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Max-Planck-Institut für Experimentelle Medizin
Butola T, Wichmann C, Moser T (2017).
Piccolo Promotes Vesicle Replenishment at a Fast Central Auditory Synapse.
Front Synaptic Neurosci. 9, 14-14

Harris SL, Kazmierczak M, Pangrši? T, Shah P, Chuchvara N, Barrantes-Freer A, Moser T, Schwander M (2017).
Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice.
Neuroscience 344, 380-393

Krinner S, Butola T, Jung S, Wichmann C, Moser T (2017).
RIM-Binding Protein 2 Promotes a Large Number of Ca(V)1.3 Ca(2+)-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones.
Front Cell Neurosci. 11, 334-334

icher MM, Oprisoreanu AM, Jung S, Michel K, Schoch S, Moser T (2017).
Rab Interacting Molecules 2 and 3 Directly Interact with the Pore-Forming Ca(V)1.3 Ca(2+) Channel Subunit and Promote Its Membrane Expression.
Front Cell Neurosci. 11, 160-160

Picher MM, Gehrt A, Meese S, Ivanovic A, Predoehl F, Jung S, Schrauwen I, Dragonetti AG, Colombo R, Van Camp G, Strenzke N, Moser T (2017).
Ca(2+)-binding protein 2 inhibits Ca(2+)-channel inactivation in mouse inner hair cells.
Proc Natl Acad Sci U S A. 114, E1717-E1726

Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro T, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO (2017).
Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
EMBO J. [Epub ahead of print]

ogl C, Butola T, Haag N, Hausrat TJ, Leitner MG, Moutschen M, Lefèbvre PP, Speckmann C, Garrett L, Becker L, Fuchs H, Hrabe de Angelis M, Nietzsche S, Kessels MM, Oliver D, Kneussel M, Kilimann MW, Strenzke N (2017).
The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.
EMBO Rep. 18, 2015-2029

Moser T, Starr A (2016).
Auditory neuropathy - neural and synaptic mechanisms.
Nat Rev Neurol. 12, 135-149

Moser T, Vogl C (2016).
New insights into cochlear sound encoding.
Faculty Rev-2081. 5, pii: F1000-pii: F1000

Ohn TL, Rutherford MA, Jing Z, Jung S, Duque-Afonso CJ, Hoch G, Picher MM, Scharinger A, Strenzke N, Moser T (2016).
Hair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes.
Proc Natl Acad Sci U S A. 113, E4716-E4725

Sommen M, Schrauwen I, Vandeweyer G, Boeckx N, Corneveaux JJ, van den Ende J, Boudewyns A, De Leenheer E, Janssens S, Claes K, Verstreken M, Strenzke N, Predöhl F, Wuyts W, Mortier G, Bitner-Glindzicz M, Moser T, Coucke P, Huentelman MJ, Van Camp G (2016).
DNA Diagnostics of Hereditary Hearing Loss: A Targeted Resequencing Approach Combined with a Mutation Classification System.
Hum Mutat. 37, 812-819

Vogl C, Panou I, Yamanbaeva G, Wichmann C, Mangosing SJ, Vilardi F, Indzhykulian AA, Pangršic T, Santarelli R, Rodriguez-Ballesteros M, Weber T, Jung S, Cardenas E, Wu X, Wojcik SM, Kwan KY, Del Castillo I, Schwappach B, Strenzke N, Corey DP, Lin SY, Moser T (2016).
Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.
EMBO J. 35, 2536-2552

Jung S, Maritzen T, Wichmann C, Jing Z, Neef A, Revelo NH, Al-Moyed H, Meese S, Wojcik SM, Panou I, Bulut H, Schu P, Ficner R, Reisinger E, Rizzoli SO, Neef J, Strenzke N, Haucke V, Moser T (2015).
Disruption of adaptor protein 2µ (AP-2µ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.
EMBO J. 34, 2686-2702

Moser T (2015).
Gene therapy for deafness: How close are we?
Sci Transl Med. 7, 295fs28-295fs28

Moser T, Strenzke N (2015).
Synaptic encoding and processing of auditory information in physiology and disease.
Hear Res. 330, 155-166

Jung S, Oshima-Takago T, Chakrabarti R, Wong AB, Jing Z, Yamanbaeva G, Picher MM, Wojcik SM, Göttfert F, Predoehl F, Michel K, Hell SW, Schoch S, Strenzke N, Wichmann C, Moser T (2015).
Rab3-interacting molecules 2a and 2ß promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.
Proc Natl Acad Sci U S A. 112, E3141-E3149

Wichmann C, Moser T (2015).
Relating structure and function of inner hair cell ribbon synapses.
Cell Tissue Res. 361, 95-114

Pangršic T, Gabrielaitis M, Michanski S, Schwaller B, Wolf F, Strenzke N, Moser T (2015).
EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.
Proc Natl Acad Sci U S A. 112, E1028-E1037

Moser T (2015).
Optogenetic stimulation of the auditory pathway for research and future prosthetics.
Curr Opin Neurobiol. 34, 29-36

Vogl C, Cooper BH, Neef J, Wojcik SM, Reim K, Reisinger E, Brose N, Rhee JS, Moser T, Wichmann C (2015).
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.
J Cell Sci. 128, 638-644

Jeschke M, Moser T (2015).
Considering optogenetic stimulation for cochlear implants.
Hear Res. 322, 224-234

Chapochnikov NM, Takago H, Huang CH, Pangrši? T, Khimich D, Neef J, Auge E, Göttfert F, Hell SW, Wichmann C, Wolf F, Moser T (2014).
Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis.
Neuron 83, 1389-1403

Revelo NH, Kamin D, Truckenbrodt S, Wong AB, Reuter-Jessen K, Reisinger E, Moser T, Rizzoli SO (2014).
A new probe for super-resolution imaging of membranes elucidates trafficking pathways.
J Cell Biol. 205, 591-606

Weiler S, Krinner S, Wong AB, Moser T, Pangrši? T (2014).
ATP hydrolysis is critically required for function of CaV1.3 channels in cochlear inner hair cells via fueling Ca2+ clearance.
J Neurosci. 34, 6843-6848

Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T (2014).
Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.
EMBO J. 33, 512-527

Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Mendoza Schulz A, Hoch G, Bartels M, Vogt G, Garnham CW, Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kügler S, Salditt T, de Hoz L, Strenzke N, Moser T (2014).
Optogenetic stimulation of the auditory pathway.
J Clin Invest. 124, 1114-1129

Wong AB, Rutherford MA, Gabrielaitis M, Pangrsic T, Göttfert F, Frank T, Michanski S, Hell S, Wolf F, Wichmann C, Moser T (2014).
Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.
EMBO J. 33, 247-264

Neef J, Jung S, Wong AB, Reuter K, Pangrsic T, Chakrabarti R, Kügler S, Lenz C, Nouvian R, Boumil RM, Frankel WN, Wichmann C, Moser T (2014).
Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.
J Neurosci. 34, 705-716

Hernandez VH, Gehrt A, Jing Z, Hoch G, Jeschke M, Strenzke N, Moser T (2014).
Optogenetic stimulation of the auditory nerve.
J Vis Exp. 92, e52069-e52069

Moser T, Predoehl F, Starr A (2013).
Review of hair cell synapse defects in sensorineural hearing impairment.
Otol Neurotol. 34, 995-1004

Gregory FD, Pangrsic T, Calin-Jageman IE, Moser T, Lee A (2013).
Harmonin enhances voltage-dependent facilitation of Cav1.3 channels and synchronous exocytosis in mouse inner hair cells.
J Physiol. 591, 3253-3269

Wong AB, Jing Z, Rutherford MA, Frank T, Strenzke N, Moser T (2013).
Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.
J Neurosci. 33, 10661-10666

Werner HB, Krämer-Albers EM, Strenzke N, Saher G, Tenzer S, Ohno-Iwashita Y, De Monasterio-Schrader P, Möbius W, Moser T, Griffiths IR, Nave KA (2013).
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.
Glia 61, 567-586

Jing Z, Rutherford MA, Takago H, Frank T, Fejtova A, Khimich D, Moser T, Strenzke N (2013).
Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.
J Neurosci. 33, 4456-4467

Defourny J, Poirrier AL, Lallemend F, Mateo Sánchez S, Neef J, Vanderhaeghen P, Soriano E, Peuckert C, Kullander K, Fritzsch B, Nguyen L, Moonen G, Moser T, Malgrange B (2013).
Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells.
Nat Commun. 4, 1438-1438

von Ameln S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, Nürnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, Nürnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A, Kubisch C (2012).
A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.
Am J Hum Genet. 91, 919-927

Pangrši? T, Reisinger E, Moser T (2012).
Otoferlin: a multi-C2 domain protein essential for hearing.
Trends Neurosci. 35, 671-680

Schrauwen I, Helfmann S, Inagaki A, Predoehl F, Tabatabaiefar MA, Picher MM, Sommen M, Seco CZ, Oostrik J, Kremer H, Dheedene A, Claes C, Fransen E, Chaleshtori MH, Coucke P, Lee A, Moser T, Van Camp G (2012).
A mutation in CABP2, expressed in cochlear hair cells, causes autosomal-recessive hearing impairment.
Am J Hum Genet. 91, 636-645

tom Dieck S, Specht D, Strenzke N, Hida Y, Krishnamoorthy V, Schmidt KF, Inoue E, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Hagiwara A, Brandstätter JH, Löwel S, Gollisch T, Ohtsuka T, Moser T (2012).
Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing.
J Neurosci. 32, 12192-12203

Meyer AC, Khimich D, Egner A, Moser T (2012).
[Super-resolution optical microscopy of the organ of Corti. Investigations on the fine structure of the inner hair cell afferent synapse by the 4Pi and STED techniques].
HNO 60, 707-714

Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN (2012).
The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.
J Neurosci. 32, 9485-9498

Degen J, Schütz M, Dicke N, Strenzke N, Jokwitz M, Moser T, Willecke K (2011).
Connexin32 can restore hearing in connexin26 deficient mice.
Eur J Cell Biol. 90, 817-824

Gregory FD, Bryan KE, Pangrši? T, Calin-Jageman IE, Moser T, Lee A (2011).
Harmonin inhibits presynaptic Cav1.3 Ca²? channels in mouse inner hair cells.
Nat Neurosci. 14, 1109-1111

Schaechinger TJ, Gorbunov D, Halaszovich CR, Moser T, Kügler S, Fakler B, Oliver D (2011).
A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.
EMBO J. 30, 2793-2804

Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Bückers J, Kastrup L, Roux I, Petit C, Hell SW, Brose N, Rhee JS, Kügler S, Brigande JV, Moser T (2011).
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.
J Neurosci. 31, 4886-4895

Helfmann S, Neumann P, Tittmann K, Moser T, Ficner R, Reisinger E (2011).
The crystal structure of the C?A domain of otoferlin reveals an unconventional top loop region.
J Mol Biol. 406, 479-490

Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoè-Pognetto M, Löwel S, Moser T, Taschenberger H, Brose N, Varoqueaux F (2011).
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
Proc Natl Acad Sci U S A. 108, 3053-3058

Schütz M, Auth T, Gehrt A, Bosen F, Körber I, Strenzke N, Moser T, Willecke K (2010).
The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndrome.
Hum Mol Genet. 20, 28-39

Frank T, Rutherford MA, Strenzke N, Neef A, Pangrši? T, Khimich D, Fejtova A, Gundelfinger ED, Liberman MC, Harke B, Bryan KE, Lee A, Egner A, Riedel D, Moser T (2010).
Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling.
Neuron 68, 724-738

Pangrsic T, Lasarow L, Reuter K, Takago H, Schwander M, Riedel D, Frank T, Tarantino LM, Bailey JS, Strenzke N, Brose N, Müller U, Reisinger E, Moser T (2010).
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells.
Nat Neurosci. 13, 869-876

Buran BN, Strenzke N, Neef A, Gundelfinger ED, Moser T, Liberman MC (2010).
Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons.
J Neurosci. 30, 7587-7597

Singer JH, Glowatzki E, Moser T, Strowbridge BW, Bhandawat V, Sampath AP (2009).
Functional properties of synaptic transmission in primary sense organs.
J Neurosci. 29, 12802-12806

Neef J, Gehrt A, Bulankina AV, Meyer AC, Riedel D, Gregg RG, Strenzke N, Moser T (2009).
The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing.
J Neurosci. 29, 10730-10740

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