ausgewählte Publikationen

Pan H, Steixner-Kumar AA, Seelbach A, Deutsch N, Ronnenberg A, Tapken D, von Ahsen N, Mitjans M, Worthmann H, Trippe R, Klein-Schmidt C, Schopf N, Rentzsch K, Begemann M, Wienands J, Stöcker W, Weissenborn K, Hollmann M, Nave KA, Lühder F, Ehrenreich H (2020).
Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury.
Mol Psychiatry. [Epub ahead of print]


Seidel J, Bockhop F, Mitkovski M, Martin S, Ronnenberg A, Krueger-Burg D, Schneider K, Röhse H, Wüstefeld L, Cosi F, Bröking K, Schacht A, Ehrenreich H (2020).
Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man. FASEB Bioadv
FASEB Bioadv. 2, 18-32


Wakhloo D, Scharkowski F, Curto Y, Javed Butt U, Bansal V, Steixner-Kumar AA, Wüstefeld L, Rajput A, Arinrad S, Zillmann MR, Seelbach A, Hassouna I, Schneider K, Qadir Ibrahim A, Werner HB, Martens H, Miskowiak K, Wojcik SM, Bonn S, Nacher J, Nave KA, Ehrenreich H (2020).
Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin.
Nat Commun. 11, 1313-1313


Ehrenreich H, Neubauer AP, Miskowiak K (2020).
Erythropoietin in Preterm Infants.
N Engl J Med. 382, 1862-1862


Begemann M, Seidel J, Poustka L, Ehrenreich H (2020).
Accumulated environmental risk in young refugees - A prospective evaluation.
EClinicalMedicine 22, 100345-100345


Ehrenreich H, Weissenborn K, Begemann M, Busch M, Vieta E, Miskowiak KW (2020).
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Mol Med. 26, 58-58


Nave KA, Ehrenreich H (2019).
Time to revisit oligodendrocytes in multiple sclerosis.
Nat Med. 25, 36-366


Garcia-Agudo LF, Janova H, Sendler LE, Arinrad S, Steixner AA, Hassouna I, Balmuth E, Ronnenberg A, Schopf N, van der Flier FJ, Begemann M, Martens H, Weber MS, Boretius S, Nave KA, Ehrenreich H (2019).
Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.
FASEB J. 33, 8634-8647


Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD, T Nguyen H, Girdhar K, Boocock J, Roussos P, Fromer M, Kramer R, Domenici E, Gamazon ER, Purcell S; CommonMind Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; iPSYCH-GEMS Schizophrenia Working Group, Demontis D, Børglum AD, Walters JTR, O'Donovan MC, Sullivan P, Owen MJ, Devlin B, Sieberts SK, Cox NJ, Im HK, Sklar P, Stahl EA (2019).
Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.
Nat Genet. [Epub ahead of print]


Hess JL, Tylee DS, Mattheisen M; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Børglum AD, Als TD, Grove J, Werge T, Mortensen PB, Mors O, Nordentoft M, Hougaard DM, Byberg-Grauholm J, Bækvad-Hansen M, Greenwood TA, Tsuang MT, Curtis D, Steinberg S, Sigurdsson E, Stefánsson H, Stefánsson K, Edenberg HJ, Holmans P, Faraone SV, Glatt SJ (2019).
A polygenic resilience score moderates the genetic risk for schizophrenia.
Mol Psychiatry. [Epub ahead of print]


Oliveira B, Ehrenreich H (2018).
Pursuing functional connectivity in NMDAR1 autoantibody carriers.
Lancet Psychiatry. 5, 21-22


Nave KA, Ehrenreich H (2018).
A bloody brake on myelin repair.
Nature 553, 31-32


Pan H, Oliveira B, Saher G, Dere E, Tapken D, Mitjans M, Seidel J, Wesolowski J, Wakhloo D, Klein-Schmidt C, Ronnenberg A, Schwabe K, Trippe R, Mätz-Rensing K, Berghoff S, Al-Krinawe Y, Martens H, Begemann M, Stöcker W, Kaup FJ, Mischke R, Boretius S, Nave KA, Krauss JK, Hollmann M, Lühder F, Ehrenreich H (2018).
Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model.
Mol Psychiatry. 24, 1489-1501


Dere E, Ronnenberg A, Tampe B, Arinrad S, Schmidt M, Zeisberg E, Ehrenreich H (2018).
Cognitive, emotional and social phenotyping of mice in an observer-independent setting.
Neurobiol Learn Mem. 150, 136-150


Ehrenreich H (2018).
Autoantibodies against N-methyl-d-aspartate receptor 1 in health and disease.
Curr Opin Neurol. 31, 306-312


Ni G, Moser G; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Wray NR, Lee SH (2018).
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.
Am J Hum Genet. 102, 1185-1194


Ursini G, Punzi G, Chen Q, Marenco S, Robinson JF, Porcelli A, Hamilton EG, Mitjans M, Maddalena G, Begemann M, Seidel J, Yanamori H, Jaffe AE, Berman KF, Egan MF, Straub RE, Colantuoni C, Blasi G, Hashimoto R, Rujescu D, Ehrenreich H, Bertolino A, Weinberger DR (2018).
Convergence of placenta biology and genetic risk for schizophrenia.
Nat Med. 24, 792-801


Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium. Electronic address: douglas.ruderfer@vanderbilt.edu; Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium. (2018).
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.
Cell 173, 1705-1715


Mitjans M, Seidel J, Begemann M, Bockhop F, Moya-Higueras J, Bansal V, Wesolowski J, Seelbach A, Ibáñez MI, Kovacevic F, Duvar O, Fañanás L, Wolf HU, Ortet G, Zwanzger P, Klein V, Lange I, Tänzer A, Dudeck M, Penke L, van Elst LT, Bittner RA, Schmidmeier R, Freese R, Müller-Isberner R, Wiltfang J, Bliesener T, Bonn S, Poustka L, Müller JL, Arias B, Ehrenreich H (2018).
Violent aggression predicted by multiple pre-adult environmental hits.
Mol Psychiatry. 24, 1549-1564


Oliveira B, Mitjans M, Nitsche MA, Kuo MF, Ehrenreich H (2018).
Excitation-inhibition dysbalance as predictor of autistic phenotypes.
J Psychiatr Res. 104, 96-99


Bansal V, Mitjans M, Burik CAP, Linnér RK, Okbay A, Rietveld CA, Begemann M, Bonn S, Ripke S, de Vlaming R, Nivard MG, Ehrenreich H, Koellinger PD (2018).
Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia.
Nat Commun. 9, 3078-3078


Babaev O, Cruces-Solis H, Piletti Chatain C, Hammer M, Wenger S, Ali H, Karalis N, de Hoz L, Schlüter OM, Yanagawa Y, Ehrenreich H, Taschenberger H, Brose N, Krueger-Burg D (2018).
IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses.
Nat Commun. 9, 5400-5400


McLaughlin RL, Schijven D, van Rheenen W, van Eijk KR, O'Brien M, Kahn RS, Ophoff RA, Goris A, Bradley DG, Al-Chalabi A, van den Berg LH, Luykx JJ, Hardiman O, Veldink JH; Project MinE GWAS Consortium.; Schizophrenia Working Group of the Psychiatric Genomics Consortium (2017).
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.
Nat Commun. 8, 14774-14774


Ehrenreich H (2017).
Autoantibodies against the N-Methyl-d-Aspartate Receptor Subunit NR1: Untangling Apparent Inconsistencies for Clinical Practice.
Front Immunol. 8, 181-181


Ehrenreich H (2017).
The impact of environment on abnormal behavior and mental disease: To alleviate the prevalence of mental disorders, we need to phenotype the environment for risk factors.
EMBO Rep. 18, 661-665


Bonnas C, Wüstefeld L, Winkler D, Kronstein-Wiedemann R, Dere E, Specht K, Boxberg M, Tonn T, Ehrenreich H, Stadler H, Sillaber I (2017).
EV-3, an endogenous human erythropoietin isoform with distinct functional relevance.
Sci Rep. 7, 3684-3684


Lepeta K, Purzycka KJ, Pachulska-Wieczorek K, Mitjans M, Begemann M, Vafadari B, Bijata K, Adamiak RW, Ehrenreich H, Dziembowska M, Kaczmarek L (2017).
A normal genetic variation modulates synaptic MMP-9 protein levels and the severity of schizophrenia symptoms.
EMBO Mol Med. 9, 1100-1116


Mitjans M, Begemann M, Ju A, Dere E, Wüstefeld L, Hofer S, Hassouna I, Balkenhol J, Oliveira B, van der Auwera S, Tammer R, Hammerschmidt K, Völzke H, Homuth G, Cecconi F, Chowdhury K, Grabe H, Frahm J, Boretius S, Dandekar T, Ehrenreich H (2017).
Sexual dimorphism of AMBRA1-related autistic features in human and mouse.
Transl Psychiatry. 7, e1247-e1247


Bartels C, Wagner M, Wolfsgruber S, Ehrenreich H, Schneider A; Alzheimer’s Disease Neuroimaging Initiative (2017).
Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer's Dementia in Individuals With Previous Depression.
Am J Psychiatry. 175, 232-241


Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, Bittner RA, Pan H, Goebbels S, Begemann M, Gerwig UC, Langner S, Werner HB, Kittel-Schneider S, Homuth G, Davatzikos C, Völzke H, West BL, Reif A, Grabe HJ, Boretius S, Ehrenreich H, Nave KA (2017).
Microglia ablation alleviates myelin-associated catatonic signs in mice.
J Clin Invest. 128, 734-745


Hassouna I, Ott C, Wüstefeld L, Offen N, Neher RA, Mitkovski M, Winkler D, Sperling S, Fries L, Goebbels S, Vreja IC, Hagemeyer N, Dittrich M, Rossetti MF, Kröhnert K, Hannke K, Boretius S, Zeug A, Höschen C, Dandekar T, Dere E, Neher E, Rizzoli SO, Nave KA, Sirén AL, Ehrenreich H (2016).
Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus.
Mol Psychiatry. 21, 1752-1767


Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJ, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Yao Y, Ho YY, Martin NG, Wright MJ; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Psychosis Endophenotypes International Consortium; Wellcome Trust Case Control Consortium 2; Enigma Consortium, O'Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF (2016).
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Nat Neurosci. 19, 420-431


Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Daly MJ, Carroll MC, Stevens B, McCarroll SA (2016).
Schizophrenia risk from complex variation of complement component 4.
Nature 530, 177-183


Castillo-Gomez E, Kästner A, Steiner J, Schneider A, Hettling B, Poggi G, Ostehr K, Uhr M, Asif AR, Matzke M, Schmidt U, Pfander V, Hammer C, Schulz TF, Binder L, Stöcker W, Weber F, Ehrenreich H (2016).
The brain as immunoprecipitator of serum autoantibodies against N-Methyl-D-aspartate receptor subunit NR1.
Ann Neurol. 79, 144-151


Tuoc T, Dere E, Radyushkin K, Pham L, Nguyen H, Tonchev AB, Sun G, Ronnenberg A, Shi Y, Staiger JF, Ehrenreich H, Stoykova A (2016).
Ablation of BAF170 in Developing and Postnatal Dentate Gyrus Affects Neural Stem Cell Proliferation, Differentiation, and Learning.
Mol Neurobiol. 54, 4618-4635


Poggi G, Boretius S, Möbius W, Moschny N, Baudewig J, Ruhwedel T, Hassouna I, Wieser GL, Werner HB, Goebbels S, Nave KA, Ehrenreich H (2016).
Cortical network dysfunction caused by a subtle defect of myelination.
Glia 64, 2025-2040


Castillo-Gómez E, Oliveira B, Tapken D, Bertrand S, Klein-Schmidt C, Pan H, Zafeiriou P, Steiner J, Jurek B, Trippe R, Prüss H, Zimmermann WH, Bertrand D, Ehrenreich H, Hollmann M (2016).
All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class.
Mol Psychiatry. 22, 1776-1784


Krueger-Burg D, Winkler D, Mitkovski M, Daher F, Ronnenberg A, Schlüter OM, Dere E, Ehrenreich H (2016).
The SocioBox: A Novel Paradigm to Assess Complex Social Recognition in Male Mice.
Front Behav Neurosci. 10, 151-151


Ehrenreich H, Mitjans M, Van der Auwera S, Centeno TP, Begemann M, Grabe HJ, Bonn S, Nave KA (2016).
OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals.
Mol Psychiatry. [Epub ahead of print]


Bulik-Sullivan BK, Loh PR, Finucane HK, Ripke S, Yang J; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson N, Daly MJ, Price AL, Neale BM (2015).
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.
Nat Genet. 47, 291-295


Netrakanti PR, Cooper BH, Dere E, Poggi G, Winkler D, Brose N, Ehrenreich H (2015).
Fast Cerebellar Reflex Circuitry Requires Synaptic Vesicle Priming by Munc13-3.
Cerebellum 14, 264-283


Hammer C, Wanitchakool P, Sirianant L, Papiol S, Monnheimer M, Faria D, Ousingsawat J, Schramek N, Schmitt C, Margos G, Michel A, Kraiczy P, Pawlita M, Schreiber R, Schulz TF, Fingerle V, Tumani H, Ehrenreich H, Kunzelmann K (2015).
A coding variant of ANO10, affecting volume regulation of macrophages, is associated with Borrelia seropositivity.
Mol Med. 21, 26-37


Zerche M, Weissenborn K, Ott C, Dere E, Asif AR, Worthmann H, Hassouna I, Rentzsch K, Tryc AB, Dahm L, Steiner J, Binder L, Wiltfang J, Sirén AL, Stöcker W, Ehrenreich H (2015).
Preexisting Serum Autoantibodies Against the NMDAR Subunit NR1 Modulate Evolution of Lesion Size in Acute Ischemic Stroke.
Stroke 46, 1180-1186


Mitkovski M, Dahm L, Heinrich R, Monnheimer M, Gerhart S, Stegmüller J, Hanisch UK, Nave KA, Ehrenreich H (2015).
Erythropoietin dampens injury-induced microglial motility.
J Cereb Blood Flow Metab. 35, 1233-1236


Kästner A, Begemann M, Michel TM, Everts S, Stepniak B, Bach C, Poustka L, Becker J, Banaschewski T, Dose M, Ehrenreich H (2015).
Autism beyond diagnostic categories: characterization of autistic phenotypes in schizophrenia.
BMC Psychiatry. 15, 115-115


Babaev O, Botta P, Meyer E, Müller C, Ehrenreich H, Brose N, Lüthi A, Krueger-Burg D (2015).
Neuroligin 2 Deletion Alters Inhibitory Synapse Function and Anxiety-Associated Neuronal Activation in the Amygdala.
Neuropharmacology 100, 56-65


Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, Stadler H, Kawabe H, Zimmermann WH, Nave KA, Schulz-Schaeffer W, Jahn O, Ehrenreich H (2015).
Widespread expression of erythropoietin receptor in brain and its induction by injury.
Mol Med. [Epub ahead of print]


Stepniak B, Papiol S, Hammer C, Ramin A, Everts S, Hennig L, Begemann M, Ehrenreich H (2015).
Accumulated environmental risk determining age at schizophrenia onset: a deep phenotyping-based study.
Lancet Psychiatry. 1, 444-453


Hammer M, Krueger-Burg D, Tuffy LP, Cooper BH, Taschenberger H, Goswami SP, Ehrenreich H, Jonas P, Varoqueaux F, Rhee JS, Brose N (2015).
Perturbed Hippocampal Synaptic Inhibition and ?-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.
Cell Rep. 13, 516-523


Hammer C, Begemann M, McLaren PJ, Bartha I, Michel A, Klose B, Schmitt C, Waterboer T, Pawlita M, Schulz TF, Ehrenreich H, Fellay J (2015).
Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses.
Am J Hum Genet. 97, 738-743


Wüstefeld L, Winkler D, Janc OA, Hassouna I, Ronnenberg A, Ostmeier K, Müller M, Brose N, Ehrenreich H, Wojcik SM (2015).
Selective expression of a constitutively active erythropoietin receptor in GABAergic neurons alters hippocampal network properties without affecting cognition.
J Neurochem. [Epub ahead of print]


Stepniak B, Kästner A, Poggi G, Mitjans M, Begemann M, Hartmann A, Van der Auwera S, Sananbenesi F, Krueger-Burg D, Matuszko G, Brosi C, Homuth G, Völzke H, Benseler F, Bagni C, Fischer U, Dityatev A, Grabe HJ, Rujescu D, Fischer A, Ehrenreich H (2015).
Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.
EMBO Mol Med. 7, 1565-1579


Janova H, Böttcher C, Holtman IR, Regen T, van Rossum D, Götz A, Ernst AS, Fritsche C, Gertig U, Saiepour N, Gronke K, Wrzos C, Ribes S, Rolfes S, Weinstein J, Ehrenreich H, Pukrop T, Kopatz J, Stadelmann C, Salinas-Riester G, Weber MS, Prinz M, Brück W, Eggen BJ, Boddeke HW, Priller J, Hanisch UK (2015).
CD14 is a key organizer of microglial responses to CNS infection and injury.
Glia 64, 635-649


Tantra M, Hammer C, Kästner A, Dahm L, Begemann M, Bodda C, Hammerschmidt K, Giegling I, Stepniak B, Castillo Venzor A, Konte B, Erbaba B, Hartmann A, Tarami A, Schulz-Schaeffer W, Rujescu D, Mannan AU, Ehrenreich H (2014).
Mild expression differences of MECP2 influencing aggressive social behavior.
EMBO Mol Med. 6, 662-684


Nave KA, Ehrenreich H (2014).
Myelination and Oligodendrocyte Functions in Psychiatric Diseases.
JAMA Psychiatry. 71, 582-584


Ehrenreich H, Nave KA (2014).
Phenotype-Based Genetic Association Studies (PGAS)-Towards Understanding the Contribution of Common Genetic Variants to Schizophrenia Subphenotypes.
Genes (Basel) 5, 97-105


Ju A, Hammerschmidt K, Tantra M, Krueger D, Brose N, Ehrenreich H (2014).
Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.
Behav Brain Res. 270, 159-164


Dahm L, Ott C, Steiner J, Stepniak B, Teegen B, Saschenbrecker S, Hammer C, Borowski K, Begemann M, Lemke S, Rentzsch K, Probst C, Martens H, Wienands J, Spalletta G, Weissenborn K, Stöcker W, Ehrenreich H (2014).
Seroprevalence of autoantibodies against brain antigens in health and disease.
Ann Neurol. 77, 184-184


Dere E, Dahm L, Lu D, Hammerschmidt K, Ju A, Tantra M, Kästner A, Chowdhury K, Ehrenreich H (2014).
Heterozygous ambra1 deficiency in mice: a genetic trait with autism-like behavior restricted to the female gender.
Front Behav Neurosci. 8, 181-181


Hammer C, Zerche M, Schneider A, Begemann M, Nave KA, Ehrenreich H (2014).
Apolipoprotein E4 carrier status plus circulating anti-NMDAR1 autoantibodies: association with schizoaffective disorder.
Mol Psychiatry. 19, 1054-1056


Gurvich A, Begemann M, Dahm L, Sargin D, Miskowiak K, Ehrenreich H (2014).
A role for prostaglandins in rapid cycling suggested by episode-specific gene expression shifts in peripheral blood mononuclear cells: a preliminary report.
Bipolar Disord. 16, 881-888


Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014).
Biological insights from 108 schizophrenia-associated genetic loci.
Nature 511, 421-427


Ehrenreich H, Steiner J (2014).
Serum autoantibodies against N-methyl-D-aspartate receptor subunit NR1 are no disease indicator.
Ann Neurol. [Epub ahead of print]


Miskowiak KW, Ehrenreich H, Christensen EM, Kessing LV, Vinberg M (2014).
Recombinant human erythropoietin to target cognitive dysfunction in bipolar disorder: a double-blind, randomized, placebo-controlled phase 2 trial.
J Clin Psychiatry. [Epub ahead of print]


Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S, Price AL; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium (2014).
Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases.
Am J Hum Genet. 95, 535-552


Miskowiak KW, Vinberg M, Macoveanu J, Ehrenreich H, Køster N, Inkster B, Paulson OB, Kessing LV, Skimminge A, Siebner HR (2014).
Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders.
Biol Psychiatry. 78, 270-277


El-Kordi A, Kästner A, Grube S, Klugmann M, Begemann M, Sperling S, Hammerschmidt K, Hammer C, Stepniak B, Patzig J, de Monasterio-Schrader P, Strenzke N, Flügge G, Werner HB, Pawlak R, Nave KA, Ehrenreich H (2013).
A single gene defect causing claustrophobia.
Transl Psychiatry. 3, e254-e254


Wojcik SM, Tantra M, Stepniak B, Man KN, Müller-Ribbe K, Begemann M, Ju A, Papiol S, Ronnenberg A, Gurvich A, Shin Y, Augustin I, Brose N, Ehrenreich H (2013).
Genetic Markers of a Munc13 Protein Family Member, BAIAP3, Are Gender-Specifically Associated with Anxiety and Benzodiazepine Abuse in Mouse and Man.
Mol Med. 19, 135-148


Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H (2013).
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.
Mol Psychiatry. 19, 1143-1149


El-Kordi A, Winkler D, Hammerschmidt K, Kästner A, Krueger D, Ronnenberg A, Ritter C, Jatho J, Radyushkin K, Bourgeron T, Fischer J, Brose N, Ehrenreich H (2013).
Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.
Behav Brain Res. 251, 41-49


Miskowiak KW, Vinberg M, Christensen EM, Bukh JD, Harmer CJ, Ehrenreich H, Kessing LV (2013).
Recombinant Human Erythropoietin for Treating Treatment-Resistant Depression: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Trial.
Neuropsychopharmacology 39, 1399-1408


Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL (2013).
Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.
Mol Med. 19, 399-408


Hagemeyer N, Goebbels S, Papiol S, Kästner A, Hofer S, Begemann M, Gerwig UC, Boretius S, Wieser GL, Ronnenberg A, Gurvich A, Heckers SH, Frahm J, Nave KA, Ehrenreich H (2012).
A myelin gene causative of a catatonia-depression syndrome upon aging.
EMBO Mol Med. 4, 528-539


Kästner A, Grube S, El-Kordi A, Stepniak B, Friedrichs H, Sargin D, Schwitulla J, Begemann M, Giegling I, Miskowiak KW, Sperling S, Hannke K, Ramin A, Heinrich R, Gefeller O, Nave KA, Rujescu D, Ehrenreich H (2012).
Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia.
Mol Med. 18, 1029-1040


Wüstenberg T, Begemann M, Bartels C, Gefeller O, Stawicki S, Hinze-Selch D, Mohr A, Falkai P, Aldenhoff JB, Knauth M, Nave KA, Ehrenreich H (2011).
Recombinant human erythropoietin delays loss of gray matter in chronic schizophrenia.
Mol Psychiatry. 16, 26-36


Grube S, Gerchen MF, Adamcio B, Pardo LA, Martin S, Malzahn D, Papiol S, Begemann M, Ribbe K, Friedrichs H, Radyushkin KA, Müller M, Benseler F, Riggert J, Falkai P, Bickeböller H, Nave KA, Brose N, Stühmer W, Ehrenreich H (2011).
A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia.
EMBO Mol Med. 3, 309-319


Sargin D, El-Kordi A, Agarwal A, Muller M, Wojcik SM, Hassouna I, Sperling S, Nave KA, Ehrenreich H (2011).
Expression of constitutively active erythropoietin receptor in cortical neurons boosts higher cognitive functions in mice.
BMC Biol. 9, 27-27


Ribbe K, Ackermann V, Schwitulla J, Begemann M, Papiol S, Grube S, Sperling S, Friedrichs H, Jahn O, Sillaber I, Gefeller O, Krampe H, Ehrenreich H (2011).
Prediction of the Risk of Comorbid Alcoholism in Schizophrenia by Interaction of Common Genetic Variants in the Corticotropin-Releasing Factor System.
Arch Gen Psychiatry. 68, 1247-1256


Papiol S, Malzahn D, Kästner A, Sperling S, Begemann M, Stefansson H, Bickeböller H, Nave K-A and Ehrenreich H (2011).
Dissociation of accumulated genetic risk and disease severity in patients with schizophrenia
Translational Psychiatry 1, e45-e45
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Treiber H, Hagemeyer N, Ehrenreich H, Simons M (2011).
BACE1 in central nervous system myelination revisited.
Mol Psychiatry. 17, 237-239


Begemann M, Grube S, Papiol S, Malzahn D, Krampe H, Ribbe K, Friedrichs H, Radyushkin KA, El-Kordi A, Benseler F, Hannke K, Sperling S, Schwerdtfeger D, Thanhäuser I, Gerchen MF, Ghorbani M, Gutwinski S, Hilmes C, Leppert R, Ronnenberg A, Sowislo J, Stawicki S, Stödtke M, Szuszies C, Reim K, Riggert J, Eckstein F, Falkai P, Bickeböller H, Nave KA, Brose N, Ehrenreich H (2010).
Modification of Cognitive Performance in Schizophrenia by Complexin 2 Gene Polymorphisms.
Arch Gen Psychiatry. 67, 879-888


Radyushkin K, El-Kordi A, Boretius S, Castaneda S, Ronnenberg A, Reim K, Bickeböller H, Frahm J, Brose N, Ehrenreich H (2010).
Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophrenia.
Genes Brain Behav. 9, 592-602


Brzózka MM, Radyushkin K, Wichert SP, Ehrenreich H, Rossner MJ (2010).
Cognitive and Sensorimotor Gating Impairments in Transgenic Mice Overexpressing the Schizophrenia Susceptibility Gene Tcf4 in the Brain.
Biol Psychiatry. 68, 33-40


Radyushkin K, Hammerschmidt K, Boretius S, Varoqueaux F, El-Kordi A, Ronnenberg A, Winter D, Frahm J, Fischer J, Brose N, Ehrenreich H. (2009).
Neuroligin-3 deficient mice: Model of a monogenic heritable form of autism with an olfactory deficit.
Genes Brain Behav. 8, 416-425


El-Kordi A, Radyushkin K, Ehrenreich H (2009).
Erythropoietin improves operant conditioning and stability of cognitive performance in mice.
BMC Biol. 7, 37-37


Jamain S, Radyushkin K, Hammerschmidt K, Granon S, Boretius S, Varoqueaux F, Ramanantsoa N, Gallego J, Ronnenberg A, Winter D, Frahm J, Fischer J, Bourgeron T, Ehrenreich H, Brose N. (2008).
Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.
Proc Natl Acad Sci U S A. 105, 1710-1715


Adamcio B, Sargin D, Stradomska A, Medrihan L, Gertler C, Theis F, Zhang M, Muller M, Hassouna I, Hannke K, Sperling S, Radyushkin K, El-Kordi A, Schulze L, Ronnenberg A, Wolf F, Brose N, Rhee JS, Zhang W, Ehrenreich H (2008).
Erythropoietin enhances hippocampal long-term potentiation and memory.
BMC Biol. 6, 37-


Sargin D, Hassouna I, Sperling S, Sirén AL, Ehrenreich H (2008).
Uncoupling of neurodegeneration and gliosis in a murine model of juvenile cortical lesion.
Glia 57, 693-702


Brinkmann BG, Agarwal A, Sereda MW, Garratt AN, Müller T, Wende H, Stassart RM, Nawaz S, Humml C, Velanac V, Radyushkin K, Goebbels S, Fischer TM, Franklin RJ, Lai C, Ehrenreich H, Birchmeier C, Schwab MH, Nave KA (2008).
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Neuron 59, 581-595


Ehrenreich H, Hinze-Selch D, Stawicki S, Aust C, Knolle-Veentjer S, Wilms S, Heinz G, Erdag S, Jahn H, Degner D, Ritzen M, Mohr A, Wagner M, Schneider U, Bohn M, Huber M, Czernik A, Pollmächer T, Maier W, Sirén AL, Klosterkötter J, Falkai P, Rüther E, Aldenhoff JB, Krampe H. (2007).
Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin.
Mol Psychiatry. 12, 206-220


Ehrenreich H, Fischer B, Norra C, Schellenberger F, Stiefel M, Sirén AL, Paulus W, Nave KA, Gold R, Bartels C (2007).
Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis.
Brain 130, 2577-2588


Nave KA, Sereda MW, Ehrenreich H (2007).
Mechanisms of disease: inherited demyelinating neuropathies-from basic to clinical research.
Nat Clin Pract Neurol. 8, 453-464


Sirén, A.L., Radyushkin, K., Boretius, S., Kämmer, D., Riechers, C.C., Natt, O., Sargin, D., Watanabe, T., Sperling, S., Michaelis, T., Price, J., Meyer, B., Frahm, J., Ehrenreich, H. (2006).
Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin
Brain 129, 480-489


Ehrenreich, H., Hasselblatt, M., Knerlich, F., von Ahsen, N., Jacob, S., Sperling, S., Woldt, H., Vehmeyer, K., Nave, K.-A., Sirén, A.-L. (2005).
A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain
Proc Natl Acad Sci U S A. 102, 862-867


Ehrenreich, H. (2004).
A boost for translational neuroscience
Science 305, 184-185


Ehrenreich, H., Degner, D., Meller, J., Brines, M., Behe, M., Hasselblatt, M., Woldt, H., Falkai, P., Knerlich, F., Jacob, S., von Ahsen, N., Maier, W., Bruck, W., Rüther, E., Cerami, A., Becker, W., Sirén, A.-L. (2004).
Erythropoietin: a candidate compound for neuroprotection in schizophrenia
Mol Psychiatry. 9, 42-54


Sirén AL, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P, Keenan S, Gleiter C, Pasquali C, Capobianco A, Mennini T, Heumann R, Cerami A, Ehrenreich H, Ghezzi P (2001).
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress.
Proc Natl Acad Sci U S A. 98, 4044-4049


Ehrenreich H, Anderson RW, Fox CH, Rieckmann P, Hoffman GS, Travis WD, Coligan JE, Kehrl JH, Fauci AS (1990).
Endothelins, peptides with potent vasoactive properties, are produced by human macrophages.
J Exp Med. 172, 1741-1748