Publications (Nave)

1.           Wu, S., Stone, S., Nave, K.A., and Lin, W. (2020). The integrated UPR and ERAD in oligodendrocytes maintains myelin thickness in adults by regulating myelin protein translation. J Neurosci., JN-RM-0604-20. Online ahead of print.

2.           Wakhloo, D., Scharkowski, F., Curto, Y., Javed Butt, U., Bansal, V., Steixner-Kumar, A.A., Wustefeld, L., Rajput, A., Arinrad, S., Zillmann, M.R., Seelbach, A., Hassouna, I., Schneider, K., Qadir Ibrahim, A., Werner, H.B., Martens, H., Miskowiak, K., Wojcik, S.M., Bonn, S., Nacher, J., Nave, K.A., and Ehrenreich, H. (2020). Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. Nat Commun 11, 1313.

3.           Stone, S., Wu, S., Nave, K.A., and Lin, W. (2020). The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP. JCI insight 5:e132364.

4.           Steyer, A.M., Ruhwedel, T., Nardis, C., Werner, H.B., Nave, K.A., and Mobius, W. (2020). Pathology of myelinated axons in the PLP-deficient mouse model of spastic paraplegia type 2 revealed by volume imaging using focused ion beam-scanning electron microscopy. J Struct Biol 210, 107492.

5.           Prukop, T., Wernick, S., Boussicault, L., Ewers, D., Jager, K., Adam, J., Winter, L., Quintes, S., Linhoff, L., Barrantes-Freer, A., Bartl, M., Czesnik, D., Zschuntzsch, J., Schmidt, J., Primas, G., Laffaire, J., Rinaudo, P., Brureau, A., Nabirotchkin, S., Schwab, M.H., Nave, K.A., Hajj, R., Cohen, D., and Sereda, M.W. (2020). Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot-Marie-Tooth disease type 1A (CMT1A) rats. J Neurosci Res 98, 1933-1952.

6.           Pan, H., Steixner-Kumar, A.A., Seelbach, A., Deutsch, N., Ronnenberg, A., Tapken, D., von Ahsen, N., Mitjans, M., Worthmann, H., Trippe, R., Klein-Schmidt, C., Schopf, N., Rentzsch, K., Begemann, M., Wienands, J., Stocker, W., Weissenborn, K., Hollmann, M., Nave, K.A., Luhder, F., and Ehrenreich, H. (2020). Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury. Mol Psychiatry, Online ahead of print.

7.           Natsubori, A., Tsunematsu, T., Karashima, A., Imamura, H., Kabe, N., Trevisiol, A., Hirrlinger, J., Kodama, T., Sanagi, T., Masamoto, K., Takata, N., Nave, K.A., Matsui, K., Tanaka, K.F., and Honda, M. (2020). Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep-wake states. Commun Biol 3, 491.

8.           Mukherjee, C., Kling, T., Russo, B., Miebach, K., Kess, E., Schifferer, M., Pedro, L.D., Weikert, U., Fard, M.K., Kannaiyan, N., Rossner, M., Aicher, M.L., Goebbels, S., Nave, K.A., Kramer-Albers, E.M., Schneider, A., and Simons, M. (2020). Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Cell Metab 32, 259-272 e210.

9.           Mukherjee, C., Kling, T., Russo, B., Miebach, K., Kess, E., Schifferer, M., Pedro, L.D., Weikert, U., Fard, M.K., Kannaiyan, N., Rossner, M., Aicher, M.L., Goebbels, S., Nave, K.A., Kramer-Albers, E.M., Schneider, A., and Simons, M. (2020). Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Cell Metab 32, 259-272.

10.        Luo, L., Ambrozkiewicz, M.C., Benseler, F., Chen, C., Dumontier, E., Falkner, S., Furlanis, E., Gomez, A.M., Hoshina, N., Huang, W.H., Hutchison, M.A., Itoh-Maruoka, Y., Lavery, L.A., Li, W., Maruo, T., Motohashi, J., Pai, E.L., Pelkey, K.A., Pereira, A., Philips, T., Sinclair, J.L., Stogsdill, J.A., Traunmuller, L., Wang, J., Wortel, J., You, W., Abumaria, N., Beier, K.T., Brose, N., Burgess, H.A., Cepko, C.L., Cloutier, J.F., Eroglu, C., Goebbels, S., Kaeser, P.S., Kay, J.N., Lu, W., Luo, L., Mandai, K., McBain, C.J., Nave, K.A., Prado, M.A.M., Prado, V.F., Rothstein, J., Rubenstein, J.L.R., Saher, G., Sakimura, K., Sanes, J.R., Scheiffele, P., Takai, Y., Umemori, H., Verhage, M., Yuzaki, M., Zoghbi, H.Y., Kawabe, H., and Craig, A.M. (2020). Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. Neuron 106, 37-65 e35.

11.        Kalinin, S., Meares, G.P., Lin, S.X., Pietruczyk, E.A., Saher, G., Spieth, L., Nave, K.A., Boullerne, A.I., Lutz, S.E., Benveniste, E.N., and Feinstein, D.L. (2020). Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis. Glia 68, 600-616.

12.        Gruenenfelder, F.I., McLaughlin, M., Griffiths, I.R., Garbern, J., Thomson, G., Kuzman, P., Barrie, J.A., McCulloch, M.L., Penderis, J., Stassart, R., Nave, K.A., and Edgar, J.M. (2020). Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease. Brain 143, 1383-1399.

13.        Fredrickx, E., Colombo, E., Canevazzi, P., La Marca, R., Pellegatta, M., Dina, G., Podini, P., Nave, K.A., Quattrini, A., and Taveggia, C. (2020). Ablation of neuronal ADAM17 impairs oligodendrocyte differentiation and myelination. Glia 68, 1148-1164.

14.        Eichel, M.A., Gargareta, V.I., D'Este, E., Fledrich, R., Kungl, T., Buscham, T.J., Luders, K.A., Miracle, C., Jung, R.B., Distler, U., Kusch, K., Mobius, W., Hulsmann, S., Tenzer, S., Nave, K.A., and Werner, H.B. (2020). CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves. Nat Commun 11, 4514.

15.        Cunnane, S.C., Trushina, E., Morland, C., Prigione, A., Casadesus, G., Andrews, Z.B., Beal, M.F., Bergersen, L.H., Brinton, R.D., de la Monte, S., Eckert, A., Harvey, J., Jeggo, R., Jhamandas, J.H., Kann, O., la Cour, C.M., Martin, W.F., Mithieux, G., Moreira, P.I., Murphy, M.P., Nave, K.A., Nuriel, T., Oliet, S.H.R., Saudou, F., Mattson, M.P., Swerdlow, R.H., and Millan, M.J. (2020). Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nature reviews. Drug discovery 19, 609-633.

16.        Cohen, C.C.H., Popovic, M.A., Klooster, J., Weil, M.T., Mobius, W., Nave, K.A., and Kole, M.H.P. (2020). Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit. Cell 180, 311-322 e315.

17.        Werner, H.B., and Nave, K.A. (2019). Enhanced Actin Dynamics: A Therapeutic Strategy for Axonal Regeneration? Neuron 103, 949-950.

18.        Stumpf, S.K., Berghoff, S.A., Trevisiol, A., Spieth, L., Duking, T., Schneider, L.V., Schlaphoff, L., Dreha-Kulaczewski, S., Bley, A., Burfeind, D., Kusch, K., Mitkovski, M., Ruhwedel, T., Guder, P., Rohse, H., Denecke, J., Gartner, J., Mobius, W., Nave, K.A., and Saher, G. (2019). Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease. Acta Neuropathol 138, 673-674.

19.        Scapin, C., Ferri, C., Pettinato, E., Zambroni, D., Bianchi, F., Del Carro, U., Belin, S., Caruso, D., Mitro, N., Pellegatta, M., Taveggia, C., Schwab, M.H., Nave, K.A., Feltri, M.L., Wrabetz, L., and D'Antonio, M. (2019). Enhanced axonal neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot-Marie-Tooth type 1B mouse model. Hum Mol Genet 28, 992-1006.

20.        Prukop, T., Stenzel, J., Wernick, S., Kungl, T., Mroczek, M., Adam, J., Ewers, D., Nabirotchkin, S., Nave, K.A., Hajj, R., Cohen, D., and Sereda, M.W. (2019). Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A). PLoS One 14, e0209752.

21.        Nave, K.A., and Ehrenreich, H. (2019). Time to revisit oligodendrocytes in multiple sclerosis. Nat Med 25, 364-366.

22.        Luders, K.A., Nessler, S., Kusch, K., Patzig, J., Jung, R.B., Mobius, W., Nave, K.A., and Werner, H.B. (2019). Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons. Glia 67, 634-649.

23.        Leitzen, E., Raddatz, B.B., Jin, W., Goebbels, S., Nave, K.A., Baumgartner, W., and Hansmann, F. (2019). Virus-triggered spinal cord demyelination is followed by a peripheral neuropathy resembling features of Guillain-Barre Syndrome. Scientific reports 9, 4588.

24.        Joseph, S., Vingill, S., Jahn, O., Fledrich, R., Werner, H.B., Katona, I., Mobius, W., Mitkovski, M., Huang, Y., Weis, J., Sereda, M.W., Schulz, J.B., Nave, K.A., and Stegmuller, J. (2019). Myelinating glia-specific deletion of Fbxo7 in mice triggers axonal degeneration in the central nervous system together with peripheral neuropathy. J Neurosci 39, 5606-5626.

25.        Jin, W., Leitzen, E., Goebbels, S., Nave, K.A., Baumgartner, W., and Hansmann, F. (2019). Comparison of Theiler's Murine Encephalomyelitis Virus Induced Spinal Cord and Peripheral Nerve Lesions Following Intracerebral and Intraspinal Infection. Int J Mol Sci 20, 5134.

26.        Goebbels, S., and Nave, K.A. (2019). Conditional Mutagenesis in Oligodendrocyte Lineage Cells. Methods Mol Biol 1936, 249-274.

27.        Garcia-Agudo, L.F., Janova, H., Sendler, L.E., Arinrad, S., Steixner, A.A., Hassouna, I., Balmuth, E., Ronnenberg, A., Schopf, N., van der Flier, F.J., Begemann, M., Martens, H., Weber, M.S., Boretius, S., Nave, K.A., and Ehrenreich, H. (2019). Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion. FASEB J, fj201900337R.

28.        Fledrich, R., Kungl, T., Nave, K.A., and Stassart, R.M. (2019). Axo-glial interdependence in peripheral nerve development. Development 146:dev151704.

29.        Fledrich, R., Akkermann, D., Schutza, V., Abdelaal, T.A., Hermes, D., Schaffner, E., Soto-Bernardini, M.C., Gotze, T., Klink, A., Kusch, K., Krueger, M., Kungl, T., Frydrychowicz, C., Mobius, W., Bruck, W., Mueller, W.C., Bechmann, I., Sereda, M.W., Schwab, M.H., Nave, K.A., and Stassart, R.M. (2019). NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies. Nat Commun 10, 1467.

30.        Erwig, M.S., Patzig, J., Steyer, A.M., Dibaj, P., Heilmann, M., Heilmann, I., Jung, R.B., Kusch, K., Mobius, W., Jahn, O., Nave, K.A., and Werner, H.B. (2019). Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin. eLife 8:e43888.

31.        Cathomas, F., Azzinnari, D., Bergamini, G., Sigrist, H., Buerge, M., Hoop, V., Wicki, B., Goetze, L., Soares, S., Kukelova, D., Seifritz, E., Goebbels, S., Nave, K.A., Ghandour, M.S., Seoighe, C., Hildebrandt, T., Leparc, G., Klein, H., Stupka, E., Hengerer, B., and Pryce, C.R. (2019). Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice. Genes Brain Behav 18, e12475.

32.        Belin, S., Ornaghi, F., Shackleford, G., Wang, J., Scapin, C., Lopez-Anido, C., Silvestri, N., Robertson, N., Williamson, C., Ishii, A., Taveggia, C., Svaren, J., Bansal, R., Schwab, M.H., Nave, K., Fratta, P., D'Antonio, M., Poitelon, Y., Feltri, M.L., and Wrabetz, L. (2019). Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy. Hum Mol Genet 28, 1260-1273.

33.        Weil, M.T., Heibeck, S., Topperwien, M., Tom Dieck, S., Ruhwedel, T., Salditt, T., Rodicio, M.C., Morgan, J.R., Nave, K.A., Mobius, W., and Werner, H.B. (2018). Axonal Ensheathment in the Nervous System of Lamprey: Implications for the Evolution of Myelinating Glia. J Neurosci 38, 6586-6596.

34.        Wang, J., Ho, W.Y., Lim, K., Feng, J., Tucker-Kellogg, G., Nave, K.A., and Ling, S.C. (2018). Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination. Proc Natl Acad Sci U S A 115, E10941-E10950.

35.        Stassart, R.M., Mobius, W., Nave, K.A., and Edgar, J.M. (2018). The Axon-Myelin Unit in Development and Degenerative Disease. Front Neurosci 12, 467.

36.        Schirmer, L., Mobius, W., Zhao, C., Cruz-Herranz, A., Ben Haim, L., Cordano, C., Shiow, L.R., Kelley, K.W., Sadowski, B., Timmons, G., Probstel, A.K., Wright, J.N., Sin, J.H., Devereux, M., Morrison, D.E., Chang, S.M., Sabeur, K., Green, A.J., Nave, K.A., Franklin, R.J., and Rowitch, D.H. (2018). Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity. eLife 7:e36428.

37.        Scapin, C., Ferri, C., Pettinato, E., Zambroni, D., Bianchi, F., Del Carro, U., Belin, S., Caruso, D., Mitro, N., Pellegatta, M., Taveggia, C., Schwab, M.H., Nave, K.A., Laura Feltri, M., Wrabetz, L., and D'Antonio, M. (2018). Enhanced axonal Neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot-Marie-Tooth type 1B mouse model. Hum Mol Genet 28, 992-1006.

38.        Pan, H., Oliveira, B., Saher, G., Dere, E., Tapken, D., Mitjans, M., Seidel, J., Wesolowski, J., Wakhloo, D., Klein-Schmidt, C., Ronnenberg, A., Schwabe, K., Trippe, R., Matz-Rensing, K., Berghoff, S., Al-Krinawe, Y., Martens, H., Begemann, M., Stocker, W., Kaup, F.J., Mischke, R., Boretius, S., Nave, K.A., Krauss, J.K., Hollmann, M., Luhder, F., and Ehrenreich, H. (2018). Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model. Mol Psychiatry 24, 1489-1501.

39.        Nave, K.A., and Ehrenreich, H. (2018). A bloody brake on myelin repair. Nature 553, 31-32.

40.        Mot, A.I., Depp, C., and Nave, K.A. (2018). An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases. Dialogues Clin Neurosci 20, 283-292.

41.        He, X., Zhang, L., Queme, L.F., Liu, X., Lu, A., Waclaw, R.R., Dong, X., Zhou, W., Kidd, G., Yoon, S.O., Buonanno, A., Rubin, J.B., Xin, M., Nave, K.A., Trapp, B.D., Jankowski, M.P., and Lu, Q.R. (2018). A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nat Med 24, 338-351.

42.        Fledrich, R., Abdelaal, T., Rasch, L., Bansal, V., Schutza, V., Brugger, B., Luchtenborg, C., Prukop, T., Stenzel, J., Rahman, R.U., Hermes, D., Ewers, D., Mobius, W., Ruhwedel, T., Katona, I., Weis, J., Klein, D., Martini, R., Bruck, W., Muller, W.C., Bonn, S., Bechmann, I., Nave, K.A., Stassart, R.M., and Sereda, M.W. (2018). Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. Nat Commun 9, 3025.

43.        Duchesne, M., Danigo, A., Richard, L., Vallat, J.M., Attarian, S., Gonnaud, P.M., Lacour, A., Pereon, Y., Stojkovic, T., Nave, K.A., Bertrand, V., Nabirotchkin, S., Cohen, D., Demiot, C., and Magy, L. (2018). Skin Biopsy Findings in Patients With CMT1A: Baseline Data From the CLN-PXT3003-01 Study Provide New Insights Into the Pathophysiology of the Disorder. J Neuropathol Exp Neurol 77, 274-281.

44.        Deakin, I.H., Godlewska, B.R., Walker, M.A., Huang, G.J., Schwab, M.H., Nave, K.A., Law, A.J., and Harrison, P.J. (2018). Altered hippocampal gene expression and structure in transgenic mice overexpressing neuregulin 1 (Nrg1) type I. Transl Psychiatry 8, 229.

45.        Cathomas, F., Azzinnari, D., Bergamini, G., Sigrist, H., Buerge, M., Hoop, V., Wicki, B., Goetze, L., Soares, S., Kukelova, D., Seifritz, E., Goebbels, S., Nave, K.A., Ghandour, M.S., Seoighe, C., Hildebrandt, T., Leparc, G., Klein, H., Stupka, E., Hengerer, B., and Pryce, C.R. (2018). Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice. Genes Brain Behav 18, e12475.

46.        Wehr, M.C., Hinrichs, W., Brzozka, M.M., Unterbarnscheidt, T., Herholt, A., Wintgens, J.P., Papiol, S., Soto-Bernardini, M.C., Kravchenko, M., Zhang, M., Nave, K.A., Wichert, S.P., Falkai, P., Zhang, W., Schwab, M.H., and Rossner, M.J. (2017). Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice. EMBO Mol Med 9, 1448-1462.

47.        Wang, L., Winnewisser, J., Federle, C., Jessberger, G., Nave, K.A., Werner, H.B., Kyewski, B., Klein, L., and Hinterberger, M. (2017). Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis. Frontiers in immunology 8, 1511.

48.        Trevisiol, A., Saab, A.S., Winkler, U., Marx, G., Imamura, H., Mobius, W., Kusch, K., Nave, K.A., and Hirrlinger, J. (2017). Monitoring ATP dynamics in electrically active white matter tracts. eLife 6:e24241.

49.        Tognatta, R., Sun, W., Goebbels, S., Nave, K.A., Nishiyama, A., Schoch, S., Dimou, L., and Dietrich, D. (2017). Transient Cnp expression by early progenitors causes Cre-Lox-based reporter lines to map profoundly different fates. Glia 65, 342-359.

50.        Syed, Y.A., Zhao, C., Mahad, D., Mobius, W., Altmann, F., Foss, F., Gonzalez, G.A., Senturk, A., Acker-Palmer, A., Lubec, G., Lilley, K., Franklin, R.J.M., Nave, K.A., and Kotter, M.R.N. (2017). Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination. Acta Neuropathol 134, 167-168.

51.        Supplie, L.M., Duking, T., Campbell, G., Diaz, F., Moraes, C.T., Gotz, M., Hamprecht, B., Boretius, S., Mahad, D., and Nave, K.A. (2017). Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo. J Neurosci 37, 4231-4242.

52.        Snaidero, N., Velte, C., Myllykoski, M., Raasakka, A., Ignatev, A., Werner, H.B., Erwig, M.S., Mobius, W., Kursula, P., Nave, K.A., and Simons, M. (2017). Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin. Cell Rep 18, 314-323.

53.        Saab, A.S., and Nave, K.A. (2017). Myelin dynamics: protecting and shaping neuronal functions. Curr Opin Neurobiol 47, 104-112.

54.        Nave, K.A., Tzvetanova, I.D., and Schirmeier, S. (2017). Glial Cell Evolution: The Origins of a Lipid Store. Cell Metab 26, 701-702.

55.        Micu, I., Plemel, J.R., Caprariello, A.V., Nave, K.A., and Stys, P.K. (2017). Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system. Nat Rev Neurosci 19, 49-58.

56.        Luders, K.A., Patzig, J., Simons, M., Nave, K.A., and Werner, H.B. (2017). Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2. Glia 65, 1762-1776.

57.        Lissek, T., Adams, M., Adelman, J., Ahissar, E., Akaaboune, M., Akil, H., al'Absi, M., Arain, F., Arango-Lasprilla, J.C., Atasoy, D., Avila, J., Badawi, A., Bading, H., Baig, A.M., Baleriola, J., Belmonte, C., Bertocchi, I., Betz, H., Blakemore, C., Blanke, O., Boehm-Sturm, P., Bonhoeffer, T., Bonifazi, P., Brose, N., Campolongo, P., Celikel, T., Chang, C.C., Chang, T.Y., Citri, A., Cline, H.T., Cortes, J.M., Cullen, K., Dean, K., Delgado-Garcia, J.M., Desroches, M., Disterhoft, J.F., Dowling, J.E., Draguhn, A., El-Khamisy, S.F., El Manira, A., Enam, S.A., Encinas, J.M., Erramuzpe, A., Esteban, J.A., Farinas, I., Fischer, E., Fukunaga, I., Gabilondo, I., Ganten, D., Gidon, A., Gomez-Esteban, J.C., Greengard, P., Grinevich, V., Gruart, A., Guillemin, R., Hariri, A.R., Hassan, B., Hausser, M., Hayashi, Y., Hussain, N.K., Jabbar, A.A., Jaber, M., Jahn, R., Janahi, E.M., Kabbaj, M., Kettenmann, H., Kindt, M., Knafo, S., Kohr, G., Komai, S., Krugers, H., Kuhn, B., Ghazal, N.L., Larkum, M.E., London, M., Lutz, B., Matute, C., Martinez-Millan, L., Maroun, M., McGaugh, J., Moustafa, A.A., Nasim, A., Nave, K.A., Neher, E., Nikolich, K., Outeiro, T., Palmer, L.M., Penagarikano, O., Perez-Otano, I., Pfaff, D.W., Poucet, B., Rahman, A.U., Ramos-Cabrer, P., Rashidy-Pour, A., Roberts, R.J., Rodrigues, S., Sanes, J.R., Schaefer, A.T., Segal, M., Segev, I., Shafqat, S., Siddiqui, N.A., Soreq, H., Soriano-Garcia, E., Spanagel, R., Sprengel, R., Stuart, G., Sudhof, T.C., Tonnesen, J., Trevino, M., Uthman, B.M., Venter, J.C., Verkhratsky, A., Weiss, C., Wiesel, T.N., Yaksi, E., Yizhar, O., Young, L.J., Young, P., Zawia, N.H., Zugaza, J.L., and Hasan, M.T. (2017). Building Bridges through Science. Neuron 96, 730-735.

58.        Kleinecke, S., Richert, S., de Hoz, L., Brugger, B., Kungl, T., Asadollahi, E., Quintes, S., Blanz, J., McGonigal, R., Naseri, K., Sereda, M.W., Sachsenheimer, T., Luchtenborg, C., Mobius, W., Willison, H., Baes, M., Nave, K.A., and Kassmann, C.M. (2017). Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy. eLife 6:e23332.

59.        Khan, S., Stott, S.R., Chabrat, A., Truckenbrodt, A.M., Spencer-Dene, B., Nave, K.A., Guillemot, F., Levesque, M., and Ang, S.L. (2017). Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins. J Neurosci 37, 2305-2316.

60.        Janova, H., Arinrad, S., Balmuth, E., Mitjans, M., Hertel, J., Habes, M., Bittner, R.A., Pan, H., Goebbels, S., Begemann, M., Gerwig, U.C., Langner, S., Werner, H.B., Kittel-Schneider, S., Homuth, G., Davatzikos, C., Volzke, H., West, B.L., Reif, A., Grabe, H.J., Boretius, S., Ehrenreich, H., and Nave, K.A. (2017). Microglia ablation alleviates myelin-associated catatonic signs in mice. J Clin Invest 128, 734-745.

61.        Goebbels, S., Wieser, G.L., Pieper, A., Spitzer, S., Weege, B., Yan, K., Edgar, J.M., Yagensky, O., Wichert, S.P., Agarwal, A., Karram, K., Renier, N., Tessier-Lavigne, M., Rossner, M.J., Karadottir, R.T., and Nave, K.A. (2017). A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nat Neurosci 20, 10-15.

62.        Ghidinelli, M., Poitelon, Y., Shin, Y.K., Ameroso, D., Williamson, C., Ferri, C., Pellegatta, M., Espino, K., Mogha, A., Monk, K., Podini, P., Taveggia, C., Nave, K.A., Wrabetz, L., Park, H.T., and Feltri, M.L. (2017). Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination. PLoS biology 15, e2001408.

63.        Feldman, E.L., Nave, K.A., Jensen, T.S., and Bennett, D.L.H. (2017). New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain. Neuron 93, 1296-1313.

64.        Feldman, E.L., Nave, K.A., Jensen, T.S., and Bennett, D.L. (2017). New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain. Neuron 93, 1296-1313.

65.        Camargo, N., Goudriaan, A., van Deijk, A.F., Otte, W.M., Brouwers, J.F., Lodder, H., Gutmann, D.H., Nave, K.A., Dijkhuizen, R.M., Mansvelder, H.D., Chrast, R., Smit, A.B., and Verheijen, M.H.G. (2017). Oligodendroglial myelination requires astrocyte-derived lipids. PLoS biology 15, e1002605.

66.        Winchenbach, J., Duking, T., Berghoff, S.A., Stumpf, S.K., Hulsmann, S., Nave, K.A., and Saher, G. (2016). Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice. F1000Research 5, 2934.

67.        Weil, M.T., Mobius, W., Winkler, A., Ruhwedel, T., Wrzos, C., Romanelli, E., Bennett, J.L., Enz, L., Goebels, N., Nave, K.A., Kerschensteiner, M., Schaeren-Wiemers, N., Stadelmann, C., and Simons, M. (2016). Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases. Cell Rep 16, 314-322.

68.        Vingill, S., Brockelt, D., Lancelin, C., Tatenhorst, L., Dontcheva, G., Preisinger, C., Schwedhelm-Domeyer, N., Joseph, S., Mitkovski, M., Goebbels, S., Nave, K.A., Schulz, J.B., Marquardt, T., Lingor, P., and Stegmuller, J. (2016). Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice. EMBO J 35, 2008-2025.

69.        Syed, Y.A., Zhao, C., Mahad, D., Mobius, W., Altmann, F., Foss, F., Senturk, A., Acker-Palmer, A., Lubec, G., Lilley, K., Franklin, R.J., Nave, K.A., and Kotter, M.R. (2016). Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination. Acta Neuropathol 131, 281-298.

70.        Syed, Y.A., Zhao, C., Mahad, D., Mobius, W., Altmann, F., Foss, F., Gonzalez, G.A., Senturk, A., Acker-Palmer, A., Lubec, G., Lilley, K., Franklin, R.J., Nave, K.A., and Kotter, M.R. (2016). Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination. Acta Neuropathol 132, 157.

71.        Saab, A.S., Tzvetavona, I.D., Trevisiol, A., Baltan, S., Dibaj, P., Kusch, K., Mobius, W., Goetze, B., Jahn, H.M., Huang, W., Steffens, H., Schomburg, E.D., Perez-Samartin, A., Perez-Cerda, F., Bakhtiari, D., Matute, C., Lowel, S., Griesinger, C., Hirrlinger, J., Kirchhoff, F., and Nave, K.A. (2016). Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism. Neuron 91, 119-132.

72.        Saab, A.S., and Nave, K.A. (2016). Neuroscience: A mechanism for myelin injury. Nature 529, 474-475.

73.        Reichel, J.M., Bedenk, B.T., Gassen, N.C., Hafner, K., Bura, S.A., Almeida-Correa, S., Genewsky, A., Dedic, N., Giesert, F., Agarwal, A., Nave, K.A., Rein, T., Czisch, M., Deussing, J.M., and Wotjak, C.T. (2016). Beware of your Cre-ation: lacZ expression impairs neuronal integrity and hippocampus-dependent memory. Hippocampus 26, 1250-1264.

74.        Quintes, S., Brinkmann, B.G., Ebert, M., Frob, F., Kungl, T., Arlt, F.A., Tarabykin, V., Huylebroeck, D., Meijer, D., Suter, U., Wegner, M., Sereda, M.W., and Nave, K.A. (2016). Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair. Nat Neurosci 19, 1050-1059.

75.        Poggi, G., Boretius, S., Mobius, W., Moschny, N., Baudewig, J., Ruhwedel, T., Hassouna, I., Wieser, G.L., Werner, H.B., Goebbels, S., Nave, K.A., and Ehrenreich, H. (2016). Cortical network dysfunction caused by a subtle defect of myelination. Glia 64, 2025-2040.

76.        Patzig, J., Kusch, K., Fledrich, R., Eichel, M.A., Luders, K.A., Mobius, W., Sereda, M.W., Nave, K.A., Martini, R., and Werner, H.B. (2016). Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking. Glia 64, 155-174.

77.        Patzig, J., Erwig, M.S., Tenzer, S., Kusch, K., Dibaj, P., Mobius, W., Goebbels, S., Schaeren-Wiemers, N., Nave, K.A., and Werner, H.B. (2016). Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction. eLife 5.

78.        Noseda, R., Guerrero-Valero, M., Alberizzi, V., Previtali, S.C., Sherman, D.L., Palmisano, M., Huganir, R.L., Nave, K.A., Cuenda, A., Feltri, M.L., Brophy, P.J., and Bolino, A. (2016). Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold. PLoS biology 14, e1002440.

79.        Mobius, W., Nave, K.A., and Werner, H.B. (2016). Electron microscopy of myelin: Structure preservation by high-pressure freezing. Brain Res 1641, 92-100.

80.        Lee, Y.I., Li, Y., Mikesh, M., Smith, I., Nave, K.A., Schwab, M.H., and Thompson, W.J. (2016). Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated synapse elimination at developing neuromuscular junctions. Proc Natl Acad Sci U S A 113, E479-487.

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82.        Ehrenreich, H., Mitjans, M., Van der Auwera, S., Centeno, T.P., Begemann, M., Grabe, H.J., Bonn, S., and Nave, K.A. (2016). OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals. Mol Psychiatry 23, 476-486.

83.        Trevisiol, A., and Nave, K.A. (2015). Brain Energy Metabolism: Conserved Functions of Glycolytic Glial Cells. Cell Metab 22, 361-363.

84.        Sun, Y., Lehmbecker, A., Kalkuhl, A., Deschl, U., Sun, W., Rohn, K., Tzvetanova, I.D., Nave, K.A., Baumgartner, W., and Ulrich, R. (2015). STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis. Neuropathol Appl Neurobiol 41, 347-370.

85.        Stassart, R.M., and Nave, K.A. (2015). Nerve regeneration: Specific metabolic demands? Exp Neurol 269, 90-92.

86.        Simons, M., and Nave, K.A. (2015). Oligodendrocytes: Myelination and Axonal Support. Cold Spring Harb Perspect Biol 8:a020479.

87.        Ott, C., Martens, H., Hassouna, I., Oliveira, B., Erck, C., Zafeiriou, M.P., Peteri, U.K., Hesse, D., Gerhart, S., Altas, B., Kolbow, T., Stadler, H., Kawabe, H., Zimmermann, W.H., Nave, K.A., Schulz-Schaeffer, W., Jahn, O., and Ehrenreich, H. (2015). Widespread Expression of Erythropoietin Receptor in Brain and Its Induction by Injury. Mol Med 21, 803-815.

88.        Mitkovski, M., Dahm, L., Heinrich, R., Monnheimer, M., Gerhart, S., Stegmuller, J., Hanisch, U.K., Nave, K.A., and Ehrenreich, H. (2015). Erythropoietin dampens injury-induced microglial motility. J Cereb Blood Flow Metab 35, 1233-1236.

89.        Maus, F., Sakry, D., Biname, F., Karram, K., Rajalingam, K., Watts, C., Heywood, R., Kruger, R., Stegmuller, J., Werner, H.B., Nave, K.A., Kramer-Albers, E.M., and Trotter, J. (2015). The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2. PLoS One 10, e0137311.

90.        Epplen, D.B., Prukop, T., Nientiedt, T., Albrecht, P., Arlt, F.A., Stassart, R.M., Kassmann, C.M., Methner, A., Nave, K.A., Werner, H.B., and Sereda, M.W. (2015). Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease. Ann Clin Transl Neurol 2, 787-796.

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92.        Bischof, M., Weider, M., Kuspert, M., Nave, K.A., and Wegner, M. (2015). Brg1-Dependent Chromatin Remodelling Is Not Essentially Required during Oligodendroglial Differentiation. J Neurosci 35, 21-35.

93.        Tzvetanova, I.D., and Nave, K.A. (2014). Axons hooked to Schwann cell metabolism. Nat Neurosci 17, 1293-1295.

94.        Snaidero, N., Mobius, W., Czopka, T., Hekking, L.H., Mathisen, C., Verkleij, D., Goebbels, S., Edgar, J., Merkler, D., Lyons, D.A., Nave, K.A., and Simons, M. (2014). Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell 156, 277-290.

95.        Richert, S., Kleinecke, S., Gunther, J., Schaumburg, F., Edgar, J., Nienhaus, G.U., Nave, K.A., and Kassmann, C.M. (2014). In vivo labeling of peroxisomes by photoconvertible mEos2 in myelinating glia of mice. Biochimie 98, 127-134.

96.        Prukop, T., Epplen, D.B., Nientiedt, T., Wichert, S.P., Fledrich, R., Stassart, R.M., Rossner, M.J., Edgar, J.M., Werner, H.B., Nave, K.A., and Sereda, M.W. (2014). Progesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model. Am J Hum Genet 94, 533-546.

97.        Nave, K.A., and Werner, H.B. (2014). Myelination of the nervous system: mechanisms and functions. Annual review of cell and developmental biology 30, 503-533.

98.        Nave, K.A., and Ehrenreich, H. (2014). Myelination and oligodendrocyte functions in psychiatric diseases. JAMA psychiatry 71, 582-584.

99.        Montani, L., Buerki-Thurnherr, T., de Faria, J.P., Pereira, J.A., Dias, N.G., Fernandes, R., Goncalves, A.F., Braun, A., Benninger, Y., Bottcher, R.T., Costell, M., Nave, K.A., Franklin, R.J., Meijer, D., Suter, U., and Relvas, J.B. (2014). Profilin 1 is required for peripheral nervous system myelination. Development 141, 1553-1561.

100.      Mita, S., de Monasterio-Schrader, P., Funfschilling, U., Kawasaki, T., Mizuno, H., Iwasato, T., Nave, K.A., Werner, H.B., and Hirata, T. (2014). Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance. Cereb Cortex.

101.      Mei, L., and Nave, K.A. (2014). Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases. Neuron 83, 27-49.

102.      Hirrlinger, J., and Nave, K.A. (2014). Adapting brain metabolism to myelination and long-range signal transduction. Glia 62, 1749-1761.

103.      Hammer, C., Zerche, M., Schneider, A., Begemann, M., Nave, K.A., and Ehrenreich, H. (2014). Apolipoprotein E4 carrier status plus circulating anti-NMDAR1 autoantibodies: association with schizoaffective disorder. Mol Psychiatry 19, 1054-1060.

104.      Haenold, R., Weih, F., Herrmann, K.H., Schmidt, K.F., Krempler, K., Engelmann, C., Nave, K.A., Reichenbach, J.R., Lowel, S., Witte, O.W., and Kretz, A. (2014). NF-kappaB controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS. J Cell Sci 127, 3052-3065.

105.      Gritsch, S., Lu, J., Thilemann, S., Wortge, S., Mobius, W., Bruttger, J., Karram, K., Ruhwedel, T., Blanfeld, M., Vardeh, D., Waisman, A., Nave, K.A., and Kuner, R. (2014). Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice. Nat Commun 5, 5472.

106.      Fledrich, R., Stassart, R.M., Klink, A., Rasch, L.M., Prukop, T., Haag, L., Czesnik, D., Kungl, T., Abdelaal, T.A., Keric, N., Stadelmann, C., Bruck, W., Nave, K.A., and Sereda, M.W. (2014). Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Nat Med 20, 1055-1061.

107.      Fields, R.D., Araque, A., Johansen-Berg, H., Lim, S.S., Lynch, G., Nave, K.A., Nedergaard, M., Perez, R., Sejnowski, T., and Wake, H. (2014). Glial Biology in Learning and Cognition. Neuroscientist 20, 426-431.

108.      Ehrenreich, H., and Nave, K.A. (2014). Phenotype-Based Genetic Association Studies (PGAS)-Towards Understanding the Contribution of Common Genetic Variants to Schizophrenia Subphenotypes. Genes 5, 97-105.

109.      Dere, E., Winkler, D., Ritter, C., Ronnenberg, A., Poggi, G., Patzig, J., Gernert, M., Muller, C., Nave, K.A., Ehrenreich, H., and Werner, H.B. (2014). Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist. Behavioural brain research 277, 254-263.

110.      Chumakov, I., Milet, A., Cholet, N., Primas, G., Boucard, A., Pereira, Y., Graudens, E., Mandel, J., Laffaire, J., Foucquier, J., Glibert, F., Bertrand, V., Nave, K.A., Sereda, M.W., Vial, E., Guedj, M., Hajj, R., Nabirotchkin, S., and Cohen, D. (2014). Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy. Orphanet journal of rare diseases 9, 201.

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112.      Wieser, G.L., Gerwig, U.C., Adamcio, B., Barrette, B., Nave, K.A., Ehrenreich, H., and Goebbels, S. (2013). Neuroinflammation in white matter tracts of Cnp1 mutant mice amplified by a minor brain injury. Glia 61, 869-880.

113.      Werner, H.B., Kramer-Albers, E.M., Strenzke, N., Saher, G., Tenzer, S., Ohno-Iwashita, Y., De Monasterio-Schrader, P., Mobius, W., Moser, T., Griffiths, I.R., and Nave, K.A. (2013). A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system. Glia 61, 567-586.

114.      Vogl, M.R., Reiprich, S., Kuspert, M., Kosian, T., Schrewe, H., Nave, K.A., and Wegner, M. (2013). Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. J Neurosci 33, 6679-6690.

115.      Verrier, J.D., Jackson, T.C., Gillespie, D.G., Janesko-Feldman, K., Bansal, R., Goebbels, S., Nave, K.A., Kochanek, P.M., and Jackson, E.K. (2013). Role of CNPase in the oligodendrocytic extracellular 2',3'-cAMP-adenosine pathway. Glia 61, 1595-1606.

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118.      Saab, A.S., Tzvetanova, I.D., and Nave, K.A. (2013). The role of myelin and oligodendrocytes in axonal energy metabolism. Curr Opin Neurobiol 23, 1065-1072.

119.      Hammer, C., Stepniak, B., Schneider, A., Papiol, S., Tantra, M., Begemann, M., Siren, A.L., Pardo, L.A., Sperling, S., Mohd Jofrry, S., Gurvich, A., Jensen, N., Ostmeier, K., Luhder, F., Probst, C., Martens, H., Gillis, M., Saher, G., Assogna, F., Spalletta, G., Stocker, W., Schulz, T.F., Nave, K.A., and Ehrenreich, H. (2013). Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry 19, 1143-1149.

120.      Grigoryan, T., Stein, S., Qi, J., Wende, H., Garratt, A.N., Nave, K.A., Birchmeier, C., and Birchmeier, W. (2013). Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A 110, 18174-18179.

121.      Fruhbeis, C., Frohlich, D., Kuo, W.P., Amphornrat, J., Thilemann, S., Saab, A.S., Kirchhoff, F., Mobius, W., Goebbels, S., Nave, K.A., Schneider, A., Simons, M., Klugmann, M., Trotter, J., and Kramer-Albers, E.M. (2013). Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS biology 11, e1001604.

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130.      Ip, C.W., Kroner, A., Groh, J., Huber, M., Klein, D., Spahn, I., Diem, R., Williams, S.K., Nave, K.A., Edgar, J.M., and Martini, R. (2012). Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse. PLoS One 7, e42554.

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181.      Gulbagci, N.T., Li, L., Ling, B., Gopinadhan, S., Walsh, M., Rossner, M., Nave, K.A., and Taneja, R. (2009). SHARP1/DEC2 inhibits adipogenic differentiation by regulating the activity of C/EBP. EMBO Rep 10, 79-86.

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183.      Edgar, J.M., and Nave, K.A. (2009). The role of CNS glia in preserving axon function. Curr Opin Neurobiol 19, 498-504.

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190.      Trapp, B.D., and Nave, K.A. (2008). Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 31, 247-269.

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214.      Grove, M., Komiyama, N.H., Nave, K.A., Grant, S.G., Sherman, D.L., and Brophy, P.J. (2007). FAK is required for axonal sorting by Schwann cells. J Cell Biol 176, 277-282.

215.      Funfschilling, U., Saher, G., Xiao, L., Mobius, W., and Nave, K.A. (2007). Survival of adult neurons lacking cholesterol synthesis in vivo. BMC Neurosci 8, 1.

216.      Ehrenreich, H., Fischer, B., Norra, C., Schellenberger, F., Stender, N., Stiefel, M., Siren, A.L., Paulus, W., Nave, K.A., Gold, R., and Bartels, C. (2007). Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis. Brain 130, 2577-2588.

217.      Dhaunchak, A.S., and Nave, K.A. (2007). A common mechanism of PLP/DM20 misfolding causes cysteine-mediated endoplasmic reticulum retention in oligodendrocytes and Pelizaeus-Merzbacher disease. Proc Natl Acad Sci U S A 104, 17813-17818.

218.      Benninger, Y., Thurnherr, T., Pereira, J.A., Krause, S., Wu, X., Chrostek-Grashoff, A., Herzog, D., Nave, K.A., Franklin, R.J., Meijer, D., Brakebusch, C., Suter, U., and Relvas, J.B. (2007). Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development. J Cell Biol 177, 1051-1061.

219.      Belvindrah, R., Graus-Porta, D., Goebbels, S., Nave, K.A., and Muller, U. (2007). Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci 27, 13854-13865.

220.      Yin, X., Baek, R.C., Kirschner, D.A., Peterson, A., Fujii, Y., Nave, K.A., Macklin, W.B., and Trapp, B.D. (2006). Evolution of a neuroprotective function of central nervous system myelin. J Cell Biol 172, 469-478.

221.      Weishaupt, J.H., Bartels, C., Polking, E., Dietrich, J., Rohde, G., Poeggeler, B., Mertens, N., Sperling, S., Bohn, M., Huther, G., Schneider, A., Bach, A., Siren, A.L., Hardeland, R., Bahr, M., Nave, K.A., and Ehrenreich, H. (2006). Reduced oxidative damage in ALS by high-dose enteral melatonin treatment. J Pineal Res 41, 313-323.

222.      Wehr, M.C., Laage, R., Bolz, U., Fischer, T.M., Grunewald, S., Scheek, S., Bach, A., Nave, K.A., and Rossner, M.J. (2006). Monitoring regulated protein-protein interactions using split TEV. Nat Methods 3, 985-993.

223.      Trajkovic, K., Dhaunchak, A.S., Goncalves, J.T., Wenzel, D., Schneider, A., Bunt, G., Nave, K.A., and Simons, M. (2006). Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites. J Cell Biol 172, 937-948.

224.      Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S.M., Nave, K.A., Franklin, R.J., Brakebusch, C., Suter, U., and Relvas, J.B. (2006). Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS. J Neurosci 26, 10110-10119.

225.      Sereda, M.W., and Nave, K.A. (2006). Animal models of Charcot-Marie-Tooth disease type 1A. Neuromolecular Med 8, 205-216.

226.      Schweitzer, J., Becker, T., Schachner, M., Nave, K.A., and Werner, H. (2006). Evolution of myelin proteolipid proteins: gene duplication in teleosts and expression pattern divergence. Mol Cell Neurosci 31, 161-177.

227.      Rossner, M.J., Hirrlinger, J., Wichert, S.P., Boehm, C., Newrzella, D., Hiemisch, H., Eisenhardt, G., Stuenkel, C., von Ahsen, O., and Nave, K.A. (2006). Global transcriptome analysis of genetically identified neurons in the adult cortex. J Neurosci 26, 9956-9966.

228.      Rosenbluth, J., Nave, K.A., Mierzwa, A., and Schiff, R. (2006). Subtle myelin defects in PLP-null mice. Glia 54, 172-182.

229.      Nobbio, L., Gherardi, G., Vigo, T., Passalacqua, M., Melloni, E., Abbruzzese, M., Mancardi, G., Nave, K.A., and Schenone, A. (2006). Axonal damage and demyelination in long-term dorsal root ganglia cultures from a rat model of Charcot-Marie-Tooth type 1A disease. Eur J Neurosci 23, 1445-1452.

230.      Nave, K.A., and Salzer, J.L. (2006). Axonal regulation of myelination by neuregulin 1. Curr Opin Neurobiol 16, 492-500.

231.      Monory, K., Massa, F., Egertova, M., Eder, M., Blaudzun, H., Westenbroek, R., Kelsch, W., Jacob, W., Marsch, R., Ekker, M., Long, J., Rubenstein, J.L., Goebbels, S., Nave, K.A., During, M., Klugmann, M., Wolfel, B., Dodt, H.U., Zieglgansberger, W., Wotjak, C.T., Mackie, K., Elphick, M.R., Marsicano, G., and Lutz, B. (2006). The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 51, 455-466.

232.      Meyer zu Horste, G., Prukop, T., Nave, K.A., and Sereda, M.W. (2006). Myelin disorders: Causes and perspectives of Charcot-Marie-Tooth neuropathy. Journal of molecular neuroscience : MN 28, 77-88.

233.      Meyer Zu Horste, G., and Nave, K.A. (2006). Animal models of inherited neuropathies. Curr Opin Neurol 19, 464-473.

234.      Kramer-Albers, E.M., Gehrig-Burger, K., Thiele, C., Trotter, J., and Nave, K.A. (2006). Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia. J Neurosci 26, 11743-11752.

235.      Kashani, A.H., Qiu, Z., Jurata, L., Lee, S.K., Pfaff, S., Goebbels, S., Nave, K.A., and Ghosh, A. (2006). Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J Neurosci 26, 8398-8408.

236.      Kaga, Y., Shoemaker, W.J., Furusho, M., Bryant, M., Rosenbluth, J., Pfeiffer, S.E., Oh, L., Rasband, M., Lappe-Siefke, C., Yu, K., Ornitz, D.M., Nave, K.A., and Bansal, R. (2006). Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation. J Neurosci 26, 12339-12350.

237.      Ip, C.W., Kroner, A., Bendszus, M., Leder, C., Kobsar, I., Fischer, S., Wiendl, H., Nave, K.A., and Martini, R. (2006). Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes. J Neurosci 26, 8206-8216.

238.      Goebbels, S., Bormuth, I., Bode, U., Hermanson, O., Schwab, M.H., and Nave, K.A. (2006). Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice. Genesis 44, 611-621.

239.      Fowler, J.H., Edgar, J.M., Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I.R., Garbern, J.Y., Nave, K.A., and Dewar, D. (2006). Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. J Neurosci Res 84, 68-77.

240.      Benninger, Y., Colognato, H., Thurnherr, T., Franklin, R.J., Leone, D.P., Atanasoski, S., Nave, K.A., Ffrench-Constant, C., Suter, U., and Relvas, J.B. (2006). Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination. J Neurosci 26, 7665-7673.

241.      Wu, S.X., Goebbels, S., Nakamura, K., Nakamura, K., Kometani, K., Minato, N., Kaneko, T., Nave, K.A., and Tamamaki, N. (2005). Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone. Proc Natl Acad Sci U S A 102, 17172-17177.

242.      Vigo, T., Nobbio, L., Hummelen, P.V., Abbruzzese, M., Mancardi, G., Verpoorten, N., Verhoeven, K., Sereda, M.W., Nave, K.A., Timmerman, V., and Schenone, A. (2005). Experimental Charcot-Marie-Tooth type 1A: a cDNA microarrays analysis. Mol Cell Neurosci 28, 703-714.

243.      Schneider, A., Lander, H., Schulz, G., Wolburg, H., Nave, K.A., Schulz, J.B., and Simons, M. (2005). Palmitoylation is a sorting determinant for transport to the myelin membrane. J Cell Sci 118, 2415-2423.

244.      Saher, G., Brugger, B., Lappe-Siefke, C., Mobius, W., Tozawa, R., Wehr, M.C., Wieland, F., Ishibashi, S., and Nave, K.A. (2005). High cholesterol level is essential for myelin membrane growth. Nat Neurosci 8, 468-475.

245.      Rasband, M.N., Tayler, J., Kaga, Y., Yang, Y., Lappe-Siefke, C., Nave, K.A., and Bansal, R. (2005). CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS. Glia 50, 86-90.

246.      Osada, T., Tamamaki, N., Song, S.Y., Kakazu, N., Yamazaki, Y., Makino, H., Sasaki, A., Hirayama, T., Hamada, S., Nave, K.A., Yanagimachi, R., and Yagi, T. (2005). Developmental pluripotency of the nuclei of neurons in the cerebral cortex of juvenile mice. J Neurosci 25, 8368-8374.

247.      Nave, K.A., and Schwab, M.H. (2005). Glial cells under remote control. Nat Neurosci 8, 1420-1422.

248.      Moosmang, S., Haider, N., Klugbauer, N., Adelsberger, H., Langwieser, N., Muller, J., Stiess, M., Marais, E., Schulla, V., Lacinova, L., Goebbels, S., Nave, K.A., Storm, D.R., Hofmann, F., and Kleppisch, T. (2005). Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. J Neurosci 25, 9883-9892.

249.      Goebbels, S., Bode, U., Pieper, A., Funfschilling, U., Schwab, M.H., and Nave, K.A. (2005). Cre/loxP-mediated inactivation of the bHLH transcription factor gene NeuroD/BETA2. Genesis 42, 247-252.

250.      Ehrenreich, H., Hasselblatt, M., Knerlich, F., von Ahsen, N., Jacob, S., Sperling, S., Woldt, H., Vehmeyer, K., Nave, K.A., and Siren, A.L. (2005). A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. Proc Natl Acad Sci U S A 102, 862-867.

251.      Skoff, R.P., Bessert, D.A., Cerghet, M., Franklin, M.J., Rout, U.K., Nave, K.A., Carlock, L., Ghandour, M.S., and Armant, D.R. (2004). The myelin proteolipid protein gene modulates apoptosis in neural and non-neural tissues. Cell Death Differ 11, 1247-1257.

252.      Michailov, G.V., Sereda, M.W., Brinkmann, B.G., Fischer, T.M., Haug, B., Birchmeier, C., Role, L., Lai, C., Schwab, M.H., and Nave, K.A. (2004). Axonal neuregulin-1 regulates myelin sheath thickness. Science 304, 700-703.

253.      Ludwig, A., Schlierf, B., Schardt, A., Nave, K.A., and Wegner, M. (2004). Sox10-rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes. Genesis 40, 171-175.

254.      Grandis, M., Leandri, M., Vigo, T., Cilli, M., Sereda, M.W., Gherardi, G., Benedetti, L., Mancardi, G., Abbruzzese, M., Nave, K.A., Nobbio, L., and Schenone, A. (2004). Early abnormalities in sciatic nerve function and structure in a rat model of Charcot-Marie-Tooth type 1A disease. Exp Neurol 190, 213-223.

255.      Edgar, J.M., McLaughlin, M., Yool, D., Zhang, S.C., Fowler, J.H., Montague, P., Barrie, J.A., McCulloch, M.C., Duncan, I.D., Garbern, J., Nave, K.A., and Griffiths, I.R. (2004). Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. J Cell Biol 166, 121-131.

256.      Brockschnieder, D., Lappe-Siefke, C., Goebbels, S., Boesl, M.R., Nave, K.A., and Riethmacher, D. (2004). Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination. Mol Cell Biol 24, 7636-7642.

257.      Stegmuller, J., Werner, H., Nave, K.A., and Trotter, J. (2003). The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling. J Biol Chem 278, 3590-3598.

258.      Sereda, M.W., Meyer zu Horste, G., Suter, U., Uzma, N., and Nave, K.A. (2003). Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A). Nat Med 9, 1533-1537.

259.      Runker, A.E., Bartsch, U., Nave, K.A., and Schachner, M. (2003). The C264Y missense mutation in the extracellular domain of L1 impairs protein trafficking in vitro and in vivo. J Neurosci 23, 277-286.

260.      Rodemer, C., Thai, T.P., Brugger, B., Kaercher, T., Werner, H., Nave, K.A., Wieland, F., Gorgas, K., and Just, W.W. (2003). Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. Hum Mol Genet 12, 1881-1895.

261.      Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P.E., Griffiths, I.R., and Nave, K.A. (2003). Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet 33, 366-374.

262.      Kleppisch, T., Wolfsgruber, W., Feil, S., Allmann, R., Wotjak, C.T., Goebbels, S., Nave, K.A., Hofmann, F., and Feil, R. (2003). Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory. J Neurosci 23, 6005-6012.

263.      Jurevics, H., Hostettler, J., Sammond, D.W., Nave, K.A., Toews, A.D., and Morell, P. (2003). Normal metabolism but different physical properties of myelin from mice deficient in proteolipid protein. J Neurosci Res 71, 826-834.

264.      Erb, M., Steck, A.J., Nave, K.A., and Schaeren-Wiemers, N. (2003). Differential expression of L- and S-MAG upon cAMP stimulated differentiation in oligodendroglial cells. J Neurosci Res 71, 326-337.

265.      Beggs, H.E., Schahin-Reed, D., Zang, K., Goebbels, S., Nave, K.A., Gorski, J., Jones, K.R., Sretavan, D., and Reichardt, L.F. (2003). FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron 40, 501-514.

266.      Al-Saktawi, K., McLaughlin, M., Klugmann, M., Schneider, A., Barrie, J.A., McCulloch, M.C., Montague, P., Kirkham, D., Nave, K.A., and Griffiths, I.R. (2003). Genetic background determines phenotypic severity of the Plp rumpshaker mutation. J Neurosci Res 72, 12-24.

267.      Yool, D., Montague, P., McLaughlin, M., McCulloch, M.C., Edgar, J.M., Nave, K.A., Davies, R.W., Griffiths, I.R., and McCallion, A.S. (2002). Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia 39, 256-267.

268.      Yool, D., Klugmann, M., Barrie, J.A., McCulloch, M.C., Nave, K.A., and Griffiths, I.R. (2002). Observations on the structure of myelin lacking the major proteolipid protein. Neuropathol Appl Neurobiol 28, 75-78.

269.      Simons, M., Kramer, E.M., Macchi, P., Rathke-Hartlieb, S., Trotter, J., Nave, K.A., and Schulz, J.B. (2002). Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease. J Cell Biol 157, 327-336.

270.      Maier, M., Berger, P., Nave, K.A., and Suter, U. (2002). Identification of the regulatory region of the peripheral myelin protein 22 (PMP22) gene that directs temporal and spatial expression in development and regeneration of peripheral nerves. Mol Cell Neurosci 20, 93-109.

271.      Genoud, S., Lappe-Siefke, C., Goebbels, S., Radtke, F., Aguet, M., Scherer, S.S., Suter, U., Nave, K.A., and Mantei, N. (2002). Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol 158, 709-718.

272.      Garbern, J.Y., Yool, D.A., Moore, G.J., Wilds, I.B., Faulk, M.W., Klugmann, M., Nave, K.A., Sistermans, E.A., van der Knaap, M.S., Bird, T.D., Shy, M.E., Kamholz, J.A., and Griffiths, I.R. (2002). Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation. Brain 125, 551-561.

273.      Edgar, J.M., Anderson, T.J., Dickinson, P.J., Barrie, J.A., McCulloch, M.C., Nave, K.A., and Griffiths, I.R. (2002). Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene. J Cell Biol 158, 719-729.

274.      Atanasoski, S., Scherer, S.S., Nave, K.A., and Suter, U. (2002). Proliferation of Schwann cells and regulation of cyclin D1 expression in an animal model of Charcot-Marie-Tooth disease type 1A. J Neurosci Res 67, 443-449.

275.      Yool, D.A., Klugmann, M., McLaughlin, M., Vouyiouklis, D.A., Dimou, L., Barrie, J.A., McCulloch, M.C., Nave, K.A., and Griffiths, I.R. (2001). Myelin proteolipid proteins promote the interaction of oligodendrocytes and axons. J Neurosci Res 63, 151-164.

276.      Yamada, M., Jung, M., Tetsushi, K., Ivanova, A., Nave, K.A., and Ikenaka, K. (2001). Mutant Plp/DM20 cannot be processed to secrete PLP-related oligodendrocyte differentiation/survival factor. Neurochem Res 26, 639-645.

277.      Werner, H., Dimou, L., Klugmann, M., Pfeiffer, S., and Nave, K.A. (2001). Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes. Mol Cell Neurosci 18, 593-605.

278.      Schneider, S., Bosse, F., D'Urso, D., Muller, H., Sereda, M.W., Nave, K., Niehaus, A., Kempf, T., Schnolzer, M., and Trotter, J. (2001). The AN2 protein is a novel marker for the Schwann cell lineage expressed by immature and nonmyelinating Schwann cells. J Neurosci 21, 920-933.

279.      Nobbio, L., Mancardi, G., Grandis, M., Levi, G., Suter, U., Nave, K.A., Windebank, A.J., Abbruzzese, M., and Schenone, A. (2001). PMP22 transgenic dorsal root ganglia cultures show myelin abnormalities similar to those of human CMT1A. Ann Neurol 50, 47-55.

280.      Kramer, E.M., Schardt, A., and Nave, K.A. (2001). Membrane traffic in myelinating oligodendrocytes. Microsc Res Tech 52, 656-671.

281.      Cerghet, M., Bessert, D.A., Nave, K.A., and Skoff, R.P. (2001). Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways. J Neurocytol 30, 841-855.

282.      Britsch, S., Goerich, D.E., Riethmacher, D., Peirano, R.I., Rossner, M., Nave, K.A., Birchmeier, C., and Wegner, M. (2001). The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev 15, 66-78.

283.      Schwab, M.H., Bartholomae, A., Heimrich, B., Feldmeyer, D., Druffel-Augustin, S., Goebbels, S., Naya, F.J., Zhao, S., Frotscher, M., Tsai, M.J., and Nave, K.A. (2000). Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J Neurosci 20, 3714-3724.

284.      Niemann, S., Sereda, M.W., Suter, U., Griffiths, I.R., and Nave, K.A. (2000). Uncoupling of myelin assembly and schwann cell differentiation by transgenic overexpression of peripheral myelin protein 22. J Neurosci 20, 4120-4128.

285.      Nave, K.A., and Trapp, B. (2000). Foreword. Glia 29, 103.

286.      Klein, L., Klugmann, M., Nave, K.A., Tuohy, V.K., and Kyewski, B. (2000). Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat Med 6, 56-61.

287.      Suter, U., and Nave, K.A. (1999). Transgenic mouse models of CMT1A and HNPP. Ann N Y Acad Sci 883, 247-253.

288.      Niemann, S., Sereda, M.W., Rossner, M., Stewart, H., Suter, U., Meinck, H.M., Griffiths, I.R., and Nave, K.A. (1999). The "CMT rat": peripheral neuropathy and dysmyelination caused by transgenic overexpression of PMP22. Ann N Y Acad Sci 883, 254-261.

289.      Montague, P., Kirkham, D., McCallion, A.S., Davies, R.W., Kennedy, P.G., Klugmann, M., Nave, K., and Griffiths, I.R. (1999). Reduced levels of a specific myelin-associated oligodendrocytic basic protein isoform in shiverer myelin. Dev Neurosci 21, 36-42.

290.      Dimou, L., Klugmann, M., Werner, H., Jung, M., Griffiths, I.R., and Nave, K.A. (1999). Dysmyelination in mice and the proteolipid protein gene family. Adv Exp Med Biol 468, 261-271.

291.      Coetzee, T., Suzuki, K., Nave, K.A., and Popko, B. (1999). Myelination in the absence of galactolipids and proteolipid proteins. Mol Cell Neurosci 14, 41-51.

292.      Bradl, M., Bauer, J., Inomata, T., Zielasek, J., Nave, K.A., Toyka, K., Lassmann, H., and Wekerle, H. (1999). Transgenic Lewis rats overexpressing the proteolipid protein gene: myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis. Acta Neuropathol 97, 595-606.

293.      Anderson, T.J., Klugmann, M., Thomson, C.E., Schneider, A., Readhead, C., Nave, K.A., and Griffiths, I.R. (1999). Distinct phenotypes associated with increasing dosage of the PLP gene: implications for CMT1A due to PMP22 gene duplication. Ann N Y Acad Sci 883, 234-246.

294.      Werner, H., Jung, M., Klugmann, M., Sereda, M., Griffiths, I.R., and Nave, K.A. (1998). Mouse models of myelin diseases. Brain Pathol 8, 771-793.

295.      Vouyiouklis, D.A., Werner, H., Griffiths, I.R., Stewart, G.J., Armin-Nave, K., and Thomson, C.E. (1998). Molecular cloning and transfection studies of M6b-2, a novel splice variant of a member of the PLP-DM20/M6 gene family. J Neurosci Res 52, 633-640.

296.      Schwab, M.H., Druffel-Augustin, S., Gass, P., Jung, M., Klugmann, M., Bartholomae, A., Rossner, M.J., and Nave, K.A. (1998). Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice. J Neurosci 18, 1408-1418.

297.      Niemann, S., Sidman, R.L., and Nave, K.A. (1998). Evidence against altered forms of MAG in the dysmyelinated mouse mutant claw paw. Mamm Genome 9, 903-904.

298.      Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M.H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., and Nave, K.A. (1998). Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 280, 1610-1613.

299.      Griffiths, I., Klugmann, M., Anderson, T., Thomson, C., Vouyiouklis, D., and Nave, K.A. (1998). Current concepts of PLP and its role in the nervous system. Microsc Res Tech 41, 344-358.

300.      Anderson, T.J., Schneider, A., Barrie, J.A., Klugmann, M., McCulloch, M.C., Kirkham, D., Kyriakides, E., Nave, K.A., and Griffiths, I.R. (1998). Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene. J Comp Neurol 394, 506-519.

301.      Thomson, C.E., Montague, P., Jung, M., Nave, K.A., and Griffiths, I.R. (1997). Phenotypic severity of murine Plp mutants reflects in vivo and in vitro variations in transport of PLP isoproteins. Glia 20, 322-332.

302.      Stewart, H.J., Zoidl, G., Rossner, M., Brennan, A., Zoidl, C., Nave, K.A., Mirsky, R., and Jessen, K.R. (1997). Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development. J Neurosci Res 50, 684-701.

303.      Rossner, M.J., Dorr, J., Gass, P., Schwab, M.H., and Nave, K.A. (1997). SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Mol Cell Neurosci 10, 460-475.

304.      Muller, H.W., Suter, U., Van Broeckhoven, C., Hanemann, C.O., Nelis, E., Timmerman, V., Sancho, S., Barrio, L., Bolhuis, P., Dermietzel, R., Frank, M., Gabreels-Festen, A., Gillen, C., Haites, N., Levi, G., Mariman, E., Martini, R., Nave, K., Rautenstrauss, B., Schachner, M., Schenone, A., Schneider, C., Schroder, M., and Willecke, K. (1997). Advances in Charcot-Marie-Tooth disease research: cellular function of CMT-related proteins, transgenic animal models, and pathomechanisms. The European CMT Consortium. Neurobiol Dis 4, 215-220.

305.      Klugmann, M., Schwab, M.H., Puhlhofer, A., Schneider, A., Zimmermann, F., Griffiths, I.R., and Nave, K.A. (1997). Assembly of CNS myelin in the absence of proteolipid protein. Neuron 18, 59-70.

306.      Forss-Petter, S., Werner, H., Berger, J., Lassmann, H., Molzer, B., Schwab, M.H., Bernheimer, H., Zimmermann, F., and Nave, K.A. (1997). Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice. J Neurosci Res 50, 829-843.

307.      Anderson, T.J., Montague, P., Nadon, N., Nave, K.A., and Griffiths, I.R. (1997). Modification of Schwann cell phenotype with Plp transgenes: evidence that the PLP and DM20 isoproteins are targeted to different cellular domains. J Neurosci Res 50, 13-22.

308.      Sereda, M., Griffiths, I., Puhlhofer, A., Stewart, H., Rossner, M.J., Zimmerman, F., Magyar, J.P., Schneider, A., Hund, E., Meinck, H.M., Suter, U., and Nave, K.A. (1996). A transgenic rat model of Charcot-Marie-Tooth disease. Neuron 16, 1049-1060.

309.      Jung, M., Sommer, I., Schachner, M., and Nave, K.A. (1996). Monoclonal antibody O10 defines a conformationally sensitive cell-surface epitope of proteolipid protein (PLP): evidence that PLP misfolding underlies dysmyelination in mutant mice. J Neurosci 16, 7920-7929.

310.      Vellutini, C., Horschowski, N., Philippon, V., Gambarelli, D., Nave, K.A., and Filippi, P. (1995). Development of lymphoid hyperplasia in transgenic mice expressing the HIV tat gene. AIDS Res Hum Retroviruses 11, 21-29.

311.      Schneider, A.M., Griffiths, I.R., Readhead, C., and Nave, K.A. (1995). Dominant-negative action of the jimpy mutation in mice complemented with an autosomal transgene for myelin proteolipid protein. Proc Natl Acad Sci U S A 92, 4447-4451.

312.      Nave, K.A. (1995). Myelin genetics: new insight into old diseases. Brain Pathol 5, 231-232.

313.      Griffiths, I.R., Schneider, A., Anderson, J., and Nave, K.A. (1995). Transgenic and natural mouse models of proteolipid protein (PLP)-related dysmyelination and demyelination. Brain Pathol 5, 275-281.

314.      Vellutini, C., Philippon, V., Gambarelli, D., Horschowski, N., Nave, K.A., Navarro, J.M., Auphan, M., Courcoul, M.A., and Filippi, P. (1994). The maedi-visna virus Tat protein induces multiorgan lymphoid hyperplasia in transgenic mice. J Virol 68, 4955-4962.

315.      Readhead, C., Schneider, A., Griffiths, I., and Nave, K.A. (1994). Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage. Neuron 12, 583-595.

316.      Nave, K.A. (1994). Neurological mouse mutants and the genes of myelin. J Neurosci Res 38, 607-612.

317.      Montag, D., Giese, K.P., Bartsch, U., Martini, R., Lang, Y., Bluthmann, H., Karthigasan, J., Kirschner, D.A., Wintergerst, E.S., Nave, K.A., and et al. (1994). Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron 13, 229-246.

318.      Bartholoma, A., and Nave, K.A. (1994). NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons. Mech Dev 48, 217-228.

319.      Fanarraga, M.L., Sommer, I.U., Griffiths, I.R., Montague, P., Groome, N.P., Nave, K.A., Schneider, A., Brophy, P.J., and Kennedy, P.G. (1993). Oligodendrocyte development and differentiation in the rumpshaker mutation. Glia 9, 146-156.

320.      Schneider, A., Montague, P., Griffiths, I., Fanarraga, M., Kennedy, P., Brophy, P., and Nave, K.A. (1992). Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene. Nature 358, 758-761.

321.      Nave, K.A., and Lemke, G. (1991). Induction of the myelin proteolipid protein (PLP) gene in C6 glioblastoma cells: functional analysis of the PLP promotor. J Neurosci 11, 3060-3069.

322.      Milner, R.J., Lai, C., Nave, K.A., Montag, D., Farber, L., and Sutcliffe, J.G. (1990). Organization of myelin protein genes: myelin-associated glycoprotein. Ann N Y Acad Sci 605, 254-261.

323.      Nave, K.A., and Milner, R.J. (1989). Proteolipid proteins: structure and genetic expression in normal and myelin-deficient mutant mice. Crit Rev Neurobiol 5, 65-91.

324.      Nave, K.A., Lai, C., Bloom, F.E., and Milner, R.J. (1987). Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin. Proc Natl Acad Sci U S A 84, 5665-5669.

325.      Nave, K.A., Bloom, F.E., and Milner, R.J. (1987). A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse. J Neurochem 49, 1873-1877.

326.      Lai, C., Brow, M.A., Nave, K.A., Noronha, A.B., Quarles, R.H., Bloom, F.E., Milner, R.J., and Sutcliffe, J.G. (1987). Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing. Proc Natl Acad Sci U S A 84, 4337-4341.

327.      Nave, K.A., Lai, C., Bloom, F.E., and Milner, R.J. (1986). Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing. Proc Natl Acad Sci U S A 83, 9264-9268.

328.      Nave, K.A., Probstmeier, R., and Schachner, M. (1985). Epidermal growth factor does not cross the blood-brain barrier. Cell Tissue Res 241, 453-457.

329.      Milner, R.J., Lai, C., Nave, K.A., Lenoir, D., Ogata, J., and Sutcliffe, J.G. (1985). Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein. Cell 42, 931-939.

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