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Max-Planck-Gesellschaft
Max-Planck-Institut für Experimentelle Medizin
Publikationen
Moser T, Starr A (2016).
Auditory neuropathy - neural and synaptic mechanisms.
Nat Rev Neurol. [Epub ahead of print]


Jung S, Maritzen T, Wichmann C, Jing Z, Neef A, Revelo NH, Al-Moyed H, Meese S, Wojcik SM, Panou I, Bulut H, Schu P, Ficner R, Reisinger E, Rizzoli SO, Neef J, Strenzke N, Haucke V, Moser T (2015).
Disruption of adaptor protein 2µ (AP-2µ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.
EMBO J. 34, 2686-2702


Moser T (2015).
Gene therapy for deafness: How close are we?
Sci Transl Med. 7, 295fs28-295fs28


Moser T, Strenzke N (2015).
Synaptic encoding and processing of auditory information in physiology and disease.
Hear Res. 330, 155-166


Jung S, Oshima-Takago T, Chakrabarti R, Wong AB, Jing Z, Yamanbaeva G, Picher MM, Wojcik SM, Göttfert F, Predoehl F, Michel K, Hell SW, Schoch S, Strenzke N, Wichmann C, Moser T (2015).
Rab3-interacting molecules 2a and 2ß promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.
Proc Natl Acad Sci U S A. 112, E3141-E3149


Wichmann C, Moser T (2015).
Relating structure and function of inner hair cell ribbon synapses.
Cell Tissue Res. 361, 95-114


Pangršic T, Gabrielaitis M, Michanski S, Schwaller B, Wolf F, Strenzke N, Moser T (2015).
EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.
Proc Natl Acad Sci U S A. 112, E1028-E1037


Moser T (2015).
Optogenetic stimulation of the auditory pathway for research and future prosthetics.
Curr Opin Neurobiol. 34, 29-36


Vogl C, Cooper BH, Neef J, Wojcik SM, Reim K, Reisinger E, Brose N, Rhee JS, Moser T, Wichmann C (2015).
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.
J Cell Sci. 128, 638-644


Jeschke M, Moser T (2015).
Considering optogenetic stimulation for cochlear implants.
Hear Res. 322, 224-234


Chapochnikov NM, Takago H, Huang CH, Pangrši? T, Khimich D, Neef J, Auge E, Göttfert F, Hell SW, Wichmann C, Wolf F, Moser T (2014).
Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis.
Neuron 83, 1389-1403


Revelo NH, Kamin D, Truckenbrodt S, Wong AB, Reuter-Jessen K, Reisinger E, Moser T, Rizzoli SO (2014).
A new probe for super-resolution imaging of membranes elucidates trafficking pathways.
J Cell Biol. 205, 591-606


Weiler S, Krinner S, Wong AB, Moser T, Pangrši? T (2014).
ATP hydrolysis is critically required for function of CaV1.3 channels in cochlear inner hair cells via fueling Ca2+ clearance.
J Neurosci. 34, 6843-6848


Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T (2014).
Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.
EMBO J. 33, 512-527


Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Mendoza Schulz A, Hoch G, Bartels M, Vogt G, Garnham CW, Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kügler S, Salditt T, de Hoz L, Strenzke N, Moser T (2014).
Optogenetic stimulation of the auditory pathway.
J Clin Invest. 124, 1114-1129


Wong AB, Rutherford MA, Gabrielaitis M, Pangrsic T, Göttfert F, Frank T, Michanski S, Hell S, Wolf F, Wichmann C, Moser T (2014).
Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.
EMBO J. 33, 247-264


Neef J, Jung S, Wong AB, Reuter K, Pangrsic T, Chakrabarti R, Kügler S, Lenz C, Nouvian R, Boumil RM, Frankel WN, Wichmann C, Moser T (2014).
Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.
J Neurosci. 34, 705-716


Hernandez VH, Gehrt A, Jing Z, Hoch G, Jeschke M, Strenzke N, Moser T (2014).
Optogenetic stimulation of the auditory nerve.
J Vis Exp. 92, e52069-e52069


Moser T, Predoehl F, Starr A (2013).
Review of hair cell synapse defects in sensorineural hearing impairment.
Otol Neurotol. 34, 995-1004


Gregory FD, Pangrsic T, Calin-Jageman IE, Moser T, Lee A (2013).
Harmonin enhances voltage-dependent facilitation of Cav1.3 channels and synchronous exocytosis in mouse inner hair cells.
J Physiol. 591, 3253-3269


Wong AB, Jing Z, Rutherford MA, Frank T, Strenzke N, Moser T (2013).
Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.
J Neurosci. 33, 10661-10666


Werner HB, Krämer-Albers EM, Strenzke N, Saher G, Tenzer S, Ohno-Iwashita Y, De Monasterio-Schrader P, Möbius W, Moser T, Griffiths IR, Nave KA (2013).
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.
Glia 61, 567-586


Jing Z, Rutherford MA, Takago H, Frank T, Fejtova A, Khimich D, Moser T, Strenzke N (2013).
Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.
J Neurosci. 33, 4456-4467


Defourny J, Poirrier AL, Lallemend F, Mateo Sánchez S, Neef J, Vanderhaeghen P, Soriano E, Peuckert C, Kullander K, Fritzsch B, Nguyen L, Moonen G, Moser T, Malgrange B (2013).
Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells.
Nat Commun. 4, 1438-1438


von Ameln S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, Nürnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, Nürnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A, Kubisch C (2012).
A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.
Am J Hum Genet. 91, 919-927


Pangrši? T, Reisinger E, Moser T (2012).
Otoferlin: a multi-C2 domain protein essential for hearing.
Trends Neurosci. 35, 671-680


Schrauwen I, Helfmann S, Inagaki A, Predoehl F, Tabatabaiefar MA, Picher MM, Sommen M, Seco CZ, Oostrik J, Kremer H, Dheedene A, Claes C, Fransen E, Chaleshtori MH, Coucke P, Lee A, Moser T, Van Camp G (2012).
A mutation in CABP2, expressed in cochlear hair cells, causes autosomal-recessive hearing impairment.
Am J Hum Genet. 91, 636-645


tom Dieck S, Specht D, Strenzke N, Hida Y, Krishnamoorthy V, Schmidt KF, Inoue E, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Hagiwara A, Brandstätter JH, Löwel S, Gollisch T, Ohtsuka T, Moser T (2012).
Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing.
J Neurosci. 32, 12192-12203


Meyer AC, Khimich D, Egner A, Moser T (2012).
[Super-resolution optical microscopy of the organ of Corti. Investigations on the fine structure of the inner hair cell afferent synapse by the 4Pi and STED techniques].
HNO 60, 707-714


Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN (2012).
The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.
J Neurosci. 32, 9485-9498


Degen J, Schütz M, Dicke N, Strenzke N, Jokwitz M, Moser T, Willecke K (2011).
Connexin32 can restore hearing in connexin26 deficient mice.
Eur J Cell Biol. 90, 817-824


Gregory FD, Bryan KE, Pangrši? T, Calin-Jageman IE, Moser T, Lee A (2011).
Harmonin inhibits presynaptic Cav1.3 Ca²? channels in mouse inner hair cells.
Nat Neurosci. 14, 1109-1111


Schaechinger TJ, Gorbunov D, Halaszovich CR, Moser T, Kügler S, Fakler B, Oliver D (2011).
A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.
EMBO J. 30, 2793-2804


Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Bückers J, Kastrup L, Roux I, Petit C, Hell SW, Brose N, Rhee JS, Kügler S, Brigande JV, Moser T (2011).
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.
J Neurosci. 31, 4886-4895


Helfmann S, Neumann P, Tittmann K, Moser T, Ficner R, Reisinger E (2011).
The crystal structure of the C?A domain of otoferlin reveals an unconventional top loop region.
J Mol Biol. 406, 479-490


Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoè-Pognetto M, Löwel S, Moser T, Taschenberger H, Brose N, Varoqueaux F (2011).
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
Proc Natl Acad Sci U S A. 108, 3053-3058


Schütz M, Auth T, Gehrt A, Bosen F, Körber I, Strenzke N, Moser T, Willecke K (2010).
The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndrome.
Hum Mol Genet. 20, 28-39


Frank T, Rutherford MA, Strenzke N, Neef A, Pangrši? T, Khimich D, Fejtova A, Gundelfinger ED, Liberman MC, Harke B, Bryan KE, Lee A, Egner A, Riedel D, Moser T (2010).
Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling.
Neuron 68, 724-738


Pangrsic T, Lasarow L, Reuter K, Takago H, Schwander M, Riedel D, Frank T, Tarantino LM, Bailey JS, Strenzke N, Brose N, Müller U, Reisinger E, Moser T (2010).
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells.
Nat Neurosci. 13, 869-876


Buran BN, Strenzke N, Neef A, Gundelfinger ED, Moser T, Liberman MC (2010).
Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons.
J Neurosci. 30, 7587-7597


Singer JH, Glowatzki E, Moser T, Strowbridge BW, Bhandawat V, Sampath AP (2009).
Functional properties of synaptic transmission in primary sense organs.
J Neurosci. 29, 12802-12806


Neef J, Gehrt A, Bulankina AV, Meyer AC, Riedel D, Gregg RG, Strenzke N, Moser T (2009).
The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing.
J Neurosci. 29, 10730-10740




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