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Max-Planck-Gesellschaft
Max-Planck-Institut für Experimentelle Medizin
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Ausgewählte Publikationen der Abteilung Neurogenetik


Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner HB, Erwig MS, Möbius W, Kursula P, Nave KA, Simons M (2017).
Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.
Cell Rep. 18, 314-323


Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Böhler C, Barrette B, Stassart R, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G (2017).
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.
Nat Commun. 8, 14241-14241


Feldman EL, Nave KA, Jensen TS, Bennett DL (2017).
New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain
Neuron 93, 1296-1313


Trevisiol A, Saab AS, Winkler U, Marx G, Imamura H, Möbius W, Kusch K, Nave KA, Hirrlinger J (2017).
Monitoring ATP dynamics in electrically active white matter tracts.
Elife [Epub ahead of print]


Kleinecke S, Richert S, de Hoz L, Brügger B, Kungl T, Asadollahi E, Quintes S, Blanz J, McGonigal R, Naseri K, Sereda MW, Sachsenheimer T, Lüchtenborg C, Möbius W, Willison H, Baes M, Nave KA, Kassmann CM (2017).
Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy.
Elife 6, e23332-e23332


Saab A.S., Tzvetavona, I.D., Trevisiol, A., Baltan, S., Dibaj, P., Kusch, K., Möbius, W., Goetze, B., Jahn, H.M., Huang, W., Steffens, H., Schomburg, E.D., Pérez-Samartín, A., Pérez-Cerdá, F., Bakhtiari, D., Matute, C., Löwel, S., Griesinger, C., Hirrlinger, J., Frank Kirchhoff, F., and Nave, K.A. (2016).
Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism.
Neuron 91, 119-132


Quintes, S., Brinkmann, B.G., Ebert, M., Fröb, F., Kungl, T., A. Arlt, F.A., Tarabykin, V., Huylebroeck, D., Meijer, D., Suter, U., Wegner, M., Sereda, M.W., and Nave, K.-A. (2016).
Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair.
Nature Neurosci. 19, 1050-1059


Patzig J, Erwig MS, Tenzer S, Kusch K, Dibaj P, Möbius W, Goebbels S, Schaeren-Wiemers N, Nave KA, Werner HB (2016).
Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.
Elife. 5, pii: e17119-pii: e17119


Goebbels S, Wieser GL, Pieper A, Spitzer S, Weege B, Yan K, Edgar JM, Yagensky O, Wichert SP, Agarwal A, Karram K, Renier N, Tessier-Lavigne M, Rossner MJ, Káradóttir RT, Nave KA (2016).
A neuronal PI(3,4,5)P(3)-dependent program of oligodendrocyte precursor recruitment and myelination.
Nat Neurosci. 20, 10-15


Ehrenreich H, Mitjans M, Van der Auwera S, Centeno TP, Begemann M, Grabe HJ, Bonn S, Nave KA (2016).
OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals.
Mol Psychiatry. [Epub ahead of print]


Snaidero N, Möbius W, Czopka T, Hekking LH, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons DA, Nave KA, Simons M (2014).
Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue.
Cell 156, 277-290


Nave KA, Ehrenreich H (2014).
Myelination and Oligodendrocyte Functions in Psychiatric Diseases.
JAMA Psychiatry. 71, 582-584


Prukop T, Epplen DB, Nientiedt T, Wichert SP, Fledrich R, Stassart RM, Rossner MJ, Edgar JM, Werner HB, Nave KA, Sereda MW (2014).
Progesterone Antagonist Therapy in a Pelizaeus-Merzbacher Mouse Model.
Am J Hum Genet. 94, 533-546


Mei L, Nave KA (2014).
Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases.
Neuron 83, 27-49


Fledrich R, Stassart RM, Klink A, Rasch LM, Prukop T, Haag L, Czesnik D, Kungl T, Abdelaal TA, Keric N, Stadelmann C, Brück W, Nave KA, Sereda MW (2014).
Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A.
Nat Med. 20, 1055-1061


Nave KA, Werner HB (2014).
Myelination of the nervous system: mechanisms and functions.
Annu Rev Cell Dev Biol. 30, 503-533


Gritsch S, Lu J, Thilemann S, Wörtge S, Möbius W, Bruttger J, Karram K, Ruhwedel T, Blanfeld M, Vardeh D, Waisman A, Nave KA, Kuner R (2014).
Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice.
Nat Commun. 5, 5472-5472


Stassart RM, Fledrich R, Velanac V, Brinkmann BG, Schwab MH, Meijer D, Sereda MW, Nave KA (2013).
A role for Schwann cell-derived neuregulin-1 in remyelination.
Nat Neurosci. 16, 48-54


Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers EM (2013).
Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication.
PLoS Biol. 11, e1001604-e1001604


Saab AS, Tzvetanova ID, Nave KA (2013).
The role of myelin and oligodendrocytes in axonal energy metabolism.
Curr Opin Neurobiol. 23, 1065-1072


Goebbels S, Oltrogge JH, Wolfer S, Wieser GL, Nientiedt T, Pieper A, Ruhwedel T, Groszer M, Sereda MW, Nave KA (2012).
Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy.
EMBO Mol Med. 4, 486-499


Fünfschilling, U., Supplie, L.M., Mahad, D., Boretius, S., Saab, A.S., Edgar, J.,Brinkmann, B.G., Kassmann, C.M., Tzvetanova, I.D., Möbius, W., Diaz, F., Meijer, D., Suter, U., Hamprecht, B., Sereda, M.W., Moraes, C.T., Frahm, J, Goebbels, S., and Nave, K.-A. (2012).
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.
Nature 485, 517-521


Saher G, Rudolphi F, Corthals K, Ruhwedel T, Schmidt KF, Löwel S, Dibaj P, Barrette B, Möbius W, Nave KA (2012).
Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet.
Nat Med. 18, 1130-1135


Saab AS, Neumeyer A, Jahn HM, Cupido A, Simek AA, Boele HJ, Scheller A, Le Meur K, Götz M, Monyer H, Sprengel R, Rubio ME, Deitmer JW, De Zeeuw CI, Kirchhoff F (2012).
Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination
Science 337, 749-753


Agarwal A, Dibaj P, Kassmann CM, Goebbels S, Nave KA, Schwab MH (2011).
In Vivo Imaging and Noninvasive Ablation of Pyramidal Neurons in Adult NEX-CreERT2 Mice.
Cereb Cortex. 22, 1473-1486


Dhaunchak AS, Colman DR, Nave KA (2011).
Misalignment of PLP/DM20 Transmembrane Domains Determines Protein Misfolding in Pelizaeus-Merzbacher Disease.
J Neurosci. 31, 14961-14971


Patzig J, Jahn O, Tenzer S, Wichert SP, de Monasterio-Schrader P, Rosfa S, Kuharev J, Yan K, Bormuth I, Bremer J, Aguzzi A, Orfaniotou F, Hesse D, Schwab MH, Möbius W, Nave KA, Werner HB (2011).
Quantitative and Integrative Proteome Analysis of Peripheral Nerve Myelin Identifies Novel Myelin Proteins and CandidateNeuropathy Loci.
J Neurosci. 31, 16369-16386


Edgar JM, McCulloch MC, Montague P, Brown AM, Thilemann S, Pratola L, Gruenenfelder FI, Griffiths IR, Nave KA (2010).
Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease.
EMBO Mol Med. 2, 42-50


Bremer J, Baumann F, Tiberi C, Wessig C, Fischer H, Schwarz P, Steele AD, Toyka KV, Nave KA, Weis J, Aguzzi A (2010).
Axonal prion protein is required for peripheral myelin maintenance.
Nat Neurosci. 13, 310-318


Nave KA (2010).
Oligodendrocytes and the "Micro Brake" of Progenitor Cell Proliferation.
Neuron 65, 577-579


Nave KA (2010).
Myelination and the trophic support of long axons.
Nat Rev Neurosci. 11, 275-283


Goebbels S, Oltrogge JH, Kemper R, Heilmann I, Bormuth I, Wolfer S, Wichert SP, Möbius W, Liu X, Lappe-Siefke C, Rossner MJ, Groszer M, Suter U, Frahm J, Boretius S, Nave KA (2010).
Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination.
J Neurosci. 30, 8953-8964


Nave KA (2010).
Myelination and support of axonal integrity by glia.
Nature 468, 244-252


Nawaz S, Kippert A, Saab AS, Werner HB, Lang T, Nave KA, Simons M (2009).
Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium.
J Neurosci. 29, 4794-4807


Saher G, Quintes S, Möbius W, Wehr MC, Krämer-Albers EM, Brügger B, Nave KA (2009).
Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction.
J Neurosci. 29, 6094-6104


Gao Z, Ure K, Ables JL, Lagace DC, Nave KA, Goebbels S, Eisch AJ, Hsieh J (2009).
Neurod1 is essential for the survival and maturation of adult-born neurons.
Nat Neurosci. 12, 1090-1092


Edgar JM, Nave KA (2009).
The role of CNS glia in preserving axon function.
Curr Opin Neurobiol. 19, 498-504


Botvinnik A, Wichert SP, Fischer TM, Rossner MJ (2009).
Integrated analysis of receptor activation and downstream signaling with EXTassays.
Nat Methods. 7, 74-80


Seuntjens E, Nityanandam A, Miquelajauregui A, Debruyn J, Stryjewska A, Goebbels S, Nave KA, Huylebroeck D, Tarabykin V (2009).
Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors.
Nat Neurosci. 12, 1373-1380


Nave, KA, Trapp, BD (2008).
Axon-Glial Signaling and the Glial Support of Axon Function
Annu Rev Neurosci. 31, 535-561


Trapp, B.D. Nave, K.-A. (2008).
Multiple Sclerosis: An Immune or A Neurodegenerative Disorder?
Annu. Rev. Neurosci. 31, 247-69


Brinkmann, B. G., Agarwal, A., Sereda, M. W., Garratt, A.N., Wende, T.H., Stassart, R.M., Nawaz, S., Humml, C. , Velanac, V., Radyuschkin, K., Goebbels, S., Fischer, T. M., Franklin, R. J., Lai, C., Ehrenreich, H., Birchmeier, C., Schwab, M. H., and Nave, K.-A. (2008).
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Neuron 59, 581-595


Werner, H. B., Kuhlmann, K., Shen, S., Uecker, M., Schardt, A., Dimova, K., Orfaniotou, F., Dhaunchak, A., Brinkmann, B.G., Möbius, W., Guarente, L., Casaccia-Bonnefil, P., Jahn, O., Nave, K.-A. (2007).
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin
J Neurosci. 27, 7717-7730


Nave K.-A., Sereda M.W., Ehrenreich, H. (2007).
Mechanisms of disease: inherited demyelinating neuropathies-from basic to clinical research.
Nat Clin Pract Neurol. 8, 453-464


He, Y., Dupree, J., Wang, J., Sandoval, J., Li, J., Liu, H., Shi, Y., Nave, K.-A., Casaccia-Bonnefil, P. (2007).
The transcription factor yin yang 1 is essential for oligodendrocyte progenitor differentiation.
Neuron 55, 217-230


Kassmann, C. M., Lappe-Siefke, C., Baes, M., Brügger, B., Mildner, A., Werner, H. B., Natt, O., Michaelis, T., Prinz, M., Frahm, J., Nave, K.-A. (2007).
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
Nat Genet. 39, 969-976


Dhaunchak AS, Nave KA. (2007).
A common mechanism of PLP/DM20 misfolding causes cysteine-mediated endoplasmic reticulum retention in oligodendrocytes and Pelizaeus-Merzbacher disease.
Proc Natl Acad Sci U S A. 104, 17813-17818


Wehr, M. C., Laage, R., Bolz, U., Fischer, T. M., Grünewald, S., Scheek, S., Bach, A., Nave, K.-A., Rossner, M. J. (2006).
Monitoring regulated protein-protein interactions using split TEV
Nat Methods. 3, 985-993


Krämer-Albers, E.-M., Gehrig-Burger, K., Thiele, C., Trotter, J., Nave, K.-A. (2006).
Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: Implications for dysmyelination in spastic paraplegia
J Neurosci. 26, 11743-11752


Nave, K.-A., Salzer, J. L. (2006).
Axonal regulation of myelination by neuregulin 1
Curr Opin Neurobiol. 16, 492-500


Nimmerjahn, A., Kirchhoff, F., Helmchen, F. (2005).
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Science 308, 1314-1318


Saher, G., Brügger, B., Lappe-Siefke, C., Möbius, W., Tozawa, R., Wehr, M. C., Wieland, F., Ishibashi, S., Nave, K.-A. (2005).
High cholesterol level is essential for myelin membrane growth
Nat Neurosci. 8, 468-475


Michailov, G. V., Sereda, M. W., Brinkmann, B. G., Fischer, T. M., Haug, B., Birchmeier, C., Role, L., Lai, C., Schwab, M. H., Nave, K. A. (2004).
Axonal neuregulin-1 regulates myelin sheath thickness
Science 304, 700-703


Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P.E., Griffiths, I.R., Nave, K.A. (2003).
Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
Nat Genet. 33, 366-374


Sereda, M.W., Meyer zur Hörste, G., Suter, U., Uzma, N., Nave, K.A. (2003).
Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-tooth disease (CMT-1A)
Nat Med. 9, 1533-1537


Griffiths I, Klugmann M, Anderson T, Yool D, Thomson C, Schwab MH, Schneider A, Zimmermann F, McCulloch M, Nadon N, Nave KA (1998).
Axonal swellings and degeneration in mice lacking the major proteolipid of myelin.
Science 280, 1610-3


Klugmann M, Schwab MH, Pühlhofer A, Schneider A, Zimmermann F, Griffiths IR, Nave KA (1997).
Assembly of CNS myelin in the absence of proteolipid protein.
Neuron 18, 59-70


Sereda M, Griffiths I, Pühlhofer A, Stewart H, Rossner MJ, Zimmerman F, Magyar JP, Schneider A, Hund E, Meinck HM, Suter U, Nave KA (1996).
A transgenic rat model of Charcot-Marie-Tooth disease.
Neuron 16, 1049-60


Readhead C, Schneider A, Griffiths I, Nave KA (1994).
Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage.
Neuron 12, 583-95


Schneider A, Montague P, Griffiths I, Fanarraga M, Kennedy P, Brophy P, Nave KA (1992).
Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.
Nature 358, 758-61




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