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Max-Planck-Gesellschaft
Max-Planck-Institut für Experimentelle Medizin
Forschung
Ausgewählte Publikationen


McLaughlin RL, Schijven D, van Rheenen W, van Eijk KR, O'Brien M, Kahn RS, Ophoff RA, Goris A, Bradley DG, Al-Chalabi A, van den Berg LH, Luykx JJ, Hardiman O, Veldink JH; Project MinE GWAS Consortium.; Schizophrenia Working Group of the Psychiatric Genomics Consortium (2017).
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.
Nat Commun. 8, 14774-14774


Ehrenreich H (2017).
Autoantibodies against the N-Methyl-d-Aspartate Receptor Subunit NR1: Untangling Apparent Inconsistencies for Clinical Practice.
Front Immunol. 8, 181-181


Ehrenreich H (2017).
The impact of environment on abnormal behavior and mental disease: To alleviate the prevalence of mental disorders, we need to phenotype the environment for risk factors.
EMBO Rep. [Epub ahead of print]


Bonnas C, Wüstefeld L, Winkler D, Kronstein-Wiedemann R, Dere E, Specht K, Boxberg M, Tonn T, Ehrenreich H, Stadler H, Sillaber I (2017).
EV-3, an endogenous human erythropoietin isoform with distinct functional relevance.
Sci Rep. 7, 3684-3684


Lepeta K, Purzycka KJ, Pachulska-Wieczorek K, Mitjans M, Begemann M, Vafadari B, Bijata K, Adamiak RW, Ehrenreich H, Dziembowska M, Kaczmarek L (2017).
A normal genetic variation modulates synaptic MMP-9 protein levels and the severity of schizophrenia symptoms.
EMBO Mol Med. [Epub ahead of print]


Hahn N, Knorr DY, Liebig J, Wüstefeld L, Peters K, Büscher M, Bucher G, Ehrenreich H, Heinrich R (2017).
The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor.
Front Mol Neurosci. 10, 223-223


Bartels C, Ehrenreich H (2017).
How to pursue EPO in MS.
Mult Scler. [Epub ahead of print]


Mitjans M, Begemann M, Ju A, Dere E, Wüstefeld L, Hofer S, Hassouna I, Balkenhol J, Oliveira B, van der Auwera S, Tammer R, Hammerschmidt K, Völzke H, Homuth G, Cecconi F, Chowdhury K, Grabe H, Frahm J, Boretius S, Dandekar T, Ehrenreich H (2017).
Sexual dimorphism of AMBRA1-related autistic features in human and mouse.
Transl Psychiatry. 7, e1247-e1247


Ehrenreich H (2017).
„Hirn-Doping“: Erythropoietin zur Verbesserung kognitiver Leistung bei Mensch und Maus.
Drug Res (Stuttg). 67, S14-S15


Hassouna I, Ott C, Wüstefeld L, Offen N, Neher RA, Mitkovski M, Winkler D, Sperling S, Fries L, Goebbels S, Vreja IC, Hagemeyer N, Dittrich M, Rossetti MF, Kröhnert K, Hannke K, Boretius S, Zeug A, Höschen C, Dandekar T, Dere E, Neher E, Rizzoli SO, Nave KA, Sirén AL, Ehrenreich H (2016).
Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus.
Mol Psychiatry. 21, 1752-1767


Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJ, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Yao Y, Ho YY, Martin NG, Wright MJ; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Psychosis Endophenotypes International Consortium; Wellcome Trust Case Control Consortium 2; Enigma Consortium, O'Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF (2016).
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Nat Neurosci. 19, 420-431


Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Daly MJ, Carroll MC, Stevens B, McCarroll SA (2016).
Schizophrenia risk from complex variation of complement component 4.
Nature 530, 177-183


Castillo-Gomez E, Kästner A, Steiner J, Schneider A, Hettling B, Poggi G, Ostehr K, Uhr M, Asif AR, Matzke M, Schmidt U, Pfander V, Hammer C, Schulz TF, Binder L, Stöcker W, Weber F, Ehrenreich H (2016).
The brain as immunoprecipitator of serum autoantibodies against N-Methyl-D-aspartate receptor subunit NR1.
Ann Neurol. 79, 144-151


Tuoc T, Dere E, Radyushkin K, Pham L, Nguyen H, Tonchev AB, Sun G, Ronnenberg A, Shi Y, Staiger JF, Ehrenreich H, Stoykova A (2016).
Ablation of BAF170 in Developing and Postnatal Dentate Gyrus Affects Neural Stem Cell Proliferation, Differentiation, and Learning.
Mol Neurobiol. [Epub ahead of print]


Poggi G, Boretius S, Möbius W, Moschny N, Baudewig J, Ruhwedel T, Hassouna I, Wieser GL, Werner HB, Goebbels S, Nave KA, Ehrenreich H (2016).
Cortical network dysfunction caused by a subtle defect of myelination.
Glia [Epub ahead of print]


Castillo-Gómez E, Oliveira B, Tapken D, Bertrand S, Klein-Schmidt C, Pan H, Zafeiriou P, Steiner J, Jurek B, Trippe R, Prüss H, Zimmermann WH, Bertrand D, Ehrenreich H, Hollmann M (2016).
All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class.
Mol Psychiatry. [Epub ahead of print]


Krueger-Burg D, Winkler D, Mitkovski M, Daher F, Ronnenberg A, Schlüter OM, Dere E, Ehrenreich H (2016).
The SocioBox: A Novel Paradigm to Assess Complex Social Recognition in Male Mice.
Front Behav Neurosci. 10, 151-151


Ehrenreich H, Mitjans M, Van der Auwera S, Centeno TP, Begemann M, Grabe HJ, Bonn S, Nave KA (2016).
OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals.
Mol Psychiatry. [Epub ahead of print]


Bulik-Sullivan BK, Loh PR, Finucane HK, Ripke S, Yang J; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson N, Daly MJ, Price AL, Neale BM (2015).
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.
Nat Genet. 47, 291-295


Netrakanti PR, Cooper BH, Dere E, Poggi G, Winkler D, Brose N, Ehrenreich H (2015).
Fast Cerebellar Reflex Circuitry Requires Synaptic Vesicle Priming by Munc13-3.
Cerebellum 14, 264-283


Hammer C, Wanitchakool P, Sirianant L, Papiol S, Monnheimer M, Faria D, Ousingsawat J, Schramek N, Schmitt C, Margos G, Michel A, Kraiczy P, Pawlita M, Schreiber R, Schulz TF, Fingerle V, Tumani H, Ehrenreich H, Kunzelmann K (2015).
A coding variant of ANO10, affecting volume regulation of macrophages, is associated with Borrelia seropositivity.
Mol Med. 21, 26-37


Zerche M, Weissenborn K, Ott C, Dere E, Asif AR, Worthmann H, Hassouna I, Rentzsch K, Tryc AB, Dahm L, Steiner J, Binder L, Wiltfang J, Sirén AL, Stöcker W, Ehrenreich H (2015).
Preexisting Serum Autoantibodies Against the NMDAR Subunit NR1 Modulate Evolution of Lesion Size in Acute Ischemic Stroke.
Stroke 46, 1180-1186


Mitkovski M, Dahm L, Heinrich R, Monnheimer M, Gerhart S, Stegmüller J, Hanisch UK, Nave KA, Ehrenreich H (2015).
Erythropoietin dampens injury-induced microglial motility.
J Cereb Blood Flow Metab. 35, 1233-1236


Kästner A, Begemann M, Michel TM, Everts S, Stepniak B, Bach C, Poustka L, Becker J, Banaschewski T, Dose M, Ehrenreich H (2015).
Autism beyond diagnostic categories: characterization of autistic phenotypes in schizophrenia.
BMC Psychiatry. 15, 115-115


Babaev O, Botta P, Meyer E, Müller C, Ehrenreich H, Brose N, Lüthi A, Krueger-Burg D (2015).
Neuroligin 2 Deletion Alters Inhibitory Synapse Function and Anxiety-Associated Neuronal Activation in the Amygdala.
Neuropharmacology 100, 56-65


Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, Stadler H, Kawabe H, Zimmermann WH, Nave KA, Schulz-Schaeffer W, Jahn O, Ehrenreich H (2015).
Widespread expression of erythropoietin receptor in brain and its induction by injury.
Mol Med. [Epub ahead of print]


Stepniak B, Papiol S, Hammer C, Ramin A, Everts S, Hennig L, Begemann M, Ehrenreich H (2015).
Accumulated environmental risk determining age at schizophrenia onset: a deep phenotyping-based study.
Lancet Psychiatry. 1, 444-453


Hammer M, Krueger-Burg D, Tuffy LP, Cooper BH, Taschenberger H, Goswami SP, Ehrenreich H, Jonas P, Varoqueaux F, Rhee JS, Brose N (2015).
Perturbed Hippocampal Synaptic Inhibition and ?-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.
Cell Rep. 13, 516-523


Hammer C, Begemann M, McLaren PJ, Bartha I, Michel A, Klose B, Schmitt C, Waterboer T, Pawlita M, Schulz TF, Ehrenreich H, Fellay J (2015).
Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses.
Am J Hum Genet. 97, 738-743


Wüstefeld L, Winkler D, Janc OA, Hassouna I, Ronnenberg A, Ostmeier K, Müller M, Brose N, Ehrenreich H, Wojcik SM (2015).
Selective expression of a constitutively active erythropoietin receptor in GABAergic neurons alters hippocampal network properties without affecting cognition.
J Neurochem. [Epub ahead of print]


Stepniak B, Kästner A, Poggi G, Mitjans M, Begemann M, Hartmann A, Van der Auwera S, Sananbenesi F, Krueger-Burg D, Matuszko G, Brosi C, Homuth G, Völzke H, Benseler F, Bagni C, Fischer U, Dityatev A, Grabe HJ, Rujescu D, Fischer A, Ehrenreich H (2015).
Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.
EMBO Mol Med. 7, 1565-1579


Janova H, Böttcher C, Holtman IR, Regen T, van Rossum D, Götz A, Ernst AS, Fritsche C, Gertig U, Saiepour N, Gronke K, Wrzos C, Ribes S, Rolfes S, Weinstein J, Ehrenreich H, Pukrop T, Kopatz J, Stadelmann C, Salinas-Riester G, Weber MS, Prinz M, Brück W, Eggen BJ, Boddeke HW, Priller J, Hanisch UK (2015).
CD14 is a key organizer of microglial responses to CNS infection and injury.
Glia 64, 635-649


Tantra M, Hammer C, Kästner A, Dahm L, Begemann M, Bodda C, Hammerschmidt K, Giegling I, Stepniak B, Castillo Venzor A, Konte B, Erbaba B, Hartmann A, Tarami A, Schulz-Schaeffer W, Rujescu D, Mannan AU, Ehrenreich H (2014).
Mild expression differences of MECP2 influencing aggressive social behavior.
EMBO Mol Med. 6, 662-684


Nave KA, Ehrenreich H (2014).
Myelination and Oligodendrocyte Functions in Psychiatric Diseases.
JAMA Psychiatry. 71, 582-584


Ehrenreich H, Nave KA (2014).
Phenotype-Based Genetic Association Studies (PGAS)-Towards Understanding the Contribution of Common Genetic Variants to Schizophrenia Subphenotypes.
Genes (Basel) 5, 97-105


Ju A, Hammerschmidt K, Tantra M, Krueger D, Brose N, Ehrenreich H (2014).
Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.
Behav Brain Res. 270, 159-164


Dahm L, Ott C, Steiner J, Stepniak B, Teegen B, Saschenbrecker S, Hammer C, Borowski K, Begemann M, Lemke S, Rentzsch K, Probst C, Martens H, Wienands J, Spalletta G, Weissenborn K, Stöcker W, Ehrenreich H (2014).
Seroprevalence of autoantibodies against brain antigens in health and disease.
Ann Neurol. 77, 184-184


Dere E, Dahm L, Lu D, Hammerschmidt K, Ju A, Tantra M, Kästner A, Chowdhury K, Ehrenreich H (2014).
Heterozygous ambra1 deficiency in mice: a genetic trait with autism-like behavior restricted to the female gender.
Front Behav Neurosci. 8, 181-181


Hammer C, Zerche M, Schneider A, Begemann M, Nave KA, Ehrenreich H (2014).
Apolipoprotein E4 carrier status plus circulating anti-NMDAR1 autoantibodies: association with schizoaffective disorder.
Mol Psychiatry. 19, 1054-1056


Gurvich A, Begemann M, Dahm L, Sargin D, Miskowiak K, Ehrenreich H (2014).
A role for prostaglandins in rapid cycling suggested by episode-specific gene expression shifts in peripheral blood mononuclear cells: a preliminary report.
Bipolar Disord. 16, 881-888


Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014).
Biological insights from 108 schizophrenia-associated genetic loci.
Nature 511, 421-427


Ehrenreich H, Steiner J (2014).
Serum autoantibodies against N-methyl-D-aspartate receptor subunit NR1 are no disease indicator.
Ann Neurol. [Epub ahead of print]


Miskowiak KW, Ehrenreich H, Christensen EM, Kessing LV, Vinberg M (2014).
Recombinant human erythropoietin to target cognitive dysfunction in bipolar disorder: a double-blind, randomized, placebo-controlled phase 2 trial.
J Clin Psychiatry. [Epub ahead of print]


Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S, Price AL; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium (2014).
Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases.
Am J Hum Genet. 95, 535-552


Miskowiak KW, Vinberg M, Macoveanu J, Ehrenreich H, Køster N, Inkster B, Paulson OB, Kessing LV, Skimminge A, Siebner HR (2014).
Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders.
Biol Psychiatry. 78, 270-277


El-Kordi A, Kästner A, Grube S, Klugmann M, Begemann M, Sperling S, Hammerschmidt K, Hammer C, Stepniak B, Patzig J, de Monasterio-Schrader P, Strenzke N, Flügge G, Werner HB, Pawlak R, Nave KA, Ehrenreich H (2013).
A single gene defect causing claustrophobia.
Transl Psychiatry. 3, e254-e254


Wojcik SM, Tantra M, Stepniak B, Man KN, Müller-Ribbe K, Begemann M, Ju A, Papiol S, Ronnenberg A, Gurvich A, Shin Y, Augustin I, Brose N, Ehrenreich H (2013).
Genetic Markers of a Munc13 Protein Family Member, BAIAP3, Are Gender-Specifically Associated with Anxiety and Benzodiazepine Abuse in Mouse and Man.
Mol Med. 19, 135-148


Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H (2013).
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.
Mol Psychiatry. 19, 1143-1149


El-Kordi A, Winkler D, Hammerschmidt K, Kästner A, Krueger D, Ronnenberg A, Ritter C, Jatho J, Radyushkin K, Bourgeron T, Fischer J, Brose N, Ehrenreich H (2013).
Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.
Behav Brain Res. 251, 41-49


Miskowiak KW, Vinberg M, Christensen EM, Bukh JD, Harmer CJ, Ehrenreich H, Kessing LV (2013).
Recombinant Human Erythropoietin for Treating Treatment-Resistant Depression: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Trial.
Neuropsychopharmacology 39, 1399-1408


Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL (2013).
Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.
Mol Med. 19, 399-408


Hagemeyer N, Goebbels S, Papiol S, Kästner A, Hofer S, Begemann M, Gerwig UC, Boretius S, Wieser GL, Ronnenberg A, Gurvich A, Heckers SH, Frahm J, Nave KA, Ehrenreich H (2012).
A myelin gene causative of a catatonia-depression syndrome upon aging.
EMBO Mol Med. 4, 528-539


Kästner A, Grube S, El-Kordi A, Stepniak B, Friedrichs H, Sargin D, Schwitulla J, Begemann M, Giegling I, Miskowiak KW, Sperling S, Hannke K, Ramin A, Heinrich R, Gefeller O, Nave KA, Rujescu D, Ehrenreich H (2012).
Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia.
Mol Med. 18, 1029-1040


Steinberg S, de Jong S, Mattheisen M, Costas J, Demontis D, Jamain S, Pietiläinen OP, Lin K, Papiol S, Huttenlocher J, Sigurdsson E, Vassos E, Giegling I, Breuer R, Fraser G, Walker N, Melle I, Djurovic S, Agartz I, Tuulio-Henriksson A, Suvisaari J, Lönnqvist J, Paunio T, Olsen L, Hansen T, Ingason A, Pirinen M, Strengman E; GROUP, Hougaard DM, Orntoft T, Didriksen M, Hollegaard MV, Nordentoft M, Abramova L, Kaleda V, Arrojo M, Sanjuán J, Arango C, Etain B, Bellivier F, Méary A, Schürhoff F, Szoke A, Ribolsi M, Magni V, Siracusano A, Sperling S, Rossner M, Christiansen C, Kiemeney LA, Franke B, van den Berg LH, Veldink J, Curran S, Bolton P, Poot M, Staal W, Rehnstrom K, Kilpinen H, Freitag CM, Meyer J, Magnusson P, Saemundsen E, Martsenkovsky I, Bikshaieva I, Martsenkovska I, Vashchenko O, Raleva M, Paketchieva K, Stefanovski B, Durmishi N, Pejovic Milovancevic M, Lecic Tosevski D, Silagadze T, Naneishvili N, Mikeladze N, Surguladze S, Vincent JB, Farmer A, Mitchell PB, Wright A, Schofield PR, Fullerton JM, Montgomery GW, Martin NG, Rubino IA, van Winkel R, Kenis G, De Hert M, Réthelyi JM, Bitter I, Terenius L, Jönsson EG, Bakker S, van Os J, Jablensky A, Leboyer M, Bramon E, Powell J, Murray R, Corvin A, Gill M, Morris D, O'Neill FA, Kendler K, Riley B; Wellcome Trust Case Control Consortium 2, Craddock N, Owen MJ, O'Donovan MC, Thorsteinsdottir U, Kong A, Ehrenreich H, Carracedo A, Golimbet V, Andreassen OA, Børglum AD, Mors O, Mortensen PB, Werge T, Ophoff RA, Nöthen MM, Rietschel M, Cichon S, Ruggeri M, Tosato S, Palotie A, St Clair D, Rujescu D, Collier DA, Stefansson H, Stefansson K (2012).
Common variant at 16p11.2 conferring risk of psychosis.
Mol Psychiatry. 19, 108-114


Wüstenberg T, Begemann M, Bartels C, Gefeller O, Stawicki S, Hinze-Selch D, Mohr A, Falkai P, Aldenhoff JB, Knauth M, Nave KA, Ehrenreich H (2011).
Recombinant human erythropoietin delays loss of gray matter in chronic schizophrenia.
Mol Psychiatry. 16, 26-36


Grube S, Gerchen MF, Adamcio B, Pardo LA, Martin S, Malzahn D, Papiol S, Begemann M, Ribbe K, Friedrichs H, Radyushkin KA, Müller M, Benseler F, Riggert J, Falkai P, Bickeböller H, Nave KA, Brose N, Stühmer W, Ehrenreich H (2011).
A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia.
EMBO Mol Med. 3, 309-319


Sargin D, El-Kordi A, Agarwal A, Muller M, Wojcik SM, Hassouna I, Sperling S, Nave KA, Ehrenreich H (2011).
Expression of constitutively active erythropoietin receptor in cortical neurons boosts higher cognitive functions in mice.
BMC Biol. 9, 27-27


Ribbe K, Ackermann V, Schwitulla J, Begemann M, Papiol S, Grube S, Sperling S, Friedrichs H, Jahn O, Sillaber I, Gefeller O, Krampe H, Ehrenreich H (2011).
Prediction of the Risk of Comorbid Alcoholism in Schizophrenia by Interaction of Common Genetic Variants in the Corticotropin-Releasing Factor System.
Arch Gen Psychiatry. 68, 1247-1256


Papiol S, Malzahn D, Kästner A, Sperling S, Begemann M, Stefansson H, Bickeböller H, Nave K-A and Ehrenreich H (2011).
Dissociation of accumulated genetic risk and disease severity in patients with schizophrenia
Translational Psychiatry 1, e45-e45
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Treiber H, Hagemeyer N, Ehrenreich H, Simons M (2011).
BACE1 in central nervous system myelination revisited.
Mol Psychiatry. 17, 237-239


Begemann M, Grube S, Papiol S, Malzahn D, Krampe H, Ribbe K, Friedrichs H, Radyushkin KA, El-Kordi A, Benseler F, Hannke K, Sperling S, Schwerdtfeger D, Thanhäuser I, Gerchen MF, Ghorbani M, Gutwinski S, Hilmes C, Leppert R, Ronnenberg A, Sowislo J, Stawicki S, Stödtke M, Szuszies C, Reim K, Riggert J, Eckstein F, Falkai P, Bickeböller H, Nave KA, Brose N, Ehrenreich H (2010).
Modification of Cognitive Performance in Schizophrenia by Complexin 2 Gene Polymorphisms.
Arch Gen Psychiatry. 67, 879-888


Radyushkin K, El-Kordi A, Boretius S, Castaneda S, Ronnenberg A, Reim K, Bickeböller H, Frahm J, Brose N, Ehrenreich H (2010).
Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophrenia.
Genes Brain Behav. 9, 592-602


Brzózka MM, Radyushkin K, Wichert SP, Ehrenreich H, Rossner MJ (2010).
Cognitive and Sensorimotor Gating Impairments in Transgenic Mice Overexpressing the Schizophrenia Susceptibility Gene Tcf4 in the Brain.
Biol Psychiatry. 68, 33-40


Radyushkin K, Hammerschmidt K, Boretius S, Varoqueaux F, El-Kordi A, Ronnenberg A, Winter D, Frahm J, Fischer J, Brose N, Ehrenreich H. (2009).
Neuroligin-3 deficient mice: Model of a monogenic heritable form of autism with an olfactory deficit.
Genes Brain Behav. 8, 416-425


El-Kordi A, Radyushkin K, Ehrenreich H (2009).
Erythropoietin improves operant conditioning and stability of cognitive performance in mice.
BMC Biol. 7, 37-37


Jamain S, Radyushkin K, Hammerschmidt K, Granon S, Boretius S, Varoqueaux F, Ramanantsoa N, Gallego J, Ronnenberg A, Winter D, Frahm J, Fischer J, Bourgeron T, Ehrenreich H, Brose N. (2008).
Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.
Proc Natl Acad Sci U S A. 105, 1710-1715


Adamcio B, Sargin D, Stradomska A, Medrihan L, Gertler C, Theis F, Zhang M, Muller M, Hassouna I, Hannke K, Sperling S, Radyushkin K, El-Kordi A, Schulze L, Ronnenberg A, Wolf F, Brose N, Rhee JS, Zhang W, Ehrenreich H (2008).
Erythropoietin enhances hippocampal long-term potentiation and memory.
BMC Biol. 6, 37-


Sargin D, Hassouna I, Sperling S, Sirén AL, Ehrenreich H (2008).
Uncoupling of neurodegeneration and gliosis in a murine model of juvenile cortical lesion.
Glia 57, 693-702


Brinkmann BG, Agarwal A, Sereda MW, Garratt AN, Müller T, Wende H, Stassart RM, Nawaz S, Humml C, Velanac V, Radyushkin K, Goebbels S, Fischer TM, Franklin RJ, Lai C, Ehrenreich H, Birchmeier C, Schwab MH, Nave KA (2008).
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Neuron 59, 581-595


Ehrenreich H, Hinze-Selch D, Stawicki S, Aust C, Knolle-Veentjer S, Wilms S, Heinz G, Erdag S, Jahn H, Degner D, Ritzen M, Mohr A, Wagner M, Schneider U, Bohn M, Huber M, Czernik A, Pollmächer T, Maier W, Sirén AL, Klosterkötter J, Falkai P, Rüther E, Aldenhoff JB, Krampe H. (2007).
Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin.
Mol Psychiatry. 12, 206-220


Ehrenreich H, Fischer B, Norra C, Schellenberger F, Stiefel M, Sirén AL, Paulus W, Nave KA, Gold R, Bartels C (2007).
Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis.
Brain 130, 2577-2588


Nave KA, Sereda MW, Ehrenreich H (2007).
Mechanisms of disease: inherited demyelinating neuropathies-from basic to clinical research.
Nat Clin Pract Neurol. 8, 453-464


Sirén, A.L., Radyushkin, K., Boretius, S., Kämmer, D., Riechers, C.C., Natt, O., Sargin, D., Watanabe, T., Sperling, S., Michaelis, T., Price, J., Meyer, B., Frahm, J., Ehrenreich, H. (2006).
Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin
Brain 129, 480-489


Ehrenreich, H., Hasselblatt, M., Knerlich, F., von Ahsen, N., Jacob, S., Sperling, S., Woldt, H., Vehmeyer, K., Nave, K.-A., Sirén, A.-L. (2005).
A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain
Proc Natl Acad Sci U S A. 102, 862-867


Ehrenreich, H. (2004).
A boost for translational neuroscience
Science 305, 184-185


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