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Max-Planck-Institut für Experimentelle Medizin
Selected Recent Publications

Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner HB, Erwig MS, Möbius W, Kursula P, Nave KA, Simons M (2017).
Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.
Cell Rep. 18, 314-323

Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, Edinger AL, Jung S, Rossner MJ, Simons M (2016).
Age-related myelin degradation burdens the clearance function of microglia during aging.
Nat Neurosci. 19, 995-998

de Hoz L, Simons M (2015).
The emerging functions of oligodendrocytes in regulating neuronal network behaviour.
Bioessays. 37, 60-69

Simons M, Nave KA (2015).
Oligodendrocytes: Myelination and Axonal Support.
Cold Spring Harb Perspect Biol. 8, a020479-a020479

Laulumaa, S, Nieminen, T, Lehtimaki, M, Aggarwal, S, Simons, M, Koza, MM, Vattulainen, I, Kursula, P, Natali, F (2015).
Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering--A Comparison between Wild-Type Protein and a Hinge Mutant
PLoS One 10, e0128954-e0128954

Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH, Schneider A (2015).
Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation
Acta Neuropathol 129, 695-713

Thumm, M, Simons, M (2015).
Myelinophagy: Schwann cells dine in
J Cell Biol 210, 9-10

Schmitt, S, Castelvetri, LC, Simons, M (2015).
Metabolism and functions of lipids in myelin
Biochim Biophys Acta 1851, 999-1005

Sharma K, Schmitt S, Bergner CG, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch UK, Philips MA, Rossner MJ, Mann M, Simons M (2015).
Cell type- and brain region-resolved mouse brain proteome.
Nat Neurosci. 18, 1819-1831

Snaidero N, Möbius W, Czopka T, Hekking LH, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons DA, Nave KA, Simons M (2014).
Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue.
Cell 156, 277-290

Ruskamo S, Yadav RP, Sharma S, Lehtimäki M, Laulumaa S, Aggarwal S, Simons M, Bürck J, Ulrich AS, Juffer AH, Kursula I, Kursula P (2014).
Atomic resolution view into the structure-function relationships of the human myelin peripheral membrane protein P2
Acta Crystallogr D Biol Crystallogr. 70, 165-176

Schweingruber N, Fischer HJ, Fischer L, van den Brandt J, Karabinskaya A, Labi V, Villunger A, Kretzschmar B, Huppke P, Simons M, Tuckermann JP, Flügel A, Lühder F, Reichardt HM (2014).
Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses.
Acta Neuropathol. 127, 713-729

Bakhti M, Aggarwal S, Simons M (2014).
Myelin architecture: zippering membranes tightly together.
Cell Mol Life Sci. 71, 1265-1277

Ghosh A, Kling T, Snaidero N, Sampaio JL, Shevchenko A, Gras H, Geurten B, Göpfert MC, Schulz JB, Voigt A, Simons M (2013).
A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons.
PLoS Genet. 9, e1003980-e1003980

Bakhti M, Aggarwal S, Simons M (2013).
Myelin architecture: zippering membranes tightly together.
Cell Mol Life Sci. [Epub ahead of print]

Aggarwal S, Snaidero N, Pähler G, Frey S, Sánchez P, Zweckstetter M, Janshoff A, Schneider A, Weil MT, Schaap IA, Görlich D, Simons M (2013).
Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork.
PLoS Biol. 11, e1001577-e1001577

Bakhti M, Snaidero N, Schneider D, Aggarwal S, Möbius W, Janshoff A, Eckhardt M, Nave KA, Simons M (2013).
Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system.
Proc Natl Acad Sci U S A. 110, 3143-3148

Simons M, Lyons DA (2013).
Axonal selection and myelin sheath generation in the central nervous system.
Curr Opin Cell Biol. 25, 512-519

Manrique-Hoyos N, Jürgens T, Grønborg M, Kreutzfeldt M, Schedensack M, Kuhlmann T, Schrick C, Brück W, Urlaub H, Simons M, Merkler D (2012).
Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis.
Ann Neurol. 71, 227-244

Treiber H, Hagemeyer N, Ehrenreich H, Simons M (2011).
BACE1 in central nervous system myelination revisited.
Mol Psychiatry. 17, 237-239

Aggarwal S, Yurlova L, Snaidero N, Reetz C, Frey S, Zimmermann J, Pähler G, Janshoff A, Friedrichs J, Müller DJ, Goebel C, Simons M (2011).
A size barrier limits protein diffusion at the cell surface to generate lipid-rich myelin-membrane sheets.
Dev Cell. 21, 445-456

Aggarwal S, Yurlova L, Simons M (2011).
Central nervous system myelin: structure, synthesis and assembly.
Trends Cell Biol. 21, 585-593

Budde H, Schmitt S, Fitzner D, Opitz L, Salinas-Riester G, Simons M (2010).
Control of oligodendroglial cell number by the miR-17-92 cluster.
Development. 137, 2127-2132

Hsu C, Morohashi Y, Yoshimura S, Manrique-Hoyos N, Jung S, Lauterbach MA, Bakhti M, Grønborg M, Möbius W, Rhee J, Barr FA, Simons M (2010).
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.
J Cell Biol. 189, 223-232

Simons M, Raposo G (2009).
Exosomes--vesicular carriers for intercellular communication.
Curr Opin Cell Biol. 21, 575-581

Nawaz S, Kippert A, Saab AS, Werner HB, Lang T, Nave KA, Simons M (2009).
Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium.
J Neurosci. 29, 4794-4807

Schneider A, Rajendran L, Honsho M, Gralle M, Donnert G, Wouters F, Hell SW, Simons M (2008).
Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.
J. Neurosci. 28, 2874-82

Simons M, Trotter J (2008).
Wrapping it up: the cell biology of myelination.
Curr. Opin. Neurobiol. 17, 533-40

Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M (2008).
Ceramide triggers budding of exosome vesicles into multivesicular endosomes.
Science 319, 1244-7

Rajendran L, Schneider A, Schlechtingen G, Weidlich S, Ries J, Braxmeier T, Schwille P, Schulz JB, Schroeder C, Simons M, Jennings G, Knölker HJ, Simons K. (2008).
Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting.
Science 320, 520-3

Kippert A, Trajkovic K, Rajendran L, Ries J, Simons M (2007).
Rho regulates membrane transport in the endocytic pathway to control plasma membrane specialization in oligodendroglial cells.
J. Neurosci. 27, 3560-70

Fitzner D, Schneider A, Kippert A, Möbius W, Willig KI, Hell SW, Bunt G, Gaus K, Simons M (2006).
Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin.
EMBO J. 25, 5037-48

Trajkovic K, Dhaunchak AS, Goncalves JT, Wenzel D, Schneider A, Bunt G, Nave KA, Simons M (2006).
Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites.
J. Cell Biol. 172, 937-48

Simons M, Trajkovic K (2006).
Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis.
J. Cell. Sci. 119, 4381-9

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