Publications

52.

Journal Article

Jochheim, F. A.; Tegunov, D.; Hillen, H. S.; Schmitzova, J.; Kokic, G.; Dienemann, C.; Cramer, P.: The structure of a dimeric form of SARS-CoV-2 polymerase. Communications Biology 4, 999 (2021)

MPG.PuRe

53.

Journal Article

Zumer, K.; Maier, K. C.; Farnung, L.; Jaeger, M. G.; Rus, P.; Winter, G.; Cramer, P.: Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo. Molecular Cell 81 (15), pp. 3096 - 3109.e8 (2021)

MPG.PuRe

54.

Journal Article

Wang, H.; Xiong, L.; Cramer, P.: Structures and implications of TBP–nucleosome complexes. Proceedings of the National Academy of Sciences of the USA 118 (30), e2108859118 (2021)

MPG.PuRe

55.

Journal Article

Schilbach, S.; Aibara, S.; Dienemann, C.; Grabbe, F.; Cramer, P.: Structure of RNA polymerase II pre-initiation complex at 2.9 Å defines initial DNA opening. Cell 184 (15), pp. 4064 - 4072.e28 (2021)

MPG.PuRe

56.

Journal Article

Chen, Y.; Vos, S. M.; Dienemann, C.; Ninov, M.; Urlaub, H.; Cramer, P.: Allosteric transcription stimulation by RNA polymerase II super elongation complex. Molecular Cell 81 (16), pp. 3386 - 3399.e10 (2021)

MPG.PuRe

57.

Journal Article

Aibara, S.; Schilbach, S.; Cramer, P.: Structures of mammalian RNA polymerase II pre-initiation complexes. Nature 594 (7861), pp. 124 - 128 (2021)

MPG.PuRe

58.

Journal Article

Rengachari, S.; Schilbach, S.; Aibara, S.; Dienemann, C.; Cramer, P.: Structure of the human Mediator-RNA polymerase II pre-initiation complex. Nature 594 (7861), pp. 129 - 133 (2021)

MPG.PuRe

59.

Journal Article

Osman, S.; Mohammad, E.; Lidschreiber, M.; Stuetzer, A.; Bazsó, F. L.; Maier, K. C.; Urlaub, H.; Cramer, P.: The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II. Journal of Biological Chemistry 296, 100734 (2021)

MPG.PuRe

60.

Journal Article

Oberbeckmann, E.; Niebauer, V.; Watanabe, S.; Farnung, L.; Moldt, M.; Schmid, A.; Cramer, P.; Peterson, C. L.; Eustermann, S.; Hopfner, K.-P. et al.; Korber, P.: Ruler elements in chromatin remodelers set nucleosome array spacing and phasing. Nature Communications 12, 3232 (2021)

MPG.PuRe

61.

Journal Article

Fianu, I.; Dienemann, C.; Aibara, S.; Schilbach, S.; Cramer, P.: Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2. Communications Biology 4, 606 (2021)

MPG.PuRe

62.

Journal Article

Caizzi, L.; Monteiro-Martins, S.; Schwalb, B.; Lysakovskaya, K.; Schmitzova, J.; Sawicka, A.; Chen, Y.; Lidschreiber, M.; Cramer, P.: Efficient RNA polymerase II pause release requires U2 snRNP function. Molecular Cell 81 (9), pp. 1920 - 1934.e9 (2021)

MPG.PuRe

63.

Journal Article

Hillen, H. S.; Markov, D. A.; Wojtas, I. D.; Hofmann, K. B.; Lidschreiber, M.; Cowan, A. T.; Jones, J. L.; Temiakov, D.; Cramer, P.; Anikin, M.: The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs. Proceedings of the National Academy of Sciences of the USA 118 (15), e2009329118 (2021)

MPG.PuRe

64.

Journal Article

Farnung, L.; Ochmann, M.; Engeholm, M.; Cramer, P.: Structural basis of nucleosome transcription mediated by Chd1 and FACT. Nature Structural and Molecular Biology 28 (4), pp. 382 - 387 (2021)

MPG.PuRe

65.

Journal Article

Choi, J.; Lysakovskaia, K.; Stik, G.; Demel, C.; Söding, J.; Tian, T. V.; Graf, T.; Cramer, P.: Evidence for additive and synergistic action of mammalian enhancers during cell fate determination. eLife 10, e65381 (2021)

MPG.PuRe

66.

Journal Article

Rawat, P.; Böhning, M.; Hummel, B.; Aprile-Garcia, F.; Pandit, A. S.; Eisenhardt, N.; Khavaran, A.; Niskanen, E.; Vos, S. M.; Palvimo, J. J. et al.; Pichler, A.; Cramer, P.; Sawarkar, R.: Stress-induced nuclear condensation of NELF drives transcriptional downregulation. Molecular Cell 81 (5), pp. 1013 - 1026.e11 (2021)

MPG.PuRe

67.

Journal Article

Endres, T.; Solvie, D.; Heidelberger, J. B.; Andriolett, V.; Baluapuri, A.; Ade, C. P.; Muhar, M.; Eilers, U.; Vos, S. M.; Cramer, P. et al.; Zuber, J.; Beli, P.; Popov, N.; Wolf, E.; Gallant, P.; Eilers, M.: Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters. Molecular Cell 81 (4), pp. 830 - 844.e13 (2021)

MPG.PuRe

68.

Journal Article

Sawicka, A.; Villamil, G.; Lidschreiber, M.; Darzacq, X.; Dugast‐Darzacq, C.; Schwalb, B.; Cramer, P.: Transcription activation depends on the length of the RNA polymerase II C‐terminal domain. EMBO Journal 40 (9), e107015 (2021)

MPG.PuRe

69.

Journal Article

Tegunov, D.; Xue, L.; Dienemann, C.; Cramer, P.; Mahamid, J.: Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.5 Å in cells. Nature Methods 18 (2), pp. 186 - 193 (2021)

MPG.PuRe

70.

Journal Article

Zhang, S.; Aibara, S.; Vos, S. M.; Agafonov, D.; Lührmann, R.; Cramer, P.: Structure of a transcribing RNA polymerase II–U1 snRNP complex. Science 371 (6526), pp. 305 - 309 (2021)

MPG.PuRe

71.

Journal Article

Kokic, G.; Hillen, H. S.; Tegunov, D.; Dienemann, C.; Seitz, F.; Schmitzova, J.; Farnung, L.; Siewert, A.; Höbartner, C.; Cramer, P.: Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nature Communications 12, 279 (2021)

MPG.PuRe

72.

Journal Article

Kokic, G.; Hillen, H. S.; Tegunov, D.; Dienemann, C.; Seitz, F.; Schmitzova, J.; Farnung, L.; Siewert, A.; Höbartner, C.; Cramer, P.: Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nature Communications 12, 279 (2021)

MPG.PuRe

73.

Journal Article

Cramer, P.; Kokic, G.; Dienemann, C.; Höbartner, C.; Hillen, H. S.: Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir. Biospektrum 27 (1), pp. 49 - 53 (2021)

MPG.PuRe

74.

Journal Article

Kim, K.-P.; Choi, J.; Yoon, J.; Bruder, J. M.; Shin, B.; Kim, J.; Arauzo-Bravo, M. J.; Han, D.; Wu, G.; Han, D. W. et al.; Kim, J.; Cramer, P.; Schöler, H. R.: Permissive epigenomes endow reprogramming competence to transcriptional regulators. Nature Chemical Biology 17 (1), pp. 47 - 56 (2021)

MPG.PuRe

75.

Journal Article

Lidschreiber, K.; Jung, L. A.; von der Emd, H.; von der Emde, H.; Dave, K.; Taipale, J.; Cramer, P.; Lidschreiber, M.: Transcriptionally active enhancers in human cancer cells. Molecular Systems Biology 17 (1), e9873 (2021)

MPG.PuRe

76.

Journal Article

Lykke-Andersen, S.; Zumer, K.; Molska, E. Š.; Rouvière, J. O.; Wu, G.; Demel, C.; Schwalb, B.; Schmid, M.; Cramer, P.; Jensen, T. H.: Integrator is a genome-wide attenuator of non-productive transcription. Molecular Cell, in Press (2020)

MPG.PuRe

77.

Journal Article

Bonekamp, N. A.; Peter, B.; Hillen, H. S.; Felser, A.; Bergbrede, T.; Choidas, A.; Horn, M.; Unger, A.; Di Lucrezia, R.; Atanassov, I. et al.; Li, X.; Koch, U.; Menninger, S.; Boros, J.; Habenberger, P.; Giavalisco, P.; Cramer, P.; Denzel, M. S.; Nussbaumer, P.; Klebl, B.; Falkenberg, M.; Gustafsson, C. M.; Larsson, N.-G.: Small-molecule inhibitors of human mitochondrial DNA transcription. Nature 588 (7839), pp. 712 - 716 (2020)

MPG.PuRe

78.

Journal Article

Osman, S.; Cramer, P.: Structural biology of RNA polymerase II transcription: 20 years on. Annual Review of Cell and Developmental Biology 36, pp. 1 - 34 (2020)

MPG.PuRe

79.

Journal Article

Maier, K. C.; Gressel, S.; Cramer, P.; Schwalb, B.: Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms. Genome Research 30 (9), pp. 1332 - 1344 (2020)

MPG.PuRe

80.

Journal Article

Cramer, P.: Rosalind Franklin and the advent of molecular biology. Cell 182 (4), pp. 787 - 789 (2020)

MPG.PuRe

81.

Journal Article

Tellier, M.; Zaborowska, J.; Caizzi, L.; Mohammad, E.; Velychko, T.; Schwalb, B.; Ferrer-Vicens, I.; Blears, D.; Nojima, T.; Cramer, P. et al.; Murphy, S.: CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation. Nucleic Acids Research 48 (14), pp. 7712 - 7727 (2020)

MPG.PuRe

82.

Journal Article

Hillen, H.; Kokic, G.; Farnung, L.; Dienemann, C.; Tegunov, D.; Cramer, P.: Structure of replicating SARS-CoV-2 polymerase. Nature 584 (7819), pp. 154 - 156 (2020)

MPG.PuRe

83.

Journal Article

O’Reilly, F. J.; Xue, L.; Graziadei, A.; Sinn, L.; Lenz, S.; Tegunov, D.; Blötz, C.; Singh, N.; Hagen, W. J. H.; Cramer, P. et al.; Stülke, J.; Mahamid, J.; Rappsilber, J.: In-cell architecture of an actively transcribing-translating expressome. Science 369 (6503), pp. 554 - 557 (2020)

MPG.PuRe

84.

Journal Article

Jaeger, M. G.; Schwalb, B.; Mackowiak, S. D.; Velychko, T.; Hanzl, A.; Imrichova, H.; Brand, M.; Agerer, B.; Chorn, S.; Nabet, B. et al.; Ferguson, F. M.; Müller, A. C.; Bergthaler, A.; Gray, N. S.; Bradner, J. E.; Bock, C.; Hnisz, D.; Cramer, P.; Winter, G. E.: Selective Mediator dependence of cell-type-specifying transcription. Nature Genetics 52 (7), pp. 719 - 727 (2020)

MPG.PuRe

85.

Journal Article

Stik, G.; Vidal, E.; Barrero, M.; Cuartero, S.; Vila-Casadesús, M.; Mendieta-Esteban, J.; Tian, T. V.; Choi, J.; Berenguer, C.; Abad, A. et al.; Borsari, B.; le Dily, F.; Cramer, P.; Marti-Renom, M. A.; Stadhouders, R.; Graf, T.: CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response. Nature Genetics 52 (7), pp. 655 - 661 (2020)

MPG.PuRe

86.

Journal Article

Vos, S. M.; Farnung, L.; Linden, A.; Urlaub, H.; Cramer, P.: Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation. Nature Structural and Molecular Biology 27 (7), pp. 668 - 677 (2020)

MPG.PuRe

87.

Journal Article

Farnung, L.; Ochmann, M.; Cramer, P.: Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations. eLife 9, e56178 (2020)

MPG.PuRe

ZIP

88.

Journal Article

Parfentev, I.; Schilbach, S.; Cramer, P.; Urlaub, H.: An experimentally generated peptide database increases the sensitivity of XL-MS with complex samples. Journal of proteomics 220, 103754 (2020)

MPG.PuRe

89.

Journal Article

Dodonova, S. O.; Zhu, F.; Dienemann, C.; Taipale, J.; Cramer, P.: Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature 580 (7805), pp. 669 - 672 (2020)

MPG.PuRe

pre-print

90.

Journal Article

Wagner, F. R; Dienemann, C.; Wang, H.; Stützer, A.; Tegunov, D.; Urlaub, H.; Cramer, P.: Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome. Nature 579 (7799), pp. 448 - 451 (2020)

MPG.PuRe

91.

Journal Article

Cramer, P.: 500 years after the first circumnavigation of the world: The efforts, rewards and drawbacks of exploration. FEBS Letters 594 (2), pp. 207 - 208 (2020)

MPG.PuRe

92.

Journal Article

Lefranc, J.; Schulze, V. K.; Hillig, R. C.; Briem, H.; Prinz, F.; Mengel, A.; Heinrich, T.; Balint, J.; Rengachari, S.; Irlbacher, H. et al.; Stockigt, D.; Bömer, U.; Bader, B.; Gradl, S. N.; Nising, C. F.; von Nussbaum, F.; Mumberg, D.; Panne, D.; Wengner, A. M.: Discovery of BAY-985, a highly selective TBK1/IKK epsilon inhibitor. Journal of Medicinal Chemistry 63 (2), pp. 601 - 612 (2020)

MPG.PuRe

93.

Journal Article

Söding, J.; Zwicker, D.; Sohrabi-Jahromi, S.; Boehning, M.; Kirschbaum, J.: Mechanisms for active regulation of biomolecular condensates. Trends in Cell Biology 30 (1), pp. 4 - 14 (2020)

MPG.PuRe

94.

Journal Article

Wang, H.; Dienemann, C.; Stützer, A.; Urlaub, H.; Cheung, A. C. M.; Cramer, P.: Structure of the transcription coactivator SAGA. Nature 577, pp. 717 - 720 (2020)

MPG.PuRe

95.

Journal Article

Wang, H.; Farnung, L.; Dienemann, C.; Cramer, P.: Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding. Nature Structural and Molecular Biology 27 (1), pp. 8 - 13 (2020)

MPG.PuRe

96.

Journal Article

Grimm, C.; Hillen, H. S.; Bedenk, K.; Bartuli, J.; Neyer, S.; Zhang, Q.; Hüttenhofer, A.; Erlacher, M.; Dienemann, C.; Schlosser, A. et al.; Urlaub, H.; Böttcher, B.; Szalay, A. A.; Cramer, P.; Fischer, U.: Structural basis of poxvirus transcription: Vaccinia RNA polymerase complexes. Cell 179 (7), pp. 1537 - 1550 (2019)

MPG.PuRe

97.

Journal Article

Hillen, H. S.; Bartuli, J.; Grimm, C.; Dienemann, C.; Bedenk, K.; Szalay, A. A.; Fischer, U.; Cramer, P.: Structural basis of poxvirus transcription: Transcribing and capping vaccinia complexes. Cell 179 (7), pp. 1525 - 1536 (2019)

MPG.PuRe

98.

Journal Article

Tegunov, D.; Cramer, P.: Real-time cryo-electron microscopy data preprocessing with Warp. Nature Methods 16, pp. 1146 - 1152 (2019)

MPG.PuRe

99.

Journal Article

Chang, C. T.; Muthukumar, S.; Weber, R.; Levdansky, Y.; Chen, Y.; Bhandari, D.; Igreja, C.; Wohlbold, L.; Valkov, E.; Izaurralde, E.: A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5 '-3 ' messenger RNA decay. Nucleic Acids Research 47 (17), pp. 9282 - 9295 (2019)

MPG.PuRe

100.

Journal Article

Zhang, S.; Tischer, T.; Barford, D.: Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C. Nature Communications 10, 3863 (2019)

MPG.PuRe