Publications

Journal Article (20)

1.
Journal Article
Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A.; Spieth, L.; Düking, T.; Schneider, L. V.; Schlaphoff, L.; Dreha-Kulaczewski, S.; Bley, A.; Burfeind, D. et al.; Kusch, K.; Mitkovski, M.; Ruhwedel, T.; Guder, P.; Röhse, H.; Denecke, J.; Gärtner, J.; Möbius, W.; Nave, K.-A.; Saher, G.: Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease. Acta Neuropathologica 138 (1), pp. 147 - 161 (2019)
2.
Journal Article
Pan, H.; Oliveira, B.; Saher, G.; Dere, E.; Tapken, D.; Mitjans, M.; Seidel, J.; Wesolowski, J.; Wakhloo, D.; Klein-Schmidt, C. et al.; Ronnenberg, A.; Schwabe, K.; Trippe, R.; Mätz-Rensing, K.; Berghoff, S.; Al-Krinawe, Y.; Martens, H.; Begemann, M.; Stöcker, W.; Kaup, F.-J.; Mischke, R.; Boretius, S.; Nave, K.-A.; Krauss, J. K.; Hollmann, M.; Lühder, F.; Ehrenreich, H.: Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model. Molecular Psychiatry, 10.1038/s41380-017-0011-3 (2018)
3.
Journal Article
Berghoff, S. A.; Düking, T.; Spieth, L.; Winchenbach, J.; Stumpf, S. K.; Gerndt, N.; Kusch, K.; Ruhwedel, T.; Möbius, W.; Saher, G.: Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model. Acta neuropathologica communications 5 (1), 94 (2017)
4.
Journal Article
Berghoff, S. A.; Gerndt, N.; Winchenbach, J.; Stumpf, S. K.; Hosang, L.; Odoardi, F.; Ruhwedel, T.; Böhler, C.; Barrette, B.; Stassart, R. et al.; Liebetanz, D.; Dibaj, P.; Möbius, W.; Edgar, J. M.; Saher, G.: Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nature Communications 8, 14241 (2017)
5.
Journal Article
Winchenbach, J.; Düking, T.; Berghoff, S. A.; Stumpf, S. K.; Hülsmann, S.; Nave, K.-A.; Saher, G.: Inducible targeting of CNS astrocytes in Aldh1/1-CreERT2 BAC transgenic mice. Faculty of 1000 Research 5, 2934 (2016)
6.
Journal Article
Saher, G.; Stumpf, S. K.: Cholesterol in myelin biogenesis and hypomyelinating disorders. Biochimica et Biophysica Acta 1851, pp. 1083 - 1094 (2015)
7.
Journal Article
Hammer, C.; Stepniak, B.; Schneider, A.; Papiol, S.; Tantra, M.; Begemann, M.; Sirén, A.-L.; Pardo, L. A.; Sperling, S.; Mohd Jofrry, S. et al.; Gurvich, A.; Jensen, N.; Ostmeier, K.; Lühder, F.; Probst, C.; Martens, H.; Gillis, M.; Saher, G.; Assogna, F.; Spalletta, G.; Stöcker, W.; Schulz, T. F.; Nave, K.-A.; Ehrenreich, H.: Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Molecular Psychiatry 19 (10), pp. 1143 - 1149 (2014)
8.
Journal Article
Werner, H. B.; Krämer-Albers, E.-M.; Strenzke, N.; Saher, G.; Tenzer, S.; Ohno-Iwashita, Y.; Monasterio-Schrader, P. d.; Möbius, W.; Moser, T.; Griffiths, I. R. et al.; Nave, K.-A.: A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system. GLIA 61 (4), pp. 567 - 586 (2013)
9.
Journal Article
Paul, D.; Hoppe, S.; Saher, G.; Krijnse-Locker, J.; Bartenschlager, R.: Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment. Journal of Virology 87 (19), pp. 10612 - 10627 (2013)
10.
Journal Article
Werner, H. B.; Krämer-Albers, E.-M.; Strenzke, N.; Saher, G.; Tenzer, S.; Ohno-Iwashita, Y.; Monasterio-Schrader, P. d.; Möbius, W.; Moser, T.; Griffiths, I. R. et al.; Nave, K.-A.: A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system. GLIA, 10.1002/glia.22456 (2012)
11.
Journal Article
Saher, G.; Rudolphi, F.; Corthals, K.; Ruhwedel, T.; Schmidt, K.-F.; Löwel, S.; Dibaj, P.; Barrette, B.; Möbius, W.; Nave, K.-A.: Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet. Nature Medicine 18 (7), pp. 1130 - 1135 (2012)
12.
Journal Article
Fünfschilling, U.; Jockusch, W. J.; Sivakumar, N.; Möbius, W.; Corthals, K.; Li, S.; Quintes, S.; Kim, Y.; Schaap, I. A. T.; Rhee, J.-S. et al.; Nave, K.-A.; Saher, G.: Critical time window of neuronal cholesterol synthesis during neurite outgrowth. Journal of Neuroscience 32 (22), pp. 7632 - 7645 (2012)
13.
Journal Article
Chrast, R.; Saher, G.; Nave, K.-A.; Verheijen, M. H. G.: Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models. Journal of Lipid Research 52 (3), pp. 419 - 434 (2011)
14.
Journal Article
Kassmann, C. M.; Quintes, S.; Rietdorf, J.; Möbius, W.; Sereda, M. W.; Nientiedt, T.; Saher, G.; Baes, M.; Nave, K.-A.: A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity. FEBS Letters 585, pp. 2205 - 2211 (2011)
15.
Journal Article
Saher, G.; Quintes, S.; Nave, K.-A.: Cholesterol: a novel regulatory role in myelin formation. The Neuroscientist 17 (1), pp. 79 - 93 (2011)
16.
Journal Article
Quintes, S.; Goebbels, S.; Saher, G.; Schwab, M. H.; Nave, K.-A.: Neuron-glia signaling and the protection of axon function by Schwann cells. Journal of the Peripheral Nervous Systems 15 (1), pp. 10 - 16 (2010)
17.
Journal Article
Saito, K.; Dubreuil, V.; Arai, Y.; Wilsch-Bräuninger, M.; Schwudke, D.; Saher, G.; Miyata, T.; Breier, G.; Thiele, C.; Shevchenko, A. et al.; Nave, K.-A.; Huttner, W. B.: Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Proceedings of the National Academy of Sciences of the United States of America 106 (20), pp. 8350 - 8355 (2009)
18.
Journal Article
Saher, G.; Quintes, S.; Möbius, W.; Wehr, M. C.; Krämer-Albers, E.-M.; Brügger, B.; Nave, K.-A.: Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction. Journal of Neuroscience 29 (19), pp. 6094 - 6104 (2009)
19.
Journal Article
Fünfschilling, U.; Saher, G.; Xiao, L.; Möbius, W.; Nave, K.-A.: Survival of adult neurons lacking cholesterol synthesis in vivo. BMC Neuroscience 8, 1471-2202/8/1 (2007)
20.
Journal Article
Saher, G.; Brügger, B.; Lappe-Siefke, C.; Möbius, W.; Tozawa, R.-i.; Wehr, M. C.; Wieland, F.; Ishibashi, S.; Nave, K.-A.: High cholesterol level is essential for myelin membrane growth. Nature Neuroscience 8 (4), pp. 468 - 475 (2005)
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