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Max-Planck-Gesellschaft
Max-Planck-Institut für Experimentelle Medizin
PD Dr. Hauke Werner
Weil MT, Heibeck S, Töpperwien M, Tom Dieck S, Ruhwedel T, Salditt T, Rodicio MC, Morgan JR, Nave KA, Möbius W, Werner HB (2018).
Axonal ensheathment in the nervous system of lamprey: Implications for the evolution of myelinating glia.
J Neurosci. [Epub ahead of print]


Myllykoski M, Eichel MA, Jung RB, Kelm S, Werner HB, Kursula P (2018).
High-affinity heterotetramer formation between the large myelin-associated glycoprotein and the dynein light chain DYNLL1.
J Neurochem. [Epub ahead of print]


Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner HB, Erwig MS, Möbius W, Kursula P, Nave KA, Simons M (2017).
Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.
Cell Rep. 18, 314-323


Kusch K, Uecker M, Liepold T, Möbius W, Hoffmann C, Neumann H, Werner HB, Jahn O (2017).
Partial Immunoblotting of 2D-Gels: A Novel Method to Identify Post-Translationally Modified Proteins Exemplified for the Myelin Acetylome.
Proteomes 5, E3-E3


Lüders KA, Patzig J, Simons M, Nave KA, Werner HB (2017).
Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.
Glia 65, 1762-1776


Wang L, Winnewisser J, Federle C, Jessberger G, Nave KA, Werner HB, Kyewski B, Klein L, Hinterberger M (2017).
Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis.
Front Immunol. 8, 1511-1511


Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, Bittner RA, Pan H, Goebbels S, Begemann M, Gerwig UC, Langner S, Werner HB, Kittel-Schneider S, Homuth G, Davatzikos C, Völzke H, West BL, Reif A, Grabe HJ, Boretius S, Ehrenreich H, Nave KA (2017).
Microglia ablation alleviates myelin-associated catatonic signs in mice.
J Clin Invest. [Epub ahead of print]


Bang ML, Vainshtein A, Yang HJ, Eshed-Eisenbach Y, Devaux J, Werner HB, Peles E (2017).
Glial M6B stabilizes the axonal membrane at peripheral nodes of Ranvier.
Glia 66, 801-812


Möbius W, Nave KA, Werner HB (2016).
Electron microscopy of myelin: structure preservation by high-pressure freezing.
Brain Res. 1641, 92-100


Werner HB (2016).
On the evolution of myelin.
Brain Res. 1641, 1-3


Poggi G, Boretius S, Möbius W, Moschny N, Baudewig J, Ruhwedel T, Hassouna I, Wieser GL, Werner HB, Goebbels S, Nave KA, Ehrenreich H (2016).
Cortical network dysfunction caused by a subtle defect of myelination.
Glia 64, 2025-2040


Patzig J, Erwig MS, Tenzer S, Kusch K, Dibaj P, Möbius W, Goebbels S, Schaeren-Wiemers N, Nave KA, Werner HB (2016).
Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.
Elife. 5, pii: e17119-pii: e17119


Hu B, Arpag S, Zhang X, Möbius W, Werner H, Sosinsky G, Ellisman M, Zhang Y, Hamilton A, Chernoff J, Li J (2016).
Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.
PLoS Genet. 12, e1006290-e1006290


Maus F, Sakry D, Binamé F, Karram K, Rajalingam K, Watts C, Heywood R, Krüger R, Stegmüller J, Werner HB, Nave KA, Krämer-Albers EM, Trotter J. (2015).
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2.
PLoS One. 10, e0137311-e0137311


Epplen DB, Prukop T, Nientiedt T, Albrecht P, Arlt FA, Stassart RM, Kassmann CM, Methner A, Nave KA, Werner HB, Sereda MW. (2015).
Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease.
Ann Clin Transl Neurol. 2, 787-796


Patzig J, Kusch K, Fledrich R, Eichel MA, Lüders KA, Möbius W, Sereda MW, Nave KA, Martini R, Werner HB (2015).
Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking.
Glia 64, 155-174


Prukop T, Epplen DB, Nientiedt T, Wichert SP, Fledrich R, Stassart RM, Rossner MJ, Edgar JM, Werner HB, Nave KA, Sereda MW (2014).
Progesterone Antagonist Therapy in a Pelizaeus-Merzbacher Mouse Model.
Am J Hum Genet. 94, 533-546


Dere E, Winkler D, Ritter C, Ronnenberg A, Poggi G, Patzig J, Gernert M, Müller C, Nave KA, Ehrenreich H, Werner HB (2014).
Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist.
Behav Brain Res. 277, 254-263


Mita S, de Monasterio-Schrader P, Fünfschilling U, Kawasaki T, Mizuno H, Iwasato T, Nave KA, Werner HB, Hirata T (2014).
Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance.
Cereb Cortex. 25, 4111-4125


Muneer Z, Wiesinger C, Voigtländer T, Werner HB, Berger J, Forss-Petter S (2014).
Abcd2 Is a Strong Modifier of the Metabolic Impairments in Peritoneal Macrophages of Abcd1-Deficient Mice.
PLoS One. 9, e108655-e108655


Nave KA, Werner HB (2014).
Myelination of the nervous system: mechanisms and functions.
Annu Rev Cell Dev Biol. 30, 503-533


Werner HB, Krämer-Albers EM, Strenzke N, Saher G, Tenzer S, Ohno-Iwashita Y, De Monasterio-Schrader P, Möbius W, Moser T, Griffiths IR, Nave KA (2013).
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.
Glia 61, 567-586


Jahn O, Tenzer S, Bartsch N, Patzig J, Werner HB
Myelin proteome analysis: methods and implications for the myelin cytoskeleton.
In: The Cytoskeleton: Imaging, Isolation, and Interaction. Neuromethods 79:335-354. Springer, ed: Dermietzel R. (2013)

El-Kordi A, Kästner A, Grube S, Klugmann M, Begemann M, Sperling S, Hammerschmidt K, Hammer C, Stepniak B, Patzig J, de Monasterio-Schrader P, Strenzke N, Flügge G, Werner HB, Pawlak R, Nave KA, Ehrenreich H. (2013).
A single gene defect causing claustrophobia.
Transl Psychiatry. 3, e254-e254


de Monasterio-Schrader P, Patzig J, Möbius W, Barrette B, Wagner TL, Edgar JM, Brophy PJ, Werner HB (2013).
Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2 (TSPAN2).
Glia 61, 1832-1847


Nawaz S, Schweitzer J, Jahn O, Werner HB (2013).
Molecular evolution of myelin basic protein, an abundant structural myelin component.
Glia 61, 1364-1377


Jahn O, Tenzer S, Werner HB (2013).
Proteomanalyse des Myelins, der Isolierschicht der Nerven.
Biospektrum 3/2013, 263-265


Patzig J, Dworschak MS, Martens AK, Werner HB (2013).
Septins in the glial cells of the nervous system.
Biol Chem. 395, 143-149


Werner HB (2013).
Do we have to reconsider the evolutionary emergence of myelin?
Front Cell Neurosci. 7, 217-217


Mostowy S, Bi E, Füchtbauer EM, Goryachev AB, Montagna C, Nagata KI, Trimble WS, Werner HB, Yao X, Zieger B, Spiliotis ET (2013).
Highlight: The 5th International Workshop on Septin Biology.
Biol Chem. 395, 119-121


Gazzerro E, Baldassari S, Giacomini C, Musante V, Fruscione F, La Padula V, Biancheri R, Scarfì S, Prada V, Sotgia F, Duncan ID, Zara F, Werner HB, Lisanti MP, Nobbio L, Corradi A, Minetti C (2012).
Hyccin, the molecule mutated in the leukodystrophy hypomyelination and congenital cataract (HCC), is a neuronal protein.
PLoS One. 7, e32180-e32180


de Monasterio-Schrader P, Jahn O, Tenzer S, Wichert SP, Patzig J, Werner HB (2012).
Systematic approaches to central nervous system myelin.
Cell Mol Life Sci. 69, 2879-2894


Patzig J, Jahn O, Tenzer S, Wichert SP, de Monasterio-Schrader P, Rosfa S, Kuharev J, Yan K, Bormuth I, Bremer J, Aguzzi A, Orfaniotou F, Hesse D, Schwab MH, Möbius W, Nave KA, Werner HB (2011).
Quantitative and integrative proteome analysis of peripheral nerve myelin identifies novel myelin proteins and candidate neuropathy loci.
J Neurosci. 31, 16369-16386


Brendel C, Belakhov V, Werner H, Wegener E, Gärtner J, Nudelman I, Baasov T, Huppke P (2011).
Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model.
J Mol Med (Berl). 89, 389-398


Werner HB, Jahn O. (2010).
Myelin matters: proteomic insights into white matter disorders.
Expert Rev Proteomics. 7, 159-164


Edgar JM, McLaughlin M, Werner HB, McCulloch MC, Barrie JA, Brown A, Faichney AB, Snaidero N, Nave KA, Griffiths IR (2009).
Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1.
Glia 57, 1815-1824


Jahn O, Tenzer S, Werner HB (2009).
Myelin proteomics: molecular anatomy of an insulating sheath.
Mol Neurobiol. 40, 55-72


Nawaz S, Kippert A, Saab AS, Werner HB, Lang T, Nave KA, Simons M (2009).
Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium.
J Neurosci. 29, 4794-4807


Schardt A, Brinkmann BG, Mitkovski M, Sereda MW, Werner HB, Nave KA (2009).
The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia.
J Neurosci Res. 87, 3465-3479


Corbeil D, Joester A, Fargeas CA, Jászai J, Garwood J, Hellwig A, Werner HB, Huttner WB (2009).
Expression of distinct splice variants of the stem cell marker prominin-1 (CD133) in glial cells.
Glia 57, 860-874


Buser AM, Erne B, Werner HB, Nave KA, Schaeren-Wiemers N (2009).
The septin cytoskeleton in myelinating glia.
Mol Cell Neurosci. 40, 156-166


Möbius W, Patzig J, Nave KA, Werner HB (2008).
Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection.
Neuron Glia Biol. 4, 111-127


Cooper B, Werner HB, Flügge G (2008).
Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum.
Brain Res. 1197, 1-12


Chatterjee N, Stegmüller J, Schätzle P, Karram K, Koroll M, Werner HB, Nave KA, Trotter J (2008).
Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells.
J Biol Chem. 283, 8310-8317


Kassmann CM, Lappe-Siefke C, Baes M, Brügger B, Mildner A, Werner HB, Natt O, Michaelis T, Prinz M, Frahm J, Nave KA (2007).
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes.
Nat Genet. 39, 969-976


Werner HB, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K, Orfaniotou F, Dhaunchak A, Brinkmann BG, Möbius W, Guarente L, Casaccia-Bonnefil P, Jahn O, Nave KA (2007).
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.
J Neurosci. 27, 7717-7730


Werner H, Nave KA
Glial cells and myelination.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, ed: Ganten D, Ruckpaul K. (2006)

Itoh T, Erdmann KS, Roux A, Habermann B, Werner H, De Camilli P (2005).
Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins.
Dev Cell. 9, 791-804


Schweitzer J, Becker T, Schachner M, Nave KA, Werner H (2005).
Evolution of myelin proteolipid proteins: gene duplication in teleosts and expression pattern divergence.
Mol Cell Neurosci. 31, 161-177


Nave KA, Werner H
Mutations of myelin-associated genes that affect axonal integrity.
In: Multiple sclerosis as a neuronal disease. Elsevier Academic Press, ed: Waxman SG. (2005)

Morgan JR, Di Paolo G, Werner H, Shchedrina VA, Pypaert M, Pieribone VA, De Camilli P (2004).
A role for talin in presynaptic function.
J Cell Biol. 167, 43-50


Rodemer C, Thai TP, Brugger B, Kaercher T, Werner H, Nave KA, Wieland F, Gorgas K, Just WW (2003).
Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice.
Hum Mol Genet. 12, 1881-1895


Stegmüller J, Werner H, Nave KA, Trotter J (2003).
The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling.
J Biol Chem. 278, 3590-3598


Werner H, Dimou L, Klugmann M, Pfeiffer S, Nave KA (2001).
Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes.
Mol Cell Neurosci. 18, 593-605


Dimou L, Klugmann M, Werner H, Jung M, Griffiths IR, Nave KA
Dysmyelination in mice and the proteolipid protein gene family.
In: Advances in Experimental Medicine and Biology 468:261. (1999)

Vouyiouklis DA, Werner H, Griffiths IR, Stewart GJ, Armin-Nave K, Thomson CE (1998).
Molecular cloning and transfection studies of M6b-2, a novel splice variant of a member of the PLP-DM20/M6 gene family.
J Neurosci Res. 52, 633-640


Werner H, Jung M, Klugmann M, Sereda M, Griffiths IR, Nave KA (1998).
Mouse models of myelin diseases.
Brain Pathol. 8, 771-793


Forss-Petter S, Werner H, Berger J, Lassmann H, Molzer B, Schwab MH, Bernheimer H, Zimmermann F, Nave KA (1997).
Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice.
J Neurosci Res. 50, 829-843




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