Färbung von TRPA1-Kanälen in der Plasmamembran von sensorischen Neuronen (Avenali et al., J Neurosci. 34, 1506-1516; 2014)
The perception of and appropriate reaction to external and internal stimuli is critical for survival. In vertebrates, chemical, mechanical (from pleasant touch to painful contact) and thermal stimuli are detected by specialized somatic sensory neurons which transfer these signals via the spinal cord to the brain. An important subset of these neurons, so-called nociceptors, senses noxious stimuli. Consequently, their activation mediates nociception and leads to the sensation of pain.
Pain is the single most common symptom for which patients seek medical assistance. While acute pain has served as a protective mechanism throughout evolution to guard the body against injury, pain can also become chronic and highly debilitating. Unfortunately, chronic pain imposes substantial challenges to medical practice: current therapies can be effective for short-term treatment however many do not provide sufficient relief to chronic conditions or cause strong side-effects. Therefore, a deeper understanding of the molecular mechanisms underlying both, acute and chronic pain is crucially needed.
Our research focuses on the comparative and quantitative analysis of somatosensory signaling networks in established mouse models of acute and chronic pain. To this purpose our lab employs interactomics, genetic profiling, calcium-imaging, electrophysiology, neuronal tracing and mouse behavioral studies in order to address key questions:
Dr. Manuela Schmidt and David Gomez Varela PhD
Emmy Noether-Nachwuchsgruppe Somatosensory Signaling
Max Planck Institute für Experimentelle Medizin
Phone: +49 (0)551 3899-572
Fax: +49 (0)551 3899-573
Academia-net profile: http://www.academia-net.de/profil/dr-manuela-schmidt/1173710
Lab Homepage: http://www.em.mpg.de/index.php?id=311