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Max-Planck-Gesellschaft
Max-Planck-Institut für Experimentelle Medizin
Publikationen
Pan H, Oliveira B, Saher G, Dere E, Tapken D, Mitjans M, Seidel J, Wesolowski J, Wakhloo D, Klein-Schmidt C, Ronnenberg A, Schwabe K, Trippe R, Mätz-Rensing K, Berghoff S, Al-Krinawe Y, Martens H, Begemann M, Stöcker W, Kaup FJ, Mischke R, Boretius S, Nave KA, Krauss JK, Hollmann M, Lühder F, Ehrenreich H (2018).
Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model.
Mol Psychiatry. [Epub ahead of print]


Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Böhler C, Barrette B, Stassart R, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G (2017).
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.
Nat Commun. 8, 14241-14241


Berghoff SA, Düking T, Spieth L, Winchenbach J, Stumpf SK, Gerndt N, Kusch K, Ruhwedel T, Möbius W, Saher G (2017).
Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model.
Acta Neuropathol Commun. 5, 94-94


Winchenbach J, Düking T, Berghoff SA, Stumpf SK, Hülsmann S, Nave KA, Saher G (2016).
Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice.
F1000Res. 5, 2934-2934


Werner HB, Krämer-Albers EM, Strenzke N, Saher G, Tenzer S, Ohno-Iwashita Y, De Monasterio-Schrader P, Möbius W, Moser T, Griffiths IR, Nave KA (2013).
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.
Glia 61, 567-586


Saher G, Rudolphi F, Corthals K, Ruhwedel T, Schmidt KF, Löwel S, Dibaj P, Barrette B, Möbius W, Nave KA (2012).
Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet.
Nat Med. 18, 1130-1135


Fünfschilling U, Jockusch WJ, Sivakumar N, Möbius W, Corthals K, Li S, Quintes S, Kim Y, Schaap IA, Rhee JS, Nave KA, Saher G (2012).
Critical time window of neuronal cholesterol synthesis during neurite outgrowth.
J Neurosci. 32, 7632-7635


Kassmann CM, Quintes S, Rietdorf J, Möbius W, Sereda MW, Nientiedt T, Saher G, Baes M, Nave KA (2011).
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.
FEBS Lett. 585, 2205-2211


Saher G, Quintes S, Nave KA (2011).
Cholesterol: a novel regulatory role in myelin formation.
Neuroscientist. 17, 79-93


Chrast R, Saher G, Nave KA, Verheijen MH (2011).
Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models.
J Lipid Res. 52, 419-434


Quintes S, Goebbels S, Saher G, Schwab MH, Nave KA (2010).
Neuron-glia signaling and the protection of axon function by Schwann cells.
J Peripher Nerv Syst. 15, 10-16


Saher G, Simons M (2010).
Cholesterol and myelin biogenesis.
Subcell Biochem. 51, 489-508


Saher G, Quintes S, Möbius W, Wehr MC, Krämer-Albers EM, Brügger B, Nave KA (2009).
Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction.
J Neurosci. 29, 6094-6104


Saito K, Dubreuil V, Arai Y, Wilsch-Bräuninger M, Schwudke D, Saher G, Miyata T, Breier G, Thiele C, Shevchenko A, Nave KA, Huttner WB (2009).
Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.
Proc Natl Acad Sci U S A. 106, 8350-8355


Fünfschilling U, Saher G, Xiao L, Möbius W, Nave KA (2007).
Survival of adult neurons lacking cholesterol synthesis in vivo.
BMC Neurosci. 8, 1-1


Saher G, Brügger B, Lappe-Siefke C, Möbius W, Tozawa R, Wehr MC, Wieland F, Ishibashi S, Nave KA (2005).
High cholesterol level is essential for myelin membrane growth.
Nat Neurosci. 8, 468-475


Hildt E, Munz B, Saher G, Reifenberg K, Hofschneider PH (2002).
The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice.
EMBO J. 21, 525-535


Saher G, Hildt E (1999).
Activation of c-Raf-1 kinase signal transduction pathway in alpha(7) integrin-deficient mice.
J Biol Chem. 274, 27651-27657


Cohn RD, Mayer U, Saher G, Herrmann R, van der Flier A, Sonnenberg A, Sorokin L, Voit T (1999).
Secondary reduction of alpha7B integrin in laminin alpha2 deficient congenital muscular dystrophy supports an additional transmembrane link in skeletal muscle.
J Neurol Sci. 163, 140-152


Mayer U, Saher G, Fässler R, Bornemann A, Echtermeyer F, von der Mark H, Miosge N, Pöschl E, von der Mark K (1997).
Absence of integrin alpha 7 causes a novel form of muscular dystrophy.
Nat Genet. 17, 318-323


Hildt E, Saher G, Bruss V, Hofschneider PH (1996).
The hepatitis B virus large surface protein (LHBs) is a transcriptional activator.
Virology. 225, 235-239




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