009).
The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia.
J Neurosci Res. 87, 3465-3479


Gulbagci NT, Li L, Ling B, Gopinadhan S, Walsh M, Rossner M, Nave KA, Taneja R (2009).
SHARP1/DEC2 inhibits adipogenic differentiation by regulating the activity of C/EBP.
EMBO Rep. 10, 79-86


Buser AM, Erne B, Werner HB, Nave KA, Schaeren-Wiemers N (2009).
The septin cytoskeleton in myelinating glia.
Mol Cell Neurosci. 40, 156-166


Delaunay D, Heydon K, Miguez A, Schwab M, Nave KA, Thomas JL, Spassky N, Martinez S, Zalc B (2009).
Genetic tracing of subpopulation neurons in the prethalamus of mice (Musmusculus).
J Comp Neurol. 512, 74-83


Nave KA, Schwab MH
Neural Crest Cell Diversification and Specification: ErbB Role
In: Encyclopedia of Neuroscience (Ed. Squire LR) (Elsevier Academic Press) (2009) pp. 135-142

2008

Corbeil D, Joester A, Fargeas CA, Jászai J, Garwood J, Hellwig A, Werner HB, Huttner WB (2008).
Expression of distinct splice variants of the stem cell marker prominin-1 (CD133) in glial cells.
Glia 57, 860-874


Buser AM, Erne B, Werner HB, Nave KA, Schaeren-Wiemers N (2008).
The septin cytoskeleton in myelinating glia.
Mol Cell Neurosci. 40, 156-166


Delaunay D, Heydon K, Miguez A, Schwab M, Nave KA, Thomas JL, Spassky N, Martinez S, Zalc B (2008).
Genetic tracing of subpopulation neurons in the prethalamus of mice (Mus musculus).
J Comp Neurol. 512, 74-83


Karram K, Goebbels S, Schwab M, Jennissen K, Seifert G, Steinhäuser C, Nave KA, Trotter J (2008).
NG2-expressing cells in the nervous system revealed by the NG2-EYFP-knockin mouse.
Genesis. 46, 743-757


Dimou L, Simon C, Kirchhoff F, Takebayashi H, Götz M (2008).
Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex.
J Neurosci. 28, 10434-10442


Nave KA (2008).
Neuroscience: An ageing view of myelin repair.
Nature 455, 478-479


Birchmeier C, Nave KA (2008).
Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation.
Glia 56, 1491-1497


Brinkmann, B. G., Agarwal, A., Sereda, M. W., Garratt, A.N., Wende, T.H., Stassart, R.M., Nawaz, S., Humml, C. , Velanac, V., Radyuschkin, K., Goebbels, S., Fischer, T. M., Franklin, R. J., Lai, C., Ehrenreich, H., Birchmeier, C., Schwab, M. H., and Nave, K.-A. (2008).
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Neuron 59, 581-595


Bröhl D, Strehle M, Wende H, Hori K, Bormuth I, Nave KA, Müller T, Birchmeier C (2008).
A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord.
Dev Biol. 322, 381-393


Rossner MJ, Oster H, Wichert SP, Reinecke L, Wehr MC, Reinecke J, Eichele G, Taneja R, Nave KA. (2008).
Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice.
PLoS ONE. 3e2762


Wehr MC, Reinecke L, Botvinnik A, Rossner MJ (2008).
Analysis of transient phosphorylation-dependent protein-protein interactions in living mammalian cells using split-TEV.
BMC Biotechnol. 8, 55-55


Yin X, Kidd GJ, Nave KA, Trapp BD (2008).
P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes.
J Neurosci. 28, 7068-7073


Wolf F, Kirchhoff F. (2008).
Neuroscience. Imaging astrocyte activity.
Science 320, 1597-1599


Ip CW, Kohl B, Kleinschnitz C, Reuss B, Nave KA, Kroner A, Martini R. (2008).
Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: Low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve.
Mol Cell Neurosci. 38, 489-494


Begemann M, Sargin D, Rossner MJ, Bartels C, Theis F, Wichert SP, Stender N, Fischer B, Sperling S, Stawicki S, Wiedl A, Falkai P, Nave KA, Ehrenreich H. (2008).
Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches.
Mol Med. 14, 546-552


Lalo U, Pankratov Y, Wichert SP, Rossner MJ, North RA, Kirchhoff F, Verkhratsky A (2008).
P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes.
J Neurosci. 28, 5473-5480


Kassmann CM, Nave KA (2008).
Oligodendroglial impact on axonal function and survival - a hypothesis.
Curr Opin Neurol. 21, 235-41


Delaunay D, Heydon K, Cumano A, Schwab MH, Thomas JL, Suter U, Nave KA, Zalc B, Spassky N. (2008).
Early neuronal and glial fate restriction of embryonic neural stem cells.
J Neurosci. 28, 2551-2562


Hamilton N, Vayro S, Kirchhoff F, Verkhratsky A, Robbins J, Gorecki DC, Butt AM (2008).
Mechanisms of ATP- and glutamate-mediated calcium signaling in white matter astrocytes.
Glia 56, 734-749


Cooper B, Werner HB, Flügge G. (2008).
Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum.
Brain Res. 1197, 1-12


Chatterjee N, Stegmüller J, Schätzle P, Karram K, Koroll M, Werner HB, Nave KA, Trotter J. (2008).
Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells.
J Biol Chem. 283, 8310-7


Moers A, Nürnberg A, Goebbels S, Wettschureck N, Offermanns S. (2008).
Galpha12/Galpha13 deficiency causes localized overmigration of neurons in the developing cerebral and cerebellar cortices.
Mol Cell Biol. 28, 1480-1488


Wessig C, Jestaedt L, Sereda MW, Bendszus M, Stoll G (2008).
Gadofluorine M-enhanced magnetic resonance nerve imaging: comparison between acute inflammatory and chronic degenerative demyelination in rats.
Exp Neurol 210, 137-143


Nave, KA, Trapp, BD (2008).
Axon-Glial Signaling and the Glial Support of Axon Function
Annu Rev Neurosci. 31, 535-561


Trapp, B.D. Nave, K.-A. (2008).
Multiple Sclerosis: An Immune or A Neurodegenerative Disorder?
Annu. Rev. Neurosci. 31, 247-69


2007

Belvindrah R, Graus-Porta D, Goebbels S, Nave KA, Müller U. (2007).
Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex.
J Neurosci. 27, 13854-13865


Dhaunchak AS, Nave KA. (2007).
A common mechanism of PLP/DM20 misfolding causes cysteine-mediated endoplasmic reticulum retention in oligodendrocytes and Pelizaeus-Merzbacher disease.
Proc Natl Acad Sci U S A. 104, 17813-17818


Newrzella D, Pahlavan PS, Krüger C, Boehm C, Sorgenfrei O, Schröck H, Eisenhardt G, Bischoff N, Vogt G, Wafzig O, Rossner M, Maurer MH, Hiemisch H, Bach A, Kuschinsky W, Schneider A (2007).
The functional genome of CA1 and CA3 neurons under native conditions and in response to ischemia.
BMC Genomics 8, 370-370


Leder C, Schwab N, Ip CW, Kroner A, Nave KA, Dornmair K, Martini R, Wiendl H. (2007).
Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice.
Mol Cell Neurosci. 36, 416-424


Ehrenreich H, Fischer B, Norra C, Schellenberger F, Stender N, Stiefel M, Sirén AL, Paulus W, Nave KA, Gold R, Bartels C. (2007).
Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis.
Brain 130, 2577-2588


Nave K.-A., Sereda M.W., Ehrenreich, H. (2007).
Mechanisms of disease: inherited demyelinating neuropathies-from basic to clinical research.
Nat Clin Pract Neurol. 8, 453-464


Kassmann, C. M., Lappe-Siefke, C., Baes, M., Brügger, B., Mildner, A., Werner, H. B., Natt, O., Michaelis, T., Prinz, M., Frahm, J., Nave, K.-A. (2007).
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
Nat Genet. 39, 969-976


He, Y., Dupree, J., Wang, J., Sandoval, J., Li, J., Liu, H., Shi, Y., Nave, K.-A., Casaccia-Bonnefil, P. (2007).
The transcription factor yin yang 1 is essential for oligodendrocyte progenitor differentiation.
Neuron 55, 217-230


Werner, H. B., Kuhlmann, K., Shen, S., Uecker, M., Schardt, A., Dimova, K., Orfaniotou, F., Dhaunchak, A., Brinkmann, B.G., Möbius, W., Guarente, L., Casaccia-Bonnefil, P., Jahn, O., Nave, K.-A. (2007).
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin
J Neurosci. 27, 7717-7730


Benninger Y, Thurnherr T, Pereira JA, Krause S, Wu X, Chrostek-Grashoff A, Herzog D, Nave KA, Franklin RJ, Meijer D, Brakebusch C, Suter U, Relvas JB. (2007).
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.
J Cell Biol. 177, 1051-1061


Verkhratsky, A., Kirchhoff, F. (2007).
Glutamate-mediated neuronal-glial transmission
J Anat. 210, 651-660


Ivanova N, Claeys KG, Deconinck T, Litvinenko I, Jordanova A, Auer-Grumbach M, Haberlova J, Löfgren A, Smeyers G, Nelis E, Mercelis R, Plecko B, Priller J, Zámecník J, Ceulemans B, Erichsen AK, Björck E, Nicholson G, Sereda MW, Seeman P, Kremensky I, Mitev V, De Jonghe P. (2007).
Hereditary spastic paraplegia 3A associated with axonal neuropathy
Arch Neurol. 64, 706-713


Chvatal, A., Anderova, M., Kirchhoff, F. (2007).
Three-dimensional confocal morphometry - a new approach for studying dynamic changes in cell morphology in brain slices
J Anat. 210, 671-683


Wigley, R., Hamilton, N., Nishiyama, A., Kirchhoff, F., Butt, A.M. (2007).
Morphological and physiological interactions of NG2-glia with astrocytes and neurons
J Anat. 210, 661-670


Giaume, C., Kirchhoff, F., Matute, C., Reichenbach, A., Verkhratsky, A. (2007).
Glia : The fulcrum of brain diseases
Cell Death Differ. 14, 1324-1335


Nadrigny, F., Li, D.D., Kemnitz, K., Ropert, N., Koulakoff, A., Rudolph, S., Vitali, M., Giaume, C., Kirchhoff, F., Oheim, M. (2007).
Systematic colocalization errors between acridine orange and EGFP in astrocyte vesicular organelles
Biophys J. 93, 969-980


Meyer zu Hörste, G., Prukop, T., Liebetanz, D., Möbius, W., Nave, K.-A., Sereda, M.W. (2007).
Antiprogesterone therapy uncouples axonal loss from demyelination in a transgenic rat model of CMT1 neuropathy.
Ann Neurol. 61, 61-72


Grove, M., Komiyama, N.H., Nave, K.-A., Grant, S.G., Sherman, D.L., Brophy, P.J. (2007).
FAK is required for axonal sorting by Schwann cells
J Cell Biol. 176, 277-282


Fünfschilling, U., Saher, G., Xiao, L., Möbius, W., Nave, K.-A. (2007).
Survival of adult neurons lacking cholesterol synthesis in vivo
BMC Neurosci. 8, 1-


Zeger, M., Popken, G., Zhang, J., Xuan, S., Lu, Q.R., Schwab, M.H., Nave, K.-A., Rowitch, D., D'Ercole. A.J., Ye, P. (2007).
Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination
Glia 55, 400-411


Karim, S.A., Barrie, J.A., McCulloch, M.C., Montague, P., Edgar, J.M., Kirkham, D., Anderson, T.J., Nave, K.-A., Griffiths, I.R., McLaughlin, M. (2007).
PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease
Glia 55, 341-351


Ip, C.W., Kroner, A., Crocker, P.R., Nave, K.-A., Martini, R. (2007).
Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice
Neurobiol Dis. 25, 105-111


2006

Goebbels, S., Bormuth, I., Bode, U., Hermanson, O., Schwab, M. H., Nave, K.-A. (2006).
Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice
Genesis 44, 611-621


Kaga, Y., Shoemaker, W. J., Furusho, M., Bryant, M., Rosenbluth, J., Pfeiffer, S. E., Oh, L., Rasband, M., Lappe-Siefke, C., Yu, K., Ornitz, D. M., Nave, K.-A., Bansal, R. (2006).
Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation
J Neurosci. 26, 12339-12350


Krämer-Albers, E.-M., Gehrig-Burger, K., Thiele, C., Trotter, J., Nave, K.-A. (2006).
Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: Implications for dysmyelination in spastic paraplegia
J Neurosci. 26, 11743-11752


Lu, Y.-B., Franze, K., Seifert, G., Steinhäuser, C., Kirchhoff, F., Wolburg, H., Guck, J., Janmey, P., Wei, E.-Q., Käs, J., Reichenbach, A. (2006).
Viscoelastic properties of individual glial cells and neurons in the CNS
Proc Natl Acad Sci U S A. 103, 17759-17764


Wehr, M. C., Laage, R., Bolz, U., Fischer, T. M., Grünewald, S., Scheek, S., Bach, A., Nave, K.-A., Rossner, M. J. (2006).
Monitoring regulated protein-protein interactions using split TEV
Nat Methods. 3, 985-993


Oheim, M., Kirchhoff, F., Stühmer, W. (2006).
Calcium microdomains in regulated exocytosis
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Fitzner, D., Schneider, A., Kippert, A., Möbius, W., Willig, K. I., Hell, S. W., Bunt, G., Gaus, K., Simons, M. (2006).
Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin
EMBO J. 25, 5037-5048


Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S. M., Nave, K.-A., Franklin, R. J. M., Brakebusch, C., Suter, U., Relvas, J. B. (2006).
Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS
J Neurosci. 26, 10110-10119


Weishaupt, J. H., Bartels, C., Pölking, E., Dietrich, J., Rohde, G., Poeggeler, B., Mertens, N., Sperling, S., Bohn, M., Hüther, G., Schneider, A., Bach, A., Sirén, A.-L., Hardeland, R., Bähr, M., Nave, K.-A., Ehrenreich, H. (2006).
Reduced oxidative damage in ALS by high-dose enteral melatonin treatment
J Pineal Res. 41, 313-323


Sözke, K., Härtel, K., Graß, D., Hirrlinger, P. G., Hirrlinger, J., Hülsmann, S. (2006).
Glycine transporter 1 expression in the ventral respiratory group is restricted to protoplasmic astrocytes
Brain Res. 1119, 182-189


Rossner, M. J., Hirrlinger, J., Wichert, S. P., Boehm, C., Newrzella, D., Hiemisch, H., Eisenhardt, G., Stuenkel, C., Ahsen, O. v., Nave, K.-A. (2006).
Global transcriptome analysis of genetically identified neurons in the adult cortex
J. Neurosci. 26, 9956-9966


Meyer zu Hörste, G., Nave, K.-A. (2006).
Animal models of inherited neuropathies
Curr Opin Neurol. 19, 464-473


Nave, K.-A., Salzer, J. L. (2006).
Axonal regulation of myelination by neuregulin 1
Curr Opin Neurobiol. 16, 492-500


Kaiser, M., Maletzki, I., Hülsmann, S., Holtmann, B., Schulz-Schaeffer, W., Kirchhoff, F., Bähr, M., Neusch, C. (2006).
Progressive loss of a glial potassium channel (KCNJ10) in the spinal cord of the SOD1 (G93A) transgenic mouse model of amyotrophic lateral sclerosis
J Neurochem. 99, 900-912


Monory, K., Massa, F., Egertova, M., Eder, M., Blaudzun, H., Westenbroek, R., Kelsch, W., Jacob, W., Marsch, R., Ekker, M., Long, J., Rubenstein, J. L., Goebbels, S., Nave, K.-A., During, M., Klugmann, M., Wölfel, B., Dodt, H.-U., Zieglgänsberger, W (2006).
The endocannabinoid system controls key epileptogenic circuits in the hippocampus
Neuron. 51, 455-466


Kashani, A. H., Qiu, Z., Jurata, L., Lee, S.-K., Pfaff, S., Goebbels, S., Nave, K.-A., Ghosh, A. (2006).
Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections
J Neurosci. 26, 8398-8408


Ip, C. W., Kroner, A., Bendszus, M., Leder, C., Kobsar, I., Fischer, S., Wiendl, H., Nave, K.-A., Martini, R. (2006).
Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes
J Neurosci. 26, 8206-8216


Benninger, Y., Colognato, H., Thurnherr, T., Franklin, R. J. M., Leone, D. P., Atanasoski, S., Nave, K.-A., ffrench-Constant, C., Suter, U., Relvas, J. B. (2006).
Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination
J Neurosci. 26, 7665-7673


Rosenbluth, J., Nave, K.-A., Mierzwa, A., Schiff, R. (2006).
Subtle myelin defects in PLP-null mice
Glia 54, 172-182


Sereda, M. W., Nave, K.-A. (2006).
Animal models of Charcot-Marie-Tooth disease type 1A
Neuromelcular Med. 8, 205-215


Meyer zu Hörste, G., Prukop, T., Nave, K.-A., Sereda, M. W. (2006).
Myelin disorders : causes and perspectives of Charcot-Marie-Tooth neuropathy
J Mol Neurosci. 28, 77-88


Meyer zu Hörste G, Prukop T, Nave KA, Sereda MW (2006).
Myelin disorders: Causes and perspectives of Charcot-Marie-Tooth neuropathy.
J. Mol. Neurosci. 28, 77-88


Fowler, J. H., Edgar, J. M., Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I. R., Garbern, J. Y., Nave, K.-A., Dewar, D. (2006).
Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein
J Neurosci Res. 84, 68-77


Hirrlinger, P. G., Scheller, A., Braun, C., Hirrlinger, J., Kirchhoff, F. (2006).
Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifen-inducible DNA recombinase variant CreERT2
Glia 54, 11-20


Nadrigny, F., Rivals, I., Hirrlinger, P. G., Koulakoff, A., Personnaz, L., Vernet, M., Allioux, M., Chaumeil, M., Ropert, N., Giaume, C., Kirchhoff, F., Oheim, M. (2006).
Detecting fluorescent protein expression and co-localisation on single secretory vesicles with linear spectral unmixing
Eur Biophys J. 35, 533-547


Nobbio, L., Gherardi, G., Vigo, T., Passalacqua, M., Melloni, E., Abbruzzese, M., Mancardi, G., Nave, K.-A., Schenone, A. (2006).
Axonal damage and demyelination in long-term dorsal root ganglia cultures from a rat model of Charcot-Marie-Tooth type 1A disease
Eur J Neurosci. 23, 1445-1452


Lalo, U., Pankratov, Y., Kirchhoff, F., North, R. A., Verkhratsky, A. (2006).
NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes
J Neurosci. 26, 2673-2683


Yin, X., Baek, R. C., Kirschner, D. A., Peterson, A., Fujii, Y., Nave, K.-A., Macklin, W. B., Trapp, B. D. (2006).
Evolution of a neuroprotective function of central nervous system myelin
J Cell Biol. 172, 469-478


Ghashghaei, H. T., Weber, J., Pevny, L., Schmid, R., Schwab, M. H., Lloyd, K. C. K., Eisenstat, D. D., Lai, C., Anton, E. S. (2006).
The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone
Proc Natl Acad Sci U S A. 103, 1930-1935


Fauré, J., Lachenal, G., Court, M., Hirrlinger, J., Chatellard-Causse, C., Blot, B., Grange, J., Schoehn, G., Goldberg, Y., Boyer, V., Kirchhoff, F., Raposo, G., Garin, J., Sadoul, R. (2006).
Exosomes are released by cultured cortical neurones
Mol Cell Neurosci. 31, 642-648


Neusch, C., Papadopoulos, N., Müller, M., Maletzki, I., Winter, S. M., Hirrlinger, J., Handschuh, M., Bähr, M., Richter, D. W., Kirchhoff, F., Hülsmann, S. (2006).
Lack of the Kir4.1 channel subunit abolishes K+ buffering properties of astrocytes in the ventral respiratory group : impact on extracellular K+ regulation
J Neurophisol. 95, 1843-1852


Schweitzer, J., Becker, T., Schachner, M., Nave, K.-A., Werner, H. (2006).
Evolution of myelin proteolipid proteins: Gene duplication in teleosts and expression pattern divergence
Mol Cell Neurosci. 31, 161-177


Wehr, M. C.
Charakterisierung regulierter Protein-Protein-Interaktionen in Säugerzellen mit Split-TEV
Ruprecht-Karls-Universität Heidelberg (2006)

Dhaunchak, A. S.
Subcellular trafficking of proteolipid protein (PLP/DM20) and novel mechanisms of ER retention in Pelizaeus-Merzbacher disease
Georg-August-Universität Göttingen (2006)

Houades, V., Rouach, N., Ezan, P., Kirchhoff, F., Koulakoff, A., Giaume, C. (2006).
Shapes of astrocyte networks in the juvenile brain
Neuron Glia Biology 2, 3-14


Meyer zu Hörste, G.
Therapeutische Anwendung des Progesteronantagonisten "Onapriston" im transgenen Rattenmodell der Charcot-Marie-Tooth-Erkrankung Typ 1A (CMT1A)
Georg-August-Universität Göttingen (2006)

Werner H, Nave KA
Glial cells and myelination.
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2005

Hirrlinger, J., Moeller, H., Kirchhoff, F., Dringen, R. (2005).
Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: A single cell RT-PCR study
Neurochem Res. 30, 1237-1244


Itoh T, Erdmann KS, Roux A, Habermann B, Werner H, De Camilli P. (2005).
Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins.
Dev Cell. 9, 791-804


Wu, S.-X., Goebbels, S., Nakamura, K., Nakamura, K., Kometani, K., Minato, N., Kaneko, T., Nave, K.-A., Tamamaki, N. (2005).
Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone
Proc Natl Acad Sci U S A. 102, 17172-17177


Nave, K.-A., Schwab, M. H. (2005).
Glial cells under remote control
Nat Neurosci. 8, 1420-1422


Moosmang, S., Haider, N., Klugbauer, N., Adelsberger, H., Langwieser, N., Müller, J., Stiess, M., Marais, E., Schulla, V., Lacinova, L., Goebbels, S., Nave, K.-A., Storm, D. R., Hofmann, F., Kleppisch, T. (2005).
channels in NMDA receptor-independent synaptic plasticity and spatial memory
J Neurosci. 25, 9883-9892


Moosmang, S., Haider, N., Klugbauer, N., Adelsberger, H., Langwieser, N., Müller, J., Stiess, M., Marais, E., Schulla, V., Lacinova, L., Goebbels, S., Nave, K.-A., Storm, D.R., Hofmann, F., Kleppisch, T. (2005).
Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory
J Neurosci. 25, 9883-9892


Hirrlinger, P. G., Scheller, A., Braun, C., Quintela-Schneider, M., Fuss, B., Hirrlinger, J., Kirchhoff, F. (2005).
Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice
Mol Cell Neurosci. 30, 291-303


Osada, T., Tamamaki, N., Song, S.-Y., Kakazu, N., Yamazaki, Y., Makino, H., Sasaki, A., Hirayama, T., Hamada, S., Nave, K.-A., Yanagimachi, R., Yagi, T. (2005).
Developmental pluripotency of the nuclei of neurons in the cerebral cortex of juvenile mice
J Neurosci. 25, 8368-8374


Goebbels, S., Bode, U., Pieper, A., Fünfschilling, U., Schwab, M. H., Nave, K.-A. (2005).
Cre/loxP-Mediated inactivation of the bHLH transcription factor gene NeuroD/BETA2
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Schneider, A., Länder, H., Schulz, G., Wolburg, H., Nave, K.-A., Schulz, J. B., Simons, M. (2005).
Palmitoylation is a sorting determinant for transport to the myelin membrane
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Nimmerjahn, A., Kirchhoff, F., Helmchen, F. (2005).
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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Vigo, T., Nobbio, L., Van Hummelen, P., Abbruzzese, M., Mancardi, G. L., Verpoorten, N., Verhoeven, K., Sereda, M. W., Nave, K.-A., Timmerman, V., Schenone, A. (2005).
Experimental Charcot-Marie-Tooth type 1A: A cDNA microarrays analysis
Mol Cell Neurosci. 28, 703-714


Saher, G., Brügger, B., Lappe-Siefke, C., Möbius, W., Tozawa, R., Wehr, M. C., Wieland, F., Ishibashi, S., Nave, K.-A. (2005).
High cholesterol level is essential for myelin membrane growth
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Neubrand, V. E., Will, R. D., Möbius, W., Poustka, A., Wiemann, S., Schu, P., Dotti, C. G., Pepperkok, R., Simpson, J. C. (2005).
Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking
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Rasband, M. N., Tayler, J., Kaga, Y., Yang, Y., Lappe-Siefke, C., Nave, K.-A., Bansal, R. (2005).
CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS
Glia 50, 86-90


Dringen, R., Pawlowski, P. G., Hirrlinger, J. (2005).
Peroxide detoxification by brain cells
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Meyer zur Hörste, G., Sereda, M. W. (2005).
Genetische Defekte der Myelinbildung: Molekulare Pathogenese der Charcot-Marie-Tooth Neuropathie (CMT1A)
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Kassmann, C.
Konditionale Inaktivierung von Peroxisomen im Nervensystem der Maus : ein transgenes Modell einer humanen Leukodystrophie
Eberhard-Karls-Universität Heidelberg (2005)

Fischer, T.
Tetracycline-dependent gene expression in cholinergic neurons of transgenic mice - a tool to study Neuregulin-1 function in vivo
Eberhard-Karls-Universität Heidelberg (2005)

Nave KA, Werner H
Mutations of myelin-associated genes that affect axonal integrity.
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2004

Nimmerjahn, A., Kirchhoff, F., Kerr, J. N., Helmchen, F. (2004).
Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
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Anton, E. S., Ghashghaei, H. T., Weber, J. L., McCann, C., Fischer, T. M., Cheung, I. D., Gassmann, M., Messing, A., Klein, R., Schwab, M. H., Lloyd, K. C. K., Lai, C. (2004).
Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain
Nat Neurosci. 7, 1319-1328


Maurer, M. H., Grünewald, S., Gassler, N., Rossner, M., Propst, F., Würz, R., Weber, D., Kuner, T., Kuschinsky, W., Schneider, A. (2004).
Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor
J Neurochem. 91, 1007-1017


Ludwig, A., Schlierf, B., Schardt, A., Nave, K. A., Wegner, M. (2004).
Sox10-rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes
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Morgan JR, Di Paolo G, Werner H, Shchedrina VA, Pypaert M, Pieribone VA, De Camilli P (2004).
A role for talin in presynaptic function.
J Cell Biol. 167, 43-50


Grandis, M., Leandri, M., Vigo, T., Cilli, M., Sereda, M. W., Gherardi, G., Benedetti, L., Mancardi, G., Abbruzzese, M., Nave, K. A., Nobbio, L., Schenone, A. (2004).
Early abnormalities in sciatic nerve function and structure in a rat model of Charcot-Marie-Tooth type 1A disease
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Hirrlinger, J., Hülsmann, S., Kirchhoff, F. (2004).
Astroglial processes show spontaneous motility at active synaptic terminals in situ
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Potrovita, I., Zhang, W., Burkly, L., Hahm, K., Lincecum, J., Wang, M. Z., Maurer, M. H., Rossner, M., Schneider, A., Schwaninger, M. (2004).
Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration
J Neurosci. 24, 8237-8244


Skoff, R. P., Bessert, D. A., Cerghet, M., Franklin, M. J., Rout, U. K., Nave, K. A., Carlock, L., Ghandour, M. S., Armant, D. R. (2004).
The myelin proteolipid protein gene modulates apoptosis in neural and non-neural tissues
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Brockschnieder, D., Lappe-Siefke, C., Goebbels, S., Boesl, M. R., Nave, K. A., Riethmacher, D. (2004).
Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination
Mol Cell Biol. 24, 7636-7642


Edgar, J. M., McLaughlin, M., Yool, D., Zhang, S. C., Fowler, J. H., Montague, P., Barrie, J. A., McCulloch, M. C., Duncan, I. D., Garbern, J., Nave, K. A., Griffiths, I. R. (2004).
Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia
J Cell Biol. 166, 121-131


Rimer, M., Prieto, A. L., Weber, J. L., Colasante, C., Ponomareva, O., Fromm, L., Schwab, M. H., Lai, C., Burden, S. J. (2004).
Neuregulin-2 is synthesized by motor neurons and terminal Schwann cells and activates acetylcholine receptor transcription in muscle cells expressing ErbB4
Mol Cell Neurosci. 26, 271-281


Tolson, J., Bogumil, R., Brunst, E., Beck, H., Elsner, R., Humeny, A., Kratzin, H., Deeg, M., Kuczyk, M., Mueller, G. A., Mueller, C. A., Flad, T. (2004).
Serum protein profiling by SELDI mass spectrometry: detection of multiple variants of serum amyloid alpha in renal cancer patients
Lab Invest. 84, 845-856


Michailov, G. V., Sereda, M. W., Brinkmann, B. G., Fischer, T. M., Haug, B., Birchmeier, C., Role, L., Lai, C., Schwab, M. H., Nave, K. A. (2004).
Axonal neuregulin-1 regulates myelin sheath thickness
Science 304, 700-703


Schneider, A., Laage, R., von Ahsen, O., Fischer, A., Rossner, M., Scheek, S., Grünewald, S., Kuner, R., Weber, D., Krüger, C., Klaussner, B., Götz, B., Hiemisch, H., Newrzella, D., Martin-Villalba, A., Bach, A., Schwaninger, M. (2004).
Identification of regulated genes during permanent focal cerebral ischemia : characterization of the protein kinase 9b5/MARKL1/MARK4
J Neurochem. 88, 1114-1126


Grass, D., Pawlowski, P. G., Hirrlinger, J., Papadopoulos, N., Richter, D. W., Kirchhoff, F., Hülsmann, S. (2004).
Diversity of functional astroglial properties in the respiratory network
J Neurosci. 24, 1358-1365


Schneider, A., Fischer, A., Weber, D., von Ahsen, O., Scheek, S., Krüger, C., Rossner, M., Klaussner, B., Faucheron, N., Kammandel, B., Goetz, B., Herrmann, O., Bach, A., Schwaninger, M. (2004).
Restriction-mediated differential display (RMDD) identifies pip92 as a pro-apoptotic gene product induced during focal cerebral ischemia
J Cereb Blood Flow Metab. 24, 224-236


Nave, K. A., Griffiths, I. R.
Models of Pelizaeus - Merzbacher disease In: Myelin biology and disorders
Acad. Pr. - Elsevier Amsterdam (2004) pp. 1125-1142

Edited by Robert A. Lazzarini, with John W. Griffin, Hans Lassman, Klaus-Armin Nave, Robert H. Miller, and Bruce D. Trapp.
Myelin biology and disorders
Acad.Pr.- Elsevier Amsterdam

Humml, C.
Untersuchungen zur Funktion von Neuregulin-1 während der Myelinisierung im peripheren Nervensystem
Ruprecht-Karls-Universität Heidelberg (2004)

2003

Hüttmann, K., Sadgrove, M., Wallraff, A., Hinterkeuser, S., Kirchhoff, F., Steinhäuser, C., Gray, W.P. (2003).
Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis
Eur J Neurosci. 18, 2769-2778


Beggs, H.E., Schahin-Reed, D., Zang, K., Goebbels, S., Nave, K.A., Gorski, J., Jones, K.R., Sretavan, D., Reichardt, L.F. (2003).
FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies
Neuron 40, 501-514


Sereda, M.W., Meyer zur Hörste, G., Suter, U., Uzma, N., Nave, K.A. (2003).
Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-tooth disease (CMT-1A)
Nat Med. 9, 1533-1537


Rodemer, C., Thai, T.-P., Brugger, B., Kaercher, T., Werner, H., Nave, K.A., Wieland, F., Gorgas, K., Just, W.W. (2003).
Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice
Hum Mol Genet. 12, 1881-1895


Rodemer, C., Thai, T.-P., Brugger, B., Kaercher, T., Werner, H., Nave, K.A., Wieland, F., Gorgas, K., Just, W.W. (2003).
Inactivation of ether phospholipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice
Hum Mol Genet. 12, 1-15


Kleppisch, T., Wolfsgruber, W., Feil, S., Allmann, R., Wotjak, C.T., Goebbels, S., Nave, K.A., Hofmann, F., Feil, R. (2003).
Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory
J Neurosci. 23, 6005-6012


Wehner, T., Böntert, M., Eyüpoglu, I., Prass, K., Prinz, M., Klett, F.F., Heinze, M., Bechmann, I., Nitsch, R., Kirchhoff, F., Kettenmann, H., Dirnagl, U., Priller, J. (2003).
Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes In Vitro and In Vivo
J Neurosci. 23, 5004-5011


Al-Saktawi, K., McLaughlin, M., Klugmann, M., Schneider, A., Barrie, J. A., McCulloch, M. C., Montague, P., Kirkham, D., Nave, K. A., Griffiths, I. R. (2003).
Genetic background determines phenotypic severity of the Plp rumpshaker mutation
J Neurosci Res. 72, 12-24


Matthias, K., Kirchhoff, F., Seifert, G., Hüttmann, K., Matyash, M., Kettenmann, H., Steinhäuser, C. (2003).
Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampus
J Neurosci. 23, 1750-1758


Malatesta, P., Hack, M. A., Hartfuss, E., Kettenmann, H., Klinkert, W., Kirchhoff, F., Götz, M. (2003).
Neuronal or glial progeny: Regional differences in radial glia fate
Neuron 37, 751-764


Jurevics, H., Hostettler, J., Sammond, D. W., Nave, K. A., Toews, A. D., Morell, P. (2003).
Normal metabolism but different physical properties of myelin from mice deficient in proteolipid protein
J Neurosci Res. 71, 826-834


Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P.E., Griffiths, I.R., Nave, K.A. (2003).
Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
Nat Genet. 33, 366-374


Erb, M., Steck, A. J., Nave, K. A., Schaeren-Wiemers, N. (2003).
Differential expression of L- and S-MAG upon cAMP stimulated differentiation in oligodendroglial cells
J Neurosci Res. 71, 326-337


Rünker, A. E., Bartsch, U., Nave, K. A., Schachner, M. (2003).
The C264Y missense mutation in the extracellular domain of L1 impairs protein trafficking in vitro and in vivo
J Neurosci. 23, 277-286


Stegmüller, J., Werner, H., Nave, K. A., Trotter, J. (2003).
The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells - Implications for glial-neuronal signaling
J Biol Chem. 278, 3590-3598


Wehr, M.
Analyse der Funktion von Cholesterin in Oligodendrozyten
Ruprecht-Karls-Universität Heidelberg (2003)

2002

Yool, D., Montague, P., McLaughlin, M., McCulloch, M. C., Edgar, J. M., Nave, K. A., Davies, R. W., Griffiths, I. R., McCallion, A. S. (2002).
Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform
Glia 39, 256-267


Genoud, S., Lappe-Siefke, C., Goebbels, S., Radtke, F., Aguet, M., Scherer, S. S., Suter, U., Nave, K. A., Mantei, N. (2002).
Notch1 control of oligodendrocyte differentiation in the spinal cord
J Cell Biol. 158, 709-718


Edgar, J. M., Anderson, T. J., Dickinson, P. J., Barrie, J. A., McCulloch, M. C., Nave, K. A., Griffiths, I. R. (2002).
Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene
J Cell Biol. 158, 719-729


Maier, M., Berger, P., Nave, K. A., Suter, U. (2002).
Identification of the regulatory region of the peripheral myelin protein 22 (PMP22) gene that directs temporal and spatial expression in development and regeneration of peripheral nerves
Mol Cell Neurosci. 20, 93-109


Simons, M., Kramer, E. M., Macchi, P., Rathke-Hartlieb, S., Trotter, J., Nave, K. A., Schulz, J. B. (2002).
Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease
J Cell Biol. 157, 327-336


Garbern, J. Y., Yool, D. A., Moore, G. J., Wilds, I. B., Faulk, M. W., Klugmann, M., Nave, K. A., Sistermans, E. A., van der Knaap, M. S., Bird, T. D., Shy, M. E., Kamholz, J. A., Griffiths, I. R. (2002).
Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation
Brain 125, 551-561


Yool, D., Klugmann, M., Barrie, J. A., McCulloch, M. C., Nave, K. A., Griffiths, I. R. (2002).
Observations on the structure of myelin lacking the major proteolipid protein
Neuropathol Appl Neurobiol. 28, 75-78


Atanasoski, S., Scherer, S.S., Nave, K.A., Suter, S. (2002).
Proliferation of Schwann cells and regulation of cyclin D1 expression in an animal model of Charcot-Marie-Tooth disease type 1A
J Neurosci Res. 67, 443-449


Schipke, C. G., Boucsein, C., Ohlemeyer, C., Kirchhoff, F., Kettenmann, H. (2002).
Astrocyte Ca2+ waves trigger responses in microglial cells in brain slices
FASEB J. 16, 255-257


Dimou, L.
Die neuralen Proteolipide M6A und M6B : eine funktionale Analyse in vivo und in vitro
Ruprecht-Karl Universität Heidelberg (2002)

Lappe-Siefke, C.
Inaktivierung des CNP-Gens in der Maus und Expression der Cre-Rekombinase in myelinisierenden Gliazellen
Ruprecht-Karl Universität Heidelberg (2002)

Göbbels, S.
Zelltyp-spezifische Expression der Rekombinase Cre im Nervensystem der Maus
Ruprecht-Karl Universität Heidelberg (2002)

Sereda MW, Schöls L and Nave KA
Molekulargenetische Grundlagen der Charcot-Marie-Tooth Neuropathie (CMT/HMSN).
In: Schöls L, Riess O Neurogenetik, Kohlhammer. (2002) pp.

2001

Cerghet M, Bessert DA, Nave KA, Skoff RP (2001).
Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways.
J. Neurocytol. 30, 841-55


Werner H, Dimou L, Klugmann M, Pfeiffer S, Nave KA (2001).
Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes.
Mol. Cell. Neurosci. 18, 593-605


Yamada M, Jung M, Tetsushi K, Ivanova A, Nave KA, Ikenaka K (2001).
Mutant Plp/DM20 cannot be processed to secrete PLP-related oligodendrocyte differentiation/survival factor.
Neurochem. Res. 26, 639-45


Nobbio L, Mancardi G, Grandis M, Levi G, Suter U, Nave KA, Windebank AJ, Abbruzzese M, Schenone A (2001).
PMP22 transgenic dorsal root ganglia cultures show myelin abnormalities similar to those of human CMT1A.
Ann. Neurol. 50, 47-55


Krämer EM, Schardt A, Nave KA (2001).
Membrane traffic in myelinating oligodendrocytes.
Microsc. Res. Tech. 52, 656-71


Yool DA, Klugmann M, McLaughlin M, Vouyiouklis DA, Dimou L, Barrie JA, McCulloch MC, Nave KA, Griffiths IR (2001).
Myelin proteolipid proteins promote the interaction of oligodendrocytes and axons.
J. Neurosci. Res. 63, 151-64


Schneider S, Bosse F, D'Urso D, Muller H, Sereda MW, Nave K, Niehaus A, Kempf T, Schnolzer M, Trotter J (2001).
The AN2 protein is a novel marker for the Schwann cell lineage expressed by immature and nonmyelinating Schwann cells.
J. Neurosci. 21, 920-933


Britsch S, Goerich DE, Riethmacher D, Peirano RI, Rossner M, Nave KA, Birchmeier C, Wegner M (2001).
The transcription factor Sox10 is a key regulator of peripheral glial development.
Genes Dev. 15, 66-78


2000

Niemann S, Sereda MW, Suter U, Griffiths IR, Nave KA (2000).
Uncoupling of myelin assembly and schwann cell differentiation by transgenic overexpression of peripheral myelin protein 22.
J. Neurosci. 20, 4120-8


Schwab MH, Bartholomae A, Heimrich B, Feldmeyer D, Druffel-Augustin S, Goebbels S, Naya FJ, Zhao S, Frotscher M, Tsai MJ, Nave KA (2000).
Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus.
J. Neurosci. 20, 3714-24


Dimou L, Klugmann M, Werner H, Jung M, Griffiths IR, Nave KA (2000).
Dysmyelination in mice and the proteolipid protein gene family.
Adv. Exp. Med. Biol. 468, 261-71


Nave KA, Trapp B (2000).
Foreword
Glia 29, 103-


Klein L, Klugmann M, Nave KA, Tuohy VK, Kyewski B (2000).
Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.
Nat. Med. 6, 56-61


Bradl M, Bauer J, Inomata T, Zielasek J, Nave KA, Toyka K, Lassmann H, Wekerle H (2000).
Transgenic Lewis rats overexpressing the proteolipid protein gene: myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis.
Acta Neuropathol. 97, 595-606


1999

Werner H, Jung M, Klugmann M, Sereda M, Griffiths IR, Nave KA (1999).
Mouse models of myelin diseases.
Brain Pathol. 8, 771-93


Sereda MW (1999).
Altered protein synthesis in sciatic nerve by transgenic overexpression of PMP22 in the CMT rat.
Ann. N. Y. Acad. Sci. 883, 530-532


Niemann S, Sereda MW, Rossner M, Stewart H, Suter U, Meinck HM, Griffiths IR, Nave KA (1999).
The "CMT rat": peripheral neuropathy and dysmyelination caused by transgenic overexpression of PMP22.
Ann. N. Y. Acad. Sci. 883, 254-61


Suter U, Nave KA (1999).
Transgenic mouse models of CMT1A and HNPP.
Ann. N. Y. Acad. Sci. 883, 247-53


Anderson TJ, Klugmann M, Thomson CE, Schneider A, Readhead C, Nave KA, Griffiths IR (1999).
Distinct phenotypes associated with increasing dosage of the PLP gene: implications for CMT1A due to PMP22 gene duplication.
Ann. N. Y. Acad. Sci. 883, 234-46


Coetzee T, Suzuki K, Nave KA, Popko B (1999).
Myelination in the absence of galactolipids and proteolipid proteins.
Mol. Cell. Neurosci. 14, 41-51


1998

Niemann S, Sidman RL, Nave KA (1998).
Evidence against altered forms of MAG in the dysmyelinated mouse mutant claw paw.
Mamm. Genome 9, 903-4


Griffiths I, Klugmann M, Anderson T, Thomson C, Vouyiouklis D, Nave KA (1998).
Current concepts of PLP and its role in the nervous system.
Microsc. Res. Tech. 41, 344-58


Vouyiouklis DA, Werner H, Griffiths IR, Stewart GJ, Armin-Nave K, Thomson CE (1998).
Molecular cloning and transfection studies of M6b-2, a novel splice variant of a member of the PLP-DM20/M6 gene family.
J Neurosci Res. 52, 633-640


Griffiths I, Klugmann M, Anderson T, Yool D, Thomson C, Schwab MH, Schneider A, Zimmermann F, McCulloch M, Nadon N, Nave KA (1998).
Axonal swellings and degeneration in mice lacking the major proteolipid of myelin.
Science 280, 1610-3


Anderson TJ, Schneider A, Barrie JA, Klugmann M, McCulloch MC, Kirkham D, Kyriakides E, Nave KA, Griffiths IR (1998).
Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene.
J. Comp. Neurol. 394, 506-19


Rossner MJ, Dörr J, Gass P, Schwab MH, Nave KA (1998).
SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation.
Mol. Cell. Neurosci. 10, 460-75


Schwab MH, Druffel-Augustin S, Gass P, Jung M, Klugmann M, Bartholomae A, Rossner MJ, Nave KA (1998).
Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice.
J. Neurosci. 18, 1408-18


Forss-Petter S, Werner H, Berger J, Lassmann H, Molzer B, Schwab MH, Bernheimer H, Zimmermann F, Nave KA (1998).
Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice.
J. Neurosci. Res. 50, 829-43


Stewart HJ, Zoidl G, Rossner M, Brennan A, Zoidl C, Nave KA, Mirsky R, Jessen KR (1998).
Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development.
J. Neurosci. Res. 50, 684-701


Rossner MJ, Dörr J, Gass P, Schwab MH, Nave KA (1998).
SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation.
Mol. Cell. Neurosci. 9, 460-75


1997

Anderson TJ, Montague P, Nadon N, Nave KA, Griffiths IR (1997).
Modification of Schwann cell phenotype with Plp transgenes: evidence that the PLP and DM20 isoproteins are targeted to different cellular domains.
J. Neurosci. Res. 50, 13-22


Thomson CE, Montague P, Jung M, Nave KA, Griffiths IR (1997).
Phenotypic severity of murine Plp mutants reflects in vivo and in vitro variations in transport of PLP isoproteins.
Glia 20, 322-32


Klugmann M, Schwab MH, Pühlhofer A, Schneider A, Zimmermann F, Griffiths IR, Nave KA (1997).
Assembly of CNS myelin in the absence of proteolipid protein.
Neuron 18, 59-70


Jung M, Sommer I, Schachner M, Nave KA (1997).
Monoclonal antibody O10 defines a conformationally sensitive cell-surface epitope of proteolipid protein (PLP): evidence that PLP misfolding underlies dysmyelination in mutant mice.
J. Neurosci. 16, 7920-9


1996

Sereda M, Griffiths I, Pühlhofer A, Stewart H, Rossner MJ, Zimmerman F, Magyar JP, Schneider A, Hund E, Meinck HM, Suter U, Nave KA (1996).
A transgenic rat model of Charcot-Marie-Tooth disease.
Neuron 16, 1049-60


Griffiths IR, Schneider A, Anderson J, Nave KA (1996).
Transgenic and natural mouse models of proteolipid protein (PLP)-related dysmyelination and demyelination.
Brain Pathol. 5, 275-81


Nave KA (1996).
Myelin genetics: new insight into old diseases.
Brain Pathol. 5, 231-2


1995

Nave KA (1995).
Neurological mouse mutants and the genes of myelin.
J. Neurosci. Res. 38, 607-12


Bartholomä A, Nave KA (1995).
NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons.
Mech. Dev. 48, 217-28


Schneider AM, Griffiths IR, Readhead C, Nave KA (1995).
Dominant-negative action of the jimpy mutation in mice complemented with an autosomal transgene for myelin proteolipid protein.
Proc. Natl. Acad. Sci. U.S.A. 92, 4447-51


Vellutini C, Horschowski N, Philippon V, Gambarelli D, Nave KA, Filippi P (1995).
Development of lymphoid hyperplasia in transgenic mice expressing the HIV tat gene.
AIDS Res. Hum. Retroviruses 11, 21-9


1994

Vellutini C, Philippon V, Gambarelli D, Horschowski N, Nave KA, Navarro JM, Auphan M, Courcoul MA, Filippi P (1994).
The maedi-visna virus Tat protein induces multiorgan lymphoid hyperplasia in transgenic mice.
J. Virol. 68, 4955-62


Montag D, Giese KP, Bartsch U, Martini R, Lang Y, Blüthmann H, Karthigasan J, Kirschner DA, Wintergerst ES, Nave KA et al. (1994).
Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.
Neuron 13, 229-46


Readhead C, Schneider A, Griffiths I, Nave KA (1994).
Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage.
Neuron 12, 583-95


1993

Fanarraga ML, Sommer IU, Griffiths IR, Montague P, Groome NP, Nave KA, Schneider A, Brophy PJ, Kennedy PG (1993).
Oligodendrocyte development and differentiation in the rumpshaker mutation.
Glia 9, 146-56


1992

Schneider A, Montague P, Griffiths I, Fanarraga M, Kennedy P, Brophy P, Nave KA (1992).
Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.
Nature 358, 758-61


1991

Nave KA, Lemke G (1991).
Induction of the myelin proteolipid protein (PLP) gene in C6 glioblastoma cells: functional analysis of the PLP promotor.
J. Neurosci. 11, 3060-9


Milner RJ, Lai C, Nave KA, Montag D, Farber L, Sutcliffe JG (1991).
Organization of myelin protein genes: myelin-associated glycoprotein.
Ann. N. Y. Acad. Sci. 605, 254-61


1989

Nave KA, Milner RJ (1989).
Proteolipid proteins: structure and genetic expression in normal and myelin-deficient mutant mice.
Crit Rev Neurobiol. 5, 65-91


1987

Nave KA, Bloom FE, Milner RJ (1987).
A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse.
J. Neurochem. 49, 1873-7


Nave KA, Lai C, Bloom FE, Milner RJ (1987).
Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin.
Proc. Natl. Acad. Sci. U.S.A. 84, 5665-9


Lai C, Brow MA, Nave KA, Noronha AB, Quarles RH, Bloom FE, Milner RJ, Sutcliffe JG (1987).
Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing.
Proc. Natl. Acad. Sci. U.S.A. 84, 4337-41


1986

Nave KA, Lai C, Bloom FE, Milner RJ (1986).
Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing.
Proc. Natl. Acad. Sci. U.S.A. 83, 9264-8


1985

Nave KA, Probstmeier R, Schachner M (1985).
Epidermal growth factor does not cross the blood-brain barrier.
Cell Tissue Res. 241, 453-7


Milner RJ, Lai C, Nave KA, Lenoir D, Ogata J, Sutcliffe JG (1985).
Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein.
Cell 42, 931-9




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