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Max-Planck-Gesellschaft
Max-Planck-Institut für Experimentelle Medizin
Literatur
Tomczak AP, Fernández-Trillo J, Bharill S, Papp F, Panyi G, Stühmer W, Isacoff EY, Pardo LA (2017).
A new mechanism of voltage-dependent gating exposed by K(V)10.1 channels interrupted between voltage sensor and pore.
J Gen Physiol. [Epub ahead of print]


Djamgoz MB, Pardo LA (2016).
Ion channels, transporters and cancer ("INCA2015"): an international meeting in honor of Prof. Dr. Walter Stühmer.
Eur Biophys J. 45, 581-583


Gomez-Lagunas F, Carrillo E, Pardo LA, Stühmer W (2016).
Gating Modulation of the Tumor-Related Kv10.1 Channel by Mibefradil.
J Cell Physiol. 232, 2019-2032


Napp J, Pardo LA, Hartung F, Tietze LF, Stühmer W, Alves F (2016).
In vivo imaging of tumour xenografts with an antibody targeting the potassium channel K(v)10.1.
Eur Biophys J. 45, 721-733


Mortensen LS, Schmidt H, Farsi Z, Barrantes-Freer A, Rubio ME, Ufartes R, Eilers J, Sakaba T, Stühmer W, Pardo LA (2015).
KV 10.1 opposes activity-dependent increase in Ca(2+) influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse.
J Physiol. 593, 181-196


Lörinczi É, Gómez-Posada JC, de la Peña P, Tomczak AP, Fernández-Trillo J, Leipscher U, Stühmer W, Barros F, Pardo LA (2015).
Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains.
Nat Commun. 6, 6672-6672


Barrantes-Freer, A, Renovanz, M, Eich, M, Braukmann, A, Sprang, B, Spirin, P, Pardo, LA, Giese, A, Kim, EL (2015).
CD133 Expression Is Not Synonymous to Immunoreactivity for AC133 and Fluctuates throughout the Cell Cycle in Glioma Stem-Like Cells
PLoS One 10, e0130519-e0130519


Martínez R, Stühmer W, Martin S, Schell J, Reichmann A, Rohde V, Pardo L (2015).
Analysis of the expression of Kv10.1 potassium channel in patients with brain metastases and glioblastoma multiforme: impact on survival.
BMC Cancer. 15, 839-839


Urrego D, Tomczak AP, Zahed F, Stühmer W, Pardo LA (2014).
Potassium channels in cell cycle and cell proliferation.
Philos Trans R Soc Lond B Biol Sci. 369, 20130094-20130094


Issy AC, Fonseca JR, Pardo LA, Stühmer W, Del Bel EA (2014).
Hippocampal ether-à-go-go1 potassium channels blockade: effects in the startle reflex and prepulse inhibition.
Neurosci Lett. 559, 13-17


Jiménez-Garduño AM, Mitkovski M, Alexopoulos IK, Sánchez A, Stühmer W, Pardo LA, Ortega A (2014).
KV10.1 K(+)-channel plasma membrane discrete domain partitioning and its functional correlation in neurons.
Biochim Biophys Acta. 1838, 921-931


Mortensen LS, Schmidt H, Farsi Z, Barrantes-Freer A, Rubio ME, Ufartes R, Eilers J, Sakaba T, Stühmer W, Pardo LA (2014).
KV10.1 opposes activity-dependent increase in Ca2+ influx into the presynaptic terminal of the parallel fibre - Purkinje cell synapse.
J Physiol. [Epub ahead of print]


Cunha LC, Del Bel E, Pardo L, Stühmer W, Titze-DE-Almeida R (2013).
RNA Interference with EAG1 Enhances Interferon Gamma Injury to Glioma Cells In Vitro.
Anticancer Res. 33, 865-870


Barrantes-Freer A, Kim E, Bielanska J, Giese A, Mortensen LS, Schulz-Schaeffer WJ, Stadelmann C, Brück W, Pardo LA (2013).
Human Glioma-Initiating Cells Show a Distinct Immature Phenotype Resembling but Not Identical to NG2 Glia.
J Neuropathol Exp Neurol. 72, 307-324


Ufartes R, Schneider T, Mortensen LS, de Juan Romero C, Hentrich K, Knoetgen H, Beilinson V, Moebius W, Tarabykin V, Alves F, Pardo LA, Rawlins JN, Stuehmer W (2013).
Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice.
Hum Mol Genet. [Epub ahead of print]


Pardo LA, Stühmer W (2013).
The roles of K(+) channels in cancer.
Nat Rev Cancer. 14, 39-48


Valero ML, Mello de Queiroz F, Stühmer W, Viana F, Pardo LA (2012).
TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells.
PLoS One. 7, e51825-e51825


Herrmann S, Ninkovic M, Kohl T, Lörinczi É, Pardo LA (2012).
Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1.
J Biol Chem. 287, 44151-44163


Ninkovic M, Mitkovski M, Kohl T, Stühmer W, Pardo LA (2012).
Physical and functional interaction of KV10.1 with Rabaptin-5 impacts ion channel trafficking.
FEBS Lett. 586, 3077-3084


Menéndez ST, Villaronga MA, Rodrigo JP, Alvarez-Teijeiro S, García-Carracedo D, Urdinguio RG, Fraga MF, Pardo LA, Viloria CG, Suárez C, García-Pedrero JM (2012).
Frequent aberrant expression of the human ether à go-go (hEAG1) potassium channel in head and neck cancer: pathobiological mechanisms and clinical implications.
J Mol Med (Berl). 90, 1173-1184


Pardo LA, Gómez-Varela D, Major F, Sansuk K, Leurs R, Downie BR, Tietze LF, Stühmer W (2012).
Approaches targeting K(V)10.1 open a novel window for cancer diagnosis and therapy.
Curr Med Chem. 19, 675-682


Ferreira NR, Mitkovski M, Stühmer W, Pardo LA, Del Bel EA (2012).
Ether-à-go-go 1(Eag1) potassium channel expression in dopaminergic neurons of basal ganglia is modulated by 6-hydroxydopamine lesion.
Neurotox Res. 21, 317-333


de Oliveira RM, Martin S, de Oliveira CL, Milani H, Schiavon AP, Joca S, Pardo LA, Stühmer W, Del Bel EA (2012).
Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia.
J Neurosci Res. 90, 632-640


Mello de Queiroz F, Sánchez A, Agarwal JR, Stühmer W, Pardo LA (2012).
Nucleofection induces non-specific changes in the metabolic activity of transfected cells.
Mol Biol Rep. 39, 2187-2194


Kohl T, Lörinczi E, Pardo LA, Stühmer W (2011).
Rapid internalization of the oncogenic K+ channel K(V)10.1.
PLoS One. 6, e26329-e26329


Ortiz CS, Montante-Montes D, Saqui-Salces M, Hinojosa LM, Gamboa-Dominguez A, Hernández-Gallegos E, Martínez-Benítez B, Del Rosario Solís-Pancoatl M, Garcia-Villa E, Ramírez A, Aguilar-Guadarrama R, Gariglio P, Pardo LA, Stühmer W, Camacho J (2011).
Eag1 potassium channels as markers of cervical dysplasia.
Oncol Rep. 26, 1377-1383


Hartung F, Stühmer W, Pardo LA (2011).
Tumor cell-selective apoptosis induction through targeting of K(V)10.1 via bifunctional TRAIL antibody.
Mol Cancer. 10, 109-109


Chen Y, Sánchez A, Rubio ME, Kohl T, Pardo LA, Stühmer W (2011).
Functional K(v)10.1 channels localize to the inner nuclear membrane.
PLoS One. 6, e19257-e19257


Grube S, Gerchen MF, Adamcio B, Pardo LA, Martin S, Malzahn D, Papiol S, Begemann M, Ribbe K, Friedrichs H, Radyushkin KA, Müller M, Benseler F, Riggert J, Falkai P, Bickeböller H, Nave KA, Brose N, Stühmer W, Ehrenreich H (2011).
A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia.
EMBO Mol Med. 3, 309-319


Stühmer W, Pardo LA (2010).
K(+) channels as therapeutic targets in oncology.
Future Med Chem. 2, 745-755


Gómez-Varela D, Kohl T, Schmidt M, Rubio ME, Kawabe H, Nehring RB, Schäfer S, Stühmer W, Pardo LA (2010).
Characterization of Eag1 channel lateral mobility in rat hippocampal cultures by single-particle-tracking with quantum dots.
PLoS One. 5, e8858-e8858


Agarwal JR, Griesinger F, Stühmer W, Pardo LA (2010).
The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia.
Mol Cancer. 9, 18-18


Wulff H, Castle NA, Pardo LA (2009).
Voltage-gated potassium channels as therapeutic targets.
Nat Rev Drug Discov. 8, 982-1001


Alves F, Dullin C, Napp J, Missbach-Guentner J, Jannasch K, Mathejczyk J, Pardo LA, Stühmer W, Tietze LF (2009).
Concept of a selective tumour therapy and its evaluation by near-infrared fluorescence imaging and flat-panel volume computed tomography in mice.
Eur J Radiol. 70, 286-293


Lörinczi E, Napp J, Contreras-Jurado C, Pardo LA, Stühmer W (2009).
The voltage dependence of hEag currents is not determined solely by membrane-spanning domains.
Eur Biophys J. 38, 279-284


Pardo LA, Stühmer W (2008).
Eag1 as a cancer target.
Expert Opin Ther Targets. 12, 837-843


Pardo LA, Stühmer W (2008).
Eag1: an emerging oncological target.
Cancer Res. 68, 1611-1613


Lörinczi E, Napp J, Contreras-Jurado C, Pardo LA, Stühmer W (2008).
The voltage dependence of hEag currents is not determined solely by membrane-spanning domains.
Eur Biophys J. 38, 279-284


Herrero-Herranz E, Pardo LA, Gold R, Linker RA (2008).
Pattern of axonal injury in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis: implications for multiple sclerosis.
Neurobiol Dis. 30, 162-173


Fraser SP, Pardo LA (2008).
Ion channels: functional expression and therapeutic potential in cancer. Colloquium on Ion Channels and Cancer.
EMBO Rep. 9, 512-515


Herrero-Herranz E, Pardo LA, Bunt G, Gold R, Stühmer W, Linker RA (2007).
Re-expression of a developmentally restricted potassium channel in autoimmune demyelination: Kv1.4 is implicated in oligodendroglial proliferation.
Am J Pathol. 171, 589-598


Gomez-Varela D, Zwick-Wallasch E, Knötgen H, Sánchez A, Hettmann T, Ossipov D, Weseloh R, Contreras-Jurado C, Rothe M, Stühmer W, Pardo LA. (2007).
Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity.
Cancer Res. 67, 7343-7349


Weber C, Mello de Queiroz F, Downie BR, Suckow A, Stühmer W, Pardo LA (2006).
Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference.
J Biol Chem. 281, 13030-13037


Stühmer W, Alves F, Hartung F, Zientkowska M, Pardo LA (2006).
Potassium channels as tumour markers.
FEBS Lett. 580, 2850-2852


Mello de Queiroz F, Suarez-Kurtz G, Stühmer W, Pardo LA (2006).
Ether à go-go potassium channel expression in soft tissue sarcoma patients.
Mol Cancer. 542


Hemmerlein B, Weseloh RM, Mello de Queiroz F, Knötgen H, Sánchez A, Rubio ME, Martin S, Schliephacke T, Jenke M, Heinz-Joachim-Radzun, Stühmer W, Pardo LA (2006).
Overexpression of Eag1 potassium channels in clinical tumours.
Mol Cancer. 541


Gómez-Varela D, Contreras-Jurado C, Furini S, García-Ferreiro R, Stühmer W, Pardo LA (2006).
Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide.
FEBS Lett. 580, 5059-5066


Pardo LA, Contreras-Jurado C, Zientkowska M, Alves F, Stühmer W (2005).
Role of voltage-gated potassium channels in cancer.
J Membr Biol. 205, 115-124


Napp J, Monje F, Stühmer W, Pardo LA (2005).
Glycosylation of Eag1 (Kv10.1) potassium channels: intracellular trafficking and functional consequences.
J Biol Chem. 280, 29506-29512


Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (2005).
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Pharmacol Rev. 57, 473-508


Pardo LA (2004).
Voltage-gated potassium channels in cell proliferation.
Physiology (Bethesda) 19, 285-292


García-Ferreiro RE, Kerschensteiner D, Major F, Monje F, Stühmer W, Pardo LA (2004).
Mechanism of block of hEag1 K+ channels by imipramine and astemizole.
J Gen Physiol. 124, 301-317


Farias LM, Ocaña DB, Díaz L, Larrea F, Avila-Chávez E, Cadena A, Hinojosa LM, Lara G, Villanueva LA, Vargas C, Hernández-Gallegos E, Camacho-Arroyo I, Dueñas-González A, Pérez-Cárdenas E, Pardo LA, Morales A, Taja-Chayeb L, Escamilla J, Sánchez-Peña C, Camacho J (2004).
Ether a go-go potassium channels as human cervical cancer markers.
Cancer Res. 64, 6996-7001


Jenke M, Sánchez A, Monje F, Stühmer W, Weseloh RM, Pardo LA (2003).
C-terminal domains implicated in the functional surface expression of potassium channels.
EMBO J. 22, 395-403


Niemeyer BA, Mery L, Zawar C, Suckow A, Monje F, Pardo LA, Stuhmer W, Flockerzi V, Hoth M (2001).
Ion channels in health and disease. 83rd Boehringer Ingelheim Fonds International Titisee Conference.
EMBO Rep. 2, 568-573


Camacho J, Sánchez A, Stühmer W, Pardo LA (2000).
Cytoskeletal interactions determine the electrophysiological properties of human EAG potassium channels.
Pflugers Arch. 441, 167-174


Pardo LA, del Camino D, Sánchez A, Alves F, Brüggemann A, Beckh S, Stühmer W (1999).
Oncogenic potential of EAG K(+) channels.
EMBO J. 18, 5540-5547


Pardo LA, Brüggemann A, Camacho J, Stühmer W (1998).
Cell cycle-related changes in the conducting properties of r-eag K+ channels.
J Cell Biol. 143, 767-775




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