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Max-Planck-Gesellschaft
Max-Planck-Institut für Experimentelle Medizin
Forschung
Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner HB, Erwig MS, Möbius W, Kursula P, Nave KA, Simons M (2017).
Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.
Cell Rep. 18, 314-323


Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Böhler C, Barrette B, Stassart R, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G (2017).
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.
Nat Commun. 8, 14241-14241


Wottawa M, Naas S, Böttger J, van Belle GJ, Möbius W, Revelo NH, Heidenreich D, von Ahlen M, Zieseniss A, Kröhnert K, Lutz S, Lenz C, Urlaub H, Rizzoli SO, Katschinski DM (2017).
Hypoxia-stimulated membrane trafficking requires T-Plastin.
Acta Physiol (Oxf). [Epub ahead of print]


Kusch K, Uecker M, Liepold T, Möbius W, Hoffmann C, Neumann H, Werner HB, Jahn O (2017).
Partial Immunoblotting of 2D-Gels: A Novel Method to Identify Post-Translationally Modified Proteins Exemplified for the Myelin Acetylome.
Proteomes 5, E3-E3


Tarasenko D, Barbot M, Jans DC, Kroppen B, Sadowski B, Heim G, Möbius W, Jakobs S, Meinecke M (2017).
The MICOS component Mic60 displays a conserved membrane-bending activity that is necessary for normal cristae morphology.
J Cell Biol. 216, 889-899


Vogelgesang S, Niebert S, Renner U, Möbius W, Hülsmann S, Manzke T, Niebert M (2017).
Analysis of the Serotonergic System in a Mouse Model of Rett Syndrome Reveals Unusual Upregulation of Serotonin Receptor 5b.
Front Mol Neurosci. [PubMed - in process]


Karamita M, Barnum C, Möbius W, Tansey MG, Szymkowski DE, Lassmann H, Probert L (2017).
Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia.
JCI Insight [Epub ahead of print]


Trevisiol A, Saab AS, Winkler U, Marx G, Imamura H, Möbius W, Kusch K, Nave KA, Hirrlinger J (2017).
Monitoring ATP dynamics in electrically active white matter tracts.
Elife [Epub ahead of print]


Kleinecke S, Richert S, de Hoz L, Brügger B, Kungl T, Asadollahi E, Quintes S, Blanz J, McGonigal R, Naseri K, Sereda MW, Sachsenheimer T, Lüchtenborg C, Möbius W, Willison H, Baes M, Nave KA, Kassmann CM (2017).
Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy.
Elife 6, e23332-e23332


Möbius W, Nave KA, Werner HB (2016).
Electron microscopy of myelin: structure preservation by high-pressure freezing.
Brain Res. 1641, 92-100


Syed YA, Zhao C, Mahad D, Möbius W, Altmann F, Foss F, González GA, Sentürk A, Acker-Palmer A, Lubec G, Lilley K, Franklin RJ, Nave KA, Kotter MR (2016).
Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.
Acta Neuropathol. 132, 157-157


Weil MT, Möbius W, Winkler A, Ruhwedel T, Wrzos C, Romanelli E, Bennett JL, Enz L, Goebels N, Nave KA, Kerschensteiner M, Schaeren-Wiemers N, Stadelmann C, Simons M (2016).
Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases.
Cell Rep. pii: S2211-1247 [Epub ahead of print], 30727-30736


Patzig J, Erwig MS, Tenzer S, Kusch K, Dibaj P, Möbius W, Goebbels S, Schaeren-Wiemers N, Nave KA, Werner HB (2016).
Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.
Elife. 5, pii: e17119-pii: e17119


Hu B, Arpag S, Zhang X, Möbius W, Werner H, Sosinsky G, Ellisman M, Zhang Y, Hamilton A, Chernoff J, Li J (2016).
Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.
PLoS Genet. 12, e1006290-e1006290


Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH, Schneider A (2015).
Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation
Acta Neuropathol 129, 695-713


Patzig J, Kusch K, Fledrich R, Eichel MA, Lüders KA, Möbius W, Sereda MW, Nave KA, Martini R, Werner HB (2015).
Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking.
Glia 64, 155-174


Syed YA, Zhao C, Mahad D, Möbius W, Altmann F, Foss F, Sentürk A, Acker-Palmer A, Lubec G, Lilley K, Franklin RJ, Nave KA, Kotter MR (2015).
Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.
Acta Neuropathol. 132, 157-157


Snaidero N, Möbius W, Czopka T, Hekking LH, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons DA, Nave KA, Simons M (2014).
Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue.
Cell 156, 277-290


Gritsch S, Lu J, Thilemann S, Wörtge S, Möbius W, Bruttger J, Karram K, Ruhwedel T, Blanfeld M, Vardeh D, Waisman A, Nave KA, Kuner R (2014).
Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice.
Nat Commun. 5, 5472-5472


Nolting JF, Möbius W, Köster S (2014).
Mechanics of Individual Keratin Bundles in Living Cells
Biophys J. 107, 2693-2699


Ufartes R, Schneider T, Mortensen LS, de Juan Romero C, Hentrich K, Knoetgen H, Beilinson V, Moebius W, Tarabykin V, Alves F, Pardo LA, Rawlins JN, Stuehmer W (2013).
Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice.
Hum Mol Genet. 22, 2247-2262


Ritter J, Schmitz T, Chew LJ, Bührer C, Möbius W, Zonouzi M, Gallo V (2013).
Neonatal hyperoxia exposure disrupts axon-oligodendrocyte integrity in the subcortical white matter.
J Neurosci. 33, 8990-9002


Viganò F, Möbius W, Götz M, Dimou L (2013).
Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain.
Nat Neurosci. 16, 1370-1372


Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers EM (2013).
Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication.
PLoS Biol. 11, e1001604-e1001604


de Monasterio-Schrader P, Patzig J, Möbius W, Barrette B, Wagner TL, Kusch K, Edgar JM, Brophy PJ, Werner HB (2013).
Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2.
Glia 61, 1832-1847


Fünfschilling U, Jockusch WJ, Sivakumar N, Möbius W, Corthals K, Li S, Quintes S, Kim Y, Schaap IA, Rhee JS, Nave KA, Saher G (2012).
Critical time window of neuronal cholesterol synthesis during neurite outgrowth.
J Neurosci. 32, 7632-7645


Saher G, Rudolphi F, Corthals K, Ruhwedel T, Schmidt KF, Löwel S, Dibaj P, Barrette B, Möbius W, Nave KA (2012).
Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet.
Nat Med. 18, 1130-1135


Fünfschilling U, Supplie LM, Mahad D, Boretius S, Saab AS, Edgar J, Brinkmann BG, Kassmann CM, Tzvetanova ID, Möbius W, Diaz F, Meijer D, Suter U, Hamprecht B, Sereda MW, Moraes CT, Frahm J, Goebbels S, Nave KA (2012).
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.
Nature 521, 517-521


Velanac V, Unterbarnscheidt T, Hinrichs W, Gummert MN, Fischer TM, Rossner MJ, Trimarco A, Brivio V, Taveggia C, Willem M, Haass C, Möbius W, Nave KA, Schwab MH (2012).
Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination.
Glia 60, 203-217


Ivanovic A, Horresh I, Golan N, Spiegel I, Sabanay H, Frechter S, Ohno S, Terada N, Möbius W, Rosenbluth J, Brose N, Peles E (2012).
The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves.
J Cell Biol. 196, 337-344


Senthilan PR, Piepenbrock D, Ovezmyradov G, Nadrowski B, Bechstedt S, Pauls S, Winkler M, Möbius W, Howard J, Göpfert MC (2012).
Drosophila auditory organ genes and genetic hearing defects.
Cell 150, 1024-1054


Patzig J, Jahn O, Tenzer S, Wichert SP, de Monasterio-Schrader P, Rosfa S, Kuharev J, Yan K, Bormuth I, Bremer J, Aguzzi A, Orfaniotou F, Hesse D, Schwab MH, Möbius W, Nave KA, Werner HB (2011).
Quantitative and integrative proteome analysis of peripheral nerve myelin identifies novel myelin proteins and candidate neuropathy loci.
J Neurosci. 31, 16369-16386


Beham AW, Puellmann K, Laird R, Fuchs T, Streich R, Breysach C, Raddatz D, Oniga S, Peccerella T, Findeisen P, Kzhyshkowska J, Gratchev A, Schweyer S, Saunders B, Wessels JT, Möbius W, Keane J, Becker H, Ganser A, Neumaier M, Kaminski WE (2011).
A TNF-regulated recombinatorial macrophage immune receptor implicated in granuloma formation in tuberculosis.
PLoS Pathog. 7, e1002375-e1002375


Schieb H, Kratzin H, Jahn O, Möbius W, Rabe S, Staufenbiel M, Wiltfang J, Klafki HW (2011).
Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid.
J Biol Chem. 286, 33747-33758


Kassmann CM, Quintes S, Rietdorf J, Möbius W, Sereda MW, Nientiedt T, Saher G, Baes M, Nave KA (2011).
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.
FEBS Lett. 585, 2205-2211


Mersmann N, Tkachev D, Jelinek R, Röth PT, Möbius W, Ruhwedel T, Rühle S, Weber-Fahr W, Sartorius A, Klugmann M (2011).
Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.
PLoS One. 6, e20336-e20336


Feldmann A, Amphornrat J, Schönherr M, Winterstein C, Möbius W, Ruhwedel T, Danglot L, Nave KA, Galli T, Bruns D, Trotter J, Krämer-Albers EM (2011).
Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7.
J Neurosci. 31, 5659-5672


Syed YA, Hand E, Möbius W, Zhao C, Hofer M, Nave KA, Kotter MR (2011).
Inhibition of CNS remyelination by the presence of semaphorin 3A.
J Neurosci. 31, 3719-3728


Möbius W, Cooper B, Kaufmann WA, Imig C, Ruhwedel T, Snaidero N, Saab AS, Varoqueaux F (2010).
Electron microscopy of the mouse central nervous system.
Methods Cell Biol. 96, 475-512


Strauss K, Goebel C, Runz H, Möbius W, Weiss S, Feussner I, Simons M, Schneider A (2010).
Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease.
J Biol Chem. 285, 26279-26288


Hsu C, Morohashi Y, Yoshimura S, Manrique-Hoyos N, Jung S, Lauterbach MA, Bakhti M, Grønborg M, Möbius W, Rhee J, Barr FA, Simons M (2010).
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.
J Cell Biol. 189, 223-232


Goebbels S, Oltrogge JH, Kemper R, Heilmann I, Bormuth I, Wolfer S, Wichert SP, Möbius W, Liu X, Lappe-Siefke C, Rossner MJ, Groszer M, Suter U, Frahm J, Boretius S, Nave KA (2010).
Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination.
J Neurosci. 30, 8953-8964


Schmitz M, Klöppner S, Klopfleisch S, Möbius W, Schwartz P, Zerr I, Althaus HH (2010).
Mutual effects of caveolin and nerve growth factor signaling in pig oligodendrocytes.
J Neurosci Res. 88, 572-588


Möbius W (2009).
Cryopreparation of biological specimens for immunoelectron microscopy.
Ann Anat. 191, 231-247


Saher G, Quintes S, Möbius W, Wehr MC, Krämer-Albers EM, Brügger B, Nave KA (2009).
Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction.
J Neurosci. 29, 6094-6104


Golan N, Adamsky K, Kartvelishvily E, Brockschnieder D, Möbius W, Spiegel I, Roth AD, Thomson CE, Rechavi G, Peles E (2008).
Identification of Tmem10/Opalin as an oligodendrocyte enriched gene using expression profiling combined with genetic cell ablation.
Glia 56, 1176-1186


Möbius W, Patzig J, Nave KA, Werner HB (2008).
Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection.
Neuron Glia Biol. 4, 111-127


Werner HB, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K, Orfaniotou F, Dhaunchak A, Brinkmann BG, Möbius W, Guarente L, Casaccia-Bonnefil P, Jahn O, Nave KA (2007).
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.
J Neurosci. 27, 7717-7730


Meyer zu Horste G, Prukop T, Liebetanz D, Mobius W, Nave KA, Sereda MW (2007).
Antiprogesterone therapy uncouples axonal loss from demyelination in a transgenic rat model of CMT1A neuropathy.
Ann Neurol. 61, 61-72


Fünfschilling U, Saher G, Xiao L, Möbius W, Nave KA (2007).
Survival of adult neurons lacking cholesterol synthesis in vivo.
BMC Neurosci. 81


Krämer-Albers EM, Bretz N, Tenzer S, Winterstein C, Möbius W, Berger H, Nave KA, Schild H, Trotter J (2007).
Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Proteomics Clin Appl. 1, 1446-1461


Fitzner D, Schneider A, Kippert A, Möbius W, Willig KI, Hell SW, Bunt G, Gaus K, Simons M (2006).
Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin.
EMBO J. 25, 5037-5048


Rodriguez D, Bárcena M, Möbius W, Schleich S, Esteban M, Geerts WJ, Koster AJ, Griffiths G, Locker JK (2006).
A vaccinia virus lacking A10L: viral core proteins accumulate on structures derived from the endoplasmic reticulum.
Cell Microbiol. 8, 427-437


Saher G, Brügger B, Lappe-Siefke C, Möbius W, Tozawa R, Wehr MC, Wieland F, Ishibashi S, Nave KA (2005).
High cholesterol level is essential for myelin membrane growth.
Nat Neurosci. 8, 468-475


Neubrand VE, Will RD, Möbius W, Poustka A, Wiemann S, Schu P, Dotti CG, Pepperkok R, Simpson JC (2005).
Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking.
EMBO J. 24, 1122-1133


Grebe M, Xu J, Möbius W, Ueda T, Nakano A, Geuze HJ, Rook MB, Scheres B (2003).
Arabidopsis sterol endocytosis involves actin-mediated trafficking via ARA6-positive early endosomes.
Curr Biol. 13, 1378-1387


Heijnen HF, Van Lier M, Waaijenborg S, Ohno-Iwashita Y, Waheed AA, Inomata M, Gorter G, Möbius W, Akkerman JW, Slot JW (2003).
Concentration of rafts in platelet filopodia correlates with recruitment of c-Src and CD63 to these domains.
J Thromb Haemost. 1, 1161-1173


Möbius W, van Donselaar E, Ohno-Iwashita Y, Shimada Y, Heijnen HF, Slot JW, Geuze HJ (2003).
Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway.
Traffic 4, 222-231


Wubbolts R, Leckie RS, Veenhuizen PT, Schwarzmann G, Möbius W, Hoernschemeyer J, Slot JW, Geuze HJ, Stoorvogel W (2003).
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation.
J Biol Chem. 278, 10963-10972


Hölttä-Vuori M, Tanhuanpää K, Möbius W, Somerharju P, Ikonen E (2002).
Modulation of cellular cholesterol transport and homeostasis by Rab11.
Mol Biol Cell. 13, 3107-3122


Möbius W, Ohno-Iwashita Y, van Donselaar EG, Oorschot VM, Shimada Y, Fujimoto T, Heijnen HF, Geuze HJ, Slot JW (2002).
Immunoelectron microscopic localization of cholesterol using biotinylated and non-cytolytic perfringolysin O.
J Histochem Cytochem. 50, 43-56


Schwarzmann G, von Coburg A, Möbius W (2000).
Using biotinylated gangliosides to study their distribution and traffic in cells by immunoelectron microscopy.
Methods Enzymol. 312, 534-562


Möbius W, Herzog V, Sandhoff K, Schwarzmann G (1999).
Gangliosides are transported from the plasma membrane to intralysosomal membranes as revealed by immuno-electron microscopy.
Biosci Rep. 19, 307-316


Möbius W, Herzog V, Sandhoff K, Schwarzmann G (1999).
Intracellular distribution of a biotin-labeled ganglioside, GM1, by immunoelectron microscopy after endocytosis in fibroblasts.
J Histochem Cytochem. 47, 1005-1014


Burkhardt JK, Hüttler S, Klein A, Möbius W, Habermann A, Griffiths G, Sandhoff K (1997).
Accumulation of sphingolipids in SAP-precursor (prosaposin)-deficient fibroblasts occurs as intralysosomal membrane structures and can be completely reversed by treatment with human SAP-precursor.
Eur J Cell Biol. 73, 10-18




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