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Max-Planck-Gesellschaft
Max-Planck-Institut für Experimentelle Medizin
Forschung
Publikationen


2017

Lai Y, Choi UB, Leitz J, Rhee HJ, Lee C, Altas B, Zhao M, Pfuetzner RA, Wang AL, Brose N, Rhee J, Brunger AT (2017).
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.
Neuron 95, 591-607


Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M (2017).
Analysis of SUMO1-conjugation at Synapses.
Elife [Epub ahead of print]


Krueger-Burg D, Papadopoulos T, Brose N (2017).
Organizers of inhibitory synapses come of age.
Curr Opin Neurobiol. 45 [Epub ahead of print], 66-77


Chehab T, Santos NC, Holthenrich A, Koerdt SN, Disse J, Schuberth C, Nazmi AR, Neeft M, Koch H, Man KNM, Wojcik SM, Martin TFJ, van der Sluijs P, Brose N, Gerke V (2017).
A novel Munc13-4/S100A10/Annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.
Mol Biol Cell. [Epub ahead of print]


Sigler A, Oh WC, Imig C, Altas B, Kawabe H, Cooper BH, Kwon HB, Rhee JS, Brose N (2017).
Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.
Neuron 94, 304-311


Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee JS, Brose N (2017).
ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.
J Cell Biol. 216, 1143-1161


Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, Toselli M, Brose N, Parenti M, Rhee J (2017).
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Elife. 6, pii: e22466-pii: e22466


Lipstein N, Verhoeven-Duif NM, Michelassi FE, Calloway N, van Hasselt PM, Pienkowska K, van Haaften G, van Haelst MM, van Empelen R, Cuppen I, van Teeseling HC, Evelein AM, Vorstman JA, Thoms S, Jahn O, Duran KJ, Monroe GR, Ryan TA, Taschenberger H, Dittman JS, Rhee JS, Visser G, Jans JJ, Brose N (2017).
Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder.
J Clin Invest. 127, 1005-1018


Lahut S, Gispert S, Ömür Ö, Depboylu C, Seidel K, Domínguez-Bautista JA, Brehm N, Tireli H, Hackmann K, Pirkevi C, Leube B, Ries V, Reim K, Brose N, den Dunnen WF, Johnson M, Wolf Z, Schindewolf M, Schrempf W, Reetz K, Young P, Vadasz D, Frangakis AS, Schröck E, Steinmetz H, Jendrach M, Rüb U, Ba?ak AN, Oertel W, Auburger G (2017).
Blood RNA biomarkers in prodromal PARK4 and REM sleep behavior disorder show role of complexin-1 loss for risk of Parkinson's disease.
Dis Model Mech. [Epub ahead of print]


Lin KH, Taschenberger H, Neher E (2017).
Dynamics of volume-averaged intracellular Ca2+ in a rat CNS nerve terminal during single and repetitive voltage-clamp depolarizations.
J Physiol. 595, 3219-3236


2016

Schreiner D, Savas JN, Herzog E, Brose N, de Wit J (2016).
Synapse biology in the 'circuit-age'-paths toward molecular connectomics.
Curr Opin Neurobiol. [Epub ahead of print]


Papadopoulos T, Rhee HJ, Subramanian D, Paraskevopoulou F, Mueller R, Schultz C, Brose N, Rhee JS, Betz H (2016).
Endosomal Phosphatidylinositol-3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses.
J Biol Chem. 292, 1160-1177


Strenzke N, Chakrabarti R, Al-Moyed H, Müller A, Hoch G, Pangrsic T, Yamanbaeva G, Lenz C, Pan KT, Auge E, Geiss-Friedlander R, Urlaub H, Brose N, Wichmann C, Reisinger E (2016).
Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.
EMBO J. 35, 2519-2535


Tirard M, Brose N (2016).
Systematic Localization and Identification of SUMOylation Substrates in Knock-In Mice Expressing Affinity-Tagged SUMO1.
Methods Mol Biol. 1475, 291-301


Frank JA, Yushchenko DA, Hodson DJ, Lipstein N, Nagpal J, Rutter GA, Rhee JS, Gottschalk A, Brose N, Schultz C, Trauner D (2016).
Photoswitchable diacylglycerols enable optical control of protein kinase C.
Nat Chem Biol. 12, 755-762


Taschenberger H, Woehler A, Neher E (2016).
Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength.
Proc Natl Acad Sci U S A. 113, E4548-E4557


Babai N, Sendelbeck A, Regus-Leidig H, Fuchs M, Mertins J, Reim K, Brose N, Feigenspan A, Brandstätter JH (2016).
Functional Roles of Complexin3 and Complexin4 at Mouse Photoreceptor Ribbon Synapses.
J Neurosci. 36, 6651-6667


Mortensen LS, Park SJ, Ke JB, Cooper BH, Zhang L, Imig C, Löwel S, Reim K, Brose N, Demb JB, Rhee JS, Singer JH (2016).
Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses.
Cell Rep. S22111247, 30579-30584


Okamoto Y, Lipstein N, Hua Y, Lin KH, Brose N, Sakaba T, Midorikawa M (2016).
Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice.
Elife. [Epub ahead of print]


Möbius W, Nave KA, Werner HB (2016).
Electron microscopy of myelin: structure preservation by high-pressure freezing.
Brain Res. 1641, 92-100


2015

Wüstefeld L, Winkler D, Janc OA, Hassouna I, Ronnenberg A, Ostmeier K, Müller M, Brose N, Ehrenreich H, Wojcik SM (2015).
Selective expression of a constitutively active erythropoietin receptor in GABAergic neurons alters hippocampal network properties without affecting cognition.
J Neurochem. [Epub ahead of print]


Man KM, Imig C, Walter AM, Pinheiro PS, Stevens DR, Rettig J, Sørensen JB, Cooper BH, Brose N, Wojcik SM (2015).
Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.
Elife. 4, pii: e10635-pii: e10635


Ludolphs M, Schneeberger D, Soykan T, Schäfer J, Papadopoulos T, Brose N, Schindelin H, Steinem C (2015).
Specificity of collybistin-phosphoinositide interactions: Impact of the individual protein domains.
J Biol Chem. 291, 244-254


Hammer M, Krueger-Burg D, Tuffy LP, Cooper BH, Taschenberger H, Goswami SP, Ehrenreich H, Jonas P, Varoqueaux F, Rhee JS, Brose N (2015).
Perturbed Hippocampal Synaptic Inhibition and ?-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.
Cell Rep. 13, 516-523


Lipina TV, Prasad T, Yokomaku D, Luo L, Connor SA, Kawabe H, Tian Wang Y, Brose N, Roder JC, Marie Craig A (2015).
Cognitive Deficits in Calsyntenin-2 Deficient Mice Associated with Reduced Gabaergic Transmission.
Neuropsychopharmacology 41, 802-810


Babaev O, Botta P, Meyer E, Müller C, Ehrenreich H, Brose N, Lüthi A, Krueger-Burg D (2015).
Neuroligin 2 Deletion Alters Inhibitory Synapse Function and Anxiety-Associated Neuronal Activation in the Amygdala.
Neuropharmacology 100, 56-65


Chang S, Reim K, Pedersen M, Neher E, Brose N, Taschenberger H (2015).
Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse.
J Neurosci. 35, 8272-8290


Ambrozkiewicz, M. C., Kawabe, H. (2015).
HECT-type E3 ubiquitin ligases in nerve cell development and synapse physiology
FEBS Lett 589, 1635-1643


Schotten S, Meijer M, Walter AM, Huson V, Mamer L, Kalogreades L, Ter Veer M, Ruiter M, Brose N, Rosenmund C, Sørensen JB, Verhage M, Cornelisse LN (2015).
Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.
Elife. 4, e05531-e05531


Papadopoulos T, Schemm R, Grubmüller H, Brose N (2015).
Lipid Binding Defects and Perturbed Synaptogenic Activity of a CollybistinR290H Mutant that Causes Epilepsy and Intellectual Disability.
J Biol Chem. 290, 8256-8270


Netrakanti PR, Cooper BH, Dere E, Poggi G, Winkler D, Brose N, Ehrenreich H (2015).
Fast Cerebellar Reflex Circuitry Requires Synaptic Vesicle Priming by Munc13-3.
Cerebellum 14, 264-283


Vogl C, Cooper BH, Neef J, Wojcik SM, Reim K, Reisinger E, Brose N, Rhee JS, Moser T, Wichmann C (2015).
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.
J Cell Sci. 128, 638-644


2014

Nguyen Truong CQ, Nestvogel D, Ratai O, Schirra C, Stevens DR, Brose N, Rhee J, Rettig J (2014).
Secretory Vesicle Priming by CAPS Is Independent of Its SNARE-Binding MUN Domain.
Cell Rep. 9, 902-909


Imig C, Min SW, Krinner S, Arancillo M, Rosenmund C, Südhof TC, Rhee J, Brose N, Cooper BH (2014).
The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.
Neuron 84, 416-431


Ishiyama S, Schmidt H, Cooper BH, Brose N, Eilers J (2014).
Munc13-3 Superprimes Synaptic Vesicles at Granule Cell-to-Basket Cell Synapses in the Mouse Cerebellum.
J Neurosci. 33, 14687-14696


Hsia HE, Kumar R, Luca R, Takeda M, Courchet J, Nakashima J, Wu S, Goebbels S, An W, Eickholt BJ, Polleux F, Rotin D, Wu H, Rossner MJ, Bagni C, Rhee JS, Brose N, Kawabe H (2014).
Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.
Proc Natl Acad Sci U S A. 111, 13205-13210


Soykan T, Schneeberger D, Tria G, Buechner C, Bader N, Svergun D, Tessmer I, Poulopoulos A, Papadopoulos T, Varoqueaux F, Schindelin H, Brose N (2014).
A conformational switch in collybistin determines the differentiation of inhibitory postsynapses.
EMBO J. 33, 2113-2133


Rossner MJ, Tirard M (2014).
Thy1.2 driven expression of transgenic His(6)-SUMO2 in the brain of mice alters a restricted set of genes.
Brain Res. 1575, 1-11


Ju A, Hammerschmidt K, Tantra M, Krueger D, Brose N, Ehrenreich H. (2014).
Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.
Behav Brain Res. 270, 159-164


Dhara M, Yarzagaray A, Schwarz Y, Dutta S, Grabner C, Moghadam PK, Bost A, Schirra C, Rettig J, Reim K, Brose N, Mohrmann R, Bruns D (2014).
Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics.
J Cell Biol. 204, 1123-1140


Brose N (2014).
All roads lead to neuroscience: the 2013 nobel prize in physiology or medicine.
Neuron 81, 723-727


Kleijer KT, Schmeisser MJ, Krueger DD, Boeckers TM, Scheiffele P, Bourgeron T, Brose N, Burbach JP (2014).
Neurobiology of autism gene products: towards pathogenesis and drug targets.
Psychopharmacology (Berl). 231, 1037-1062


Biesemann C, Grønborg M, Luquet E, Wichert SP, Bernard V, Bungers SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, Jahn O, Brose N, Herzog E (2014).
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
EMBO J. 33, 157-170


2013

Ferro-Novick S, Brose N (2013).
Nobel 2013 Physiology or medicine: Traffic control system within cells.
Nature 504, 98-98


Mayer S, Kumar R, Jaiswal M, Soykan T, Ahmadian MR, Brose N, Betz H, Rhee JS, Papadopoulos T (2013).
Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission.
Proc Natl Acad Sci U S A. 110, 20795-20800


Pettem KL, Yokomaku D, Luo L, Linhoff MW, Prasad T, Connor SA, Siddiqui TJ, Kawabe H, Chen F, Zhang L, Rudenko G, Wang YT, Brose N, Craig AM (2013).
The Specific ?-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development.
Neuron 80, 113-128


Jedlicka P, Vnencak M, Krueger DD, Jungenitz T, Brose N, Schwarzacher SW (2013).
Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo.
Brain Struct Funct. 220, 47-58


Siddiqui TJ, Tari PK, Connor SA, Zhang P, Dobie FA, She K, Kawabe H, Wang YT, Brose N, Craig AM (2013).
An LRRTM4-HSPG Complex Mediates Excitatory Synapse Development on Dentate Gyrus Granule Cells.
Neuron 79, 680-695


Lipstein N, Sakaba T, Cooper BH, Lin KH, Strenzke N, Ashery U, Rhee JS, Taschenberger H, Neher E, Brose N (2013).
Dynamic Control of Synaptic Vesicle Replenishment and Short-Term Plasticity by Ca(2+)-Calmodulin-Munc13-1 Signaling.
Neuron 79, 82-96


Wojcik SM, Tantra M, Stepniak B, Man KN, Müller-Ribbe K, Begemann M, Ju A, Papiol S, Ronnenberg A, Gurvich A, Shin Y, Augustin I, Brose N, Ehrenreich H (2013).
Genetic Markers of a Munc13 Protein Family Member, BAIAP3, Are Gender-Specifically Associated with Anxiety and Benzodiazepine Abuse in Mouse and Man.
Mol Med. [Epub ahead of print]


Krueger DD, Brose N (2013).
Evidence for a common endocannabinoid-related pathomechanism in autism spectrum disorders.
Neuron 78, 408-410


Dolev I, Fogel H, Milshtein H, Berdichevsky Y, Lipstein N, Brose N, Gazit N, Slutsky I (2013).
Spike bursts increase amyloid-? 40/42 ratio by inducing a presenilin-1 conformational change.
Nat Neurosci. 16, 587-595


Brose N (2013).
Why we need more synaptogenic cell-adhesion proteins.
Proc Natl Acad Sci U S A. 110, 3717-3718


El-Kordi A, Winkler D, Hammerschmidt K, Kästner A, Krueger D, Ronnenberg A, Ritter C, Jatho J, Radyushkin K, Bourgeron T, Fischer J, Brose N, Ehrenreich H (2013).
Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.
Behav Brain Res. 251, 41-49


2012

Nair R, Lauks J, Jung S, Cooke NE, de Wit H, Brose N, Kilimann MW, Verhage M, Rhee J (2012).
Neurobeachin regulates neurotransmitter receptor trafficking to synapses.
J Cell Biol. 200, 61-80


Zhao S, Studer D, Chai X, Graber W, Brose N, Nestel S, Young C, Rodriguez EP, Saetzler K, Frotscher M (2012).
Structural plasticity of spines at giant mossy fiber synapses.
Front Neural Circuits. 6, 103-103


Tirard M, Hsiao HH, Nikolov M, Urlaub H, Melchior F, Brose N (2012).
In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice.
Proc Natl Acad Sci U S A. 109, 21122-21127


El-Kordi A, Winkler D, Hammerschmidt K, Kästner A, Krueger D, Ronnenberg A, Ritter C, Jatho J, Radyushkin K, Bourgeron T, Fischer J, Brose N, Ehrenreich H (2012).
Development of an autism severity score for mice using Nlgn4 null mutants construct-valid model of heritable monogenic autism.
Behav Brain Res. [Epub ahead of print]


Lipstein N, Schaks S, Dimova K, Kalkhof S, Ihling C, Kölbel K, Ashery U, Rhee J, Brose N, Sinz A, Jahn O (2012).
Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.
Mol Cell Biol. 32, 4628-4641


Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL (2012).
The RacGAP ?2-Chimaerin Selectively Mediates Axonal Pruning in the Hippocampus.
Cell 149, 1594-1606


Burgalossi A, Jung S, Man KN, Nair R, Jockusch WJ, Wojcik SM, Brose N, Rhee JS (2012).
Analysis of neurotransmitter release mechanisms by photolysis of caged Ca(2+) in an autaptic neuron culture system.
Nat Protoc. 7, 1351-1365


Landgraf I, Mühlhans J, Dedek K, Reim K, Brandstätter JH, Ammermüller J (2012).
The absence of Complexin 3 and Complexin 4 differentially impacts the ON and OFF pathways in mouse retina.
Eur J Neurosci. [Epub ahead of print]


Cooper B, Hemmerlein M, Ammermüller J, Imig C, Reim K, Lipstein N, Kalla S, Kawabe H, Brose N, Brandstätter JH, Varoqueaux F (2012).
Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses.
J Neurosci. 32, 8040-8052


Poulopoulos A, Soykan T, Tuffy LP, Hammer M, Varoqueaux F, Brose N (2012).
Homodimerization and isoform-specific heterodimerization of neuroligins.
Biochem J. 446, 321-330


Krueger DD, Tuffy LP, Papadopoulos T, Brose N (2012).
The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses.
Curr Opin Neurobiol. 22, 412-422


Ivanovic A, Horresh I, Golan N, Spiegel I, Sabanay H, Frechter S, Ohno S, Terada N, Möbius W, Rosenbluth J, Brose N, Peles E (2012).
The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves.
J Cell Biol. [Epub ahead of print]


Ivanovic A, Horresh I, Golan N, Spiegel I, Sabanay H, Frechter S, Ohno S, Terada N, Möbius W, Rosenbluth J, Brose N, Peles E (2012).
The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves.
J Cell Biol. 196, 337-344


Zhao S, Studer D, Chai X, Graber W, Brose N, Nestel S, Young C, Rodriguez EP, Saetzler K, Frotscher M (2012).
Structural plasticity of hippocampal mossy fiber synapses as revealed by high-pressure freezing.
J Comp Neurol. 520, 2340-2351


Halt AR, Dallapiazza RF, Zhou Y, Stein IS, Qian H, Juntti S, Wojcik S, Brose N, Silva AJ, Hell JW (2012).
CaMKII binding to GluN2B is critical during memory consolidation.
EMBO J. 31, 1203-1216


2011

Herzog E, Nadrigny F, Silm K, Biesemann C, Helling I, Bersot T, Steffens H, Schwartzmann R, Nägerl UV, El Mestikawy S, Rhee J, Kirchhoff F, Brose N (2011).
In Vivo Imaging of Intersynaptic Vesicle Exchange Using VGLUT1Venus Knock-In Mice.
J Neurosci. 31, 15544-15559


Burkhardt P, Stegmann CM, Cooper B, Kloepper TH, Imig C, Varoqueaux F, Wahl MC, Fasshauer D (2011).
Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis.
Proc Natl Acad Sci U S A. 108, 15264-15269


Kawabe H, Brose N (2011).
The role of ubiquitylation in nerve cell development.
Nat Rev Neurosci. 12, 251-268


Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Bückers J, Kastrup L, Roux I, Petit C, Hell SW, Brose N, Rhee JS, Kügler S, Brigande JV, Moser T (2011).
Probing the Functional Equivalence of Otoferlin and Synaptotagmin 1 in Exocytosis.
J Neurosci. 31, 4886-4895


Weston MC, Nehring RB, Wojcik SM, Rosenmund C (2011).
Interplay between VGLUT Isoforms and Endophilin A1 Regulates Neurotransmitter Release and Short-Term Plasticity.
Neuron 69, 1147-1159


Grube S, Gerchen MF, Adamcio B, Pardo LA, Martin S, Malzahn D, Papiol S, Begemann M, Ribbe K, Friedrichs H, Radyushkin KA, Müller M, Benseler F, Riggert J, Falkai P, Bickeböller H, Nave KA, Brose N, Stühmer W, Ehrenreich H (2011).
A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia.
EMBO Mol Med. 3, 309-319


Nouvian R, Neef J, Bulankina AV, Reisinger E, Pangrši? T, Frank T, Sikorra S, Brose N, Binz T, Moser T (2011).
Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins.
Nat Neurosci. 14, 411-433


Wang WZ, Oeschger FM, Montiel JF, García-Moreno F, Hoerder-Suabedissen A, Krubitzer L, Ek CJ, Saunders NR, Reim K, Villalón A, Molnár Z (2011).
Comparative aspects of subplate zone studied with gene expression in sauropsids and mammals.
Cereb Cortex. 21, 2187-2203


Kimura T, Kawabe H, Jiang C, Zhang W, Xiang YY, Lu C, Salter MW, Brose N, Lu WY, Rotin D (2011).
Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease.
Proc Natl Acad Sci U S A. 108, 3216-3221


Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoè-Pognetto M, Löwel S, Moser T, Taschenberger H, Brose N, Varoqueaux F (2011).
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
Proc Natl Acad Sci U S A. 108, 3053-3058


Helfmann S, Neumann P, Tittmann K, Moser T, Ficner R, Reisinger E (2011).
The crystal structure of the C2A domain of otoferlin reveals an unconventional top loop region.
J Mol Biol. 406, 479-490


Yang J, Seo J, Nair R, Han S, Jang S, Kim K, Han K, Paik SK, Choi J, Lee S, Bae YC, Topham MK, Prescott SM, Rhee JS, Choi SY, Kim E (2011).
DGKl regulates presynaptic release during mGluR-dependent LTD.
EMBO J. 30, 165-180


2010

Ribbe K, Friedrichs H, Begemann M, Grube S, Papiol S, Kastner A, Gerchen MF, Ackermann V, Tarami A, Treitz A, Flogel M, Adler L, Aldenhoff JB, Becker-Emner M, Becker T, Czernik A, Dose M, Folkerts H, Freese R, Gunther R, Herpertz S, Hesse D, Kruse G, Kunze H, Franz M, Lohrer F, Maier W, Mielke A, Muller-Isberner R, Oestereich C, Pajonk FG, Pollmacher T, Schneider U, Schwarz HJ, Kroner-Herwig B, Havemann-Reinecke U, Frahm J, Stuhmer W, Falkai P, Brose N, Nave KA, Ehrenreich H (2010).
The cross-sectional GRAS sample: A comprehensive phenotypical data collection of schizophrenic patients.
BMC Psychiatry. 10, 91-91


Burgalossi A, Jung S, Meyer G, Jockusch WJ, Jahn O, Taschenberger H, O'Connor VM, Nishiki T, Takahashi M, Brose N, Rhee JS (2010).
SNARE Protein Recycling by aSNAP and ßSNAP Supports Synaptic Vesicle Priming.
Neuron 68, 473-487


Liu Y, Schirra C, Edelmann L, Matti U, Rhee J, Hof D, Bruns D, Brose N, Rieger H, Stevens DR, Rettig J (2010).
Two distinct secretory vesicle-priming steps in adrenal chromaffin cells.
J Cell Biol. 190, 1067-1077


Begemann M, Grube S, Papiol S, Malzahn D, Krampe H, Ribbe K, Friedrichs H, Radyushkin KA, El-Kordi A, Benseler F, Hannke K, Sperling S, Schwerdtfeger D, Thanhäuser I, Gerchen MF, Ghorbani M, Gutwinski S, Hilmes C, Leppert R, Ronnenberg A, Sowislo J, Stawicki S, Stödtke M, Szuszies C, Reim K, Riggert J, Eckstein F, Falkai P, Bickeböller H, Nave KA, Brose N, Ehrenreich H (2010).
Modification of Cognitive Performance in Schizophrenia by Complexin 2 Gene Polymorphisms.
Arch Gen Psychiatry. 67, 879-888


Pangrsic T, Lasarow L, Reuter K, Takago H, Schwander M, Riedel D, Frank T, Tarantino LM, Bailey JS, Strenzke N, Brose N, Müller U, Reisinger E, Moser T (2010).
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells.
Nat Neurosci. 13, 869-876


Kawabe H, Brose N (2010).
The ubiquitin E3 ligase Nedd4-1 controls neurite development.
Cell Cycle. 9, 2477-2478


Jedlicka P, Hoon M, Papadopoulos T, Vlachos A, Winkels R, Poulopoulos A, Betz H, Deller T, Brose N, Varoqueaux F, Schwarzacher SW (2010).
Increased Dentate Gyrus Excitability in Neuroligin-2-Deficient Mice in Vivo.
Cereb Cortex. 21, 357-367


Radyushkin K, El-Kordi A, Boretius S, Castaneda S, Ronnenberg A, Reim K, Bickeböller H, Frahm J, Brose N, Ehrenreich H (2010).
Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophrenia.
Genes Brain Behav. 9, 592-602


Brose N, O'Connor V, Skehel P (2010).
Synaptopathy: dysfunction of synaptic function?
Biochem Soc Trans. 38, 443-444


Kawabe H, Neeb A, Dimova K, Young SM Jr, Takeda M, Katsurabayashi S, Mitkovski M, Malakhova OA, Zhang DE, Umikawa M, Kariya KI, Goebbels S, Nave KA, Rosenmund C, Jahn O, Rhee J, Brose N (2010).
Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development.
Neuron 65, 358-372


Shin OH, Lu J, Rhee JS, Tomchick DR, Pang ZP, Wojcik SM, Camacho-Perez M, Brose N, Machius M, Rizo J, Rosenmund C, Südhof TC (2010).
Munc13 C(2)B domain is an activity-dependent Ca(2+) regulator of synaptic exocytosis.
Nat Struct Mol Biol. 17, 280-288


Groffen AJ, Martens S, Arazola RD, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, McMahon HT, Verhage M (2010).
Doc2b Is a High-Affinity Ca2+ Sensor for Spontaneous Neurotransmitter Release.
Science 327, 1614-1618


Rodríguez-Castañeda F, Maestre-Martínez M, Coudevylle N, Dimova K, Junge H, Lipstein N, Lee D, Becker S, Brose N, Jahn O, Carlomagno T, Griesinger C (2010).
Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca(2+) and possible function in short-term synaptic plasticity.
EMBO J. 29, 680-691


Breustedt J, Gundlfinger A, Varoqueaux F, Reim K, Brose N, Schmitz D (2010).
Munc13-2 differentially affects hippocampal synaptic transmission and plasticity.
Cereb Cortex. 20, 1109-1120


2009

Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D (2009).
The ubiquitin ligase NEDD4-1 is required for heart development and is a suppressor of thrombospondin-1.
J Biol Chem. 285, 6770-6780


Rodríguez-Castañeda F, Coudevylle N, Becker S, Brose N, Carlomagno T, Griesinger C (2009).
(1)H, (13)C and (15)N resonance assignments of the Calmodulin-Munc13-1 peptide complex.
Biomol NMR Assign. [Epub ahead of print]


Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Bräuer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R (2009).
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Cell 138, 1222-1235


Poulopoulos A, Aramuni G, Meyer G, Soykan T, Hoon M, Papadopoulos T, Zhang M, Paarmann I, Fuchs C, Harvey K, Jedlicka P, Schwarzacher SW, Betz H, Harvey RJ, Brose N, Zhang W, Varoqueaux F (2009).
Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin.
Neuron 63, 628-642


Brose N, Neher E (2009).
Flowers for synaptic endocytosis.
Cell 138, 836-837


Breustedt J, Gundlfinger A, Varoqueaux F, Reim K, Brose N, Schmitz D (2009).
Munc13-2 Differentially Affects Hippocampal Synaptic Transmission and Plasticity.
Cereb Cortex. [Epub ahead of print]


Wittenmayer N, Körber C, Liu H, Kremer T, Varoqueaux F, Chapman ER, Brose N, Kuner T, Dresbach T (2009).
Postsynaptic Neuroligin1 regulates presynaptic maturation.
Proc Natl Acad Sci U S A. 106, 13564-13569


Siksou L, Varoqueaux F, Pascual O, Triller A, Brose N, Marty S (2009).
A common molecular basis for membrane docking and functional priming of synaptic vesicles.
Eur J Neurosci. 30, 49-56


Hoon M, Bauer G, Fritschy JM, Moser T, Falkenburger BH, Varoqueaux F (2009).
Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retina.
J Neurosci. 29, 8039-8050


Strenzke N, Chanda S, Kopp-Scheinpflug C, Khimich D, Reim K, Bulankina AV, Neef A, Wolf F, Brose N, Xu-Friedman MA, Moser T (2009).
Complexin-I is required for high-fidelity transmission at the endbulb of held auditory synapse.
J Neurosci. 29, 7991-8004


Dimova K, Kalkhof S, Pottratz I, Ihling C, Rodriguez-Castaneda F, Liepold T, Griesinger C, Brose N, Sinz A, Jahn O (2009).
Structural Insights into the Calmodulin-Munc13 Interaction Obtained by Cross-Linking and Mass Spectrometry.
Biochemistry 48, 5908-5921


Garcia-Garcia AL, Elizalde N, Matrov D, Harro J, Wojcik SM, Venzala E, Ramírez MJ, Del Rio J, Tordera RM (2009).
Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1.
Biol Psychiatry. 66, 275-282


Reim K, Regus-Leidig H, Ammermüller J, El-Kordi A, Radyushkin K, Ehrenreich H, Brandstätter JH, Brose N (2009).
Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4.
J Cell Sci. 122, 1352-1361


Brose N (2009).
Synaptogenic proteins and synaptic organizers: "many hands make light work".
Neuron 61, 650-652


Radyushkin K, Hammerschmidt K, Boretius S, Varoqueaux F, El-Kordi A, Ronnenberg A, Winter D, Frahm J, Fischer J, Brose N, Ehrenreich H. (2009).
Neuroligin-3 deficient mice: Model of a monogenic heritable form of autism with an olfactory deficit.
Genes Brain Behav. 8, 416-425


Brose N, Neher E (2009).
Flowers for synaptic endocytosis.
Cell 138, 836-837


Wozny C, Breustedt J, Wolk F, Varoqueaux F, Boretius S, Zivkovic AR, Neeb A, Frahm J, Schmitz D, Brose N, Ivanovic A. (2009).
The function of glutamatergic synapses is not perturbed by severe knockdown of 4.1N and 4.1G expression.
J Cell Sci. 122, 735-744


Schenck S, Wojcik SM, Brose N, Takamori S (2009).
A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles.
Nat Neurosci. 12, 156-162


Blundell J, Tabuchi K, Bolliger MF, Blaiss CA, Brose N, Liu X, Südhof TC, Powell CM (2009).
Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2.
Genes Brain Behav. 8, 114-126


Brunk I, Blex C, Speidel D, Brose N, Ahnert-Hilger G (2009).
Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake.
J Biol Chem. 284, 1050-1060


2008

Cai H, Reim K, Varoqueaux F, Tapechum S, Hill K, Sørensen JB, Brose N, Chow RH (2008).
Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming.
Proc Natl Acad Sci U S A. 105, 19538-19543


Blundell J, Tabuchi K, Bolliger MF, Blaiss CA, Brose N, Liu X, Südhof TC, Powell CM (2008).
Increased Anxiety-like Behavior in Mice Lacking the Inhibitory Synapse Cell Adhesion Molecule Neuroligin 2.
Genes Brain Behav. [Epub ahead of print]


Hoerder-Suabedissen A, Wang WZ, Lee S, Davies KE, Goffinet AM, Rakic S, Parnavelas J, Reim K, Nicolic M, Paulsen O, Molnár Z (2008).
Novel Markers Reveal Subpopulations of Subplate Neurons in the Murine Cerebral Cortex
Cereb Cortex. [Epub ahead of print]


Brunk I, Blex C, Speidel D, Brose N, Ahnert-Hilger G (2008).
Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake.
J Biol Chem. [Epub ahead of print]


Adamcio B, Sargin D, Stradomska A, Medrihan L, Gertler C, Theis F, Zhang M, Muller M, Hassouna I, Hannke K, Sperling S, Radyushkin K, El-Kordi A, Schulze L, Ronnenberg A, Wolf F, Brose N, Rhee JS, Zhang W, Ehrenreich H. (2008).
Erythropoietin enhances hippocampal long-term potentiation and memory.
BMC Biol. 6, 37-


Patrizi A, Scelfo B, Viltono L, Briatore F, Fukaya M, Watanabe M, Strata P, Varoqueaux F, Brose N, Fritschy JM, Sassoè-Pognetto M. (2008).
Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptors.
Proc Natl Acad Sci U S A. 105, 13151-13156


Lou X, Korogod N, Brose N, Schneggenburger R (2008).
Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on Both Munc13 and protein kinase C.
J Neurosci. 28, 8257-8267


Zhao L, Reim K, Miller DJ (2008).
Complexin-I-deficient sperm are subfertile due to a defect in zona pellucida penetration.
Reproduction. 136, 323-334


Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, Brose N, Stambolic V, Rotin D. (2008).
The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization.
Proc Natl Acad Sci U S A. 105, 8585-8590


Xue M, Stradomska A, Chen H, Brose N, Zhang W, Rosenmund C, Reim K. (2008).
Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system.
Proc Natl Acad Sci U S A. 105, 7875-7880


Liu Y, Schirra C, Stevens DR, Matti U, Speidel D, Hof D, Bruns D, Brose N, Rettig J. (2008).
CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles.
J Neurosci. 28, 5594-601


Pivot-Pajot C, Varoqueaux F, de Saint Basile G, Bourgoin SG (2008).
Munc13-4 regulates granule secretion in human neutrophils
J Immunol. 180, 6786-6797


Brose N. (2008).
For Better or for Worse: Complexins Regulate SNARE Function and Vesicle Fusion.
Traffic. 9, 1403-1413


Brose N. (2008).
Altered Complexin Expression in Psychiatric and Neurological Disorders: Cause or Consequence?
Mol Cells. 25, 7-19


Zikich D, Mezer A, Varoqueaux F, Sheinin A, Junge HJ, Nachliel E, Melamed R, Brose N, Gutman M, Ashery U. (2008).
Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulin.
J Neurosci. 28, 1949-1960


Jamain S, Radyushkin K, Hammerschmidt K, Granon S, Boretius S, Varoqueaux F, Ramanantsoa N, Gallego J, Ronnenberg A, Winter D, Frahm J, Fischer J, Bourgeron T, Ehrenreich H, Brose N. (2008).
Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.
Proc Natl Acad Sci U S A. 105, 1710-1715


Speidel D, Salehi A, Obermueller S, Lundquist I, Brose N, Renström E, Rorsman P. (2008).
CAPS1 and CAPS2 Regulate Stability and Recruitment of Insulin Granules in Mouse Pancreatic beta Cells.
Cell Metab. 7, 57-67


2007

Jockusch WJ, Speidel D, Sigler A, Sørensen JB, Varoqueaux F, Rhee JS, Brose N. (2007).
CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.
Cell. 131, 796-808


Yang CB, Kiser PJ, Zheng YT, Varoqueaux F, Mower GD (2007).
Bidirectional regulation of Munc13-3 protein expression by age and dark rearing during the critical period in mouse visual cortex.
Neuroscience 150, 603-608


Xue M, Reim K, Chen X, Chao HT, Deng H, Rizo J, Brose N, Rosenmund C. (2007).
Distinct domains of complexin I differentially regulate neurotransmitter release.
Nat Struct Mol Biol. 14, 949-958


Wegmeyer H, Egea J, Rabe N, Gezelius H, Filosa A, Enjin A, Varoqueaux F, Deininger K, Schnütgen F, Brose N, Klein R, Kullander K, Betz A. (2007).
EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin.
Neuron. 55, 756-767


Wojcik, S.M., Brose, N. (2007).
Regulation of membrane fusion in synaptic excitation-secretion coupling: Speed and accuracy matter
Neuron 55, 11-24


Chubykin, A.A., Atasoy, D., Etherton, M.R., Brose, N., Kavalali, E.T., Gibson, J.R., Südhof, T.C. (2007).
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2
Neuron 54, 919-931


Glynn, D., Reim, K., Brose, N., Morton, A.J. (2007).
Depletion of complexin II does not affect disease progression in a mouse model of Huntington's disease (HD); Support for role for complexin II in behavioural pathology in a mouse model of HD
Brain Research Bulletin 72, 108-120


Basu, J., Betz, A., Brose, N., Rosenmund, C. (2007).
Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion
Journal of Neuroscience 27, 1200-1210


Tordera, R.M., Totterdell, S., Wojcik, S.M., Brose , N., Elizalde, N., Lasheras, B., Del Rio, J. (2007).
Enhanced anxiety, depressive-like behaviour and impaired recognition memory in mice with reduced expression of vesicular glutamate transporter 1 (VGLUT1)
European Journal of Neuroscience 25, 281-290


Zhao, L., Burkin, H. R., Shi, X., Li, L., Reim, K., Miller, D. J. (2007).
Complexin I is required for mammalian sperm acrosomal exocytosis
Developmental biology 309, 236-244


Tirard, M., Almeida, O.F.X., Hutzler, P., Melchior, F., Michaelidis, T.M. (2007).
Sumoylation and proteasomal activity determine the transactivation properties of the mineralocorticoid receptor
Molecular and cellular endocrinology 268, 20-29


Brose, N. (2007).
Autismus - wenn Nervenzellen kontaktscheu sind.
Biospektrum 06.07, 614-616


2006

Kalla, S., Stern, M., Basu, J., Varoqueaux, F., Reim, K., Rosenmund, C., Ziv, N. E., Brose, N. (2006).
Molecular dynamics of a presynaptic active zone protein studied in Munc13-1-enhanced yellow fluorescent protein knock-in mutant mice
Journal of neuroscience 26, 13054-13066


Dimova, K., Kawabe, H., Betz, A., Brose, N. and Jahn, O. (2006).
Characterisation of the Munc13-calmodulin interaction by photoaffinity labeling
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1763, 1256-1265


Varoqueaux, F., Aramuni, G., Rawson, R. L., Mohrmann, R., Missler, M., Gottmann, K., Zhang, W., Südhof, T. C., Brose, N. (2006).
Neuroligins determine synapse maturation and function
Neuron 51, 741-754


Herzog, E., Takamori, S., Jahn, R., Brose, N., Wojcik, S. M. (2006).
Synaptic and vesicular co-localization of the glutamate transporters VGLUT1 and VGLUT2 in the mouse hippocampus
Journal of Neurochemistry 99, 1011-1018


Andrews-Zwilling, Y. S., Kawabe, H., Reim, K., Varoqueaux, F., Brose, N. (2006).
Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2
Journal of Biological Chemistry 281, 19720-19731


Wojcik, S. M., Katsurabayashi, S., Guillemin, I., Friauf, E., Rosenmund, C., Brose, N., Rhee, J.-S. (2006).
A shared vesicular carrier allows synaptic corelease of GABA and glycine
Neuron 50, 575-587


Kang, L. J., He, Z., Xu, P., Fan, J., Betz, A., Brose, N., Xu, T. (2006).
Munc13-1 is required for the sustained release of insulin from pancreatic ? cells
Cell Metabolism 3, 463-468


Kwan, E. P., Xie, L., Sheu, L., Nolan, C. J., Prentki, M., Betz, A., Brose, N., Gaisano, H. Y. (2006).
Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance
Diabetes 55, 1421-1429


Vinatier, J., Herzog, E., Plamont, M.-A., Wojcik, S. M., Schmidt, A., Brose, N., Daviet, L., El Mestikawy, S., Giros, B. (2006).
Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis
Journal of Neurochemistry 97, 1111-1125


Martin, H. G. S., Henley, J. M., Meyer, G. (2006).
Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and ?/? soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor ?PIX
Journal of Cellular Biochemistry 99, 1203-1215


Bungers, S. R.
Involvement of RasGRP1 in dendritogenesis and spinogenesis of cultured rat hippocampal neurons
Julius-Maximilians-Universität Würzburg (2006)

Kalla, S.
Durchführung und Anwendung einer in-vivo-Markierung von Munc13-Proteinen
Westfälische Wilhelms-Universität Münster (2006)

Holt, M., Varoqueaux, F., Wiederhold, K., Takamori, S., Urlaub, H., Fasshauer, D., Jahn, R. (2006).
Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression
Journal of Biological Chemistry 281, 17076-17083


Juengling, K., Eulenburg, V., Moore, R., Kemler, R., Lessmann, V., Gottmann, K. (2006).
N-cadherin transsynaptically regulates short-term plasticity at glutamatergic synapses in embryonic stem cell-derived neurons
Journal of Neuroscience 26, 6968-6978


Schlüter, O. M., Basu, J., Südhof, T. C., Rosenmund, C. (2006).
Rab3 superprimes synaptic vesicles for release: Implications for short-term synaptic plasticity
Journal of Neuroscience 26, 1239-1246


2005

Stevens, D. R., Wu, Z.-X., Matti, U., Junge, H. J., Schirra, C., Becherer, U., Wojcik, S. M., Brose, N., Rettig, J. (2005).
Identification of the minimal protein domain required for priming activity of Munc13-1
Current Biology 15, 2243-2248


Gibson, H. E., Reim, K., Brose, N., Morton, A. J., Jones, S. (2005).
A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse
European Journal of Neuroscience 22, 1701-1712


Glynn, D., Drew, C. J., Reim, K., Brose, N., Morton, A. J. (2005).
Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits
Human Molecular Genetics 14, 2369-2385


Varoqueaux, F., Sons, M. S., Plomp, J. J., Brose, N. (2005).
Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse
Molecular and Cellular Biology 25, 5973-5984


Reim, K., Wegmeyer, H., Brandstatter, J. H., Xue, M., Rosenmund, C., Dresbach, T., Hofmann, K., Brose, N. (2005).
Structurally and functionally unique complexins at retinal ribbon synapses
Journal of Cell Biology 169, 669-680


Speidel, D., Bruederle, C. E., Enk, C., Voets, T., Varoqueaux, F., Reim, K., Becherer, U., Fornal, F., Ruggieri, S., Holighaus, Y., Weihe, E., Bruns, D., Brose, N., Rettig, J. (2005).
CAPS1 regulates catecholamine loading of large dense-core vesicles
Neuron 46, 75-88


Steinacker, P., Schwarz, P., Reim, K., Brechlin, P., Jahn, O., Kratzin, H., Aitken, A., Wiltfang, J., Aguzzi, A., Bahn, E., Baxter, H. C., Brose, N., Otto, M. (2005).
Unchanged survival rates of 14-3-3 gamma knockout mice after inoculation with pathological prion protein
Molecular and Cellular Biology 25, 1339-1346


Neeft, M., Wieffer, M., de Jong, A. S., Negroiu, G., Metz, C. H. G., van Loon, A., Griffith, J., Krijgsveld, J., Wulffraat, N., Koch, H., Heckt, A. J. R., Brose, N., Kleijmeer, M., van der Sluijs, P. (2005).
Munc13-4 is an effector of Rab27a and controls secretion of lysosomes in hematopoietic cells
Molecular Biology of the Cell 16, 731-741


Wolk, F.
Charakterisierung von 4.1 N-defizienten Mäusen
Georg-August-Universität Göttingen (2005)

Fornai, F., Schlüter, O. M., Lenzi, P., Gesi, M., Ruffoli, R., Ferrucci, M., Lazzeri, G., Busceti, C. L., Pontarelli, F., Battaglia, G., Pellegrini, A., Nicoletti, F., Ruggieri, S., Paparelli, A., Südhof, T. C. (2005).
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and alpha-synuclein
Proceedings of the National Academy of Sciences of the United States of America 102, 3413-3418


Speidel, D.
Regulation der Hormon- und Transmitterausschüttung durch Mitglieder der CAPS-Proteinfamilie
Rheinische Friedrich-Wilhelms-Universität Bonn (2005)

Andrews-Zwilling, Y.
Targeting and anchoring of Munc13-1 and ubMunc13-2 to active zones by RIM1alpha
Georg-August-Universität Göttingen (2005)

2004

Varoqueaux, F., Jamain, S., Brose, N. (2004).
Neuroligin 2 is exclusively localized to inhibitory synapses
European Journal of Cell Biology 83, 449-456


Dresbach, T., Neeb, A., Meyer, G., Gundelfinger, E. D., Brose, N. (2004).
Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding
Molecular and Cellular Neuroscience 27, 227-235


Meyer, G., Varoqueaux, F., Neeb, A., Oschlies, M., Brose, N. (2004).
The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin
Neuropharmacology 47, 724-733


Junge, H. J., Rhee, J. S., Jahn, O., Varoqueaux, F., Spiess, J., Waxham, M. N., Rosenmund, C., Brose, N. (2004).
Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity
Cell 118, 389-401


Brose, N., Betz, A., Wegmeyer, H. (2004).
Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals
Current Opinion in Neurobiology 14, 328-340


Rossner, S., Fuchsbrunner, K., Lange-Dohna, C., Hartlage-Rübsamen, M., Bigl, V., Betz, A., Reim, K., Brose, N. (2004).
Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing
Journal of Biological Chemistry 279, 27841-27844


Wojcik, S. M., Rhee, J. S., Herzog, E., Sigler, A., Jahn, R., Takamori, S., Brose, N., Rosenmund, C. (2004).
An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size
Proceedings of the National Academy of Sciences of the United States of America 101, 7158-7163


Nagy, G., Reim, K., Matti, U., Brose, N., Binz, T., Rettig, J., Neher, E., Sørensen, J. B. (2004).
Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25
Neuron 41, 417-429


Schlüter, O. M., Schmitz, F., Jahn, R., Rosenmund, C., Südhof, T. C. (2004).
A complete genetic analysis of neuronal Rab3 function
Journal of Neuroscience 24, 6629-6637


Kattenstroth, G., Tantalaki, E., Südhof, T. C., Gottmann, K., Missler, M. (2004).
Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins
Proceedings of the National Academy of Sciences of the United States of America 101, 2607-2612


Herzog, E. (2004).
Understanding glutamatergic neurons in mammalians: un ménage à trois
M S-Medecine Sciences 20, 1063-1066


2003

Meyer, G., Brose, N. (2003).
SPARring with spines
Science 302, 1341-1344


Rosenmund, C., Rettig, J., Brose, N. (2003).
Molecular mechanisms of active zone function
Current Opinion in Neurobiology 13, 509-519


Speidel, D., Varoqueaux, F., Enk, C., Nojiri, M., Grishanin, R.N., Martin, T.F.J., Hofmann, K., Brose, N., Reim, K. (2003).
A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.
Journal of Biological Chemistry 278, 52802-52809


Tobaben, S., Varoqueaux, F., Brose, N., Stahl, B., Meyer, G. (2003).
A brain specific isoform of small glutamine-rich tetratricopeptide repeat containing protein (SGT) binds to Hsc70 and the cysteine string protein
Journal of Biological Chemistry 278, 38376-38383


Sheu, L., Pasyk, E.A., Ji, J., Huang, X., Gao, X., Varoqueaux, F., Brose, N., Gaisano, H.Y. (2003).
Regulation of insulin exocytosis by Munc13-1
Journal of Biological Chemistry 278, 27556-27563


Sørensen, J.B., Nagy, G., Varoqueaux, F., Nehring, R.B., Brose, N., Wilson, M.C., Neher, E. (2003).
Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23
Cell 114, 75-86


Junge, H.
Funktion von Munc13-Proteinen in präsynaptischen Regulationsmechanismen der Neurotransmission
Philipps-Universität Marburg (2003)

Neeb, A.J.
Neuroligin : Charakterisierung eines neuronalen Transmembranproteins
Georg-August-Universität Göttingen (2003)

Schlüter, O.M., Fornai, F., Alessandrí, M.G., Takamori, S., Geppert, M., Jahn, R., Südhof, T.C. (2003).
Role of ?-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
Neuroscience 118, 985-1002


Sylvester, M.
Studien zur Verankerung von Munc 13-1 am Zytoskelett
Freie Universität Berlin (2003)

Kriegstein, K., Schmitz, F. (2003).
The expression pattern and assembly profile of synaptic membrane proteins in ribbon synapses of the developing mouse retina
Cell and Tissue Research 311, 159-173


2002

Brose, N., Neher, E. (2002).
Specificity emerges in the dissection of diacylglycerol- and protein kinase C-mediated signalling pathways
Proceedings of the National Academy of Sciences of the United States of America 99, 16522-16523


Brose, N., Rosenmund, C. (2002).
Move over protein kinase C, you've got company: Alternative cellular effectors of diacylglycerol and phorbol esters
Journal of Cell Science 115, 4399-4411


Varoqueaux, F., Sigler, A., Rhee, J. S., Brose, N., Enk, C., Reim, K., Rosenmund, C. (2002).
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming
Proceedings of the National Academy of Sciences of the United States of America 99, 9037-9042


Antonin, W., Wagner, M., Riedel, D., Brose, N., Jahn, R. (2002).
Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion
Molecular and Cellular Biology 22, 1545-1554


Rosenmund, C., Sigler, A., Augustin, I., Reim, K., Brose, N., Rhee, J. S. (2002).
Differential control of vesicle priming and short-term plasticity by Munc13 isoforms
Neuron 33, 411-424


Rhee, J. S., Betz, A., Pyott, S., Reim, K., Varoqueaux, F., Augustin, I., Hesse, D., Südhof, T. C., Takahashi, M., Rosenmund, C., Brose, N. (2002).
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs
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Schlüter, O.
Alpha-Synuclein: Synaptische Funktion und Rolle bei der Pathogenese der Parkinson-Syndrome
Georg-August Universität Göttingen (2002)

Wegmeyer, H.
Analyse der neuartigen Complexin-Isoformen III und IV
Universität Hannover (2002)

Tobaben, S., Südhof, T. C., Stahl, B. (2002).
Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha
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Schlüter, O. M., Khvotchev, M., Jahn, R., Sudhof, T. C. (2002).
Localization versus function of Rab3 proteins - Evidence for a common regulatory role in controlling fusion
Journal of Biological Chemistry 277, 40919-40929


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Academic Press / Elsevier Amsterdam (2002) pp. 531-544



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